Gene Information

Name : NRG857_30100 (NRG857_30100)
Accession : YP_006162239.1
Strain :
Genome accession: NC_017659
Putative virulence/resistance : Resistance
Product : dihydrofolate reductase type I DhfrA1
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 53974 - 54447 bp
Length : 474 bp
Strand : +
Note : Sequence similarity to: YP_002527542.1 dihydrofolate reductase type I DhfrA1 [Escherichia coli]; pfam00186, DHFR_1, Dihydrofolate reductase

DNA sequence :
GTGAAACTATCACTAATGGTAGCTATATCGAAGAATGGAGTTATCGGGAATGGCCCTGATATTCCATGGAGTGCCAAAGG
TGAACAGCTCCTGTTTAAAGCTATTACCTATAACCAATGGCTGTTGGTTGGACGCAAGACTTTTGAATCAATGGGAGCAT
TACCCAACCGAAAGTATGCGGTCGTAACACGTTCAAGTTTTACATCTGACAATGAGAACGTAGTGATCTTTCCATCAATT
AAAGATGCTTTAACCAACCTAAAGAAAATAACGGATCATGTCATTGTTTCAGGTGGTGGGGAGATATACAAAAGCCTGAT
CGATCAAGTAGATACACTACATATATCTACAATAGACATCGAGCCGGAAGGTGATGTTTACTTTCCTGAAATCCCCAGCA
ATTTTAGGCCAGTTTTTACCCAAGACTTCGCCTCTAACATAAATTATAGTTACCAAATCTGGCAAAAGGGTTAA

Protein sequence :
MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYAVVTRSSFTSDNENVVIFPSI
KDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDIEPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
dfrA1 AAX48777.1 DfrA1 trimethoprim-insensitive dihydrofolate reductase Not tested SGI2 Protein 5e-69 99
dfrI CAJ77029.1 dihydrofolate reductase type I Not tested AbaR1 Protein 5e-69 99
dfrA1 AGF34987.1 DfrA1 dihydrofolate reductase Not tested SGI1 Protein 5e-69 99
dfrA15 AGK07099.1 DfrA15 dihydrofolate reductase Not tested SGI1 Protein 6e-66 92
dfrA1 ADZ05803.1 trimethoprim-insensitive dihydrofolate reductase Not tested AbaR3 Protein 1e-55 76
unnamed AEL12695.1 DfrA5 Not tested AbaR21 Protein 1e-55 76
dfrA5 AET25387.1 dihydrofolate reductase Not tested PAGI-2(C) Protein 1e-53 75
dfrA5 AFG30110.1 dihydrofolate reductase Not tested PAGI-2 Protein 1e-53 75