Gene Information

Name : siaB (NMV_0070)
Accession : YP_005877667.1
Strain : Neisseria meningitidis 8013
Genome accession: NC_017501
Putative virulence/resistance : Virulence
Product : N-acylneuraminate cytidylyltransferase (CMP-N-acetylneuraminic acid synthetase; CMP-NeuNAc synthetase; CMP-sialic acid synthetase)
Function : -
COG functional category : -
COG ID : -
EC number : 2.7.7.43
Position : 76505 - 77191 bp
Length : 687 bp
Strand : -
Note : Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7830552; Product type e : enzyme

DNA sequence :
ATGGAAAAACAAAATATTGCGGTTATACTTGCGCGCCAAAACTCCAAAGGATTGCCATTAAAAAATCTCCGGAAAATGAA
TGGCATATCATTACTTGGTCATACAATTAATGCTGCTATATCATCAAAGTGTTTTGACCGCATAATTGTTTCGACTGATG
GCGGGTTAATTGCAGAAGAAGCTAAAAATTTCGGTGTCGAAGTCGTCCTACGCCCTGCAGAGCTGGCCTCCGATACAGCC
AGCTCTATTTCAGGTGTAATACATGCTTTAGAAACAATTGGCAGTAATTCCGGCACAGTAACCCTATTACAACCAACCAG
TCCATTACGCACAGGGGCTCATATTCGTGAAGCTTTTTCTCTATTTGATGAGAAAATAAAAGGATCCGTTGTCTCTGCAT
GCCCAATGGAGCATCATCCACTAAAAACCCTGCTTCAAATCAATAATGGCGAATATGCCCCCATGCGCCATCTAAGCGAT
TTGGAGCAGCCTCGCCAACAATTACCTCAGGCATTTAGGCCTAATGGTGCAATTTACATTAATGATACTGCTTCACTAAT
TGCAAATAATTGTTTTTTTATCGCCCCAACCAAACTTTATATTATGTCTCATCAAGACTCTATCGATATTGATACTGAGC
TTGATTTACAACAGGCAGAAAACATTCTTAATCACAAGGAAAGCTAA

Protein sequence :
MEKQNIAVILARQNSKGLPLKNLRKMNGISLLGHTINAAISSKCFDRIIVSTDGGLIAEEAKNFGVEVVLRPAELASDTA
SSISGVIHALETIGSNSGTVTLLQPTSPLRTGAHIREAFSLFDEKIKGSVVSACPMEHHPLKTLLQINNGEYAPMRHLSD
LEQPRQQLPQAFRPNGAIYINDTASLIANNCFFIAPTKLYIMSHQDSIDIDTELDLQQAENILNHKES

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
siaB NP_273133.1 polysialic acid capsule biosynthesis protein SiaB Not tested IHT-A Protein 6e-105 100

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
siaB YP_005877667.1 N-acylneuraminate cytidylyltransferase (CMP-N-acetylneuraminic acid synthetase; CMP-NeuNAc synthetase; CMP-sialic acid synthetase) VFG0253 Protein 2e-105 100