Gene Information

Name : HPSH112_04285 (HPSH112_04285)
Accession : YP_006227551.1
Strain : Helicobacter pylori Shi112
Genome accession: NC_017741
Putative virulence/resistance : Virulence
Product : cag pathogenicity island protein CagA
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 862696 - 865695 bp
Length : 3000 bp
Strand : -
Note : -

DNA sequence :
ATGGCTAACGAAACCATCGATCAAACAAAAAAACCAGATCAAACACCAATCGTTGATAAGAACGATAATAAAGCGATCAA
AAATCCCACCAAAAAGAATCAGTTTTTTTCAAAACTTACCGATTTGTTTGCACTTGGCAAAAAACAATCTTCCGATCTCG
AAGAAACGCTCAATCAAGAGCCAAGGTCTAATGTTGAACAAAATATAGCCACTACCACCAACATGCAAGGTTTACCTCAA
GCTAGGGATTTGCTTGATGGAAGGGGTAATTTTCCTAAATTCACTCTTGGTGATATGGAAATGTTGGATGTTGAGGGTAT
CGCCGACATTGATCCTAATTACAAGTTCAGCCAGTTATTGGTTCACAGTAATGTTCTGTCTTCTATGTCAATGGGGAGTC
ATAGCAACATGGAACCTGAAAAAGTTTCATTGTTGTATGGGGATAATGGTGGTCCTGAAGCTAGGCATGATTGGAACGCC
ACCGTTGGTTATAAAAACCAACAAGGCAACAATGTGGCCACACTCATCAATATGCATCTTAAAAACGGCAGTGGGTTAGT
CATAGCGGGTAATGAAGGTGGGATTAACAACCCTAGCTTCTATCTCTACAAAAAAGACCAACTCACAGGCTTGGAACAAG
CGTTGAGTCAAGAAGAGATCCAAAACAAAGTGGATTTCATGGAATTTCTTGCACAAAACAGCACTAAATTAGATAACTTG
AGCGAGAAAGAGAAAGAAAAGTTCCAAACTGAAATTGGAAATTTCCAAAAAGACCCTAAGGCTTATTTAGACACCCTAGG
GAGTGATCACATTGCTTTTGTTTCTAAAAAAGACAACAAGCATTTAGCTTTGGTTACCGATTTTGGTAATGGGGAATTGA
GCTATACCCTCAAAGATTATGGGAAAGAACAAGATAGAGCTTTAGATAGGGAGACAAAAACCACTTTTCAAGGTAACCTA
AAAGATGATGGCGTGATGTTTGTCAATTATTCCAATTTCAAATACACCAACGCCTCCAAGAGTCCTAATGAGGGTATAGG
CGCTACGAATGGCGTTTCCCATTTGGAAGCAAATTTTAGCAAGGTAGCTATCTTTAATTTGCCTAAATTAAATGGTCTCG
TTCTCTCTAATCATCCTGTAAGGCAAAATTTAGAGGATAAGGTGATCGCTAAAGGATTGTCCCCAAAAGAAGCTAATAAG
CTCGTCAAAGACTTTTTGAACAGTAACAAGGAATTGGTTGGAAAAGTTTCAAGTTTCAATAAAGCTGTAGCTGAAGCTAA
AAATACAGGCAATTATGGCGGAGTGAAAAAAGCTCAAAAAGATCTTGAAAAATCTATAAGGAAACGAGAGCATTTAGAGA
AAGAAGTAACGAAAAAAATTGAGAGCAAGAGCGGCAACAAAAATAAAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAA
GATGAGATTTTTGCGCTTATCAATCAAGAGACTTATAAGGAAGCAAGAAATGCCAGTTACGATCAGAATCTTGAAGGCAT
CAGGAGGGAATTGTCTGATAAAATTGAAAATATCAACAAGAATTTGAAAGACTTTAATAAATCTTTTGATGCGCTCAAAA
GTGGCAACAATAAGGATTTCAGCAAGGTAGAAGAAACGCTAAAAGCCCTTAAAAGCTCGGTGAAAGATTTGGGTATCAAT
CCAGAATGGATTTCAAAAGTTGAAAACCTTAGTACAGCTTTGAATGAATTTAAAAATGGCAAAAATAAGGATTTCAGCAA
GGTAACACAAGCAAAAAGCGACCTTGAAAATTCCATTAAGGATGCGATCGTCAATCAAGAGATAACGGATAAAGTTGACA
ATCTCAATCAGGCTGTATTAGTGGCTAAAACGGCATGCAATTTCAGTATGTTAGATCAAGCGCTAGCCGACCTCAAAAAC
TTCTCAACGGATCAAAAATTGGATCAAAAAAATGAAAGTTTCAATGTTGGAAAAGATTCTGATCTACAAAAATCCGTTAA
AAATCGTGTGAATGGAACCCTAGTCGGTAATGGGTTATCTAAAACAGAAGCCACAACGCTCACCGGAAAAATTTCGGGTA
TTAAGAAAGAATTGAATGAGAAATTTGCAAATTTCAACAATAATAATGGACTCAAAAACAGTGCAGAGCCCATTTACGCT
CAAGTTAATAAAAAGAAAACAGGACAAGTAACTAGCCCTGAAGGGTCCATTTACGATCAAGTTGCTAAAGATGTAAGTGC
AAAAATTGACAAACTCAATAAAATTGCATCAGCAAGTAAAGGAGTGGACGATTTCAGTGGATTAGGATTAGGGCGATTAG
CAACGCGATTAGATGGCCGTGAACCCATTTATGTTACGATTGATGATCTCGGCGGACCTTATACTTTGAAAATGCATGCT
GGAGATGATAATCTCAGGAGTAAGGTAGGGCTTTCAAGGGATCAAGAATTGACTCAGAAAATTGGCAATCTCAATCAGGC
AGTGTTAGAAGCTAAAGCAGGTCTTTTTGTAAACCCACAACAAATGACACATCTAGAACAAATGATGCATGGACTCAAAG
ATTCTACAAAAAAGAATGTTGTGAATCTATGGTTTGAAGGTGCAAAAAAAGTGCCTACTAGTTTGCAAGCGAAATTGGAC
AATTACGCTACTAACAGCCACATACACATTAATAGCAATGTCAAAAATGGAGCAATCAATGAAAAAGCGACCGGCATGCT
AACGCAAAAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCGCATAATGTGGGAAGCGTTCCTTTGTCAG
ATTATGATAAAATTGGATTCAACCAAAAGAATATGAAAGGTTATTCTGATTCGTTCAAGTTTTCCACCAAGTTCAACAAT
GCCGTAAAAAACATTAAGTCTGGCTTTGAGCAATTTTTAACCGATTGCTTTTCTACAGGATCTTATAGCCCGAAGAAAGC
GGAATATGGAGTTACAAAAAGTGGTTTCCAGAAATCTTAA

Protein sequence :
MANETIDQTKKPDQTPIVDKNDNKAIKNPTKKNQFFSKLTDLFALGKKQSSDLEETLNQEPRSNVEQNIATTTNMQGLPQ
ARDLLDGRGNFPKFTLGDMEMLDVEGIADIDPNYKFSQLLVHSNVLSSMSMGSHSNMEPEKVSLLYGDNGGPEARHDWNA
TVGYKNQQGNNVATLINMHLKNGSGLVIAGNEGGINNPSFYLYKKDQLTGLEQALSQEEIQNKVDFMEFLAQNSTKLDNL
SEKEKEKFQTEIGNFQKDPKAYLDTLGSDHIAFVSKKDNKHLALVTDFGNGELSYTLKDYGKEQDRALDRETKTTFQGNL
KDDGVMFVNYSNFKYTNASKSPNEGIGATNGVSHLEANFSKVAIFNLPKLNGLVLSNHPVRQNLEDKVIAKGLSPKEANK
LVKDFLNSNKELVGKVSSFNKAVAEAKNTGNYGGVKKAQKDLEKSIRKREHLEKEVTKKIESKSGNKNKMEAKAQANSQK
DEIFALINQETYKEARNASYDQNLEGIRRELSDKIENINKNLKDFNKSFDALKSGNNKDFSKVEETLKALKSSVKDLGIN
PEWISKVENLSTALNEFKNGKNKDFSKVTQAKSDLENSIKDAIVNQEITDKVDNLNQAVLVAKTACNFSMLDQALADLKN
FSTDQKLDQKNESFNVGKDSDLQKSVKNRVNGTLVGNGLSKTEATTLTGKISGIKKELNEKFANFNNNNGLKNSAEPIYA
QVNKKKTGQVTSPEGSIYDQVAKDVSAKIDKLNKIASASKGVDDFSGLGLGRLATRLDGREPIYVTIDDLGGPYTLKMHA
GDDNLRSKVGLSRDQELTQKIGNLNQAVLEAKAGLFVNPQQMTHLEQMMHGLKDSTKKNVVNLWFEGAKKVPTSLQAKLD
NYATNSHIHINSNVKNGAINEKATGMLTQKNPEWLKLVNDKIVAHNVGSVPLSDYDKIGFNQKNMKGYSDSFKFSTKFNN
AVKNIKSGFEQFLTDCFSTGSYSPKKAEYGVTKSGFQKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cagA BAD51752.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 77
cagA BAC10435.1 CagA Virulence cag PAI Protein 0.0 76
HP0547 BAD14072.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
HP0547 BAD13880.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA YP_005775747.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA AAF17597.1 CagA Virulence cag PAI Protein 0.0 76
cagA BAD51766.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 76
cagA YP_005777288.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 75
cagA BAC10426.1 CagA Virulence cag PAI Protein 0.0 75
cagA BAD51755.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 75
cagA BAC10431.1 CagA Virulence cag PAI Protein 0.0 75
cagA YP_005779046.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 75
HP0547 BAD13963.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 75
cagA BAC10421.1 CagA Virulence cag PAI Protein 0.0 75
cagA BAC10420.1 CagA Virulence cag PAI Protein 0.0 75
HP0547 BAD13799.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 75
cagA BAD51754.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 75
cagA BAD51762.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 75
cagA BAC10419.1 CagA Virulence cag PAI Protein 0.0 75
cagA BAD51749.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 75
cagA BAD51764.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 75
cagA BAD51758.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 75
cagA BAD51756.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 75
cagA BAD51751.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 75
cagA BAD51760.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 75
cagA BAD51750.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 75
cagA BAD51753.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 75
cagA YP_003728762.1 cytotoxin-associated protein A Virulence cag PAI Protein 0.0 75
cagA AGC69806.1 cag pathogenicity island protein A Virulence cag PAI Protein 0.0 75
cagA BAD51761.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 75
cagA BAC10433.1 CagA Virulence cag PAI Protein 0.0 75
HP0547 BAD14018.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 75
cagA BAD51759.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 74
cagA BAD51744.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 74
cagA YP_005774524.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 74
cagA AAR03881.1 CagA Virulence cag PAI Protein 0.0 74
cagA AAC44706.1 CagA Virulence cag PAI Protein 0.0 73
cagA AAR03970.1 CagA Virulence cag PAI Protein 0.0 73
cagA AAR03909.1 CagA Virulence cag PAI Protein 0.0 73
HP0547 BAD14045.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 73
HP0547 NP_207343.1 cag pathogenicity island protein (cag26) Virulence cag PAI Protein 0.0 73
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen Virulence cag PAI Protein 0.0 72
cagA BAC10428.1 CagA Virulence cag PAI Protein 0.0 72
HP0547 BAD13908.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 72
cagA BAC10429.1 CagA Virulence cag PAI Protein 0.0 71
HP0547 BAD13935.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 71
cagA BAD51747.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 71
cagA BAC10423.1 CagA Virulence cag PAI Protein 0.0 64
cagA BAC10422.1 CagA Virulence cag PAI Protein 0.0 63
HP0547 BAD13826.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 63
cagA BAC10424.1 CagA Virulence cag PAI Protein 0.0 62

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HPSH112_04285 YP_006227551.1 cag pathogenicity island protein CagA VFG0306 Protein 0.0 73