Gene Information

Name : HPSH169_04745 (HPSH169_04745)
Accession : YP_006226126.1
Strain : Helicobacter pylori Shi169
Genome accession: NC_017740
Putative virulence/resistance : Virulence
Product : cag pathogenicity island protein CagA
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 979647 - 982919 bp
Length : 3273 bp
Strand : -
Note : COG0419 ATPase involved in DNA repair

DNA sequence : 
ATGGCTAACGAAACCATCGATCAAACAAAAAATCCAGATCAAACACCAAGCCAAACGGCTTTTGATTCACAACAATTTAT
CAATAATCTTCAAGTGGTTTTCACTAAAGTTGATAGCGCTGTCGCTTCATTTGATCCCGATCAAAAACCAATCGTTGATA
AGAACGATAAGGATAACAGGCAAGCTTTTAATGGAATCTCGCAATTAAGGGAAGAATACGCCAATAAAGCGATCAAAAAT
CCTACCAAAAAGAATCAGTATTTTTCAGACTTTATCAGTAAGAGCAATGATTTGATCAACAAAGACAATCTCATTGATAC
AGATTCTTCCACAAAGAGCTTTCAGAAATTTGGGACTGAGCGTTACCAAATTTTTATGAATTGGGTGTCCCATCAAAAAG
ATCCGTCTAAAATCAACACCCAAAAAATCCGAAATTTTATGGAAAATATCGTACAACCCCCTATCTCTGATGATAAAGAA
AAAGCGGAGTTTTTGAGGTCTGCCAAACAATCTTTTGCAGGAATTATCATAGGAAACCAAATCCGATCGGATGAAAAATT
CATGGGCGTGTTTGAAGAATCTTTGGATGAATCTTTGGATGAATCTTTGGATGAATCTTTGGATGAATCTTTGGATGAAT
CTTTGGATGAATCTTTGGATGAATCTTTGAAAGAGAAGCAAGAAGCACAAAACAATGGAGATCCTGGTGGGGATTGGCTT
GATATTTTTTTATCGTTTGCATTTGACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATCAAGAGTCAAGGCCTAA
TGTTGAACAAAATATAGCCACTACCCCCACCCCCATACAAGGCTTACCGCTTGAAGCTAGGGATTTGCTTGATGAAAGGG
GTGATTTTTCTAAATTCACTCTTGGTGATCCTAATTACAAGTTCAACCAGTTAGTGGTTCACAATAACGCTCTGTCTTCT
ATGCTAATGGGGAGTCATGGCAACATAAAACCTGAAAAAGTTTCATTGTTGTATGGGGATAATGGTGGCCCTGAAGCTAG
GCATGATTGGAACGCCACCGTTGGTTATAAAAACCAACAAGGCAACAATGTGGCCACACTCATCAATGCACATCTTAAAA
ACGGCAGTGGGTTAATCATAGCGGGTAATGAAAATGGGATTAACAACCCTAGCTTCTATCTCTACAAAAAAGACCAACTC
ACAGGCTTGGAGCAAGCGTTGAGTCAAGAAGAGATCCAAAACAAACTAGGTTTCATGGAACTTCTTGCACAAAACAACGC
TAAATTAGATAACTTGAGCAAGGAAGAGAAAGAAAAGTTCCAAACTGAGATTGGAAATTTCCAAAAAGACCCTAAGGCTT
ATTTAGACTCCCTAGGGAATGATCGCATTGCTTTTGTTTCTAAAAAAGACAACAAGCATTTAGCTTTGGTTACTGAGTTT
GGCAATGGGGAATTGAGCTATACCCTCAAAGATTATGGGAAAAGACAAGATAGAGCTTTAGATAGGGAGATAAAAACCAC
TCTTCAAGGTAACCTAAAAGATGATGGCGTGATGTTTGTCAATTATTCCAATTTCAAATACACCAACGCCTCCAAGAGTC
CTAATGAGGGTATAGGCGCTACGAATGGCGTTTCCCATTTGGAAGCAAATTTTAGCAAGGTAGCTGTCTTTAATTTGCCT
AAATTAAATGGTCTCGCTGTCTCTAGTTTTGCAAGGCGGAATTTAGAGAATAAACTGATCGCTAAAGGATTTCCCCCAAA
AGAAGCTAGTAAGATCATCAAAGACTTTTTGAACAGCAACAAGGAATTGCTTGGAAAAGCTTTAAACTTCAATAAAGCTG
TAGCTGAAGCTAAAAATACAGGCAATTATGGCGGAGTGAAAAAAGCTCAAAAAGATCTTGAAAAATCTATAAGGAAACGA
GAGCGTTTAGAGAAAGAAATAACGAAACAATTTGAGAGCAAGAGCGGCAACAAAAATAAAATGGAAGCAAAAGCTCAAGC
TAACAGCCAAAAAGATGAGATTTTTAAGCTTATCAATGAAGGGGCTTATAAGGAAGCAAGAATCATCGCTTACGATCAGA
ATCTTAAAGGCATCAGGAGGGAATTGAGGGAATTGTTTGATAAAATTGAAAATCTCAACAAGAATTTGAAAGACTTTGGT
GAATCTTTTGATGCGCTCAAAAGTGGCAAAAATAAGGATTTCAGCAAGGCAGAAGAAACGCTAAAAGCCCTTGAAAGCTC
GGTGAAAGATTTGGGTATCAATCCAGAATGGATTTCAAAAGTTGAAAACCTTAATGCAGCTTTGAATGAATTCAAAAATG
GCAAAAATAAGGATTTCAGCAAGGTAACACAAGCAAAAAGCGACCTTGAAAATTCCATTAAGGATGTGATCATCAATCAA
GAGATAACGGATAAAGTTGACAATCTCAATCAGGCTGTATCAATAGCTAAAGCGACAGGCGATTTCAGTGGGTTAGATCA
AGCGCTAGCCGAACTCAAAAACTTCAATGTTGGAAAAAATTCTGATAGGTCTGAACCCATTTACGCTACGATTGATGATC
TCGACGGATCTTCCCCTTTGAAAAGGTATGCTAAAGTTGATGATCTCAGTAAGGTAGGGCAATCAGATAGCCCTGAACCC
ATTTACGCTAATCTCGGCGGATCTTCCCCTTTGAAAAGGTATGCTAAAGTTGATGATCTCAGTAAGGTAGGGCTTTCAAG
GGAGCAAGAATTGACTCAGAAAATTGGCAATCTCAATCAGGCAGTGTCAGAAGCTAAAGCAGGTTCTTTTGGCAACCTAG
AACAAACGATGCATGGACTCAAAGATTCTACAAAAAAGAATGTTGTGAATCTATGGTTTGAAGGTGCAAGAAAAGTGCCT
ATTAGTTTGCCTAGTTCGCAAGCGAAATTGGACAATTACGCTACTAACAGCCACACACGCATTAATAGCAATGTCAAAAA
TGGAACAATCAATGAAAAAGCGATCGGCATGCTAACGCAAAAAAACCCTGAGTGGCTCAAGCTAGTGAATGATAAGATAG
TTGCGCATAATGTGGGAAGCACTCCTTTGTCAGATTATGATAAAATTGGATTCAACCAAAAGGATATGAAAGGTTATTCT
GATTCGTTCAAGTTTTCCACCAAGTTGAGCAATGCCGTAAAAAACATTAAGCCTGGCTTTGTGCAATGTTTAACCGATTG
CATTTCTGCAGGATCTTACAGCCCAAAGAAAGCGGAACATGGAGTTACAAAAAGTGGTTTCCAGAAATCTTAA

Protein sequence : 
MANETIDQTKNPDQTPSQTAFDSQQFINNLQVVFTKVDSAVASFDPDQKPIVDKNDKDNRQAFNGISQLREEYANKAIKN
PTKKNQYFSDFISKSNDLINKDNLIDTDSSTKSFQKFGTERYQIFMNWVSHQKDPSKINTQKIRNFMENIVQPPISDDKE
KAEFLRSAKQSFAGIIIGNQIRSDEKFMGVFEESLDESLDESLDESLDESLDESLDESLDESLKEKQEAQNNGDPGGDWL
DIFLSFAFDKKQSSDLKETLNQESRPNVEQNIATTPTPIQGLPLEARDLLDERGDFSKFTLGDPNYKFNQLVVHNNALSS
MLMGSHGNIKPEKVSLLYGDNGGPEARHDWNATVGYKNQQGNNVATLINAHLKNGSGLIIAGNENGINNPSFYLYKKDQL
TGLEQALSQEEIQNKLGFMELLAQNNAKLDNLSKEEKEKFQTEIGNFQKDPKAYLDSLGNDRIAFVSKKDNKHLALVTEF
GNGELSYTLKDYGKRQDRALDREIKTTLQGNLKDDGVMFVNYSNFKYTNASKSPNEGIGATNGVSHLEANFSKVAVFNLP
KLNGLAVSSFARRNLENKLIAKGFPPKEASKIIKDFLNSNKELLGKALNFNKAVAEAKNTGNYGGVKKAQKDLEKSIRKR
ERLEKEITKQFESKSGNKNKMEAKAQANSQKDEIFKLINEGAYKEARIIAYDQNLKGIRRELRELFDKIENLNKNLKDFG
ESFDALKSGKNKDFSKAEETLKALESSVKDLGINPEWISKVENLNAALNEFKNGKNKDFSKVTQAKSDLENSIKDVIINQ
EITDKVDNLNQAVSIAKATGDFSGLDQALAELKNFNVGKNSDRSEPIYATIDDLDGSSPLKRYAKVDDLSKVGQSDSPEP
IYANLGGSSPLKRYAKVDDLSKVGLSREQELTQKIGNLNQAVSEAKAGSFGNLEQTMHGLKDSTKKNVVNLWFEGARKVP
ISLPSSQAKLDNYATNSHTRINSNVKNGTINEKAIGMLTQKNPEWLKLVNDKIVAHNVGSTPLSDYDKIGFNQKDMKGYS
DSFKFSTKLSNAVKNIKPGFVQCLTDCISAGSYSPKKAEHGVTKSGFQKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cagA BAD51750.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA BAC10429.1 CagA Virulence cag PAI Protein 0.0 76
HP0547 BAD13935.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA BAD51747.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 75
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen Virulence cag PAI Protein 0.0 70
cagA BAD51759.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 69
cagA BAD51752.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 69
cagA BAD51758.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 69
cagA AAF17598.1 CagA Virulence cag PAI Protein 0.0 69
cagA AAR03939.1 CagA Virulence cag PAI Protein 0.0 69
cagA BAD51760.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 68
cagA BAD51751.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 68
cagA BAD51761.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 68
cagA BAD51766.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 68
cagA AAC44706.1 CagA Virulence cag PAI Protein 0.0 66
cagA YP_005777288.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 65
HP0547 BAD13880.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 65
cagA BAC10420.1 CagA Virulence cag PAI Protein 0.0 65
cagA AAF17597.1 CagA Virulence cag PAI Protein 0.0 65
cagA BAC10435.1 CagA Virulence cag PAI Protein 0.0 65
cagA BAD51754.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 65
HP0547 BAD14072.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 65
cagA YP_005775747.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 65
cagA BAC10431.1 CagA Virulence cag PAI Protein 0.0 65
cagA BAD51755.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 65
HP0547 BAD13963.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 65
cagA BAD51753.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 65
cagA BAD51756.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 65
cagA YP_005779046.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 65
cagA BAD51762.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 65
cagA BAC10419.1 CagA Virulence cag PAI Protein 0.0 65
cagA BAD51749.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 65
cagA YP_005774524.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 65
cagA BAC10433.1 CagA Virulence cag PAI Protein 0.0 65
HP0547 BAD14018.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 65
cagA BAC10426.1 CagA Virulence cag PAI Protein 0.0 64
cagA AGC69806.1 cag pathogenicity island protein A Virulence cag PAI Protein 0.0 64
cagA BAD51744.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 64
cagA BAD51764.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 64
cagA BAC10421.1 CagA Virulence cag PAI Protein 0.0 64
HP0547 BAD13799.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 64
cagA AAR03909.1 CagA Virulence cag PAI Protein 0.0 64
HP0547 NP_207343.1 cag pathogenicity island protein (cag26) Virulence cag PAI Protein 0.0 64
cagA AAR03881.1 CagA Virulence cag PAI Protein 0.0 64
cagA YP_003728762.1 cytotoxin-associated protein A Virulence cag PAI Protein 0.0 63
cagA AAR03970.1 CagA Virulence cag PAI Protein 0.0 63
HP0547 BAD14045.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 62

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HPSH169_04745 YP_006226126.1 cag pathogenicity island protein CagA VFG0306 Protein 0.0 64