Gene Information

Name : TtJL18_0903 (TtJL18_0903)
Accession : YP_006058589.1
Strain : Thermus thermophilus JL-18
Genome accession: NC_017587
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 817987 - 819360 bp
Length : 1374 bp
Strand : +
Note : PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: mercuric reductase

DNA sequence :
ATGACCTACGACCTCCTCATCGTAGGCTCGGGCTCCGCCGGGGTGGCGGCGGCCCTGGAGGCGAGCGCCCTCGGGGCCAA
GGCGGCCGTGGTGGAGGCGGGGGTTTTGGGGGGGACCTGCGTCAACGTGGGGTGCGTGCCCTCCAAGTACCTCCTCCGGG
CGGCCGACGCCTTCCACCGGGCGGGCCGCCCCGCCTTCCCCGGCCTCCGCACGGAGGCCCTCGAGGTGGACTGGATGTCC
CTCCTCGCGGGCAAGGAGGGCCTGATCGCGGCCCTCAGGAAGGAGAAGTACCAGGAGGTTCTGGAGGCGGCCGGGGTTCC
CGTGCTCCGGGGGAGGGCCCGTTTCCTGGACGGGGAAAGGATGGAGGTAGAGGGGCGGGAGGTCTTGGCCGGGCGGTACC
TCCTCGCCACCGGGGCGAGGCCCTTCCTTCCGCCCATCCCCGGCCTCCAGGAGAGCGCGCCCTGGACCTACCTCGAGGCC
CTCTCCGCCCCCGCCCTTCCCGAAAGCCTCCTGGTGGTGGGGGGTGGGCCCATCGGGCTTGAGCTCGCCCAGGCCTTCGC
CAGGCTTGGGAGCCGGGTGACGGTCCTCGAGGCCCTGCCCGAGGTCCTGCCCCAGGAGGACCGGGAGCTTGCCCGGCTCC
TCCGGGGCTACCTGGAGGAGGAGGGCCTTAGGGTCCACACCGGGGTCCGGGTGGAGGCCGTGGCCCGGGAAGGGGCCTTC
CGCGTCCGGACCGACCGGGGGGTTTTTGAGGCGGAGAGGCTCCTTGTGGCCACGGGGAGGAGGCCGGACCTAGAAGGGCT
CGGCCTGGAGCGGGCGGGCGTGGAGCGGGACGAGCGGGGCTTCCTCCGGCTGGACCCGAGCCTGCGCACCACCAACCCCC
GGGTCTACGCCGCCGGGGACGCGGCGGGGCTTCCCCAGTTCGTCTACGTGGCCGCCCAGTCGGGCAGGGTGGCGGCCCGC
AACGCCTTGGGGGTAAAGGCGCCCCTGGACCTCGCCGCCCTCCCCCGGGTCACCTTCACCGACCCCGCCCTGGCCGCGGT
GGGCCTCACGGAGGAGGAGGCGAGGAGGCGGTACGGCGCGGGGGTGCGGGCGGCCACCCTTCCCCTTTCCCAGGTGCCCA
AGGCCCTCACCGCCCGCGACACCCGGGGGGCCTTCAAGATCGTGGTGGACGAAGAGGGCACGGTCCTCGGCCTCCACGTC
CTGGCCCACGAGGCGGGGGACGTCATCCAGGAGGGCATCCTGGCGGTGAAGTACGGCCTCGGCTACCGGGACCTCATAGA
CACCTTCCACCCCTACCTGACCCTGGCCGAGGGGATAAGGCTCGTGGCCCAGGCCCTGGACGCCGATCCCAAAAAGCTTT
CCTGCTGCGCCTGA

Protein sequence :
MTYDLLIVGSGSAGVAAALEASALGAKAAVVEAGVLGGTCVNVGCVPSKYLLRAADAFHRAGRPAFPGLRTEALEVDWMS
LLAGKEGLIAALRKEKYQEVLEAAGVPVLRGRARFLDGERMEVEGREVLAGRYLLATGARPFLPPIPGLQESAPWTYLEA
LSAPALPESLLVVGGGPIGLELAQAFARLGSRVTVLEALPEVLPQEDRELARLLRGYLEEEGLRVHTGVRVEAVAREGAF
RVRTDRGVFEAERLLVATGRRPDLEGLGLERAGVERDERGFLRLDPSLRTTNPRVYAAGDAAGLPQFVYVAAQSGRVAAR
NALGVKAPLDLAALPRVTFTDPALAAVGLTEEEARRRYGAGVRAATLPLSQVPKALTARDTRGAFKIVVDEEGTVLGLHV
LAHEAGDVIQEGILAVKYGLGYRDLIDTFHPYLTLAEGIRLVAQALDADPKKLSCCA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 1e-61 44
SE0085 NP_763640.1 dihydrolipoamide dehydrogenase Not tested SCCpbp4 Protein 7e-64 43
merA BAB47642.1 mercuric reductase Not tested Type-III SCCmec Protein 6e-64 43
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 2e-61 42
merA AFG30120.1 MerA Not tested PAGI-2 Protein 2e-61 42
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 3e-61 42
merA AGK07079.1 MerA Not tested SGI1 Protein 1e-63 42
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 7e-63 42
merA ABQ57371.1 MerA Not tested SGI1 Protein 1e-63 42
merA AGK07021.1 MerA Not tested SGI1 Protein 1e-63 42
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 3e-62 42
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 2e-62 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
TtJL18_0903 YP_006058589.1 mercuric reductase BAC0651 Protein 3e-64 43
TtJL18_0903 YP_006058589.1 mercuric reductase BAC0653 Protein 2e-62 43
TtJL18_0903 YP_006058589.1 mercuric reductase BAC0650 Protein 4e-59 42
TtJL18_0903 YP_006058589.1 mercuric reductase BAC0652 Protein 4e-64 41