Gene Information

Name : Tsac_0772 (Tsac_0772)
Accession : YP_006391393.1
Strain : Thermoanaerobacterium saccharolyticum JW/SL-YS485
Genome accession: NC_017992
Putative virulence/resistance : Resistance
Product : D-alanine--D-alanine ligase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 810577 - 811665 bp
Length : 1089 bp
Strand : +
Note : TIGRFAM: D-alanine--D-alanine ligase; HAMAP: D-alanine--D-alanine ligase; KEGG: txy:Thexy_0178 D-alanine--D-alanine ligase; PFAM: D-alanine--D-alanine ligase, C-terminal; D-alanine--D-alanine ligase, N-terminal

DNA sequence :
ATGGATAAGCTTAAAGTAGCTGTATTGTTTGGGGGGCAGTCTGGAGAACATGAAGTTTCAAGGGTTTCAGCCACTTCTAT
AATTAACAATATAGATAGAGAAAAGTACGAAGTCTACATGGTAGGCATAACGAAAAATGGTCAATGGTATTTATACAGTG
GAGATGTCCACAAGATCGCCACAGGCGAATGGGAAAAAGAAGCTGTGCCTGCTTTGATAGGACCTTCTACTAAGTACAAG
GGGATAATCGCATTTAAAGACGGGAGCTACGAATTTTATCCCATTGATGTAGTTTTTCCAGTTTTGCATGGGCCCAATGG
AGAAGATGGAACGGTACAGGGCCTTTTGGAGCTTCTTGAGATGCCGTATGTGGGGCCTAACGTGCTTTCGTCATCGTTGT
GTATGGATAAGGTCTTTTCAAAGAGGATTTTTTTGGAGTCTGGCATACCTACGCCGAAGTTTACAGTCGTATACAGAAAA
GATGTAAATGATGCAGAGAAGTATGAATATATAAAAAGCGAAATATTAGAAAAGATTGGATATCCTTGTTTTGTAAAGCC
GGCAAACATGGGTTCAAGTGTTGGAATAACAAAAGTTCACAATGAAGGCGAGCTGTTTGATGCCTTGAAAATTGCTGCAA
AGTATGATAGAAAGATTATTGTAGAAGAAGGCATTGATGCAAGAGAAATTGAGTGCTCCGTTTTAGGCAATGACAATCCA
GAAGCGTCTGTCGCTGGCGAGATTGTTCCGGCACATGAATTTTACGATTACGATGCAAAGTATTTTGATGAAGCATCAAA
ACTTTTCATTCCGGCGCCTATACCTGATGCTAAGATGGAGGAGATAAGAGATTTGGCAATAAAAGCGTATACGGCATTAG
ACGTGAGGGGAATGGCCAGAGTAGACTTTTTGATGGACAAAAATACGGGTAAAGTCTACTTGAATGAATTAAATACGATT
CCAGGATTTACCCAAATCAGCATGTATCCTAAGCTCTGGGAGGCATCGGGAAAGCCATACAGCAAATTGATTGATGAGCT
TATACAATTGGCTTTATCTGCTTACAATGAGAAATGTACAAACTGGTAA

Protein sequence :
MDKLKVAVLFGGQSGEHEVSRVSATSIINNIDREKYEVYMVGITKNGQWYLYSGDVHKIATGEWEKEAVPALIGPSTKYK
GIIAFKDGSYEFYPIDVVFPVLHGPNGEDGTVQGLLELLEMPYVGPNVLSSSLCMDKVFSKRIFLESGIPTPKFTVVYRK
DVNDAEKYEYIKSEILEKIGYPCFVKPANMGSSVGITKVHNEGELFDALKIAAKYDRKIIVEEGIDAREIECSVLGNDNP
EASVAGEIVPAHEFYDYDAKYFDEASKLFIPAPIPDAKMEEIRDLAIKAYTALDVRGMARVDFLMDKNTGKVYLNELNTI
PGFTQISMYPKLWEASGKPYSKLIDELIQLALSAYNEKCTNW

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
vanB YP_008394259.1 Vancomycin B-type resistance protein vanB, D-alanine--D-lactate ligase Not tested Not named Protein 5e-56 41
vanB NP_815951.1 D-alanine--D-lactate ligase Not tested Not named Protein 3e-56 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Tsac_0772 YP_006391393.1 D-alanine--D-alanine ligase AF277571.gene.p01 Protein 6e-56 42
Tsac_0772 YP_006391393.1 D-alanine--D-alanine ligase AY489045.gene.p01 Protein 3e-55 42
Tsac_0772 YP_006391393.1 D-alanine--D-alanine ligase U00456.gene.p01 Protein 1e-56 41
Tsac_0772 YP_006391393.1 D-alanine--D-alanine ligase AF310956.2.orf5.gene Protein 1e-56 41
Tsac_0772 YP_006391393.1 D-alanine--D-alanine ligase U35369.1.gene6.p01 Protein 1e-56 41
Tsac_0772 YP_006391393.1 D-alanine--D-alanine ligase AE016830.1.gene2250. Protein 1e-56 41
Tsac_0772 YP_006391393.1 D-alanine--D-alanine ligase AY145441.gene.p01 Protein 4e-57 41
Tsac_0772 YP_006391393.1 D-alanine--D-alanine ligase AF130997.1.orf4.gene Protein 9e-53 41