Gene Information

Name : HPPC18_02620 (HPPC18_02620)
Accession : YP_006228790.1
Strain : Helicobacter pylori PeCan18
Genome accession: NC_017742
Putative virulence/resistance : Virulence
Product : cag pathogenicity island protein CagA
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 543699 - 547160 bp
Length : 3462 bp
Strand : +
Note : COG0419 ATPase involved in DNA repair

DNA sequence : 
ATGGCTAACGAAACCATCAATCAAACAAAAAAACCAGATCAAACACCAAGCCAAACGGCTTTTAATCCACAACAATTTAT
CGGTAGTATTCAAGTGGCTTTTATTAAACTTGGTAGTGCTGTCGCTTCATTTGATCCCGATCAAAAACCAATCGTTGATA
AGAACGATAGGGATAACAGGCAAGCTTTTAATGGAATCTCGCAATTAAGGGAAGAATACGCCAATAAAGCGATCAAAAAT
CCCACCAAAAAGAATCAGTATTTTTCAGACTTTATCAATGGGAGCAATGATTTGATCAACAAAAACAATCTCATTGATAT
AGATTCTTCCACAAAGAGCTTTGAGAAATTTGGGGATCAGCGTTACCGAATTTTTGTGAATTGGGTGTCCCATCAAGATC
CGTCTAAAATCAACACCCAAAAAATCCGAAATTTTATGGAAAACATCATACAACCTCCTATCTCTGATGATAAAGAAAAA
GCGGAGTTTTTGAAGTCTGCCAAACAAGCTTTTGCAGGAATTATCATAGGAAATCAAATCCAATCGGATGAAAAATTCAT
GGGCGTGTTTGGTGAATCTTTGAAAGAGAGGCAAGAAGCAGAAAAAAATGGAGATCCTGTTGGTGGGGATTGGCTTGATA
TTTTTTTATCGCTTGTATTTGGCAAAGAACAATCTTCCGATCTCAAAGAAACGCTCAATCAAGAGCCAAGGCCTAATGTT
GGACAAAATATAGCCTCTACCCCCACCCCCATACAAGGCTTACCGCCTGAAGCTAGGGATTTGCTTGATAAAAGGAGTGA
TTTTTCTAAATTCACTCTTGGTGATATGGAAATGTTGGATGTTGAGGGTATCGCCGACATTGATCCTAATTACAAGTTCA
ACCAGTTAGTGGTTCACAATAACGCTCTGTCTTCTATGCTAATGGGGAGTCATAGCGACATAAAACCTGAAAAAGTTTCA
TTGTTGTATGGGGATAATGGTGGCCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTTATAAAAACCAACAAGGCAA
CAATGTGGCCACACTCATCAATGTGCATCTTAAAAACGGCAGTGGGCTAGTCATAACGGGTAATGGAAGTGGGATTAACA
ACCCTAGCTTCTATCTCTACAAAAAAGACCAACTCACAGGCTTGGAACAAGCGTTGAGTCAAGAAGAGATCCAAAACAAA
GTGGGTTTCATGGAACTTCTTGCACAAAACAACGCTAGATTAGATAACTTGAGCGAGGAAGAGAAAGAAAAGTTCCAAAC
TGAGATTGGAAATTTCCAAAAAGACCCTAAGGCTTATTTAGACGCCCTAGGGAAGGATCAGATTGCTTTTGTTTCTCAAA
AAGACCCAAAGCATTTAGCTTTGGTTACTGAGTTGGGTAATGGGGAATTGAGCTATACCCTCAAAGATTATGGGAAAAGA
CAAGATAGAGCTTTAGATAGGGAGACAAAAACCACTCTTCAAGGCAACCTAAAACATGATGGCGTGATGTTTGTCAATTA
TTCCAATTTCAAATACACCAACGCCTCCAAGAGTCCTAATGAGGGTATAGGCGCTACGAATGGCGTTTCCCATTTGGAAG
CAAATTTTAGCAAGGTAGCTGTCTTTAATTTGTCTAAATTAAATGGTCTCGCTATCTTTAGTTTTGCAAGGCAGAATTTA
GAGGGTAAACTGATCGCTAAAGGATTGAACGGAAAAGAAGCTAATAAGCTCATCAAAGACTTTTTGAACAGCAACGAGGA
ATTGGTTGGAAAAGCTTTAGACTTCAATAAAGCTGTAGCTGAAGCTAAAAATACAGGCAATTATGACGGAGTGAAAAAAA
CTCAAAAAGATCTTGAAAAATCTATAAGGAAACGAGAGCGTTTAGAGAAAGAAATAACGAAAAAATTTGAGAGCAAGAGC
GGCAACAAAAATAAAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATGAGGTTTTTAAGCTTATCAATGAAGAGGC
TCATAAGGAAGCAAGAATCGCCACTTACACTCAGAATCTTGAAGGCATCGGGAGGGAATTGTCTGATAAAATTGAAAATA
TCAACAAGAATTTGAAAGACTTTGGTGAATCTTTTGATGCGCTCAAAAGTGGCAAAAATAAGGATTTTAGCAAGGTAGAA
GAAACGCTAAAAGCCCTTGAAAGCTCGGTGAAAGATTTGGGTATCCCAGAATGGATTTCAAAAGTTGAAAACCTTAATGC
AGCTTTGAATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACACAAGCAAAAAGCGACCTTGAAAATTCCA
TTAAGGATGCGATCATCAATCAAGAGATAACGGATAAAGTTGGCAATCTCAATCAGGCTGTATTAATAGCTAAAGCGATA
GGCGATTTTAGTGGGGTAGATCAAATGCTAGCCGAACTCAAAAACTTCTCAACGGATCAAAAATTGGATCAAAAAAATGA
AAGTTTCAATGTTGGAAAAAATTCTGATCTACAAAAATCCGTTAAAAATGGTGTAAATGGAACCCTAGTCGGTAATGGGT
TATCTAAAACAGAAGCCACAACGCTCACCAAAAAAATTTCGGACATTAAGAAAGAATTGAATGAGAAATTTGCAAATTTC
AACAGCAATAATAATGGATTCAAAAACAACACAGAGCCCATTTATGCTAAAGTTAATAAAAAGAAAACAGGACAAGTAGT
TAGCCCTGAAGAGTCTATTTACGATCAACTTGCTAAAGATGTAAAAGCAAAAATTGACAAACTCAACAAAATTGCATCAG
CAAGTAAAGGAGTGGGCGATTTCAGTGGATTAGGGCGATCAGATAGCTCTGAACCCATTTACGCTACGATTGATGATCTC
GGCGGACCTTTCCCTTTGAATAAGGTAGGGCTTTCAAGGGAGCAAAAATTGACTCAGGAAATTGGCAATCTCAATCAGGC
AGTGTCAGAAGCTAAAGCATGTTCTTTTAACAACCTAGAACAAACGATGCATAGACTCAAAGATTCTACAAAAAAGAATG
TTGTGAATCTATGGGTTGAAAGTGCAAAAGAAGTGCCTGCTATTTTGCAAGAGAAATTGGACAATTACGCTACTAACAGC
CACGTACACATTAATAGCAATGTCAAAAATGGAACAATCAATGAAAAAGCGACCGGCATGCTAACGCAAAAAAACCCTGA
GTGGCTCAAGCTCGTGAATGATAAGATAGTTGCGCATAATGTGGGAAGTGCTCCTTTGTCAGATTATGATAAAATTGGAT
TCAACCAAAAGAATATGAAAGGTTATTCTGATTCGTTCAAGTTTTCCACCAAGTTGAGCAATGCCGTAAAAAACATTAAG
TTTGGCTTTATGCAATATTTAACCCATTGCTTTTCTGCAGGATTTTACAGCCCGAAGAAAGCGGAATATGGAGTTACAAA
AAGTGGTTTCCAAAAATCTTAA

Protein sequence : 
MANETINQTKKPDQTPSQTAFNPQQFIGSIQVAFIKLGSAVASFDPDQKPIVDKNDRDNRQAFNGISQLREEYANKAIKN
PTKKNQYFSDFINGSNDLINKNNLIDIDSSTKSFEKFGDQRYRIFVNWVSHQDPSKINTQKIRNFMENIIQPPISDDKEK
AEFLKSAKQAFAGIIIGNQIQSDEKFMGVFGESLKERQEAEKNGDPVGGDWLDIFLSLVFGKEQSSDLKETLNQEPRPNV
GQNIASTPTPIQGLPPEARDLLDKRSDFSKFTLGDMEMLDVEGIADIDPNYKFNQLVVHNNALSSMLMGSHSDIKPEKVS
LLYGDNGGPEARHDWNATVGYKNQQGNNVATLINVHLKNGSGLVITGNGSGINNPSFYLYKKDQLTGLEQALSQEEIQNK
VGFMELLAQNNARLDNLSEEEKEKFQTEIGNFQKDPKAYLDALGKDQIAFVSQKDPKHLALVTELGNGELSYTLKDYGKR
QDRALDRETKTTLQGNLKHDGVMFVNYSNFKYTNASKSPNEGIGATNGVSHLEANFSKVAVFNLSKLNGLAIFSFARQNL
EGKLIAKGLNGKEANKLIKDFLNSNEELVGKALDFNKAVAEAKNTGNYDGVKKTQKDLEKSIRKRERLEKEITKKFESKS
GNKNKMEAKAQANSQKDEVFKLINEEAHKEARIATYTQNLEGIGRELSDKIENINKNLKDFGESFDALKSGKNKDFSKVE
ETLKALESSVKDLGIPEWISKVENLNAALNEFKNGKNKDFSKVTQAKSDLENSIKDAIINQEITDKVGNLNQAVLIAKAI
GDFSGVDQMLAELKNFSTDQKLDQKNESFNVGKNSDLQKSVKNGVNGTLVGNGLSKTEATTLTKKISDIKKELNEKFANF
NSNNNGFKNNTEPIYAKVNKKKTGQVVSPEESIYDQLAKDVKAKIDKLNKIASASKGVGDFSGLGRSDSSEPIYATIDDL
GGPFPLNKVGLSREQKLTQEIGNLNQAVSEAKACSFNNLEQTMHRLKDSTKKNVVNLWVESAKEVPAILQEKLDNYATNS
HVHINSNVKNGTINEKATGMLTQKNPEWLKLVNDKIVAHNVGSAPLSDYDKIGFNQKNMKGYSDSFKFSTKLSNAVKNIK
FGFMQYLTHCFSAGFYSPKKAEYGVTKSGFQKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cagA BAD51759.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA BAD51764.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA BAD51753.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA BAD51756.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA BAC10432.1 CagA Virulence cag PAI Protein 0.0 78
HP0547 BAD13990.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
HP0547 BAD13853.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
cagA YP_005777288.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAC10426.1 CagA Virulence cag PAI Protein 0.0 77
cagA BAD51755.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 77
cagA BAC10431.1 CagA Virulence cag PAI Protein 0.0 77
HP0547 BAD13799.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
HP0547 BAD13963.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA YP_005779046.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
HP0547 BAD13880.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA AAF17597.1 CagA Virulence cag PAI Protein 0.0 77
cagA YP_005775747.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAC10435.1 CagA Virulence cag PAI Protein 0.0 77
cagA BAD51754.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 77
HP0547 BAD14072.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAC10420.1 CagA Virulence cag PAI Protein 0.0 77
cagA BAC10421.1 CagA Virulence cag PAI Protein 0.0 77
cagA BAC10419.1 CagA Virulence cag PAI Protein 0.0 77
cagA YP_005774524.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAD51762.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 77
cagA BAD51749.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 77
cagA BAD51752.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 77
cagA BAD51758.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 77
cagA BAD51750.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 77
cagA BAD51760.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 77
cagA AGC69806.1 cag pathogenicity island protein A Virulence cag PAI Protein 0.0 77
cagA YP_003728762.1 cytotoxin-associated protein A Virulence cag PAI Protein 0.0 77
cagA BAD51766.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 77
HP0547 NP_207343.1 cag pathogenicity island protein (cag26) Virulence cag PAI Protein 0.0 77
cagA BAC10433.1 CagA Virulence cag PAI Protein 0.0 77
HP0547 BAD14018.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAC10427.1 CagA Virulence cag PAI Protein 0.0 77
cagA AAF17598.1 CagA Virulence cag PAI Protein 0.0 77
cagA AAR03939.1 CagA Virulence cag PAI Protein 0.0 77
cagA BAD51744.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 76
cagA BAD51751.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 76
cagA AAR03970.1 CagA Virulence cag PAI Protein 0.0 76
cagA BAD51761.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 76
cagA AAR03881.1 CagA Virulence cag PAI Protein 0.0 76
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen Virulence cag PAI Protein 0.0 75
cagA AAC44706.1 CagA Virulence cag PAI Protein 0.0 75
cagA AAR03909.1 CagA Virulence cag PAI Protein 0.0 75
HP0547 BAD14045.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 75
cagA BAD51747.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 74
cagA BAC10428.1 CagA Virulence cag PAI Protein 0.0 74
HP0547 BAD13908.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 74
cagA BAC10429.1 CagA Virulence cag PAI Protein 0.0 74
HP0547 BAD13935.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 74
cagA BAC10423.1 CagA Virulence cag PAI Protein 0.0 68
HP0547 BAD13826.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 67
cagA BAC10430.1 CagA Virulence cag PAI Protein 0.0 67
cagA BAC10422.1 CagA Virulence cag PAI Protein 0.0 67
cagA BAC10424.1 CagA Virulence cag PAI Protein 0.0 66

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HPPC18_02620 YP_006228790.1 cag pathogenicity island protein CagA VFG0306 Protein 0.0 77