Gene Information

Name : lipA (NMV_0086)
Accession : YP_005877677.1
Strain : Neisseria meningitidis 8013
Genome accession: NC_017501
Putative virulence/resistance : Virulence
Product : polysialic acid capsule modification protein LipA
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 89394 - 91508 bp
Length : 2115 bp
Strand : +
Note : Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8326861; Product type e : enzyme

DNA sequence :
ATGTTCCTCTTTTCAGACGGCCTACAATCTATTAATAACAATAATCGACGAAAACGCATTGTGAAAAACGCCTACATCCC
CTCTCGCGGCATCCGCAAAATCCCCCATCTCTCCACCCTATTGCCCGAGTTTCATATCTACAAAGACGGAAAAGGAGCAG
AGGCTGTTGTCGGCTGGGGTTTGCGCCCGACGACACACAAAGCGCGTGCTTTTGCCACCGAACACCAGCTTCCCTTTATT
GCTTTGGAAGACGGCTTTTTACGCTCGCTCGGACTGGGCGTCTCCGGTTATCCCCCCTACTCCATCGTCTATGACGACAT
CGGCATCTACTACGACACTACCCGCCCTTCTCGTTTGGAACAACTGATTCTTGCCGCCGATACCATGCCGTCTGAAACCT
TGGCTCAGGCGCGGCAGGCGATGGATTTCATCCTGCAACACCATCTGTCCAAATACAACCACGCGCCCGAACTTTCAGAC
GATCATCCTTTACGCTCCCCATCCAAGTCTGAAACCGTCCTCATTATCGACCAAACCTTCGGCGATATGGCTATCCAATA
TGGCGGTGCAGACGCCTCTACGTTTGAATTGATGTTTCAGACGGCCTTAAATGAAAACCCGCAAGCCGATATTTGGGTCA
AAACCCATCCCGATGTTTTGTGCGGCAAAAAACAAGGCTATCTGACCCAGCTTGTGCAGCAACACCGCGTCCATCTTCTG
GCAGAAGACATCAATCCGATTTCTTTGTTGCAAAACGTCGATAAAGTTTATTGCGTTACCTCGCAAATGGGTTTTGAGGC
GCTTTTGTGCGGCAAGCCGCTGACCACTTTCGGCCTGCCGTGGTATGCCGGATGGGGCGTGAGTGACGACCGCCACCCAA
AAATCGGCAGCCTTATTCAAACCCAACGCCGCGCCCCCCGCAACTTGCTGCAACTCTTCGCCGCAGCCTATCTGCAATAC
AGCCGCTACCTCAATCCCAATACCGGCGAAGCAGGCAGCCTCTTTGATGTCATCGACTATCTGGCGACGGTCAAACGTAA
AAACGACAAATTGCGTGGCGAGTTATATTGCGTCGGTATGTCTTTGTGGAAACGCGCGGTTGCCAAACCGTTCTTTAACG
TACCCTCTTGCCATCTGAAATTTATCTCTTCCACCCAAAAACTGGCAAGGGTCAAACTGTCCGACGATGCACGCATCCTG
GCTTGGGGCAACGGCAAAGAGGCCATCGTCCGCTTTGCCGAACAACACCACATCCCCCTGCTGCGCATGGAAGACGGCTT
TATCCGCTCGGTCGGACTCGGCTCCAACTTAGTGCCGCCGCTGTCGCTCGTTACCGACGATATGAGCATTTATTTCAATG
CCGAAACCCCGTCCCGTCTTGAATACATCCTACAAAACCAAAACTTCGACGATCAAGACTTTCAGACGGCCTTGAAGCTG
CAAAAAATGCTGACCGAAAACCACATCAGTAAATACAACGTCGGCAGCTCAGACTTCACCGCCCCGTCAACCGACAAAAC
CGTGATCCTCGTTCCCGGCCAGGTTGAAGATGATGCGTCTATCCGCTACGGTTCGCCCCAAATCTACCGCAATCTGGATT
TGCTCCGTACCGTACGCGAACGAAACCCCAATGCCTATATCATCTACAAACCGCATCCCGATGTAGTCAGCGGTAACCGC
ATCGGCCATATTTCCCCTGAAGATGCTGCACGATATGCCGACCAAACCGCCGAACAAGCCGACATCCTGACCTGTCTCCA
ATACGCAGACGAAATACATACCATGACTTCGCTGACCGGTTTTGAAGCCTTGTTGCGCGGCAAAAAAGTCAGCTGCTACG
GCCTGCCTTTTTACGCAGGCTGGGGGCTTACCCAAGATCTGCTCCCCATCCCGCGCCGTAGCCGCAGACTTGAGCTTTGG
CAGCTGATTGCCGGCACGCTCATCCACTATCCCGACTACATCCACCCCGAAACCCATCAGGCCATAAATGCAGAAACCGC
AGCCCAAATCCTGATACGACAAAAAAATATGCAAAAAAACAACAACGGATTACATCGCGGGTACTTTGCCAAAAAATTAG
GTAAAATCAAACAACTATATCGATCTTTCAAATAA

Protein sequence :
MFLFSDGLQSINNNNRRKRIVKNAYIPSRGIRKIPHLSTLLPEFHIYKDGKGAEAVVGWGLRPTTHKARAFATEHQLPFI
ALEDGFLRSLGLGVSGYPPYSIVYDDIGIYYDTTRPSRLEQLILAADTMPSETLAQARQAMDFILQHHLSKYNHAPELSD
DHPLRSPSKSETVLIIDQTFGDMAIQYGGADASTFELMFQTALNENPQADIWVKTHPDVLCGKKQGYLTQLVQQHRVHLL
AEDINPISLLQNVDKVYCVTSQMGFEALLCGKPLTTFGLPWYAGWGVSDDRHPKIGSLIQTQRRAPRNLLQLFAAAYLQY
SRYLNPNTGEAGSLFDVIDYLATVKRKNDKLRGELYCVGMSLWKRAVAKPFFNVPSCHLKFISSTQKLARVKLSDDARIL
AWGNGKEAIVRFAEQHHIPLLRMEDGFIRSVGLGSNLVPPLSLVTDDMSIYFNAETPSRLEYILQNQNFDDQDFQTALKL
QKMLTENHISKYNVGSSDFTAPSTDKTVILVPGQVEDDASIRYGSPQIYRNLDLLRTVRERNPNAYIIYKPHPDVVSGNR
IGHISPEDAARYADQTAEQADILTCLQYADEIHTMTSLTGFEALLRGKKVSCYGLPFYAGWGLTQDLLPIPRRSRRLELW
QLIAGTLIHYPDYIHPETHQAINAETAAQILIRQKNMQKNNNGLHRGYFAKKLGKIKQLYRSFK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
lipA NP_273145.1 capsule polysaccharide modification protein Not tested IHT-A Protein 0.0 99
kpsC YP_854335.1 capsule polysaccharide export protein KpsC Not tested PAI I APEC-O1 Protein 2e-133 49
kpsC AAZ04470.1 capsule polysaccharide export protein Virulence PAI I APEC-O1 Protein 1e-133 49

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
lipA YP_005877677.1 polysialic acid capsule modification protein LipA VFG0259 Protein 0.0 99
lipA YP_005877677.1 polysialic acid capsule modification protein LipA VFG0704 Protein 7e-157 58
lipA YP_005877677.1 polysialic acid capsule modification protein LipA VFG0692 Protein 6e-180 58