Gene Information

Name : MWE_0973 (MWE_0973)
Accession : YP_006338465.1
Strain : Helicobacter pylori XZ274
Genome accession: NC_017926
Putative virulence/resistance : Virulence
Product : cytotoxin-associated protein A
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 883301 - 886894 bp
Length : 3594 bp
Strand : -
Note : -

DNA sequence :
ATGACTAACGAAACCATTGATCAAACAACAACACCAGATCAAACACTAAACCAAACGGATTTTGTTCCGCAACGATTTAT
CAATAATCTTCAAGTAGCTTTCCTTAAAGTTGATGACGCTGTCGCTTCATTTGATCCCGATCAAAAACCAATCGTTGATA
AGAATGATAGGGATAATAGGCAAGCTTTTGAGAAAATCTCGCAACTAAGGGAAGAATACGCCAATAAAGCGATCAAAAAT
CCCACCAAAAAGAATCAGTATTTTTCAGACTTTATCAATAAGAGCAATGATTTGATCAACAAAGACAATCTCATTGCTGT
AGATTCTTCCGTAGAGAGCTTTAAGAAATTTGGGGATCAGCGTTACCAAATTTTTACGAGTTGGGTGTCCCTTCAAAAAG
ATCCGTCTAAAATCAACACCCAACAAATCCGAAATTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAGGAA
AAAGCAGAGTTTTTGAGGTCTGCCAAACAATCTTTTGCAGGAATTATCATAGGGAATCAAATCCGATCGGATGAAAAATT
CATGGGCGTGTTTGATGAATCTTTGAAAGAAAGGCAAGAAGCAGAAAAAAATGGAGAGCCTGATGGTGGGGATTGGTTGG
ATATTTTTTTATCATTTGTATTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCCATCAAGAGCCAAGGCCTGAT
TTTGAACAAAATATAGCCACTACCACCACCGACATACAAGGCTTACCGCCTGAAGCTAGAGATTTGCTTGATGAAAGGGG
TAATTTTTCTAAATTCACTCTTGGTGATATGGAAATGTTAGATGCTGAGGGAGTCGCCGATATTGATCCTAATTACAAGT
TTAATCAATTATTGATCCACAATAACGCTCTATCTTCTGTGTTAATGGGGAGTCATAGTAACATAGAACCTGAAAAGGTT
TCATTATTGTATGGGGATAATGGTGGTCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTTATAAAAACCAACAAGG
CAGTAATGTGGCCACACTCATTAATGCGCATCTTAATAACGGTAGTGGGTTAGTCATAGCGGGTAATGAGGATGGGATTA
AGAACCCTAGCTTCTATCTCTACAAACAAGACCAACTCACAGGCTTGAAACAAGCGTTGAGTCAAGAAGAGATCCAAAAC
AAAGTAGATTTCATGGAATTTCTTGCGCAAAACAATGCTAGGTTAGATAGCTTGAGCGAGAAAGAGAAAGAAAAATTCCA
AACTGAGATTGAAGATTTCCAAAAAGACCGTAAGGCTTATTTAGACGCTCTAGGGAATGATCACATTGCTTTTGTTTCTA
AAAAAGACCCAAAACATTTAGCTTTGGTTACTGAGTTTGGTAATGGGGAAGTGAGCTATACTCTCAAAGATTATGGGAAA
AAACAAGATAAAGCTTTAGATGGGGAGACAAAAACCACTCTTCAAGGTAGCCTAAAATATGATGGCGTGATGTTTGTCAA
TTATTCCAATTTCAAATACACCAACGCCTCCAAGAGTCCTGATAAGGGTGTAGGCACTACGAATGGCGTTTCCCATTTGG
AAGCAAATTTTAGCAAAGTAGCTGTCTTTAATTTGCCTAATTTAAATAATCTCGCTATCACTAATTATATAAGGCGAGAT
TTAGAAGATAAACTGTGGGCTAAAGGATTGTCCTCGCAAGAAGCTAATAAGCTCATCAAAGACTTTTTGAACAGCAACAA
GGAATTGGTTGGAAAAGTTTCAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAATTATGATGAAGTGAAAA
AAGCTCAGAAAGATCTTGAAAAATCTATAAGGAAACGAGAGCATTTAGAGAAAGAAGTAGCGAAAAAATTGGAGAGCAGA
AACGACAACAAAAATGGGATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCGCTTATCAATCAAGA
GGCTAGTAAGGAAGCAAGAGCGGCCGCTTTTGATCCGAATCTTAAAGGCATTAGGAGCGAATTGTCTGATAAACTTGAAA
ATATCAACAAGAATTTGAAAGACTTTGGCAAATCTTTTGATGAACTCAAAAATGGCAACAATAAAGATTTCAGCAAGGCA
GAAGAAACGCTAAAAACCCTTAAAGACTCGATGAAAGATTTAGGCATCAATCCAGAATGGATTTCAAAAGTTGAAAACCT
TAATGCAGCTTTGAATGATTTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACACAAGCAAAAAGCGACCTTGAAA
ATTCCATTAAGGATGTGTCCATCAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAGGCTGTATCAGAGGCTAAA
TTAACAGGCGATTTCAGTAAGGTAGAGCAAGCCCTAGCCGAACTCAAAAACTTGTCATTGGATCAAATTGGAAAAAATTC
TGATCTACAAAAATCCGTTAAAAATGGTGTAAATGGAACCCTAGTCGGTAATGGGTTATCTAAAACAGAAGCCACAACGC
TCACCAAAAATTTTTCGGACATCAGGAAAGAATTGAACGAGAAATTATTTGGAAATTCCAATAACAATAATAATGGACTC
AAAAACAACACAGAGCCTATTTATGCTCAAGTTAATAAAAAGAAAGCAGGACAAGCAACTAGCCCTGAAGAGCCCATTTA
TGCTCAAGTTAATAAAAAGAAAGCAGGACAAGCAACTAGCCCTGAAGAGCCCATTTATACTCAAGTTGCTAAAAAGGTGA
ATGCAAGAATTGATCGACTCAACAAAATTGCATCAACAATAAATGGAAAAATTGACCAACTCAACAGAACTGCGTCAGCA
AATAAAGGAGTGGGCGATTTCAGTGGAGTGGGGCAAGCAGCTAGCCCTGAACCCATTTACGCTACAATTGATTTTGATGA
GGCAAATCAAGCAGGCTTCCCTTTGAGAAGAAGTGCTGCAGTTAATGATCTCAGTAAAGTAGGGCTTTCAAGGGAACAAG
AATTGACTCGTAGAATTGGCGATCTCAATCAGGCAGTATCAGAAGCTAAAACAGGTCATTTTGGCAAACTAGAACAAAAG
ATAGATGAACTCAAAGATTCTACAAAAAAGAATGCTGTGAGTCTATGGGTTGAAAGCGCGAAACAAGTGCCTACTGGTTT
GCAAGCGAAATTGGACAATTACGCTACTAACAGCCACACACGCATTAATAGCAATGTCAAAAATGGAGGAATTAATGAGA
AAGCGACCGGTATGCTAACGCAAAAAAACCCTGAGTGGCTCAAGCTCGTGAATAATAAGATAGTTGCGCATAATGTGGGA
AGCATTCCTTTGTCAGATTATGATAAAATTGGATTCAACCAAAAGAATATGAAAGATTATTCTGATTCGTTCAAGTTTTC
CACCAAGTTGAACAACGCCGTAAAAGACATTAAGTCTAGCTTTGTGCAATTTTTGACCAATACATTTTCTCAAGGATCTT
ACAACTTGATGAAAGCAAATGTGGAACATGGAGTCAAAAATACTAATACAAAAAGTGGTTTCCAGAAATCTTAA

Protein sequence :
MTNETIDQTTTPDQTLNQTDFVPQRFINNLQVAFLKVDDAVASFDPDQKPIVDKNDRDNRQAFEKISQLREEYANKAIKN
PTKKNQYFSDFINKSNDLINKDNLIAVDSSVESFKKFGDQRYQIFTSWVSLQKDPSKINTQQIRNFMENIIQPPISDDKE
KAEFLRSAKQSFAGIIIGNQIRSDEKFMGVFDESLKERQEAEKNGEPDGGDWLDIFLSFVFNKKQSSDLKETLHQEPRPD
FEQNIATTTTDIQGLPPEARDLLDERGNFSKFTLGDMEMLDAEGVADIDPNYKFNQLLIHNNALSSVLMGSHSNIEPEKV
SLLYGDNGGPEARHDWNATVGYKNQQGSNVATLINAHLNNGSGLVIAGNEDGIKNPSFYLYKQDQLTGLKQALSQEEIQN
KVDFMEFLAQNNARLDSLSEKEKEKFQTEIEDFQKDRKAYLDALGNDHIAFVSKKDPKHLALVTEFGNGEVSYTLKDYGK
KQDKALDGETKTTLQGSLKYDGVMFVNYSNFKYTNASKSPDKGVGTTNGVSHLEANFSKVAVFNLPNLNNLAITNYIRRD
LEDKLWAKGLSSQEANKLIKDFLNSNKELVGKVSNFNKAVAEAKNTGNYDEVKKAQKDLEKSIRKREHLEKEVAKKLESR
NDNKNGMEAKAQANSQKDKIFALINQEASKEARAAAFDPNLKGIRSELSDKLENINKNLKDFGKSFDELKNGNNKDFSKA
EETLKTLKDSMKDLGINPEWISKVENLNAALNDFKNGKNKDFSKVTQAKSDLENSIKDVSINQKITDKVDNLNQAVSEAK
LTGDFSKVEQALAELKNLSLDQIGKNSDLQKSVKNGVNGTLVGNGLSKTEATTLTKNFSDIRKELNEKLFGNSNNNNNGL
KNNTEPIYAQVNKKKAGQATSPEEPIYAQVNKKKAGQATSPEEPIYTQVAKKVNARIDRLNKIASTINGKIDQLNRTASA
NKGVGDFSGVGQAASPEPIYATIDFDEANQAGFPLRRSAAVNDLSKVGLSREQELTRRIGDLNQAVSEAKTGHFGKLEQK
IDELKDSTKKNAVSLWVESAKQVPTGLQAKLDNYATNSHTRINSNVKNGGINEKATGMLTQKNPEWLKLVNNKIVAHNVG
SIPLSDYDKIGFNQKNMKDYSDSFKFSTKLNNAVKDIKSSFVQFLTNTFSQGSYNLMKANVEHGVKNTNTKSGFQKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cagA BAC10430.1 CagA Virulence cag PAI Protein 0.0 95
cagA BAC10424.1 CagA Virulence cag PAI Protein 0.0 93
cagA BAC10422.1 CagA Virulence cag PAI Protein 0.0 93
HP0547 BAD13826.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 93
cagA YP_005777288.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 92
HP0547 BAD13963.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 92
cagA YP_005779046.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 92
cagA BAC10435.1 CagA Virulence cag PAI Protein 0.0 92
cagA BAC10421.1 CagA Virulence cag PAI Protein 0.0 92
HP0547 BAD14072.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 92
HP0547 BAD13799.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 92
cagA BAD51755.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 92
cagA BAC10431.1 CagA Virulence cag PAI Protein 0.0 92
HP0547 BAD13880.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 92
cagA AAF17597.1 CagA Virulence cag PAI Protein 0.0 92
cagA YP_005775747.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 92
cagA BAD51754.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 92
cagA BAD51749.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 92
cagA BAD51762.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 92
cagA BAC10433.1 CagA Virulence cag PAI Protein 0.0 92
HP0547 BAD14018.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 92
cagA BAC10426.1 CagA Virulence cag PAI Protein 0.0 91
cagA BAD51744.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 91
cagA BAC10420.1 CagA Virulence cag PAI Protein 0.0 91
cagA YP_005774524.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 91
cagA BAC10419.1 CagA Virulence cag PAI Protein 0.0 91
cagA BAC10423.1 CagA Virulence cag PAI Protein 0.0 90
cagA BAC10427.1 CagA Virulence cag PAI Protein 0.0 89
HP0547 BAD13853.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 89
cagA BAD51764.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 84
cagA BAD51752.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51756.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
HP0547 BAD13935.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAC10429.1 CagA Virulence cag PAI Protein 0.0 81
cagA BAD51759.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51751.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51758.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51760.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA AGC69806.1 cag pathogenicity island protein A Virulence cag PAI Protein 0.0 80
cagA BAD51753.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA YP_003728762.1 cytotoxin-associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51766.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51750.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA BAD51761.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA AAR03939.1 CagA Virulence cag PAI Protein 0.0 79
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen Virulence cag PAI Protein 0.0 78
cagA AAR03909.1 CagA Virulence cag PAI Protein 0.0 78
cagA AAR03970.1 CagA Virulence cag PAI Protein 0.0 78
HP0547 NP_207343.1 cag pathogenicity island protein (cag26) Virulence cag PAI Protein 0.0 78
cagA AAR03881.1 CagA Virulence cag PAI Protein 0.0 78
cagA AAC44706.1 CagA Virulence cag PAI Protein 0.0 77
HP0547 BAD14045.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAC10428.1 CagA Virulence cag PAI Protein 0.0 77
HP0547 BAD13908.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAC10432.1 CagA Virulence cag PAI Protein 0.0 77
HP0547 BAD13990.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAD51747.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 77
cagA AAF17598.1 CagA Virulence cag PAI Protein 0.0 75

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
MWE_0973 YP_006338465.1 cytotoxin-associated protein A VFG0306 Protein 0.0 78