Gene Information

Name : flu2 (EC042_4511)
Accession : YP_006098789.1
Strain : Escherichia coli 042
Genome accession: NC_017626
Putative virulence/resistance : Virulence
Product : antigen 43 autotransporter (fluffing protein) [contains: antigen 4 alpha chain; antigen 43 beta chain]
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 4839993 - 4843118 bp
Length : 3126 bp
Strand : -
Note : known to control colony form variation and autoaggregation. may also function as an adhesin; highly similar (87.199% id) to EC042_2242

DNA sequence :
ATGCTGATGAAACGACATCTGAATACCTGCTACAGGCTGGTATGGAATCACATTACGGGCGCTTTCGTGGTTGCCTCCGA
ACTGGCCCGCGCACGGGGTAAACGTGGCGGTGTGGCGGTTGCACTGTCTCTTGCCGCAGTCACGTCACTCCCGGTGCTGG
CTGCTGACATCGTTGTGCACCCGGGTGAAACAGTGAATGGCGGAACACTGGTAAACCATGACAACCAGTTTGTATCCGGA
ACAGCTGATGGCGTGACTGTCAGTACCGGGCTTGAGCTGGGGCCGGACTCTGATGACAACACCGGCGGTCAGCAGATAGC
CCGGGGTGGCACTGCCAGAAACACCACGGTCACCGCAAACGGTCTGCAGGATGTCATGGCAGGTGGCAGTGCCACGGATA
CGGTTATCAGTGCCGGTGGAGGACAGAATCTGCGCGGGCAGGCTTACGGTACTGTCCTTAACGGTGGTGAACAATGGATA
CATGCAGGCGGCAGTGCATCCGGAACGGTGATTAACCAGTCTGGCTACCAGACCATTAAACATGGCGGGCAGGCAACCGG
AACCATCGTCAACACCGGTGCAGAAGGTGGTCCGGAGTCTGAAAATGTGTCCAGCGGTCAGATGGTCGGAGGGACGGCTG
AATCCACCACCATCAACAAAAATGGCCGGCAGGTTATCTGGTCTTCGGGGATGGCACGGGACACCCTCATTTACGCCGGC
GGTGACCAGACGGTACACGGCGAGGCACATAACACCCGGCTGGAGGGAGGAAACCAGTATGTGCACAAATACGGACTTGC
GCTGAACACGGTAATTAACGAGGGGGGCTGGCAGGTGATTAAGGAAGGAGGAACTACCGCGCATACCACCATCAACCAGA
AAGGAAAGCTGCAGGTGAATGCCGGCGGTAAAGCGTCTGATGTCACCCAGAACACGGGAGGTGCACTGGTTACCAGCACA
GCTGCAACCGTCACCGGCACAAACCGCCTGGGAGCATTCTCCGTTCTGGCGGGTAAGGCTGATAATGTCGTACTGGAAAA
TGGCGGACGTCTGGATGTGCTGAGCGGACACACAGCCACTAATACCCGTGTGGATGATGGCGGAACGCTGGATGTCCGCA
ACGGTGGTGCCGCCACCACCGTATCCATGGGGAATGGCGGTGTACTGCTGGCCGATTCCGGGGCCGCTGTCAGTGGTACC
CGGAGCGACGGAACGGCATTCCGTATCGGGGGCGGTCAGGCGGATGCCCTGATGCTGGAAAAAGGCAGTTCATTCACGCT
GAACGCCGGTGATACGGCCACGGATACCACGGTAAATGGCGGACTGTTCACTGCCAGAGGGGGCTCGCTGGCGGGCACCA
CCACGCTGAATAACGGTGCCACGCTTACCCTTTCCGGGAAAACGGTGAATAACGATACCCTGACCATCCGTGAAGGTGAT
GCACTCCTGCAGGGAGGCGCTCTTACCGGTAACGGCAGGGTGGAAAAATCAGGAAGTGGCACACTCACTGTCAGCAACAC
CACACTCACCCAGAAAACCGTCAACCTGAATGAAGGCACGCTGACGCTGAACGACAGTACCGTCACCACGGATGTCATCG
CTCAGCGCGGCACGGCCCTGAAGCTGACCGGCAGCACAGTGCTGAACGGTGCCATTGACCCCACGAATGTCACCCTGACA
TCCGGTGCCACCTGGAATATCCCTGATAACGCCACGGTGCAGTCGGTGGTGGATGACCTCAGCCATGCCGGACAGATTCA
TTTCACCTCCACCCGCACAGGGAAGTTCGTACCGGCAACCCTGCAGGTGAAAAACCTGAACGGGCAGAATGGCACCATCA
GCCTGCGTGTACGCCCGGATATGGCGCAGAACAATGCTGACAGACTGGTCATTGACGGTGGCAGGGCAACCGGAAAAACC
ATCCTGAATCTGGTGAACGCCGGCAACAGTGGTACGGGGCTGGCGACCACCGGTAAGGGTATTCAGGTGGTTGAGGCCAT
TAACGGTGCCACCACGGAGGAAGGGGCTTTTGTCCAGGGGAATATGCTGCAGGCCGGGGCCTTTAACTACACCCTCAACC
GGGACAGTGATGAGAGCTGGTATCTGCGCAGTGAAGAACGTTATCGTGCTGAAGTCCCCCTGTACGCCTCCATGCTGACA
CAGGCAATGGACTATGACCGGATTCTGGCAGGCTCACGCAGCCATCAGACCGGTGTAAACGGTGAAAATAACAGCGTCCG
TCTCAGCATTCAGGGCGGCCATCTCGGTCACGATAACAACGGCGGTATTGCCCGTGGGGCCACGCCGGAAAGCAGCGGCA
GCTATGGCTTCGTCCGTCTGGAGGGTGACCTGCTCAGAACAGAGGTCGCCGGTATGTCACTGACGACAGGAGTGTATGGT
GCTGCAGGCCATTCTTCCGTTGATGTTAAGGATGATGACGGCTCCCGCGCCGGCACGGTCCGGGATGATGCCGGCAGCCT
GGGCGGATATATGAACCTGACACACACCTCCTCCGGCCTGTGGGCTGACATTGTGGCACAGGGAACCCGCCACAGTATGA
AAGCGTCATCGGGCAATAACGACTTCCGCGCACGGGGCTGGGGCTGGCTGGGCTCACTGGAAACCGGTCTGCCCTTCAGT
ATTACTGACAACCTGATGCTGGAGCCACGGCTGCAGTACACCTGGCAGGGGCTTTCGCTGGATGACGGTAAGGACAACGC
CGGTTATGTGAAGTTCGGGCATGGCAGTGCACAACATGTGCGTGCCGGTTTCCGTCTGGGCAGCCACAACGATATGACCT
TTGGTGAAGGCACCTCATCCCGTGCCCCCCTGCGTGACAGTGCAAAACACAGTGTGCGTGAACTGCCGGTGAACTGGTGG
GTACAGCCTTCCGTTATCCGCACCTTCAGCTCCCGGGGTGATATGCGTGTGGGGACCTCCACCGCAGGCAGCGGGATGAC
GTTCTCTCCCTCACAGAATGGCACTTCACTGGATCTGCAGGCCGGACTGGAAGCCCGTGTCCGGGAAAATATCACCCTGG
GCGTTCAGGCCGGTTATGCCCACAGCGTCAGCGGCAGCAGCGCTGAAGGTTATAACAGTCAGGCCACGCTGAATGTGACC
TTCTGA

Protein sequence :
MLMKRHLNTCYRLVWNHITGAFVVASELARARGKRGGVAVALSLAAVTSLPVLAADIVVHPGETVNGGTLVNHDNQFVSG
TADGVTVSTGLELGPDSDDNTGGQQIARGGTARNTTVTANGLQDVMAGGSATDTVISAGGGQNLRGQAYGTVLNGGEQWI
HAGGSASGTVINQSGYQTIKHGGQATGTIVNTGAEGGPESENVSSGQMVGGTAESTTINKNGRQVIWSSGMARDTLIYAG
GDQTVHGEAHNTRLEGGNQYVHKYGLALNTVINEGGWQVIKEGGTTAHTTINQKGKLQVNAGGKASDVTQNTGGALVTST
AATVTGTNRLGAFSVLAGKADNVVLENGGRLDVLSGHTATNTRVDDGGTLDVRNGGAATTVSMGNGGVLLADSGAAVSGT
RSDGTAFRIGGGQADALMLEKGSSFTLNAGDTATDTTVNGGLFTARGGSLAGTTTLNNGATLTLSGKTVNNDTLTIREGD
ALLQGGALTGNGRVEKSGSGTLTVSNTTLTQKTVNLNEGTLTLNDSTVTTDVIAQRGTALKLTGSTVLNGAIDPTNVTLT
SGATWNIPDNATVQSVVDDLSHAGQIHFTSTRTGKFVPATLQVKNLNGQNGTISLRVRPDMAQNNADRLVIDGGRATGKT
ILNLVNAGNSGTGLATTGKGIQVVEAINGATTEEGAFVQGNMLQAGAFNYTLNRDSDESWYLRSEERYRAEVPLYASMLT
QAMDYDRILAGSRSHQTGVNGENNSVRLSIQGGHLGHDNNGGIARGATPESSGSYGFVRLEGDLLRTEVAGMSLTTGVYG
AAGHSSVDVKDDDGSRAGTVRDDAGSLGGYMNLTHTSSGLWADIVAQGTRHSMKASSGNNDFRARGWGWLGSLETGLPFS
ITDNLMLEPRLQYTWQGLSLDDGKDNAGYVKFGHGSAQHVRAGFRLGSHNDMTFGEGTSSRAPLRDSAKHSVRELPVNWW
VQPSVIRTFSSRGDMRVGTSTAGSGMTFSPSQNGTSLDLQAGLEARVRENITLGVQAGYAHSVSGSSAEGYNSQATLNVT
F

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed CAD66200.1 hypothetical protein Virulence PAI III 536 Protein 0.0 93
SF2991 NP_708765.1 outer membrane fluffing protein Not tested SHI-1 Protein 0.0 92
sap AAK00474.1 Sap Not tested SHI-1 Protein 0.0 92
aidA ADD91708.1 AidA Not tested PAI-I AL862 Protein 0.0 87
flu CAI43838.1 antigen 43 Not tested LEE Protein 0.0 87
Z1211 NP_286746.1 adhesin Not tested TAI Protein 0.0 58
Z1651 NP_287154.1 adhesin Not tested TAI Protein 0.0 58
unnamed AAL08472.1 putative autotransporter Not tested SRL Protein 0.0 57
unnamed CAE85197.1 antigen43 protein orthologue Not tested PAI V 536 Protein 0.0 57

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
flu2 YP_006098789.1 antigen 43 autotransporter (fluffing protein) [contains: antigen 4 alpha chain; antigen 43 beta chain] VFG1675 Protein 0.0 93
flu2 YP_006098789.1 antigen 43 autotransporter (fluffing protein) [contains: antigen 4 alpha chain; antigen 43 beta chain] VFG0655 Protein 0.0 92
flu2 YP_006098789.1 antigen 43 autotransporter (fluffing protein) [contains: antigen 4 alpha chain; antigen 43 beta chain] VFG1063 Protein 0.0 57