Gene Information

Name : hpaE (PflA506_3396)
Accession : YP_006324855.1
Strain : Pseudomonas fluorescens A506
Genome accession: NC_017911
Putative virulence/resistance : Virulence
Product : 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
Function : -
COG functional category : -
COG ID : -
EC number : 1.2.1.60
Position : 3800744 - 3802204 bp
Length : 1461 bp
Strand : +
Note : identified by similarity to SP:P42269; match to protein family HMM PF00171; match to protein family HMM TIGR02299

DNA sequence :
ATGATCAAACACTGGATCAACGGCCGTGAGGTCGAAAGCAAAGACACCTTTATCAACTACAACCCGGCCACCGGCGAGGC
CATCGGTGAAGTGGCCAGCGGCGGTGCCGAAGAAGTCGCGCAGGCCGTGGCGGCGGCCAAGGCCGCGTTCCCCAAGTGGG
CCAATACGCCGGCCAAAGAGCGCGCGCGCTTGATGCGCAAGCTGGGCGAGCTGATCGAACAGAACGTGCCACACCTGGCC
GAGCTGGAGACCCTGGACACCGGCCTGCCGATCCACCAGACCAAGAATGTGTTGATCCCGCGTGCCTCGCACAACTTCGA
TTTCTTCGCTGAAGTCTGCACCCGCATGGACGGCCACACCTACCCGGTGGACGACCAGATGCTCAATTACACCCTGTACC
AGCCAGTGGGCGTGTGCGGACTGGTGTCGCCCTGGAACGTGCCGTTCATGACCGCCACCTGGAAGACCGCGCCGTGCCTG
GCGCTGGGCAATACGGCGGTGTTGAAGATGTCGGAACTGTCGCCGCTGACCGCCAATGAACTGGGGCGCCTGGCGGTGGA
AGCCGGGATTCCCAATGGCGTGCTCAATGTGATCCAGGGCTACGGCGCCACCGCCGGTGATGCACTGGTGCGCCACCCGG
ACGTGCGGGCGATTTCCTTTACCGGCGGCACCGCCACCGGTAAGAAAATCATGCAGAGCGCCGGCCTGAAAAAGTACTCC
ATGGAACTGGGGGGCAAGTCGCCGGTGCTGATTTTCGAAGACGCCGACCTGGAACGCGCCCTCGACGCCGCACTCTTCAC
GATCTTCTCCCTCAACGGCGAGCGTTGCACCGCTGGCAGCCGGATCTTTATCCAGGAAAGCGTCTACCCGCAATTTGTCG
CCGAATTCGCGGCGCGGGCCAAGCGCCTGATCGTGGGCGACCCCCAGGACCCGAAGACCCAGGTCGGCTCGATGATCACC
CAGGCCCATTACGACAAGGTCACCGGCTATATCAAGATCGGTCTGGAGGAAGGCGCCACGCTGCTGGCCGGTGGCCTGGA
GCGTCCTGCCAACCTGCCGGCGCACCTGAGCCGCGGCCAGTTTATCCAGCCGACGGTGTTTGCCGACGTGAATAACCGGA
TGCGCATCGCCCAGGAGGAAATCTTCGGGCCGGTGGTGTGCCTGATTCCGTTCAAGGATGAAGCCGAGGCACTGCAATTG
GCCAACGACACCGAATACGGGCTGGCCTCCTACATCTGGACCCAGGACATCGGCAAGGCCCACCGCCTGGCGCGCGGTAT
CGAAGCGGGCATGGTATTTATCAACAGCCAGAACGTACGGGATTTGCGCCAGCCGTTCGGCGGGGTCAAAGGCTCGGGCA
CCGGGCGTGAAGGCGGCCAGTACAGCTTCGAAGTGTTTGCCGAGATCAAGAACGTGTGTATTTCCATGGGCAGTCATCAC
ATTCCGCGCTGGGGCGTGTAG

Protein sequence :
MIKHWINGREVESKDTFINYNPATGEAIGEVASGGAEEVAQAVAAAKAAFPKWANTPAKERARLMRKLGELIEQNVPHLA
ELETLDTGLPIHQTKNVLIPRASHNFDFFAEVCTRMDGHTYPVDDQMLNYTLYQPVGVCGLVSPWNVPFMTATWKTAPCL
ALGNTAVLKMSELSPLTANELGRLAVEAGIPNGVLNVIQGYGATAGDALVRHPDVRAISFTGGTATGKKIMQSAGLKKYS
MELGGKSPVLIFEDADLERALDAALFTIFSLNGERCTAGSRIFIQESVYPQFVAEFAARAKRLIVGDPQDPKTQVGSMIT
QAHYDKVTGYIKIGLEEGATLLAGGLERPANLPAHLSRGQFIQPTVFADVNNRMRIAQEEIFGPVVCLIPFKDEAEALQL
ANDTEYGLASYIWTQDIGKAHRLARGIEAGMVFINSQNVRDLRQPFGGVKGSGTGREGGQYSFEVFAEIKNVCISMGSHH
IPRWGV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hpaE AAO17179.1 HpaE Not tested tcd island Protein 7e-173 78
ORF SG19 AAN62241.1 putative aldehyde dehydrogenase Not tested PAGI-3(SG) Protein 4e-66 42
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 1e-61 41
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 7e-62 41
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 7e-62 41
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 7e-62 41
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 2e-61 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
hpaE YP_006324855.1 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase VFG0082 Protein 5e-62 41