Gene Information

Name : TtJL18_0458 (TtJL18_0458)
Accession : YP_006058153.1
Strain : Thermus thermophilus JL-18
Genome accession: NC_017587
Putative virulence/resistance : Resistance
Product : D-alanine--D-alanine ligase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 398684 - 399643 bp
Length : 960 bp
Strand : +
Note : PFAM: D-ala D-ala ligase C-terminus; D-ala D-ala ligase N-terminus; TIGRFAM: D-alanine--D-alanine ligase

DNA sequence :
ATGAGGGTTCTTTTGATCGCCGGGGGCGTAAGCCCCGAGCACGAGGTCTCCCTCCTCTCCGCGGAAGGGGTTCTGCGCCA
CATGCCCTTCCCCATGGACCTCGCCGTGATCGCCCGGGACGGGCGCTGGCTTCTGGGGGAAAAGGCCTTGGCCGCCTTGG
AGGCCAAGGCGGCGCCCGAGGGGGAGCATCCCTTCCCCCCGCCCCTCCCCTGGGAGCGCTACGATGTGGTCTTTCCCCTG
CTCCACGGCCGCTTCGGCGAGGACGGGACGGTCCAGGGCTTTCTGGAGCTTTTGGGCAAGCCCTACGTGGGGGCGGGGGT
GGCGGCGAGCGCCCTCTGCATGGACAAGGACCTGAGCAAGCGGGTCCTCGCCCAGGCGGGGGTGCCCGTGGTCCCCTGGG
TGGCGGTGCGGAAGGGCGAGCCCCCCATGGTGCCCTTTGACCCCCCCTTCTTCGTCAAGCCGGCCAATACCGGCTCCAGC
GTGGGGATAAGCCGGGTGGAACGCTTTCAGGACCTGGAGGCCGCCCTGGCCTTGGCCTTCCGCTACGACGAGAAAGCGGT
GGTGGAGAAGGCCCTCTCCCCGGTGCGGGAGCTGGAGGTGGGGGTCTTGGGCAACGTCTTCGGCGAGGCGAGCCCCGTGG
GGGAGGTGCGCTACGAGGCGCCCTTCTACGATTACGAGACCAAGTACACCCCGGGCCGGGCCGAGCTCCTCATCCCCGCG
CCCTTGGACCCCGGCACCCAGGAGACCGTCCAGGAGCTCGCCCTCAAGGCCTACAAGGTGCTCGGGGTGCGGGGGATGGC
CCGGGTGGACTTCTTCCTCGCGGAGGGGGAGCTTTACCTGAACGAGCTCAACACCATCCCCGGCTTCACCCCCACGAGCA
TGTACCCCCGCCTCTTTGAGGCGGGGGGGGTGGCCTACCCGGAGCTTCTCAGGCGCCTGGTGGAGCTCGCCCTCACCTAA

Protein sequence :
MRVLLIAGGVSPEHEVSLLSAEGVLRHMPFPMDLAVIARDGRWLLGEKALAALEAKAAPEGEHPFPPPLPWERYDVVFPL
LHGRFGEDGTVQGFLELLGKPYVGAGVAASALCMDKDLSKRVLAQAGVPVVPWVAVRKGEPPMVPFDPPFFVKPANTGSS
VGISRVERFQDLEAALALAFRYDEKAVVEKALSPVRELEVGVLGNVFGEASPVGEVRYEAPFYDYETKYTPGRAELLIPA
PLDPGTQETVQELALKAYKVLGVRGMARVDFFLAEGELYLNELNTIPGFTPTSMYPRLFEAGGVAYPELLRRLVELALT

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
vanB YP_008394259.1 Vancomycin B-type resistance protein vanB, D-alanine--D-lactate ligase Not tested Not named Protein 3e-34 41
vanB NP_815951.1 D-alanine--D-lactate ligase Not tested Not named Protein 6e-34 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
TtJL18_0458 YP_006058153.1 D-alanine--D-alanine ligase NC_014475.1.orf3.gen Protein 1e-33 42
TtJL18_0458 YP_006058153.1 D-alanine--D-alanine ligase NC_005054.2598280.p0 Protein 1e-33 42
TtJL18_0458 YP_006058153.1 D-alanine--D-alanine ligase AY489045.gene.p01 Protein 2e-35 42
TtJL18_0458 YP_006058153.1 D-alanine--D-alanine ligase AF277571.gene.p01 Protein 2e-36 42
TtJL18_0458 YP_006058153.1 D-alanine--D-alanine ligase AF310956.2.orf5.gene Protein 2e-33 41
TtJL18_0458 YP_006058153.1 D-alanine--D-alanine ligase AY145441.gene.p01 Protein 8e-34 41
TtJL18_0458 YP_006058153.1 D-alanine--D-alanine ligase U00456.gene.p01 Protein 3e-34 41
TtJL18_0458 YP_006058153.1 D-alanine--D-alanine ligase U35369.1.gene6.p01 Protein 3e-34 41
TtJL18_0458 YP_006058153.1 D-alanine--D-alanine ligase AE016830.1.gene2250. Protein 3e-34 41
TtJL18_0458 YP_006058153.1 D-alanine--D-alanine ligase AF130997.1.orf4.gene Protein 2e-36 41