Gene Information

Name : clpC (HMPREF9231_0891)
Accession : YP_005838223.1
Strain : Gardnerella vaginalis HMP9231
Genome accession: NC_017456
Putative virulence/resistance : Virulence
Product : negative regulator of genetic competence ClpC/MecB
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 1064656 - 1067145 bp
Length : 2490 bp
Strand : -
Note : -

DNA sequence :
ATGTTTGAACGGTTCACTGACCGCGCTCGGCGTGTGATTGTGCTAGCTCAGGAAGAAGCGCGCTCTCTTCAGCATAACTA
TATTGGTACCGAGCATATTCTCTTAGGTCTTATTAGAGAAGGCGAAGGAATAGCAGCAAAAGCTTTAAACGCCAAAGGCG
TAGAATTAGACAATACTCGTAAACAAATAAAAGAAATGATTGGCACTGGTACTGTCTCGCCTAGTGGACACATACCTTTT
ACTCCGCATGCTAAACAAGTGCTTGAGCTTAGTTTGCGTGAAGCATTGCAATTGGGGCACAGCTATATTGGTACCGAGCA
TATTCTCTTAGGTCTTATTAGAGAAGGCGAAGGTGTTGGAACGCAGGTGCTTATTAAGATGGAGGTCGATTTAGGAGATC
TTCGTAGCACTGCAATGGATTTGATTCGAGGAAATTCTGGATTACCAGAAGACGGTCAGAAGGGTGATTTGGCTAATGCT
GGAGGAGTGCAGGATAAGAGGAATCAGTCTGGTTCTGCGCTGCTAGATCAGTTCGGAAGGAATCTTACTACAGAAGCTGA
GCAAGGGAAGCTTGATCCTGTTATTGGTCGTTCAAAAGAGATTGAGCGCGTTATGGTTGTGCTTTCTCGCAGAACTAAGA
ATAATCCTGTTCTTATAGGTGAACCTGGTGTTGGTAAAACAGCTGTTGTAGAAGGTCTTGCACAGAAGATTGTTGCTGGA
GATGTGCCAGAAACGTTAAAGGGCAAGCAGGTTTATTCTCTTGACTTGGGTTCGATGGTTGCTGGATCTCGTTATCGTGG
CGATTTTGAAGAGCGCTTAAAGAAGGTGCTTAAAGAAATTAAGACTCGTGGAGATATAGTTCTATTTATTGATGAGATTC
ATACTATTGTTGGTGCTGGGTCTGCAGATGGTGCTTTGGGTGCTTCTGACATGCTTAAACCTATGCTTGCGCGTGGTGAG
CTACAGACGATTGGTGCTACAACTACCGATGAGTATAGAAAGTATATTGAAAAGGATGCGGCTTTGGAACGAAGATTCCA
GCCTATTCAAGTTCAAGAGCCTTCTATTGCAGAGACAATTGAGATTCTGAAAGGTTTGCGTGCGCGCTACGAGAATCATC
ATCACGTAACTATTACGGATGCTGCTTTGCAGTCTGCAGCAGAAATGTCTGCTCGCTATATTCAAGATAGGAATTTGCCA
GATAAGGCGATTGATCTTATTGATGAAGCTGGAGCTCGCCTACGTATTAAGCGATTGACAGAGCCACCAGAGCTTAAGGA
ACTTGATTCTAAGATTTCTAAACTTTCAGAAAAGAAAGATGAAGCTATTAAGAATCAGGACTTTGAGAAGGCTGCCGACT
TGCGAGATGAGCAGGAAAAGCTTGAGGAAGAACGTAAGAATAAAGAGCAGGCTTGGCGTGAGGGCGAGTCTAATGTGAAT
ATGGTTGTAGACGAGGATGTTATTGCATCTGTTGTTTCTAATACAACTGGTATTCCTGTTGTTAAGCTAACTCAAGCGGA
ATCCAAAAAGTTGCTCGGTATGGAAGCGGAGCTTCATAAGCGTATTATTGGTCAAGATGAGGCTGTTTCTGCACTTTCTC
GTTCTATTCGTCGTGCGCGAGTAGGATTGAAAGATCCAAAGCGTCCTTCTGGATCGTTTATTTTCGCTGGTCCTACAGGA
GTTGGTAAGACAGAGCTTGCGAAAACCTTAGCTCAATTCCTGTTCGACGATGATGATGCTTTGATTCGTGTTGATATGTC
GGAGTTTGCGGAAAAGTATGCGGCTTCTCGTCTTTTCGGTGCTCCTCCAGGATATGTTGGCTACGAGGAGGGTGGCGAGC
TTACAGAGAAGGTTCGTAGAAAGCCATTCTCGGTGGTGCTTTTTGACGAAATTGAAAAGGCTCATCCAGATATTTTCAAC
ACGCTTTTGCAAGTGTTAGACGACGGTCATTTAACAGATGGCCAGGGAAGAAAAGTTGATTTTAAGAACACGATTATTAT
CTTGACTACAAATCTTGGTACTCGTGATATTGCTAAGTCAGCGAATACTGGTTTTAGTCTTGGCAATAATGCGGATGCAT
CTTACCAGAGGATGAAGGATCAGGTTAATTCGGAATTGAAGCGTCAGTTCCGTCCGGAATTCCTAAACCGTTTGGATGAT
ACGATTGTGTTCCGTCAGCTTACTGAGCCAGAGGTTCGTCAGATTGTTGATTTGGACGTTAAGCATTTGAATGACCGTCT
GTTTGAACGTCATATGACTTTGGAGCTTACAGATGCAGCTAAGAATCTTCTTGCGCAAAAGGGCTTTGATCCTCTTCTTG
GAGCAAGACCGTTGCGAAGAGTTATTCAGCGCGATATTGAGGATGCCATAAGTGAGAAGATTTTGCTTGGCGACTTAACA
GATGGTGAACGCGTTGAAGTTGATGCAGAAGGCGAAGGTTTGCTGGGGGAGTTTATTTTCCGCGGCATAAAGTTTGATGT
TGAGTCTTGA

Protein sequence :
MFERFTDRARRVIVLAQEEARSLQHNYIGTEHILLGLIREGEGIAAKALNAKGVELDNTRKQIKEMIGTGTVSPSGHIPF
TPHAKQVLELSLREALQLGHSYIGTEHILLGLIREGEGVGTQVLIKMEVDLGDLRSTAMDLIRGNSGLPEDGQKGDLANA
GGVQDKRNQSGSALLDQFGRNLTTEAEQGKLDPVIGRSKEIERVMVVLSRRTKNNPVLIGEPGVGKTAVVEGLAQKIVAG
DVPETLKGKQVYSLDLGSMVAGSRYRGDFEERLKKVLKEIKTRGDIVLFIDEIHTIVGAGSADGALGASDMLKPMLARGE
LQTIGATTTDEYRKYIEKDAALERRFQPIQVQEPSIAETIEILKGLRARYENHHHVTITDAALQSAAEMSARYIQDRNLP
DKAIDLIDEAGARLRIKRLTEPPELKELDSKISKLSEKKDEAIKNQDFEKAADLRDEQEKLEEERKNKEQAWREGESNVN
MVVDEDVIASVVSNTTGIPVVKLTQAESKKLLGMEAELHKRIIGQDEAVSALSRSIRRARVGLKDPKRPSGSFIFAGPTG
VGKTELAKTLAQFLFDDDDALIRVDMSEFAEKYAASRLFGAPPGYVGYEEGGELTEKVRRKPFSVVLFDEIEKAHPDIFN
TLLQVLDDGHLTDGQGRKVDFKNTIIILTTNLGTRDIAKSANTGFSLGNNADASYQRMKDQVNSELKRQFRPEFLNRLDD
TIVFRQLTEPEVRQIVDLDVKHLNDRLFERHMTLELTDAAKNLLAQKGFDPLLGARPLRRVIQRDIEDAISEKILLGDLT
DGERVEVDAEGEGLLGEFIFRGIKFDVES

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 67

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpC YP_005838223.1 negative regulator of genetic competence ClpC/MecB VFG0079 Protein 0.0 56
clpC YP_005838223.1 negative regulator of genetic competence ClpC/MecB VFG0080 Protein 5e-143 51