Gene Information

Name : cadA (SMD_1565)
Accession : YP_006184296.1
Strain : Stenotrophomonas maltophilia D457
Genome accession: NC_017671
Putative virulence/resistance : Resistance
Product : Lead, cadmium, zinc and mercury transporting ATPase
Function : -
COG functional category : -
COG ID : -
EC number : 3.6.3.3
Position : 1727504 - 1730416 bp
Length : 2913 bp
Strand : -
Note : -

DNA sequence :
ATGAACAAAGAACCTTCCAGCCCATGCGCCTGCTCCGGCGGCAATGGCCAACAGACGGCGTGCGCCAGTGAGCAGGCCAG
CACTGAAACCACCGTTTTCCACGTGAGCAACATGGATTGCCGCAATGAGGAAGCACTGGTGCGGCGAACGCTGGAGGGCA
TGCCCGGTGTCGAGCGGCTCCTGTTCGATCTTCCGCAGCGTTTGTTGACCATTTCGCACCGCGAAGTCTCGGCCGATGCC
TTGGAGCAAGCGCTGAATTCGGTGGGCATGAAGGCTCAGGCTGTCCGAGACGCCGCCGTGTCGACCACCTACCGCATCGA
GAACATGGACTGCCCGAGCGAGGAGAAACTCATCCGCTCGCACCTCGGGGCAGTCGAGGGAATTCAGGACCTCGACTTCG
ACCTCGCTGAGCGCACCCTGTCGGTGAAACACCTCGCTCAGGCACGCGCGCAGATGGAGCAGGTCCTGGCCTCGATCGGC
ATGCGCGCCAAGGAGCAGACCTTCGGCCACACGGGGCCGATCGAAGCCGCGGCTGTGATCCCATCCTCGGCCCTGCAGCA
GCAACCAACCGCTGCCGTTTCCGCGCCGCCGATCGGCGAGCGGGTGACGTACCGGATCGAGAACATGGATTGCCCGACGG
AAGAAGCGCTGATCCGCGACCGGCTGGGCAAGCTGCCGGGTGTGACCGCGCTCGACTTCAATCTGATGCAGCGTGTGCTG
GGAGTCCAGCACACGCTGGCGACCTCAGCGCCGATCGAGAAGGCGCTTGCTTCCATTGGAATGCAGGCTGCGCGGCAGGA
CATGCAGACAGCCACCACGGTACTTCGCATCGCGAAGATGGACTGTCCGACCGAGGAAAGTCTGATCCGCGGCAAGCTGC
AAGGCATGCCGGGCGTGCAGGGAATGGATTTCAACCTGATGCAGCGCACGCTCACGGTTCGGCACACACCCGACGCGATC
AAGCCGGCAGTCGAAGCCATCGAATCGCTGGGCATGGAAGCCGAGGTCCAGAGGACTGATGAGCCGCGCGATGCCCCGGT
GGCCGCGCACAAGACCAATTGGTGGCCGATGGCGGTTTCGGGCGTTGCGGCGGTGGCCGCCGAAGGCGTGTACTGGGTCA
ACGACGGCAATCATTGGGCCGTGATCGTGCTGGCACTGGTTTCGATCTTCACCGGCGGCCTCAGCACCTACAAGAAGGGC
TGGATCGCGCTGAAGAACCTCAACCTGAACATGAACGCCCTGATGGCCATCGCGGTCACCGGCGGCATGGCGATCGGCCA
CTGGCCGGAGGCCGCCATGGTCATGTTCCTGTTCGCGTTGGCGGAAGTGATCGAGGCGAAGTCGCTGGACCGCGCCCGCA
ACGCCATTCGGGGGCTGATGGACTTGGCGCCCGAGACCGCGACCGTGCGGCAGGCCGATGGCTCATGGACAGAGCTGCCG
GCCAAGGAGGTCGCAAAGGGCGCGGTGGTCCGCGTGCGTCCTGGCGAGCGCATCGCACTGGACGGCCTGATCACCTCGGG
TCGATCGGCCATCAACCAGGCGCCCATCACCGGCGAGAGCCTGCCCGTCGAGAAGGCCGAAGGTGACCAGGTCTTCGCCG
GAACCATCAATGAGACCGGCTCTTTCGAATACAAGGTGACCGCAGGCGCCAGCGACTCGACGCTCGCGCGCATCATCCAT
GCCGTGGAGTCCGCGCAGGGCAGCCGTGCGCCCACGCAGCGCTTCGTCGACCAGTTCGCCCGCGTCTACACGCCGGCGGT
GTTCGCGGTGTCCGTGCTGGTTGCCGTCGTGCCGCCGCTCGCCTTCGGCGGCGCATGGTTTGACTGGGTCTACAAGGCCC
TGGTACTGCTGGTGATCGCCTGCCCCTGCGCTCTGGTCATCTCCACGCCGGTCACCATCGTCAGCGGCTTGGCCGCTGCC
GCCCGACGCGGCATCCTGATCAAGGGTGGCGTCTACCTGGAGGGCGGGCGCAAGCTCAAGGCGTTGGCCCTGGACAAGAC
CGGCACACTCACACATGGCAAGCCCGAGCAGACCGACTTCGTGCCGCTGATCGGCGAGGCGCAGGAAGTTGCCGCCTGGG
CCGCAAGCCTCGCGGCACGCTCGGACCATCCTGTGTCTCAGGCCATCGCCCGCAAGGCGAACCGTGACGGCATCGCGCTG
CACGAGGTCGACGACTTCGCGGCGCTGCCTGGCCGCGGCGTGCGCGGCCGCGTCGCCGGGCGCATGTTGCACATGGGCAA
CCACAGGCTCGCCCAGGAGCTGGGCCTGAGCGAAGCGACGCTCCAGGCTCGGCTGGAGACCCTGGAGCGCCAAGGCAAGA
CAGCGATCCTGCTGATGGACGATGCGACCGTGCTCGGCATTTTTGCAGTGGCCGACACCGTGAAGGAAACCAGCCGTGAG
GCGGTGGCCGACCTGCAGGCGCTGGGTGTGCGCACGCTGATGCTGACGGGGGACAACCAGCACACGGCCGCGGCCATCGC
TGCCCAGGTCGGAATCTCTGAAGCCCGTGGTGACCAACTGCCCGAAGACAAGCTCAAGACCATCGAAAGCCTGGTCGGCG
GCGAGGGCCAGGTGGGCATGGTGGGCGACGGCATCAACGATTCGCCCGCGCTCGCCCGTGCCGACATCGGCTTCGCCATG
GGCGCGGCCGGCACCGACACCGCGATCGAAACAGCCGACGTCGCCCTGATGGACGACGACCTGCGCAAGATCCCCGCCTT
CATCCGGCTGTCGCGTAGCACTGCGGCGATCCTCACGCAGAACATCGTTCTGGCCCTTGGCATCAAGGCGGTGTTCCTTG
CGTTGACGTTCACAGGGCATGCCACCATGTGGATGGCTGTGTTCGCTGACATGGGGGCAAGTCTTTTGGTTGTCGTCAAT
GGGCTGCGCCTCCTGAAGTTCAAGGCGGCATGA

Protein sequence :
MNKEPSSPCACSGGNGQQTACASEQASTETTVFHVSNMDCRNEEALVRRTLEGMPGVERLLFDLPQRLLTISHREVSADA
LEQALNSVGMKAQAVRDAAVSTTYRIENMDCPSEEKLIRSHLGAVEGIQDLDFDLAERTLSVKHLAQARAQMEQVLASIG
MRAKEQTFGHTGPIEAAAVIPSSALQQQPTAAVSAPPIGERVTYRIENMDCPTEEALIRDRLGKLPGVTALDFNLMQRVL
GVQHTLATSAPIEKALASIGMQAARQDMQTATTVLRIAKMDCPTEESLIRGKLQGMPGVQGMDFNLMQRTLTVRHTPDAI
KPAVEAIESLGMEAEVQRTDEPRDAPVAAHKTNWWPMAVSGVAAVAAEGVYWVNDGNHWAVIVLALVSIFTGGLSTYKKG
WIALKNLNLNMNALMAIAVTGGMAIGHWPEAAMVMFLFALAEVIEAKSLDRARNAIRGLMDLAPETATVRQADGSWTELP
AKEVAKGAVVRVRPGERIALDGLITSGRSAINQAPITGESLPVEKAEGDQVFAGTINETGSFEYKVTAGASDSTLARIIH
AVESAQGSRAPTQRFVDQFARVYTPAVFAVSVLVAVVPPLAFGGAWFDWVYKALVLLVIACPCALVISTPVTIVSGLAAA
ARRGILIKGGVYLEGGRKLKALALDKTGTLTHGKPEQTDFVPLIGEAQEVAAWAASLAARSDHPVSQAIARKANRDGIAL
HEVDDFAALPGRGVRGRVAGRMLHMGNHRLAQELGLSEATLQARLETLERQGKTAILLMDDATVLGIFAVADTVKETSRE
AVADLQALGVRTLMLTGDNQHTAAAIAAQVGISEARGDQLPEDKLKTIESLVGGEGQVGMVGDGINDSPALARADIGFAM
GAAGTDTAIETADVALMDDDLRKIPAFIRLSRSTAAILTQNIVLALGIKAVFLALTFTGHATMWMAVFADMGASLLVVVN
GLRLLKFKAA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ORF C97 AAN62190.1 putative metal-transporting P-type ATPase Not tested PAGI-2(C) Protein 0.0 100
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 1e-113 41
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 9e-114 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cadA YP_006184296.1 Lead, cadmium, zinc and mercury transporting ATPase BAC0298 Protein 0.0 71