Gene Information

Name : ST398NM01_0600 (ST398NM01_0600)
Accession : YP_006194665.1
Strain : Staphylococcus aureus 71193
Genome accession: NC_017673
Putative virulence/resistance : Virulence
Product : Negative regulator of genetic competence clpC/mecB
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 511049 - 513505 bp
Length : 2457 bp
Strand : +
Note : TlyB; hemolysin

DNA sequence :
ATGTTATTTGGTAGATTAACTGAACGTGCACAGCGCGTATTAGCACATGCACAAGAAGAAGCAATTCGTTTAAATCATTC
AAATATAGGAACAGAACACCTATTATTGGGGTTAATGAAAGAACCTGAAGGAATTGCTGCAAAAGTATTAGAAAGTTTTA
ATATCACTGAAGATAAAGTAATTGAAGAAGTTGAAAAATTAATCGGACATGGTCAAGATCATGTTGGTACATTGCATTAT
ACACCTAGAGCTAAAAAAGTCATTGAATTATCGATGGATGAAGCTAGAAAATTACATCACAATTTTGTTGGAACGGAACA
TATTTTATTAGGCTTGATTCGTGAAAATGAAGGTGTTGCAGCAAGAGTTTTTGCAAATCTAGATTTAAATATTACTAAAG
CACGTGCACAAGTTGTGAAAGCTTTAGGAAACCCTGAAATGAGTAATAAAAATGCACAAGCTAGTAAGTCAAATAATACT
CCAACTTTAGATAGTTTAGCTCGTGACTTAACAGTCATTGCCAAAGACGGTACATTAGATCCTGTTATAGGACGTGATAA
AGAAATTACACGTGTAATTGAAGTATTAAGTAGACGTACGAAAAACAATCCTGTGCTTATTGGAGAGCCAGGTGTTGGTA
AAACTGCTATTGCTGAAGGTTTAGCGCAAGCCATAGTGAATAATGAGGTACCAGAGACATTAAAAGATAAGCGTGTTATG
TCTTTAGATATGGGAACAGTAGTTGCAGGTACTAAATATCGTGGTGAATTTGAAGAGCGTCTGAAAAAGGTTATGGAAGA
AATCCAACAAGCAGGTAATGTCATCCTATTTATTGATGAGTTGCATACTTTAGTTGGTGCTGGTGGTGCTGAAGGTGCTA
TCGATGCTTCGAATATTTTGAAACCGGCATTAGCACGTGGTGAATTACAATGCATTGGTGCTACTACATTAGATGAATAT
CGCAAAAATATTGAAAAAGACGCGGCTTTAGAACGTCGTTTCCAACCTGTACAAGTTGATGAACCTTCAGTAGTAGATAC
AGTTGCTATTTTAAAAGGATTAAGAGATCGTTACGAAGCACACCATCGTATTAATATTTCAGACGAAGCTATTGAAGCAG
CTGTTAAATTAAGTAACAGATACGTTTCAGATCGTTTCTTACCAGATAAAGCAATTGATTTAATTGACGAAGCAAGTTCT
AAAGTAAGACTTAAGAGTCATACGACACCTAATAATTTAAAAGAAATTGAACAAGAAATTGAAAAAGTTAAAAATGAAAA
AGATGCGGCAGTGCATGCTCAAGAGTTTGAAAATGCTGCTAATCTGCGTGATAAACAAACAAAACTTGAAAAGCAATATG
AAGAAGCTAAAAATGAATGGAAGAACGCACAAAATGGCATGTCAACTTCATTGTCAGAAGAAGATATTGCTGAAGTCATT
GCAGGATGGACAGGTATCCCATTAACTAAAATCAACGAAACAGAATCTGAAAAACTTCTTAGTCTAGAAGATACATTACA
TGAGAGAGTTATTGGGCAAAAAGATGCTGTTAATTCAATCAGTAAAGCGGTTAGACGTGCCCGTGCAGGGTTAAAAGATC
CTAAACGACCAATTGGTAGCTTTATCTTCCTTGGACCAACTGGTGTTGGTAAAACTGAATTAGCTAGAGCTTTAGCTGAA
TCAATGTTTGGCGATGATGATGCGATGATCCGTGTAGACATGAGTGAATTTATGGAAAAACACGCAGTGAGCCGATTAGT
TGGTGCTCCTCCAGGATATGTTGGTCATGATGATGGTGGACAATTAACTGAAAAAGTTAGACGTAAACCATATTCTGTAA
TTTTATTTGATGAAATTGAAAAAGCACATCCAGATGTATTTAATATTCTATTACAAGTTTTAGATGACGGACATTTGACA
GATACAAAAGGACGTACAGTTGATTTCAGAAATACAATTATCATAATGACATCAAACGTTGGAGCACAAGAATTACAAGA
TCAACGATTTGCTGGATTCGGTGGTTCAAGTGATGGACAAGATTATGAAACAATTCGAAAAACGATGTTAAAAGAATTAA
AAAATTCATTCCGTCCAGAATTTTTAAACCGTGTAGATGATATCATTGTATTCCATAAACTAACAAAAGAAGAATTAAAA
GAAATTGTAACTATGATGGTTAATAAATTAACAAATCGATTATCCGAACAAAACATAAATATTATTGTTACTGATAAAGC
GAAAGATAAAATCGCAGAAGAAGGATATGATCCAGAATATGGTGCAAGACCATTAATTAGAGCGATACAAAAAACTATCG
AAGATAATTTAAGTGAATTAATATTAGATGGTAATCAAATTGAAGGTAAGAAAGTTACAGTAGATCATGATGGTAAAGAG
TTTAAATATGACATTGCTGAACAAACTTCAGAAACTAAAACACCATCGCAAGCATAA

Protein sequence :
MLFGRLTERAQRVLAHAQEEAIRLNHSNIGTEHLLLGLMKEPEGIAAKVLESFNITEDKVIEEVEKLIGHGQDHVGTLHY
TPRAKKVIELSMDEARKLHHNFVGTEHILLGLIRENEGVAARVFANLDLNITKARAQVVKALGNPEMSNKNAQASKSNNT
PTLDSLARDLTVIAKDGTLDPVIGRDKEITRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQAIVNNEVPETLKDKRVM
SLDMGTVVAGTKYRGEFEERLKKVMEEIQQAGNVILFIDELHTLVGAGGAEGAIDASNILKPALARGELQCIGATTLDEY
RKNIEKDAALERRFQPVQVDEPSVVDTVAILKGLRDRYEAHHRINISDEAIEAAVKLSNRYVSDRFLPDKAIDLIDEASS
KVRLKSHTTPNNLKEIEQEIEKVKNEKDAAVHAQEFENAANLRDKQTKLEKQYEEAKNEWKNAQNGMSTSLSEEDIAEVI
AGWTGIPLTKINETESEKLLSLEDTLHERVIGQKDAVNSISKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAE
SMFGDDDAMIRVDMSEFMEKHAVSRLVGAPPGYVGHDDGGQLTEKVRRKPYSVILFDEIEKAHPDVFNILLQVLDDGHLT
DTKGRTVDFRNTIIIMTSNVGAQELQDQRFAGFGGSSDGQDYETIRKTMLKELKNSFRPEFLNRVDDIIVFHKLTKEELK
EIVTMMVNKLTNRLSEQNINIIVTDKAKDKIAEEGYDPEYGARPLIRAIQKTIEDNLSELILDGNQIEGKKVTVDHDGKE
FKYDIAEQTSETKTPSQA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 57

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ST398NM01_0600 YP_006194665.1 Negative regulator of genetic competence clpC/mecB VFG0079 Protein 0.0 71
ST398NM01_0600 YP_006194665.1 Negative regulator of genetic competence clpC/mecB VFG0080 Protein 2e-165 52