Gene Information

Name : cadA (SPSE_1488)
Accession : YP_006015586.1
Strain : Staphylococcus pseudintermedius ED99
Genome accession: NC_017568
Putative virulence/resistance : Resistance
Product : cadmium-translocating P-type ATPase
Function : -
COG functional category : -
COG ID : -
EC number : 3.6.3.3
Position : 1517182 - 1519356 bp
Length : 2175 bp
Strand : -
Note : identified by match to protein family HMM PF00122, match to protein family HMM PF00403, match to protein family HMM PF00702, match to protein family HMM TIGR01494, match to protein family HMM TIGR01512, match to protein family HMM TIGR01525

DNA sequence :
ATGATTCAAAGTCGTAAAACTTACAGAATAGAAGGTTTATCATGCGCCAATTGTGCTGGGAAATTTGAAAGAAATGTCCG
GGGTCTTGCGTCAGTTGAAGAGGCACAAGTCAATTTTGGTGCTTCGAAAATTTATGTAACGGGCGACCCAACTGTAGAAG
AATTAGAAGGGGCGGGCGCATTTGAAAATTTAAAATTGACATTAGATGAGCGGAAAAAGATTAGTGCGAACGCTGACCGA
AGCACAATGGCGCAACCGACCTCTTGGTTTGATAAGGTCAAACAGTTTTATAAAGCGCATCAATCTATATGTGTAGCGAC
GTTGTTCATGCTACTTGGTTACATTTCACATTTGATGAGCGGCGAAAACCATTTGATGACAATTTTACTATTCGCTTGTT
CGATATTATTAAGTGGAAGCGCGCTACTCATCCGTGGTGTTAAAAATTTAGTGCATGTTGAATTTGATATGCATACATTG
ATGACGATTGCGGTTATCGGTGGTGCAATCATTGGTCAATGGGGAGAAGTTGCAGTGGTCGTCATTTTATTTGCGATGAG
TGAGGCACTTGAAACGTTTTCTATGGATAAAGCACGTCAGTCGATGCAATTTTTAATGGATATCGCGCCAGATGAAGCGA
CAGTTTTAAGGGACGGTCAACATGTAAAGGTACCTGTGGATGACATTGTAATCGGTGAAAAGTTATATATTAAACCGGGA
CAAAAAATTGCGTTAGACGGTGTTGTCGTTGAGGGCCGTGCTGCAGTGAATCAGGCCGCGATTACTGGTGAGTCGATGCC
GGTTGAAAAAGTGGGAGGTGCAGAAGTTTTTGCTGGGACATTGAATGAAGATGGCATCCTTGAAGTGCGTGTCACGAAAA
CAGCAGCACATACGACATTAGCGAAAATGATTCAACTCGTTGAAGAAGCACAATTAAATCAAACACCAGCACAAGCATTC
ATTGAAAAGTTTGCGCGTTATTATACTCCTGCCATTATGGTTATCGCGTTACTCGTTGCGATAGTGCCGCCAGTAGTGTT
ACATCAATCGTTTTTAACATGGGTTTATCAAGGTTTGGCCGTGCTTGTTGTCGGCTGCCCTTGTGCGTTAGTCATTGCAA
CTCCAATTTCTATCGTATCAAGTATTGGTAATGCAGCAAAAAATGGTGTGCTCATTAAAGGGGGCATCCACCTAGAACAA
ATCAGTCGTGTTCGTGCGTTAGCTTTTGATAAAACAGGGACACTGACGAAGGGGCACCCTGAAGTGACCACTGTTCTGCC
ATTAACAGAGATGCGTGATGACACCGAGCTGATTGGTCAAATTGCAGCTATCGAAAGTCGTTCGGATCATCCGTTAGCAC
GGGCAATTGTTCGTTATGCCGAAACAAAGCATCACCATTTTGATTCATATGATGTGACAGATTTTCATTCACAAACAGGC
CAAGGGGTGAGGGCGAACGTTGAAGGGCGTCAATTCATCATTGGACAACCGCAAATGTTTAAAATGGCGCAATCGACGAT
GAAAACGCAAATTCAACAATTACAAGAGCAAGGAAATACAGTCATTATCGTGTCAGTGGATGATGTGTTACGTCTATTAA
TTGCAGTGCGAGATGAAGTGCGTGAACAGTCTCAAAAAGCGATACAGACGCTTCATGAGCTTGGCATTCAACATACCGTT
ATGTTGACAGGAGACAATGAGAAAACAGCACGAGCAATTGCGCAAACACTTCACATGTCAGATGTTAAAGCAGATTTGAT
GCCTGTTGATAAATTAAATGAAATTGAACAGCTTAAACAGCAATATGGGACAGTTGCGATGGTCGGTGACGGGGTGAATG
ACGCACCAGCACTGGCGAGCGCATCAGTGGGTATTGCGATGGGGGGTGCGAGTACAGATACCGCACTTGAAACTGCGGAC
ATTGCACTCCTTAGTGACGATATGTCGAAGTTACCTTTTACATATCGTTTGAGTCAAAAAACAATGCGTATGATTAAGGC
AAATATTACGTTTGCAATTGCGATTAAATTATTAGCGTTGTTACTTGTGATTCCAGGTTGGTTAACGTTGTGGATTGCGG
TATTTTCTGATATGGGTGCAACATTGATTGTCGCTTTAAATGCAATTCGTCTCCTGTATGTTAAAGCAGATAATACTGAG
GTGACGACAGAGTAA

Protein sequence :
MIQSRKTYRIEGLSCANCAGKFERNVRGLASVEEAQVNFGASKIYVTGDPTVEELEGAGAFENLKLTLDERKKISANADR
STMAQPTSWFDKVKQFYKAHQSICVATLFMLLGYISHLMSGENHLMTILLFACSILLSGSALLIRGVKNLVHVEFDMHTL
MTIAVIGGAIIGQWGEVAVVVILFAMSEALETFSMDKARQSMQFLMDIAPDEATVLRDGQHVKVPVDDIVIGEKLYIKPG
QKIALDGVVVEGRAAVNQAAITGESMPVEKVGGAEVFAGTLNEDGILEVRVTKTAAHTTLAKMIQLVEEAQLNQTPAQAF
IEKFARYYTPAIMVIALLVAIVPPVVLHQSFLTWVYQGLAVLVVGCPCALVIATPISIVSSIGNAAKNGVLIKGGIHLEQ
ISRVRALAFDKTGTLTKGHPEVTTVLPLTEMRDDTELIGQIAAIESRSDHPLARAIVRYAETKHHHFDSYDVTDFHSQTG
QGVRANVEGRQFIIGQPQMFKMAQSTMKTQIQQLQEQGNTVIIVSVDDVLRLLIAVRDEVREQSQKAIQTLHELGIQHTV
MLTGDNEKTARAIAQTLHMSDVKADLMPVDKLNEIEQLKQQYGTVAMVGDGVNDAPALASASVGIAMGGASTDTALETAD
IALLSDDMSKLPFTYRLSQKTMRMIKANITFAIAIKLLALLLVIPGWLTLWIAVFSDMGATLIVALNAIRLLYVKADNTE
VTTE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 0.0 58
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 0.0 58
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 0.0 58

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cadA YP_006015586.1 cadmium-translocating P-type ATPase BAC0298 Protein 1e-108 45
cadA YP_006015586.1 cadmium-translocating P-type ATPase BAC0092 Protein 2e-94 42