Gene Information

Name : pykA (NMAA_1882)
Accession : YP_005892877.1
Strain : Neisseria meningitidis WUE 2594
Genome accession: NC_017512
Putative virulence/resistance : Virulence
Product : pyruvate kinase II (PK-2)
Function : -
COG functional category : -
COG ID : -
EC number : 2.7.1.40
Position : 2152248 - 2153720 bp
Length : 1473 bp
Strand : +
Note : MultiFUN-ID: 1.3.1

DNA sequence :
ATGAACCAGACAAGCCGCGATCTGACCCGCATCAGCCACAACACCAAAATCGTCGCCACCCTTGGGCCGGGCAGCAACAA
CGTCGAACTGTTGGAAGATATGATCCGCGTCGGCGGCCTGAACGTCGTCCGCTTCAACTTCAGCCACGGTACGCCCGAAT
TCCATCAGGAAAACGCCCGCATCGTGCGCGAGGCGGCAAAACGCGCCGGACAGGAAATCGCCATCATTGCCGACCTGCAA
GGGCCGAAAATCCGCGTGGGCAAAATCGCCGGCGGCGGCATCGAATTGAACAAAGGCGAAACATTGGTACTCGATGCCGC
GCTCGAAGGCGAAGGCACGCGCGAAGCGGTCGGTTTGGACTACCGCGACCTGCCCGACGACGTTGCCGCAGGCGACGTAT
TGTGGCTGGACGACGGCCTGCTGACCCTGACCGTGGAATCCGTCGAAGGCAGCAGGATTATCACAAGGGTGGAAAACAGC
CATGTCCTGAAAAGCAACAAAGGCATCAACAAACGCGGCGGCGGTCTGTCCGCAGGCGCGTTGACCGAAAAAGACTTCCG
CGACCTGAAAACCGCGATTGCCATCGGTTGCGACTACCTCGCCATCAGCTTTGTGAAATCCGCCGAAGATTTGCACATCG
CGCGCGCCAAAGTCGAAGAAGAAATGAAGGGCAGCACGGCCGTGCGCCCCGGTTTGGTTTCCAAAATCGAACGCGTGGAA
GCGATTGAAAACCTTGATGAAATCATCCTTGCCGGCGACGGCATTATGGTTGCGCGCGGCGACTTGGCGGTCGAAGTCGG
ACACGCCGCCGTCCCCGCCCTGCAAAAACGGATGATCCGCCGCGCCCGCGAGTTGCGCCGCTTCAGCATTACGGCGACGC
AAATGATGGAATCGATGATTACCAACCCCGTGCCGACCCGCGCGGAAGTCAGCGACGTGGCAAACGCGGTATTGGACGGT
ACCGATGCGGTGATGTGTTCCGCCGAAACCGCCGTCGGCGCGTATCCGTTTGAAACCGTCAGCCAAATGGCAATTATCTG
CGCGGCTGCGGAAAAAGAGCAGGATTCGCTCAACGGCGTTGCCGAACAGGCGGAGTATCCCGAAGCGGTCAGCACCAACC
TGGCGGTTGCCGGCGGCGCGGTCAGCGTGGCGCGCGCGGTTCACGCCAAAGCCATCGTCGCCCTGACCGAAAGCGGTTCG
ACCGCCTTTGAAATCAGCCGCCACAACATCACCCTGCCGATTTTCGCGCTGACCCCGAGCGTTTCCGCCCAACGCCGTAT
GGCAATGTACCGCGGCGTGCGTCCGTTGATTTTGGCAACCAGCACCGACCACGACACAGCGTTGAACGAAGTTGAAACCA
TGCTAGTGGAACACAACATCCTGCATTCCGGCGACCAATACATCATTACCAGCGGCTCGCAAATGCGCGAATCCGGTTCG
ACCAATACGCTGGAAGTGCTGCGCGTCAAATAA

Protein sequence :
MNQTSRDLTRISHNTKIVATLGPGSNNVELLEDMIRVGGLNVVRFNFSHGTPEFHQENARIVREAAKRAGQEIAIIADLQ
GPKIRVGKIAGGGIELNKGETLVLDAALEGEGTREAVGLDYRDLPDDVAAGDVLWLDDGLLTLTVESVEGSRIITRVENS
HVLKSNKGINKRGGGLSAGALTEKDFRDLKTAIAIGCDYLAISFVKSAEDLHIARAKVEEEMKGSTAVRPGLVSKIERVE
AIENLDEIILAGDGIMVARGDLAVEVGHAAVPALQKRMIRRARELRRFSITATQMMESMITNPVPTRAEVSDVANAVLDG
TDAVMCSAETAVGAYPFETVSQMAIICAAAEKEQDSLNGVAEQAEYPEAVSTNLAVAGGAVSVARAVHAKAIVALTESGS
TAFEISRHNITLPIFALTPSVSAQRRMAMYRGVRPLILATSTDHDTALNEVETMLVEHNILHSGDQYIITSGSQMRESGS
TNTLEVLRVK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
pykA NP_273151.1 pyruvate kinase Not tested IHT-A Protein 0.0 99
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 3e-53 42
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 8e-53 42
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 4e-53 42
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 4e-53 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pykA YP_005892877.1 pyruvate kinase II (PK-2) VFG0479 Protein 1e-53 42