Gene Information

Name : A225_3756 (A225_3756)
Accession : YP_006499452.1
Strain : Klebsiella oxytoca E718
Genome accession: NC_018106
Putative virulence/resistance : Resistance
Product : Cobalt-zinc-cadmium resistance protein CzcA, Cation efflux system protein CusA
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 3948902 - 3951964 bp
Length : 3063 bp
Strand : +
Note : -

DNA sequence :
ATGGATATTTCCCGCCAGTTTATTAACAACCCGGTCCGCGTCTGGCTGACCATTTTGCTGCTGGGCATCGGCGGGATCTT
CGCTCTGCTGAATATTGGCCGCCTGGAAGATCCGGCGTTTACCATCAAAACCGCGGTGGTGGTCACCCACTATCCCGGCG
CGTCGGCGCAGCAGGTGGAAGAAGAAGTCACCCTGCCGCTGGAAAACGCGCTGCAGCAGCTGCCGTATCTCGACAACGTC
AGCTCAATTTCCTCCAACGGCCTGTCGCAAATTACCGTCAATATCGCCTCGCGCTACCACTCCCGCGAGCTGCCGCAAAT
CTGGGATGAACTGCGCCGCCGGGTGGGCGACGCCGCCCGCCAGTTTCCTCCCGGCGTCGCCGCTCCGTTTGTGAACGACG
ATTTTGGCGATGTCTTTGGCTTCTTCTTTGCCCTCTCCGGCGAGAGCTTTACCAACCCTGAGCTGGTTCGCTATGCCGAG
CAGCTGCGTCGCGAACTGGTGCTGGTCCCCGGCGTCGGCAAAGTCGCCATCGGCGGGGCGATCCCCCAGCAAATCAACAT
CGATATCTCGCTGGCGAAAATGGCCGCCCGCGGAATCACGCTCAACCAGCTGGCGGCGATACTGAGCAGGTTGAACGTGG
TGTCTAACGCCGGTGAGATTAAATCCGGCAGCGAATCGATTCGCCTGCATCCCACGGGCGAGTTTGCCAACCTCGACGAG
CTTGGCGACCTGTTAATCAGCCCGCACGGCTCGGCAACGGCGACGCGGCTGCGCGATATTGCCACGCTCTCGCGCGGGCT
GAGCGAATCGCCTTCCAGCATTTACCACGCCAACGGTCGACAGGCGGTCACTATGGGGGTGTCGTTTATACCCGGGGTTA
ACGTGATTGACGTTGGCCGCGCGCTGGAAAGCAAGCTGGAGCAGATGTCGGCGGAAAAACCGGCCGGGATCAACATTGAC
CTGTTCTACGATCAGGCGGCGGAAGTCGCCCATTCGGTCAACGGCTTTATCACCAACTTCCTGATGGCGCTGGCGATTGT
GGTTGGCGTGCTGCTGATCTTTATGGGCGTACGCAGCGGCATTATTATCGCCCTGTCGCTGGCGCTCAACGTGCTCGGTA
CGCTGCTGATCATGTACCTGTGGGGTATCGAGCTGCAGCGTATCTCGCTGGGGGCGTTGATTATCGCCCTGAGCATGCTG
GTCGATAACGCGATCGTCATCGTCGAAGGCGTGCTGATCGCCCGCCAGCAGGGGTCAACGCTGCTCATGGCGATTAACTA
TGTGATCCGCCGTTCGGCGCTGCCGCTGCTGGGGGCCACGGTGATTGCTATTCTCGCCTTTGCGCCGATTGGCCTGTCGC
AGGACTCGACCGGCGAATACTGTAAATCGCTGTTCCAGGTGCTGCTGATTTCGCTCATGCTGAGCTGGTTCTCGGCGCTG
ACCATTACCCCGGTGCTGATTAAATGGTGGCTGTTTAAAAATCAATCGCAGCCGGTGGCGCAGGCCGACGCCAATCCGTA
CGGCGGGCGATTTTACCGTCTGTACCAGCAGGCTCTGCGTGCTCTTCTGCTGCGCAAAACCATTACGCTGACCGTCATGG
CGGCGCTGCTGGCCGCCGCTATCTGGGGATTCGGCTCGGTGCGGCAAAACTTTTTCCCCTCTTCAAACACGCCCATTTTC
TTTGTCGATCTCTGGCTACCCTACGGTACCGATATCGCGACCACCGAAAAGATGACCAGCGATATTGAGACCACCATTAA
CGGCCAGCCGGGCGTGGTCACCACCGTGGCCACCGTCGGTCAGGGCAGCATGCGGTTTATCCTCACCTACAGCGGGCAAC
GGCAGTACAGCAACTATGCGCAAATCATGGTGCGCATGGACGACCAGCGCAGCATTGCCGCCCTGACGCAGCACGTGGAT
CGCTATATTGCGCGCAACTACCCGCAGGTGAACGCCAGCACGAAACGCGTGATGTTCGGTCCCTCCGGCGACAGCGCCAT
CGAGGTGCGGATTAAAGGTCCGGACCCCGACCGTCTGCGCCTGCTCGCCAGCCAGGTTGGCGATATCCTCTCCGCGGACC
CGGCCACCGACGGCGTTCGCAACGACTGGCAAAACCGTAGCAAAGTTATTCGTCCGCAGTACTCCCCCGCGCTTGGGCGC
GAGCTGGGCGTTGATAAACAGGATATTGATAACGCCCTGGAGATGAACTTCTCCGGCAGCCGCGTTGGATTGTACCGTGA
GGGGGCCGACCTGCTGCCGACGATCGTCCGCCCGCCCGCCGCCGAGCGCCAGGACGCGAATCACCTGAATAACGTGCTGG
TCTGGAGCCAGAGCCGCCAGCAGTATATTCCGCTCAGTAACGTGGTCAGCGGCTTTCACCTTGAATGGGAAGATCCGCTG
ATTCTGCGCCGCGATCGCAGCCGGGTGCTGACGGTACAGACCGATCCCGACCCGCTCAGCCACCAGACGTCGGGGGATAT
CCTGTCCCGCGTGAAGCCGCAGATTGATGCGCTCGCTCTGCCGCACGGTTACAGCATTGAGTGGGGTGGCGATGCGGAGA
ACTCCAGCGAGGCGCAGCAGGGGCTGTTTACTACCCTGCCGCTGGGTTACCTGGTGATGTTTGTCATCACCGTCCTGATG
TTCAGTTCGCTGAAAAATGCGATCGCCATCTGGCTGACCGTGCCGCTGGCGCTGATTGGCGTTACGCCGGGCTTTTTAAT
TACCGGGATCCCTTTTGGATTTATGGCGTTAATCGGTCTGCTGAGCCTGAGCGGAATGCTGATCCGTAACGGCATCGTGC
TGGTAGAAGAGATTGAACAGCAGAAACAGGAAAAAGCGCAGCAGGAGGCGATTATTGATGCCGCCACTTCGCGTCTGCGC
CCTATCCTGCTGACGGCGTTTACCACCGTGCTCGGCCTGGCGCCTTTATTACTCGACGTTTTCTTCCAGAGCATGGCGGT
CGTTATCATGTTTGGTCTGGGTTTTGCTACTATTCTGACGCTGCTGGTTCTGCCGGTAATCTACGCCTGTTTCCACAATC
AGAATATGAAGCGACAACCATGA

Protein sequence :
MDISRQFINNPVRVWLTILLLGIGGIFALLNIGRLEDPAFTIKTAVVVTHYPGASAQQVEEEVTLPLENALQQLPYLDNV
SSISSNGLSQITVNIASRYHSRELPQIWDELRRRVGDAARQFPPGVAAPFVNDDFGDVFGFFFALSGESFTNPELVRYAE
QLRRELVLVPGVGKVAIGGAIPQQINIDISLAKMAARGITLNQLAAILSRLNVVSNAGEIKSGSESIRLHPTGEFANLDE
LGDLLISPHGSATATRLRDIATLSRGLSESPSSIYHANGRQAVTMGVSFIPGVNVIDVGRALESKLEQMSAEKPAGINID
LFYDQAAEVAHSVNGFITNFLMALAIVVGVLLIFMGVRSGIIIALSLALNVLGTLLIMYLWGIELQRISLGALIIALSML
VDNAIVIVEGVLIARQQGSTLLMAINYVIRRSALPLLGATVIAILAFAPIGLSQDSTGEYCKSLFQVLLISLMLSWFSAL
TITPVLIKWWLFKNQSQPVAQADANPYGGRFYRLYQQALRALLLRKTITLTVMAALLAAAIWGFGSVRQNFFPSSNTPIF
FVDLWLPYGTDIATTEKMTSDIETTINGQPGVVTTVATVGQGSMRFILTYSGQRQYSNYAQIMVRMDDQRSIAALTQHVD
RYIARNYPQVNASTKRVMFGPSGDSAIEVRIKGPDPDRLRLLASQVGDILSADPATDGVRNDWQNRSKVIRPQYSPALGR
ELGVDKQDIDNALEMNFSGSRVGLYREGADLLPTIVRPPAAERQDANHLNNVLVWSQSRQQYIPLSNVVSGFHLEWEDPL
ILRRDRSRVLTVQTDPDPLSHQTSGDILSRVKPQIDALALPHGYSIEWGGDAENSSEAQQGLFTTLPLGYLVMFVITVLM
FSSLKNAIAIWLTVPLALIGVTPGFLITGIPFGFMALIGLLSLSGMLIRNGIVLVEEIEQQKQEKAQQEAIIDAATSRLR
PILLTAFTTVLGLAPLLLDVFFQSMAVVIMFGLGFATILTLLVLPVIYACFHNQNMKRQP

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
VC0395_A1355 YP_001217299.1 AcrB/AcrD/AcrF family transporter Not tested VPI-2 Protein 4e-157 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
A225_3756 YP_006499452.1 Cobalt-zinc-cadmium resistance protein CzcA, Cation efflux system protein CusA BAC0519 Protein 0.0 50
A225_3756 YP_006499452.1 Cobalt-zinc-cadmium resistance protein CzcA, Cation efflux system protein CusA BAC0428 Protein 0.0 50
A225_3756 YP_006499452.1 Cobalt-zinc-cadmium resistance protein CzcA, Cation efflux system protein CusA BAC0526 Protein 0.0 47
A225_3756 YP_006499452.1 Cobalt-zinc-cadmium resistance protein CzcA, Cation efflux system protein CusA BAC0425 Protein 2e-157 41