Gene Information

Name : TtJL18_0004 (TtJL18_0004)
Accession : YP_006057719.1
Strain : Thermus thermophilus JL-18
Genome accession: NC_017587
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 4106 - 5530 bp
Length : 1425 bp
Strand : +
Note : PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase

DNA sequence : 
ATGCCGCCTTTTAAGCGCACCAAGATCGTGGCCACCCTGGGGCCGGCCACGGACGACAAGGAGGTGATCCGTGCCCTGGC
GGAGGCCGGGGCCGAGGTCTTCCGCCTGAACTTCAGCCACGGCGCCCCCGAGGACCACAGGCGCCGGGTGGGCTGGGTGC
GGGAGGTGGCGGAGGAGCTCGGCCGGACCCTGGCCGTCCTCCAGGACCTCCAGGGCCCGAAGATCCGTGTGGGCCGTTTC
CGGGAGGGCCAGGTCCTCCTCCGCCCGGGGCAGAGGTTCGTCCTCACCGCCGAGCCCGTGGAGGGGGACGAGCACCGCGT
TTCCGTGAGCTACAAGGGGCTTCCCGAGGACGTTTCCCCAGGACAGACCCTCCTTTTGGACGACGGCCGCATCCGGCTCA
AGGTCCTGGAGGTCCGGGGCCCGGAGATTCACACGGAGGTGGAGGTGGGCGGGGTCCTCTCCAACAACAAGGGGATCAAC
ATCCCCGGGGCGGACCTCTCCATCCCCGCCCTCTCGGAGAAGGACATCCAGGACCTGGCCCTGGGGGCGGAGCTCGGGGT
GGACTGGGTGGCGGTCTCCTTCGTCCGCACGCGGGACGACCTCCTCCTCGCCCGGCACTACCTCTCCCGCTACGGCTCCA
AGGCCAGGCTCATGGCCAAGATCGAGAAGCCCTCGGCCGTGGCCCGGTTTGAGGAGATCCTGGAGGAGGCGGACGGGATC
ATGGTGGCCCGGGGGGACCTCGGGGTGGAGATGCCCCTGGAGGAGGTGCCCATCGTCCAGAAGCGCCTCATCCTCCGGTG
CATCGCCGCCGGGAAGCCGGTGATCACCGCCACCCAGATGCTGGAGTCCATGGTGCAGAACCCGAGCCCCACCCGGGCCG
AGGCCTCGGACGTGGCCAACGCCATCTTTGACGGGACCGACGCGGTGATGCTCTCCGCGGAGACGGCGGCCGGGGCCTAC
CCGGTGGAGGCGGTGGCCATGATGGCGAGGATCGCCAAGGCGGTGGAGTCCTCCCCGGAGTTCTTGCAGAAGCTCAACGT
CCTCCGCCCCGCCCCCACCCCCACCACCCAGGACGCCATCGCCCAGGCGGCGGACGACGTGGTGGAGGCGGTGGGGGCAC
GGGCCATCGTGGTCTTCACGGCCACGGGCGGCTCGGCGCGGAGGATCGCCCGCACCCGGCCCCAGGTGCCCATCCTGGCC
CTCACCCCGAACCCCGAGGTGCGGAACCAGCTGGCCTTGGTCTGGGGGGTCTACCCCCATCTCGCCCCCGACCCCCAGGA
CACCGACGACATGGTCCGCATCGCCCTCAGGGAGGTGAAGGCCCTGGGGCTCGCCCAGGTGGGGGACCGGGTGGTCATCG
CCGCCGGGGTTCCCTTCGGGGTCCGGGGGACGACGAACCTCATCCGCGTGGAGCGGGTGGGGTAG

Protein sequence : 
MPPFKRTKIVATLGPATDDKEVIRALAEAGAEVFRLNFSHGAPEDHRRRVGWVREVAEELGRTLAVLQDLQGPKIRVGRF
REGQVLLRPGQRFVLTAEPVEGDEHRVSVSYKGLPEDVSPGQTLLLDDGRIRLKVLEVRGPEIHTEVEVGGVLSNNKGIN
IPGADLSIPALSEKDIQDLALGAELGVDWVAVSFVRTRDDLLLARHYLSRYGSKARLMAKIEKPSAVARFEEILEEADGI
MVARGDLGVEMPLEEVPIVQKRLILRCIAAGKPVITATQMLESMVQNPSPTRAEASDVANAIFDGTDAVMLSAETAAGAY
PVEAVAMMARIAKAVESSPEFLQKLNVLRPAPTPTTQDAIAQAADDVVEAVGARAIVVFTATGGSARRIARTRPQVPILA
LTPNPEVRNQLALVWGVYPHLAPDPQDTDDMVRIALREVKALGLAQVGDRVVIAAGVPFGVRGTTNLIRVERVG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 6e-78 45
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 1e-77 45
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 6e-78 45
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 6e-78 45
pykA NP_273151.1 pyruvate kinase Not tested IHT-A Protein 6e-63 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
TtJL18_0004 YP_006057719.1 pyruvate kinase VFG0479 Protein 3e-78 45