Gene Information

Name : W7S_05425 (W7S_05425)
Accession : YP_006304795.1
Strain : Mycobacterium sp. MOTT36Y
Genome accession: NC_017904
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : -
COG ID : -
EC number : 2.5.1.48
Position : 1102313 - 1103491 bp
Length : 1179 bp
Strand : +
Note : COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases

DNA sequence :
ATGAGCGACGACGGCAACCCACACCCCGAGTTCACCGGGCTGGCCACCAAAGCGATTCACGCCGGCTACCGGCCGGACCC
GGCGACCGGAGCGGTCAACGCCCCGATCTACGCCAGCAGCACCTTCGCCCAGGACGGCGTCGGCGCATTGCGGGGCGGAT
TCGAATACGCGCGCACCGGCAACCCGACCCGCGCCGCGCTGGAGGCCGCGCTGGCCGCCGTCGAGGAGGGCAGCTACGGG
CGGGCCTTCGCCTCGGGAATGGCCGCCACCGACTGCGCCCTGCGCGCGGTGCTGCGGCCGGGTGATCACGTCGTGATCCC
GAATGACGCCTACGGCGGCACGTTCCGGCTGATCGACAAGGTCTTCACCCAGTGGAACGTCGACTACACGCCCGTCGCGC
TGCACGAGGTGGACGCCGTCGCCGCCGCGATCACGCCGCGCACCCGGATGATCTGGGTGGAAACCCCGACCAACCCGTTG
CTGTCGGTCGCCGATATCGCCGCCATTGCCGAGCTAGCGGCCGGGCAGGCCGCAAAAAATCGAGCGAAAGTGTTGGTGGA
CAACACCTTTGCCTCACCCGCGCTTCAGCAGCCGCTGACGCTGGGGGCGGACATCGTGCTGCACTCCACCACCAAATACA
TCGGCGGCCATTCCGACGTGGTGGGCGGCGCGCTGGTCACCAACGACCAGGAACTCGACGACGCGTTCGGCTTCCTGCAG
AACGGGGCCGGCGCGGTCCCCGGCCCGTTCGACGCCTACCTGACGATGCGCGGACTGAAGACCCTGGTTCTGCGCATGCA
GCGGCACAGCGAAAACGCCATGGCCGTAGCGGAATTCCTCGCGGGCCATCGCGCGGTGAGCGCGGTGCTGTACCCCGGGC
TGCCCAGCCACCCCGGGCACGAGGTCGCCGCGCGGCAGATGCGCGGGTTCGGCGGCATGGTCTCGGTGCGCATGAAAGGC
GGACGGGACGCCGCCCGGGATCTGTGCGCCAACACCAAGGTGTTCATCCTGGCCGAATCGCTCGGCGGGGTCGAGTCGCT
GATCGAGCACCCCAGCGCGATGACGCATGCGTCGACGGCCGGGTCGCAATTGGAAGTCCCCGACGATCTGGTGCGCCTGT
CGGTCGGCATCGAGGACGTCGCCGACCTGCTGGCCGATCTGGAGCAGGCCCTGGGCTAG

Protein sequence :
MSDDGNPHPEFTGLATKAIHAGYRPDPATGAVNAPIYASSTFAQDGVGALRGGFEYARTGNPTRAALEAALAAVEEGSYG
RAFASGMAATDCALRAVLRPGDHVVIPNDAYGGTFRLIDKVFTQWNVDYTPVALHEVDAVAAAITPRTRMIWVETPTNPL
LSVADIAAIAELAAGQAAKNRAKVLVDNTFASPALQQPLTLGADIVLHSTTKYIGGHSDVVGGALVTNDQELDDAFGFLQ
NGAGAVPGPFDAYLTMRGLKTLVLRMQRHSENAMAVAEFLAGHRAVSAVLYPGLPSHPGHEVAARQMRGFGGMVSVRMKG
GRDAARDLCANTKVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVGIEDVADLLADLEQALG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-69 46
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-70 46
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 6e-50 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
W7S_05425 YP_006304795.1 cystathionine gamma-synthase BAC0207 Protein 3e-58 45