Gene Information

Name : HPPC18_02525 (HPPC18_02525)
Accession : YP_006228771.1
Strain : Helicobacter pylori PeCan18
Genome accession: NC_017742
Putative virulence/resistance : Virulence
Product : cag pathogenicity island protein Y VirB10-like protein
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 518341 - 523641 bp
Length : 5301 bp
Strand : -
Note : COG2948 Type IV secretory pathway, VirB10 components

DNA sequence :
ATGAATGAAGAAAACGATAAACTTGAAACTTCTAAAAAAACCCAACAACATTCACCCCAAGATTTATCCAATGAAGAAAC
AATAAAAGCCAATCACTTTGAAGATTCTTCAAAAGAATCCAAAGAAAGCTCAGATCATCATCTTGACAACCCCACAGAAA
CTAAAACCAATTTTGATGGAGAAAAGTCAGAAGAAACCCAAACTCAAATGGATTCTGGAGGTAATGAAACTTCAGAATCT
AGCAATCTAGCAGACAAGTTATTCAAAAAAGCCAGAAAATTAGTTGATAATAAAAGACCTTTCACTCAGCAAAAGAATTT
AGATGAAGAAATCCAAGAACCGAACGAAGAAGACGATCAAGAAAATAATGGGTATCAAGAAGAAACCCAAATGGACTTAA
TTGATGATGAAACTTCTAAAAAAACCCAACAACATTCACCCCAAGATTTATCCAATGAAGAAACAATAAAAGCCAATCAC
TTTGAAGATTCTTCAAAAGAATCCAAAGAAAGCTCAGATCATCATCTTGACAACTCCACAGAAACTAAAACCAATTTTGA
TGGAGAAAAGTCAGAAGAAATAACTGACGACTCTAACGATCAAGAGATTATCAAAGGAAGCAAAAAGAAATACATTATTG
GTGGCATTGTAGTCGCTGTTCTTATCGTGATTATTTTATTTTCTAGAAGCATTTTTCACTACTTTGTACCTTTGGAAGAT
AAAAGCTCTCGTTTTAGCAAAGACAGGAATCTTTATGTCAATGATGAAATCCAAATAAGGCAAGAGTATAACCGATTGCT
GAAAGAACGGAATGAAAAAGGCAATATGATCGATAAGAATCTTTTCTTCAATGACGATCCCAATAGAACCTTATACAACT
ATTTGAATATTGCAGAAATTGAGGACAAAAACCCATTGAAGGCCTTTTATGAATGTATTAGTAATGGTGGCAACTATGAA
GAATGTTTGAAGCTTATCAAAGACAAAAAACTTCAAGATCAAATGAAAAAGACTTTAGAGGCTTATAATGACTGCATCAA
AAATGCCAAAACTGAAGAAGAAAGGATCAAGTGTTTAGATTTAATCAAAGATGAAAACCTGAAAAAAAGCTTACTGAACC
AACAAAAAGTTCAAGTGGCGCTAGATTGTTTGAAAAACGCTAAAACCGATGAAGAACGAAACGAGTGCCTAAAACTCATA
AATGACCCTGAGATTAGAGAGAAATTCCGTAAGGAATTAGAGCTTCAAAAAGAGCTTCAAGAGTATAAGGATTGTATCAA
AAACGCCAAAACAGAAGCTGAGAGAAACAAATGCTTGAAAGGCTTGTCTAAAGAAGCTATAGAAAGATTGAAACAGCAAG
CGCTAGATTGTTTGAAAAACGCTAAAACCGATGAAGAACGAAACGAGTGCTTGAAAAATATTCCCCAAGACTTGCAAAAA
GAACTACTAGCTGATATGAGCGTCAAGGCTTACAAGGATTGCGTATCAAAAGCTAGGAATGAAAAAGAGAAAAAAGAATG
CGAGAAATTGCTCACCCCTGAAGCGAGAAAAAAGCTAGAACAACAGGTTCTAGATTGTTTGAAAAACGCTAAAACTGATG
AAGAACGAAAAAAGTGTTTGAAAGATCTCCCTAAAGACTTACAAAGCGATATTTTAGCTAAAGAGAGCGTTAAAGCTTAT
AAAGACTGCGTATCTCAAGCCAAAACTGAAGCTGAAAAAAAAGAATGCGAGAAATTGCTCACCCCTGAAGCAAAAAAACT
TTTAGAAGAAGAAGCCAAAGAAAGCGTTAAGGCTTATTTGGATTGCGTATCTCAAGCCAAAACTGAAGCTGAGAAAAAAG
AATGCGAGAAATTACTCACGCCTGAAGCGAAAAAAAAGTTAGAAGAAGCCAAAGAAAGCGTTAAGGCTTATTTGGACTGC
GTATCTCAAGCCAAAACTGAAGCTGAGAAAAAAGAATGCGAAAAATTGCTCACGCCTGAAGCGAAAAAACTTTTAGAGCA
ACAAGCGCTGGATTGTTTAAAAAACGCTAAAACCGAAGCTGAGAGAAAAAGGTGTGTCAAAGATCTCCCTAAAGACTTGC
AGAAAAAGGTTTTAGCTAAAGAGAGCGTTAAGGCTTATTTGGATTGCGTATCTCAAGCCAAAACTGAAGCTGAGAAAAAA
GAATGCGAGAAATTGCTCACGCCTGAAGCGAAAAAACTTTTAGAAGAAGCTAAAGAGAGTCTTAAAGCTTATAAAGACTG
CGTTTCAAGAGCTAGGAATGAAAAAGAGAAAAAAGAATGCGAGAAATTACTCACGCCTGAAGCAAAAAAACTCTTAGAGC
AAGAAGTTAAGAGGAGCGTTAAGGCTTATTTGGATTGCGTATCTCAAGCCAAAACTGAAGCTGAGAAAAAAGAATGCGAG
AAATTGCTCACGCCTGAAGCAAAAAAACTTTTAGAAGAAGCTAAAGAGAGTCTTAAAGCTTATAAAGACTGCGTTTCAAG
AGCTAGGAATGAAAAAGAGAAACAAGAATGCGAGAAATTACTCACGCCTGAAGCGAAAAAACTCTTAGAGCAAGAAGTTA
AAAAAAGCGTTAAGGCTTATTTGGATTGCGTATCTCAAGCCAAAACTGAAGCTGAGAAAAAAGCTTGCGAGAAATTACTC
ACGCCTGAAGCGAAAAAACTCTTAGAGCAAGAAGTTAAAAAAAGCGTTAAGGCTTATTTGGATTGCGTATCTCAAGCCAA
AACTGAAGCTGAGAAAAAAGCTTGCGAGAAATTACTCACGCCTGAAGCGAAAAAAAAGTTAGAAGAAGCTAAAAAAAGCG
TTAAGGCTTATTTGGATTGCGTTTCAAGAGCTAGGAATGAAAAAGAGAAAAAAGAATGCGAGAAATTGCTCACGCCTGAA
GCGAAAAAGCTTTTAGAGCAACAAGCGCTAGATTGTTTGAAAAGTGCCAAAACTGAAGCTGAGAAAAAAAGGTGTGTCAA
AGATCTCCCTAAAGACTTGCAGAAAAAGGTTTTAGCCAAAGAGAGCGTTAAGGCTTATTTGGACTGCGTTTCAAGAGCTA
GGAATGAAAAAGAGAAAAAAGAATGCGAGAAATTGCTCACCCCTGAAGCGAAAAAACTTTTAGAAGAAGCTAAAGAGAGT
CTTAAAGCTTATAAAGACTGCCTCTCTCAAGCTAGAAATGAAGAAGAAAGAAAAGCTTGTGAGAAATTACTCACCCCTGA
AGCGAGAAAACTCTTAGAGCAAGAAGTTAAGAAGAGCGTTAAGGCTTATTTGGATTGCGTTTCAAGAGCTAGGAATGAAA
AAGAGAAAAAAGAATGCGAGAAATTACTCACCCCTGAAGCGAGAAAATTTTTAGCGAAGCAAGTGCTAAGTTGTTTGGAA
AAAGCTAGAAATGAAGAAGAAAGAAAAGCATGTCTTAAAAATATCCCTAAAGACTTACAGAAAAATGTTTTAGCTAAAGA
GAGTCTTAAAGCTTATAAAGACTGCCTCTCTCAAGCTAGAAATGAAGAAGAAAGAAAAGCTTGTGAGAAATTGCTCACCC
CTGAAGCGAGAAAACTCTTAGAGCAAGAAGTTAAGAAGAGCGTTAAGGCTTATTTGGACTGCGTTTCAAGAGCTAGGAAT
GAAAAAGAGAAACAAGAATGCGAGAAATTGCTCACCCCTGAAGCGAGAAAATTTTTAGCGAAAGAGCTCCAACAAAAAGA
TAAAGCGATCAAAGATTGCTTGAAAAACGCCGATCCTAACGACAGAGCAGCTATTATGAAGTGTTTGGATGGTTTGAGCG
ATGAAGAGAAGCTCAAATACCTGCAAGAAGCTAGAGAAAAGGCTGTCTTGGATTGTTTGAAAACGGCTAGGACCGATGAA
GAAAAAAGGAAATGTCAAAACCTTTATAGCGATTTGATCCAAGAAATCCAAAATAAAAGGACACAAAGCAAACAAAATCA
ATTGAGTAAAACAGAAAGATTGCATCAAGCAAGCGAGTGCTTGGATAACTTAGATGACCCTACTGATCAAGAAGCCATAG
AGAAATGTTTAGAAGGCTTGAGCGATAGTGAAAGGGCACTAATTCTAGGAATTAAACGACAAGCTGATGAAGTGGATCTG
ATTTATAGCGATCTAAGAAACCGCAAAACCTTTGATAACATGGCGGCTAAAGGTTATCCATTGTTGCCAATGGATTTCAA
AAATGGCGGCGATATTGCCACTATTAACGCCACTAATGTTGATGCGGACAAAATAGCTAGCGATAATCCTATTTATGCTT
CCATAGAGCCTGATATTACTAAGCAATACGAAACAGAAAAAACCATTAAGGATAAGAGTTTAGAAGCTAAATTAGCTAAG
GCTTTAGGTGGCGATAAAAAAGATGACGATAAAGAAAAAAGTAAAAAACCCACAGCAGAAACTAAAGCAGAAAGCAATAA
GATAGACAAAGATGTCGCAGAAACTGCCAAAAATATCAGCGAAATCGCTCTTAAGAACAAAAAAGAAAAGAGTGGGGAAT
TTGTAGATGAAAATGGTAATCCCATTGACGATAAAAAGAAAGAAGAAAAACAAGATGAAACAAGCCCTGTCAAACAGGCC
TTTATAGGCAAGAGTGATCCCACATTTGTTTTAGCGCAATACACCCCCATTGAAATCACTCTGACTTCTAAAGTAGATGC
CACTCTCACAGGTATAGTGAGTGGGGTTGTAGCCAAAGATGTATGGAACATGAACGGCACTATGATCTTATTAGACAAAG
GCACTAAGGTGTATGGGAATTATCAAAGCGTGAAAGGTGGCACACCCATTATGACACGCTTAATGATAGTTTTTACTAAA
GCCATTACGCCTGATGGGGTGATTATACCTCTAGCAAACGCTCAAGCAGCAGGCATGTTGGGTGAAGCAGGGGTAGATGG
CTATGTGAATAACCACTTCATGAAGCGCATAGGCTTTGCTGTGATAGCAAGCGTGGTTAATAGCTTCTTGCAAACCGCGC
CTATCATAGCCCTAGATAAACTCATAGGCCTTGGCAAAGGCAGAAGTGAAAGGACACCTGAATTTAATTACGCTTTGGGT
CAAGCTATCAATGGTAGTATGCAAAGTTCAGCTCAGATGTCTAATCAAATTCTAGGGCAACTGATGAATATCCCCCCAAG
TTTTTACAAAAACGAGGGCGATAGTATTAAGATTCTCACAATGGACGATATTGATTTTAGTGGCGTGTATGATGTTAAAA
TTACCAACAAATCTGTGGTAGATGAAATTATCAAACAAAGCACCAAAACTTTGTCTAGAGAACATGAAGAAATCACCACA
AGCCCCAAAGGTGGCAATTAA

Protein sequence :
MNEENDKLETSKKTQQHSPQDLSNEETIKANHFEDSSKESKESSDHHLDNPTETKTNFDGEKSEETQTQMDSGGNETSES
SNLADKLFKKARKLVDNKRPFTQQKNLDEEIQEPNEEDDQENNGYQEETQMDLIDDETSKKTQQHSPQDLSNEETIKANH
FEDSSKESKESSDHHLDNSTETKTNFDGEKSEEITDDSNDQEIIKGSKKKYIIGGIVVAVLIVIILFSRSIFHYFVPLED
KSSRFSKDRNLYVNDEIQIRQEYNRLLKERNEKGNMIDKNLFFNDDPNRTLYNYLNIAEIEDKNPLKAFYECISNGGNYE
ECLKLIKDKKLQDQMKKTLEAYNDCIKNAKTEEERIKCLDLIKDENLKKSLLNQQKVQVALDCLKNAKTDEERNECLKLI
NDPEIREKFRKELELQKELQEYKDCIKNAKTEAERNKCLKGLSKEAIERLKQQALDCLKNAKTDEERNECLKNIPQDLQK
ELLADMSVKAYKDCVSKARNEKEKKECEKLLTPEARKKLEQQVLDCLKNAKTDEERKKCLKDLPKDLQSDILAKESVKAY
KDCVSQAKTEAEKKECEKLLTPEAKKLLEEEAKESVKAYLDCVSQAKTEAEKKECEKLLTPEAKKKLEEAKESVKAYLDC
VSQAKTEAEKKECEKLLTPEAKKLLEQQALDCLKNAKTEAERKRCVKDLPKDLQKKVLAKESVKAYLDCVSQAKTEAEKK
ECEKLLTPEAKKLLEEAKESLKAYKDCVSRARNEKEKKECEKLLTPEAKKLLEQEVKRSVKAYLDCVSQAKTEAEKKECE
KLLTPEAKKLLEEAKESLKAYKDCVSRARNEKEKQECEKLLTPEAKKLLEQEVKKSVKAYLDCVSQAKTEAEKKACEKLL
TPEAKKLLEQEVKKSVKAYLDCVSQAKTEAEKKACEKLLTPEAKKKLEEAKKSVKAYLDCVSRARNEKEKKECEKLLTPE
AKKLLEQQALDCLKSAKTEAEKKRCVKDLPKDLQKKVLAKESVKAYLDCVSRARNEKEKKECEKLLTPEAKKLLEEAKES
LKAYKDCLSQARNEEERKACEKLLTPEARKLLEQEVKKSVKAYLDCVSRARNEKEKKECEKLLTPEARKFLAKQVLSCLE
KARNEEERKACLKNIPKDLQKNVLAKESLKAYKDCLSQARNEEERKACEKLLTPEARKLLEQEVKKSVKAYLDCVSRARN
EKEKQECEKLLTPEARKFLAKELQQKDKAIKDCLKNADPNDRAAIMKCLDGLSDEEKLKYLQEAREKAVLDCLKTARTDE
EKRKCQNLYSDLIQEIQNKRTQSKQNQLSKTERLHQASECLDNLDDPTDQEAIEKCLEGLSDSERALILGIKRQADEVDL
IYSDLRNRKTFDNMAAKGYPLLPMDFKNGGDIATINATNVDADKIASDNPIYASIEPDITKQYETEKTIKDKSLEAKLAK
ALGGDKKDDDKEKSKKPTAETKAESNKIDKDVAETAKNISEIALKNKKEKSGEFVDENGNPIDDKKKEEKQDETSPVKQA
FIGKSDPTFVLAQYTPIEITLTSKVDATLTGIVSGVVAKDVWNMNGTMILLDKGTKVYGNYQSVKGGTPIMTRLMIVFTK
AITPDGVIIPLANAQAAGMLGEAGVDGYVNNHFMKRIGFAVIASVVNSFLQTAPIIALDKLIGLGKGRSERTPEFNYALG
QAINGSMQSSAQMSNQILGQLMNIPPSFYKNEGDSIKILTMDDIDFSGVYDVKITNKSVVDEIIKQSTKTLSREHEEITT
SPKGGN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
HP0527 BAD13998.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 95
HP0527 BAD14052.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 95
HP0527 BAD13833.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 94
cagY YP_005777271.1 cag pathogenicity island protein Y VirB10-like protein Virulence cag PAI Protein 0.0 94
cagY AGC69789.1 cag pathogenicity island protein Y Virulence cag PAI Protein 0.0 94
cagY AGC69792.1 cag pathogenicity island protein Y Virulence cag PAI Protein 0.0 94
HP0527 BAD13970.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 93
HP0527 NP_207323.1 cag pathogenicity island protein (cag7) Virulence cag PAI Protein 0.0 93
cagY YP_005774542.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 93
HP0527 BAD14026.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 92
HP0527 BAD13888.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 91
cagY AGC69786.1 cag pathogenicity island protein Y Virulence cag PAI Protein 0.0 91
HP0527 BAD13915.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 89
cag-Y AAF80198.1 Cag-Y Virulence cag PAI Protein 0.0 88
HP0527 BAD13943.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 88
cagY AGC69787.1 cag pathogenicity island protein Y Virulence cag PAI Protein 0.0 87
HP0527 BAD13860.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 85
cagY YP_005775730.1 cag pathogenicity island protein Y VirB10-like protein Virulence cag PAI Protein 0.0 85
HP0527 BAD13806.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 85
orf13/14 NP_223194.1 cag island protein Virulence cag PAI Protein 0.0 84
HP0527 BAD13779.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 84
cagY YP_005779063.1 cag island protein Virulence cag PAI Protein 0.0 84

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HPPC18_02525 YP_006228771.1 cag pathogenicity island protein Y VirB10-like protein VFG0287 Protein 0.0 93