Gene Information

Name : siaC (NMV_0069)
Accession : YP_005877666.1
Strain : Neisseria meningitidis 8013
Genome accession: NC_017501
Putative virulence/resistance : Virulence
Product : sialic acid synthase (N-acetylneuraminate synthase; N-acetylneuraminic acid synthase)
Function : -
COG functional category : -
COG ID : -
EC number : 2.5.1.56
Position : 75455 - 76504 bp
Length : 1050 bp
Strand : -
Note : 'Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7830552, 8045888; Product type e : enzyme'

DNA sequence :
ATGCAAAACAACAACGAATTTAAAATTGGTAATCGTTCAGTAGGTTACAACCACGAACCATTGATTATCTGTGAAATCGG
CATCAATCATGAAGGCTCTTTAAAAACAGCTTTTGAAATGGTTGATGCTGCCTATAATGCAGGCGCTGAAGTTGTTAAAC
ATCAAACACACATCGTTGAAGACGAAATGTCTGATGAGGCCAAACAAGTCATTCCAGGCAATGCAGATGTCTCTATTTAT
GAAATTATGGAACGTTGCGCCCTGAATGAAGAAGATGAGATTAAATTAAAAGAATACGTAGAGAGTAAGGGTATGATTTT
TATCAGTACTCCTTTCTCTCGTGCAGCTGCTTTACGATTACAACGTATGGATATTCCAGCATATAAAATCGGCTCTGGCG
AATGTAATAACTACCCATTAATTAAACTGGTGGCCTCTTTTGGTAAGCCTATTATTCTCTCTACCGGCATGAATTCTATT
GAAAGCATCAAAAAGTCGGTAGAAATTATTCGAGAAGCAGGGGTACCTTATGCTTTGCTTCACTGTACCAACATCTACCC
AACCCCTTACGAAGATGTTCGATTGGGTGGTATGAACGATTTATCTGAAGCCTTTCCAGACGCAATCATTGGCCTGTCTG
ACCATACCTTAGATAACTATGCTTGCTTAGGAGCAGTAGCTTTAGGCGGTTCGATTTTAGAGCGTCACTTTACTGACCGC
ATGGATCGCCCAGGTCCGGATATTGTATGCTCTATGAATCCGGATACTTTTAAAGAGCTCAAGCAAGGCGCTCATGCTTT
AAAATTGGCACGCGGCGGCAAAAAAGACACGATTATCGCGGGAGAAAAGCCAACTAAAGATTTCGCCTTTGCATCTGTCG
TAGCAGATAAAGACATTAAAAAAGGAGAACTGTTGTCCGGAGATAACCTATGGGTTAAACGCCCAGGCAATGGAGACTTC
AGCGTCAACGAATATGAAACATTATTTGGTAAGGTCGCTGCTTGCAATATTCGCAAAGGTGCTCAAATCAAAAAAACTGA
TATTGAATAA

Protein sequence :
MQNNNEFKIGNRSVGYNHEPLIICEIGINHEGSLKTAFEMVDAAYNAGAEVVKHQTHIVEDEMSDEAKQVIPGNADVSIY
EIMERCALNEEDEIKLKEYVESKGMIFISTPFSRAAALRLQRMDIPAYKIGSGECNNYPLIKLVASFGKPIILSTGMNSI
ESIKKSVEIIREAGVPYALLHCTNIYPTPYEDVRLGGMNDLSEAFPDAIIGLSDHTLDNYACLGAVALGGSILERHFTDR
MDRPGPDIVCSMNPDTFKELKQGAHALKLARGGKKDTIIAGEKPTKDFAFASVVADKDIKKGELLSGDNLWVKRPGNGDF
SVNEYETLFGKVAACNIRKGAQIKKTDIE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
siaC NP_273132.1 polysialic acid capsule biosynthesis protein SiaC Not tested IHT-A Protein 7e-158 100

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
siaC YP_005877666.1 sialic acid synthase (N-acetylneuraminate synthase; N-acetylneuraminic acid synthase) VFG0252 Protein 3e-158 100