Gene Information

Name : Spith_1475 (Spith_1475)
Accession : YP_006045455.1
Strain : Spirochaeta thermophila DSM 6578
Genome accession: NC_017583
Putative virulence/resistance : Virulence
Product : ATP-dependent chaperone ClpB
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 1659440 - 1662052 bp
Length : 2613 bp
Strand : -
Note : PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associated with various cellular activities (AAA); TIGRFAM: ATP-dependent chaperone ClpB; COGs: COG0542 ATPase with chaperone activi

DNA sequence :
ATGGATCTCGAACGTTTCACGGTGAAGGCGCAGGAGGCCTTGCAGAACGCGACCAAACTCATGCACCAGTACGATCACAC
CCTTCTCGAGCCGGAGCACATCGCCCTTGCGATCGTCCAGCAGGAGGAGGGGATCATCAAACCGTTGGTGGAGCGGTTGG
GCGCATCCCGTGCCCAGATCGAACACGAGCTTGTAGCCCTGCTTGAAAAGAAGCCAAAGGTCTATGCAGAAGGGGGGTCG
ACCACTGGAGTGAGTCTCTCCAACCAGGCGGCTCGTGTCCTCAGCAAGGCCGAGATGGAAGCCAAGCGCATGCAGGACGA
GTACGTGAGTGTGGAGCATATCCTCCTCTCTCTTGCCCAGGAACCGGGGGAGGTAGGACGTGTGTTCCAGCGCAACGGCC
TCACCTATGAGGGCATAAAGCACGCCATAGAGGGTATCCGCCAGGGGAGACGGGTGACGAGTCAGGATCCCGAGAGCACC
TACCAGGCCCTCGAGAAGTACTGCCGTGACCTCACCGCACTCGCCAGGCAGGAGAAACTCGACCCGGTGATCGGCCGCGA
CGAGGAGATCCGCCGCATGATCCAGGTGCTCCTGCGGCGCACCAAGAACAACCCTGTGCTCATGGGGCCGCCGGGTGTGG
GTAAGACGGCCATCGTGGAAGGCCTTGCGCGCAGAATCGTGGCAGGCGACGTGCCCGATTCCCTCAAGGACAAGCGGATC
CTCGCACTCGACCTCGGGGCCCTCGTGGCAGGGGCCAAGTATCGCGGCGAGTTCGAAGAACGCCTCAAGGCCGTGATCAA
CGAGGTCATCGCCTCTGAAGGAAAGATCATCCTCTTCATCGACGAGCTGCACACCCTCATCGGTGCAGGTGCGGCTGAAG
GCGCCACCGACGCCGCCAACCTCCTCAAGCCCCCGCTCTCCCGTGGTGAGCTGAGGACCATCGGTGCCACCACGGTGGAC
GAGTACCGGAAACACATCGAAAAGGACGCGGCCTTCGAGCGCAGGTTCCAGCCCATCTACGTTGCGGAGCCCTCGGTGGA
GGACACCATCTCCATCCTCCGCGGGCTCAAGGAGCGCTACGAGGTGCACCACGGTGTGCGCATCACCGACGAGGCCATCG
TGGCCGCGGCGGTGCTCTCGGACAGGTACATCACCTCGCGTTTCCTCCCGGATAAGGCCATCGACCTCATCGACGAGGCG
GCCAGCCGGCTCAAGATGGAGATAGAGAGCATGCCCACTGAGCTCGACCAGCTCGACAGGAGGATCCTCCAGCTCACGAT
AGAACGCCAGGCCCTCTCCAAAGAGAAGGACCCCGCCTCTCAGGAGCGGCTCAAGAAGATCGAGCAGCAGCTCTCCCAGC
TCAAGGAAGAGCGCGACAAGCTCTACCTCAAGTGGCAGAACGAGAAGAAGATCATCGACGAGATCCGGAAGCTCAACGCC
GAGATCGAGGAGCTCACCATACAGGAGACCCAGTACGAACGGCAGGGGAACCTCGACAAGGCGGCCGAGATAAAGTACGG
CCTCCTGCCTCAGAAGCGGCGTGAGCTCGAGGAGAAGACCAAGGAGCTCGAGCGGCTCAAGGGCGAGGAAAGCTCGCTCC
TGAGGGAAGAAGTGACAGAGGAGGACATCGCCCGCGTGGTCTCGAGCTGGACCGGCATACCGGTGACCAAGATGATGGCC
TCCGAGAAGGAGAAGCTCCTTCACCTTGAAGAGGAGCTCGGCAGACGGGTGATAGGGCAGGAGGAGGCCATAAGGGCCGT
GGCCGATGCGATCCGAAGGAACCGGAGCGGCCTCTCCGACCCGAGACGGCCGATGGGCGTCTTCCTCTTCCTTGGCCCGA
CCGGTGTGGGAAAGACCGAGCTTGCCCGTACCCTGGCCGACTACCTCTTCAACGACGAGCGGGCCATGGTGCGCATCGAC
ATGAGCGAGTACATGGAGCGGCATGCGGTCTCCAGGCTCATCGGTGCCCCGCCGGGGTATGTGGGCTATGAAGAAGGCGG
TCAGCTCACCGAGGCTGTGCGCAGAAGGCCGTACTCGGTGATCCTCTTCGACGAGGTGGAGAAGGCCCATCCCGATGTGT
TCAACATCATGCTCCAGATCTTCGATGACGGAAGGCTCACCGATAGCCAGGGGCACGTGGTGGACTTCAAGAACACCATC
ATCATCATGACGAGTAACATAGGGAGTGATCTCATCCTCGAGGCCGACGATCTGGAGAAGGTCAAACCGCAGGTCAACAG
CCTCCTGAGGGCGAGCTTCAAGCCCGAGTTCCTCAACCGGATCGATGAGATGATCGTCTTCCACAGGCTCACGCAGGAGC
ACATCTACAAGATCCTCGATCTCGAGATCGCACGCCTCAACGAGCGGCTTTCGGAGCAGCACCTCTCCATAGAGGTGGAT
CAAAAGGCCAAGGAGATCCTGGTGAGGGAAGGCTTCAGCCCCGAGTTCGGCGCACGACCCCTCAAACGCAGCGTACAGCG
CCTCATCTACAACCCCCTTGCAAAAGAACTCATTGCAGGCAAGTATAGCGAGGGAGATACGGTGTTCGTGACCGCCGAGC
ACGGCCAGCTCCTCTTCACACGGAAAGTAGGAGAGGCAGTAGCCTCTTCATAG

Protein sequence :
MDLERFTVKAQEALQNATKLMHQYDHTLLEPEHIALAIVQQEEGIIKPLVERLGASRAQIEHELVALLEKKPKVYAEGGS
TTGVSLSNQAARVLSKAEMEAKRMQDEYVSVEHILLSLAQEPGEVGRVFQRNGLTYEGIKHAIEGIRQGRRVTSQDPEST
YQALEKYCRDLTALARQEKLDPVIGRDEEIRRMIQVLLRRTKNNPVLMGPPGVGKTAIVEGLARRIVAGDVPDSLKDKRI
LALDLGALVAGAKYRGEFEERLKAVINEVIASEGKIILFIDELHTLIGAGAAEGATDAANLLKPPLSRGELRTIGATTVD
EYRKHIEKDAAFERRFQPIYVAEPSVEDTISILRGLKERYEVHHGVRITDEAIVAAAVLSDRYITSRFLPDKAIDLIDEA
ASRLKMEIESMPTELDQLDRRILQLTIERQALSKEKDPASQERLKKIEQQLSQLKEERDKLYLKWQNEKKIIDEIRKLNA
EIEELTIQETQYERQGNLDKAAEIKYGLLPQKRRELEEKTKELERLKGEESSLLREEVTEEDIARVVSSWTGIPVTKMMA
SEKEKLLHLEEELGRRVIGQEEAIRAVADAIRRNRSGLSDPRRPMGVFLFLGPTGVGKTELARTLADYLFNDERAMVRID
MSEYMERHAVSRLIGAPPGYVGYEEGGQLTEAVRRRPYSVILFDEVEKAHPDVFNIMLQIFDDGRLTDSQGHVVDFKNTI
IIMTSNIGSDLILEADDLEKVKPQVNSLLRASFKPEFLNRIDEMIVFHRLTQEHIYKILDLEIARLNERLSEQHLSIEVD
QKAKEILVREGFSPEFGARPLKRSVQRLIYNPLAKELIAGKYSEGDTVFVTAEHGQLLFTRKVGEAVASS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 2e-100 42
aec27 AAQ96721.1 Aec27 Not tested AGI-1 Protein 2e-94 42
aec27 YP_851418.1 ATPase Not tested PAI II APEC-O1 Protein 3e-94 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Spith_1475 YP_006045455.1 ATP-dependent chaperone ClpB VFG2084 Protein 4e-99 43