Gene Information

Name : iucA (ECNA114_4701)
Accession : YP_006141824.1
Strain : Escherichia coli NA114
Genome accession: NC_017644
Putative virulence/resistance : Virulence
Product : Citrate:6-N-acetyl-6-N-hydroxy-L-lysine ligase, alpha subunit, aerobactin biosynthesis protein / Siderophore synthetase superfamily, group A / Siderophore synthetase large component, acetyltransferase
Function : -
COG functional category : -
COG ID : -
EC number : 6.3.2.27
Position : 4848677 - 4850401 bp
Length : 1725 bp
Strand : -
Note : -

DNA sequence :
ATGACCCTGCCCTCTGAAAAACCAGCCACAGATGTGGCTGCGCAGTGCTTCCTGAATGCACTGATTCGTGAAACCACAGA
CTGGAAACTGACAGAATACCCGCCAGACGAATTGCTCATCCCGCTGGATGAGCAGAAATCGCTCCATTTCAGAGTGGCTT
ATTTCTCCCCAACCCAGCATCACCGCTTTGCATTTCCTGCACGTCTGGTCACGGCATCAGGCAGTTATCCTGTCGACTTT
ACCACTCTCTCCCGGCTTATTATTGATAAGCTACGCCATCAACTGTTTCTGCCCGTTCCCCTCTGCGAAACTTTCCACCA
GCGCGTGCTGGAAAGCCATGTCCATACGCAACAGGCAATTGATGCCCGTCATGACTGGGCCGCTCTGCGTGAAAAAGCGT
TGAATTTTGGCGAGGCTGAGCAGGCGCTGCTGACAGGACACGCTTTCCACCCTGCGCCTAAGTCTCATGAACCGTTTAAC
CGGCGGGAGGCTGAACGCTACCTGCCTGATATGGCACCCCACTTCCCACTGCGGTGGTTTTCGGTGGATAAAACGCAAAT
CGCCGGTGAAAGTTTGCATCTCAACCTTCAACAGCGGCTGACGCGATTTGCCGCAGAGAATGCGCCTCAGTTACTCAACG
AATTAAGTGACAACCAATGGCTGTTCCCGTTGCACCCGTGGCAGGGGGAATATCTTTTGCAGCAGGGGTGGTGCCAGGCA
CTTGTTGCTAAAGGGCTGATTAAAGACTTAGGTGAGGCCGGCACGTCGTGGCTGCCGACCACCTCTTCCCGTTCCCTCTA
CTGTGCCACCAGCCGCGATATGATCAAGTTCTCCCTGAGCGTACGGCTGACCAACTCCATCCGTACTCTGTCCGTGAAAG
AAGTGAAGCGTGGGATGCGCCTGGCACGCCTGGCTCAAACCGACGGCTGGCAGATGCTACAGGTCCGCTTCCCGACTTTC
CGGGTAATGCAGGAGGATGGCTGGGCCGGGCTGCGCGATCTTAACGGCAACATCATGCAGGAAAGTCTGTTTGCCCTGCG
TGAAAATCTGCTGGTGGATCAGCCGAAAAGCCAGACTAACGTACTGGTCTCCCTGACTCAGGCCGCACCTGATGGCGGTG
ATTCGCTGCTGGTTTCGGCGGTAAAACGCCTGAGCGATCGCCTCGGTATCACTGTGCAACAGGCCGCCCATGCATGGGTC
GATGCATACTGTCAGCAAGTGCTAAAGCCGCTGTTTACGGCTGAAGCGGATTACGGCCTGGTGCTGCTGGCGCATCAGCA
AAATATTCTTGTCCAGATGCTTGGGGATCTGCCGGTCGGATTTATTTACCGTGACTGTCAGGGCAGCGCTTTTATGCCTC
ACGCGACAGACTGGCTCGATTCTATTGGCGAGGCGCAGGCGGAAAATATTTTCACCCATGAGCAGTTGCTGCGCTATTTC
CCTTATTACCTGCTGGTTAACTCCACTTTTGCTGTGACCGCTGCGCTGGGGGCTGCCGGGCTGGACAGCGAATCGAATCT
GATGGCTCGTGTACGAGCATCGCTGGCTGAAGTGCGTGATCAGGTGACTCATAAAACCTGTCTCAACTACGTGCTGGAAA
GTCCGTACTGGAACGTAAAAGGTAACTTTTTCTGTTATCTGAACGATCATAACGAGAACACCATTGTTGACCCTTCGGTG
ATCTATTTCGATTTCGCTAACCCGCTGCAGGCTCAGGAGGTCTGA

Protein sequence :
MTLPSEKPATDVAAQCFLNALIRETTDWKLTEYPPDELLIPLDEQKSLHFRVAYFSPTQHHRFAFPARLVTASGSYPVDF
TTLSRLIIDKLRHQLFLPVPLCETFHQRVLESHVHTQQAIDARHDWAALREKALNFGEAEQALLTGHAFHPAPKSHEPFN
RREAERYLPDMAPHFPLRWFSVDKTQIAGESLHLNLQQRLTRFAAENAPQLLNELSDNQWLFPLHPWQGEYLLQQGWCQA
LVAKGLIKDLGEAGTSWLPTTSSRSLYCATSRDMIKFSLSVRLTNSIRTLSVKEVKRGMRLARLAQTDGWQMLQVRFPTF
RVMQEDGWAGLRDLNGNIMQESLFALRENLLVDQPKSQTNVLVSLTQAAPDGGDSLLVSAVKRLSDRLGITVQQAAHAWV
DAYCQQVLKPLFTAEADYGLVLLAHQQNILVQMLGDLPVGFIYRDCQGSAFMPHATDWLDSIGEAQAENIFTHEQLLRYF
PYYLLVNSTFAVTAALGAAGLDSESNLMARVRASLAEVRDQVTHKTCLNYVLESPYWNVKGNFFCYLNDHNENTIVDPSV
IYFDFANPLQAQEV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
iucA NP_839223.1 siderophore biosynthesis protein Virulence SHI-2 Protein 0.0 99
iucA NP_709454.2 siderophore biosynthesis protein Virulence SHI-2 Protein 0.0 99
iucA AAD44746.1 IucA Virulence SHI-2 Protein 0.0 99
iucA YP_002414046.1 aerobactin siderophore biosynthesis protein Virulence Not named Protein 0.0 99
iucA AAK71631.1 IucA Virulence SHI-3 Protein 0.0 94

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
iucA YP_006141824.1 Citrate:6-N-acetyl-6-N-hydroxy-L-lysine ligase, alpha subunit, aerobactin biosynthesis protein / Siderophore synthetase superfamily, group A / Siderophore synthetase large component, acetyltransferase VFG0615 Protein 0.0 99
iucA YP_006141824.1 Citrate:6-N-acetyl-6-N-hydroxy-L-lysine ligase, alpha subunit, aerobactin biosynthesis protein / Siderophore synthetase superfamily, group A / Siderophore synthetase large component, acetyltransferase VFG0940 Protein 0.0 99
iucA YP_006141824.1 Citrate:6-N-acetyl-6-N-hydroxy-L-lysine ligase, alpha subunit, aerobactin biosynthesis protein / Siderophore synthetase superfamily, group A / Siderophore synthetase large component, acetyltransferase VFG1081 Protein 0.0 94