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Name : ureC (B2K_05560) Accession : YP_006187960.1 Strain : Paenibacillus mucilaginosus K02 Genome accession: NC_017672 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : - COG ID : - EC number : 3.5.1.5 Position : 1254981 - 1256714 bp Length : 1734 bp Strand : + Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : GTGGCACACATGGACCGCAAGGCCTATGCCCTTACTTTCGGGCCGACGACGGGAGACGCTGTCCGTCTTGCCGATACCGA GCTGTGGGCGGAGATCGAGGAAGACCGCACCGTCTACGGGGATGAGTGCAAATTCGGCGGAGGCAAGGTCATTCGCGACG GGATGGGCCAATCCAGCCGGCATACCCGGGATCAAGGTGTGATCGACACCCTGATTACCAACGCGGTCATTATTGACCAT AGTGGAATTATCAAGGCGGACATCGGGATCAAGGACGGGGTGATCGTCGGGATCGGCAAGGCGGGCAATCCCGATATTAT GGACGGCGTGGACCCGAATATGGTGGTCGGCGCTTCAACCGAAGTCATTGCCGGGGAAGGCAAGATCATTACGGCCGGCG GGATCGACTCGCATATCCATTATATATGTCCGCAGCAGATCGAGACGGCGCTGTCCTCGGGAGTGACCACGATGATCGGC GGCGGTACGGGGCCGGCGGCCGGTACCAGCGCGACGACCTGCACGCCGGGAGCCTGGCACATGCGGCGCATGCTGGAGGC GGCCGAAGCGTTCCCGATGAATCTCGGCTTCACCGGCAAGGGGAATGCCGCGTTCCCGGGCCCGCTTGAGGAGCAGGTGG AAGCGGGGGCGATCGGCCTGAAGCTTCACGAGGACTGGGGGACGACGCCCGCTGCGATCGATACCTGCCTCGCGGTTGCT GACAAGTACGACGTGCAGGTGGCCATCCATACGGACACGCTGAACGAATCCGGCTTCGTGGAAGATACGATCCGGGCGAT CGGCGGCCGGACGATTCATACATATCATACGGAGGGGGCCGGAGGCGGGCATGCGCCGGACATTATCCGGATCGCCTCGG AGCTCAATGTGCTTCCTTCCTCGACGAATCCGACGCGTCCCTATACGGTCAATACCGTAGAAGAGCATCTCGACATGCTG ATGGTCTGTCATCATCTCGACAGCCGGATTCCCGAGGACGTCGCTTTTGCGGATTCGCGGATCCGTCCGGAGACGATCGC TGCGGAGGACATCCTGCACGATCTGGGCGTGTTCTCCATGATCTCTTCGGACTCCCAGGCGATGGGCCGGGTGGGTGAAG TGATCACGAGGACGTGGCAGACGGCGGACAAGATGAAGAAGCAGCGCGGTTATCTGCCGGCTCCGGACGAGAGCCCGGAA GCGGCACACCCGGACAATGACAACTACCGGATCAAACGGTATGTGGCCAAATATACGATCAACCCGGCGATCACCCATGG CGTGTCCCACTTGGTGGGATCCGTCGAGGTCGGCAAGCTGGCGGACCTCGTCGTATGGACCCCTGCCTTCTTTGGCGTCA AGCCCGACATGGTGCTCAAGGGCGGGATCATCGCGTTCGCCCAGATGGGCGATCCGAACGCCTCCATCCCCACGCCGCAG CCGGTCTTCGGCCGCCCGATGTTCGGCGCCTTCGGCCGCGCGCTGAACCACTGCATTACCTTCGTGTCGCAGGCGGCTTA CGACAAGGGAGTTCACCTCGAGCTAGGCCTGCAGAAGCGGATCGAGCCGGTGAAGGGCTGCCGGAGCGTCACGAAGAAGG ATATGATCCATAACGGCGAAACCCCGTCGATCGAGGTGAACCCCGAAACCTATGAAGTGAAGGTGGACGGGAAGCCGGTT ACCTGCGAGCCGGCCGACGTGCTGCCGATGGCACAGCGGTACTTTTTATTCTAA Protein sequence : MAHMDRKAYALTFGPTTGDAVRLADTELWAEIEEDRTVYGDECKFGGGKVIRDGMGQSSRHTRDQGVIDTLITNAVIIDH SGIIKADIGIKDGVIVGIGKAGNPDIMDGVDPNMVVGASTEVIAGEGKIITAGGIDSHIHYICPQQIETALSSGVTTMIG GGTGPAAGTSATTCTPGAWHMRRMLEAAEAFPMNLGFTGKGNAAFPGPLEEQVEAGAIGLKLHEDWGTTPAAIDTCLAVA DKYDVQVAIHTDTLNESGFVEDTIRAIGGRTIHTYHTEGAGGGHAPDIIRIASELNVLPSSTNPTRPYTVNTVEEHLDML MVCHHLDSRIPEDVAFADSRIRPETIAAEDILHDLGVFSMISSDSQAMGRVGEVITRTWQTADKMKKQRGYLPAPDESPE AAHPDNDNYRIKRYVAKYTINPAITHGVSHLVGSVEVGKLADLVVWTPAFFGVKPDMVLKGGIIAFAQMGDPNASIPTPQ PVFGRPMFGAFGRALNHCITFVSQAAYDKGVHLELGLQKRIEPVKGCRSVTKKDMIHNGETPSIEVNPETYEVKVDGKPV TCEPADVLPMAQRYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 4e-160 | 67 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 4e-160 | 67 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-149 | 63 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-149 | 62 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-149 | 62 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 3e-149 | 62 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_006187960.1 | urease subunit alpha | VFG0270 | Protein | 1e-160 | 67 |
