Gene Information

Name : HPPN120_02680 (HPPN120_02680)
Accession : YP_005788210.1
Strain : Helicobacter pylori Puno120
Genome accession: NC_017378
Putative virulence/resistance : Virulence
Product : cag pathogenicity island protein (cagA, cag26)
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 535240 - 538758 bp
Length : 3519 bp
Strand : +
Note : -

DNA sequence :
ATGGCTAACGAAACCATCAATCAAACAGAAAAACTAGATCAAACACCAAACCAAACGGCTTTTGATCCACAACAATTCAT
CAATAATCTTCAAGTGGCTTTCATTAAAGTTGATAGCGCTGTCGCTTCATTTGATCCCGATCAAAAACCAATCGTTGATA
AGAACGATAGGGATAACAGGCAAGCTTTTAATGGAATCTCGCAATTAAGGGAAGAATACGCCAATAAAGCGATCAAAAAT
CCCACCAAAAAGAATCAGTATTTTTCAGACTTTATTGATAAGAGCAATGATTTGATCAACAAAGACAATCTCATTGATAC
AGATTCTTCCACAAAGAGCTTTCAGAAATTTGGGACTGAGCGTTACCAGATTTTTATGAATTGGGTGTCCCATCAAAAAG
ATCCGTCTAAAATCAACACCCAAAAAATCCGAAATTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAAGAA
AAAGCGGAGTTTTTGAGGTCTGCCAAACAATCTTTTGCAGGAATTATCATAGGAAACCAAATCCGATCGGATGAAAAATT
CATGGGCATTTTTGATGAATCTTTGAAAGAGAGGCAAGAAGCAGAAAAAAATGGAGAGCCTGCTAGTGGGGATTGGCTTG
ATATTTTTTTATCGTTTGTATTTGGCAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATCAAGAGCCAAGGCCTAAT
GTTGAACAAAATATAGCCGCTACCACCACCCCCATACAAGGCTTACCGCTTGAAGCTAGGGATTTGCTTGATGAAAGGGG
TAATTTTTCTAAATTCACTCTTGGTGATATGGAAATGTTGGATGTTGAGGGTGTCGCCGACATTGATCCTAATTACAAGT
TCAACCAGTTATTGATTCACAATAACGCTCTGTCTTCTATGCTAATGGGGAGTCGTAGCAACATAGAACTTGAAAAAGTT
TCATTGTTGTATGGGGATAATGGTGGTCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTTATAAAAACCAACAAGG
CAACAATGTGGCCACACTCATCAATGCGCATCTTAAAAACGGCAGTGGGTTAGTCATAGCGGGTAATGAAAATGGGATTA
ACAACCCTAGCTTCTATCTCTACAAAGAAGACCAACTCACAGGCTTGAAAAAAGCGTTGAGTCAAGAAGAGATCCAAAAT
AAACTAGGTTTCATGGAACTTCTTGCACAAAACAACGCTAAATTGGATAACTTGAGCAAGGAAGAGAAAGAAAAGTTCCA
AACTGAGATTGGAAATTTCCAAAAAGACCCTAAGGCTTATTTAGACTCCCTAGGGAAGGATCGCATTGCTTTTGTTTCTA
AAAAAGACCAAAAGCATTTAGCTTTAGTTACTGAGTTTGGTAATGGGGAATTGAGCTATACCCTCAAAGATTATGGGAAA
AAACAAGATAGAGCTTTAGATAGGGAGACAAAAACCACTCTTCAAGGTAACCTAAAACATGATGGCGTGATGTTTGTCAA
TTATTCCAATTTCAAATACACCAACGCCTCCAAGAGTCCTAATGAAGGTATAGGCGCTACGAATGGCGTTTCCCATTTGG
AAGCAAATTTTAGCAAGGTAGCTGTCTTTGATTTGCCTGATTTAAATGGTCTCGCTATCTCTGGTTTTGTAAGGCGGAAT
TTAGAGGATAAACTGATCGCTAAAGGATTGCCCCCAAAAGAAGCTAATAAGATCATCAAAGACTTTTTGAACAGCAATAA
GGAGTTGGTTGGAAAAGCTTTAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAATACAGGCAATTATGACGGAGTGAAAA
AAGCTCAAAAAGATCTTGAAAAATCTATAAGGAAACGAGAGCGTTTAGAGAAAGAAATAACGAAAAAATTTGAGAACAAG
AGCAGCAACAAAAATAAAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATGAGGTTTTTAAGCTTATCAATGAAGG
GGCTCATAAGGAAGCAAGAATCGCCGCTTACGCTCAGAATCTTAAAGGCATCAGGAGAGAATTGTTTGATAAAATTGAAA
ATACCAACAAGAATTTGAAGGACTTTGGTGAATCTTTTGATGCGCTCAAAAGTGGCAAAAATAAGGATTTCAGCAAGGCA
GAAGAAACGCTAAAAGCCCTTCAAAGCTCGGTGAAAGATTTGGGTATCAATCCAGAATGGACTTCAAAAGTTGAAAACCT
TAATGCAGCTTTGAATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACACAAGCAAAAAGCGATCTTGAGA
ATTCCATTAAGGATGTGATCATCAATCAAGAGATAACGGATAAAGTTGACAATCTCAATCAGGCTGTATTAATGGCTAAA
GCGATAGGCGATTTTAGTGGGGTAGAGCAAGCGCTAGCCGAACTCAAGAACTTCTCAACGGATCAAAAAAATGAAAGTTT
CAATGTTCAAAAATCCGTTAAAAATGGTGTAAATGGAACCCTAGTTGGTAATGGGTTATCTGAAACAGAAGCCACAACGC
TCACCAAAAAAATTTCGGACATTAGGAAAGAATTGAATGAGAAATTTGCAAATTCCAACAACAATAATAATGGACTCAAA
AACAGTGCAGAGCCCATTTATGCTAAAGTTAATAAAAAGAAAACAGGACAAGTAGCTAGCCCTGAAGAGTCTATTTACGA
TCAACTTGCTAAAGAGGTAAAAGCAAAAATTGACAAACTCAACAAAATTGCATCAGCAAGTAAATCAGATAGCTCCGAAC
CCATTTACGCTACGATTGATGATCTCGGCGGACCTTTCCCTTTGAGTAGATTAGGGCGATCAGATAGCTCTGAACCCATT
TACGCTACGATTGATGATCTTGGCGGACCTTCCTTGAAAAGGTATGCTAAAGTTGATGATCTCAGTAAGGTAGGGCTTTC
AAGGGATCAAAAATTGACTCAGAAAATTGGCAATCTCGATCAGGCAGTGTCAGAAGCTAAAGCAGGTTTTTTTGGCAACC
TAGAACAAACGATAGATAGACTCAAAGATTCTACAAAAAAGAATGTTGTGAATCTATGGGTTGAAAGTGCAAAAAAAGTG
CCTGCTATTTTGCAAGAGAAATTGGACAATTACGCTACTAACAGCCACACACGTATTAATAGCAATGTCAAAAATGGAAC
AATCAATGAAAAAGCGACCGGCATGCTAACGCAAAAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCGC
ATAATGTGGGAAGCACTCCTTTGTCAGATTATGATAAAATTGGATTCAACCAAAAGAATATGAAAGGTTATTCTGATTCG
TTCAAGTTTTCCACCAAGTTGAACAATGCCGTAAAAAACATTAAGTCTGGCTTTGAGCAATTTTTAACCGATTGCATTTC
TGCAGGATCTTACAACCCGATCAAAGCGGAACATGGAGTTAAAAATATTAACACAAAAAGTGGTTTCCAAAAATCTTAA

Protein sequence :
MANETINQTEKLDQTPNQTAFDPQQFINNLQVAFIKVDSAVASFDPDQKPIVDKNDRDNRQAFNGISQLREEYANKAIKN
PTKKNQYFSDFIDKSNDLINKDNLIDTDSSTKSFQKFGTERYQIFMNWVSHQKDPSKINTQKIRNFMENIIQPPISDDKE
KAEFLRSAKQSFAGIIIGNQIRSDEKFMGIFDESLKERQEAEKNGEPASGDWLDIFLSFVFGKKQSSDLKETLNQEPRPN
VEQNIAATTTPIQGLPLEARDLLDERGNFSKFTLGDMEMLDVEGVADIDPNYKFNQLLIHNNALSSMLMGSRSNIELEKV
SLLYGDNGGPEARHDWNATVGYKNQQGNNVATLINAHLKNGSGLVIAGNENGINNPSFYLYKEDQLTGLKKALSQEEIQN
KLGFMELLAQNNAKLDNLSKEEKEKFQTEIGNFQKDPKAYLDSLGKDRIAFVSKKDQKHLALVTEFGNGELSYTLKDYGK
KQDRALDRETKTTLQGNLKHDGVMFVNYSNFKYTNASKSPNEGIGATNGVSHLEANFSKVAVFDLPDLNGLAISGFVRRN
LEDKLIAKGLPPKEANKIIKDFLNSNKELVGKALNFNKAVAEAKNTGNYDGVKKAQKDLEKSIRKRERLEKEITKKFENK
SSNKNKMEAKAQANSQKDEVFKLINEGAHKEARIAAYAQNLKGIRRELFDKIENTNKNLKDFGESFDALKSGKNKDFSKA
EETLKALQSSVKDLGINPEWTSKVENLNAALNEFKNGKNKDFSKVTQAKSDLENSIKDVIINQEITDKVDNLNQAVLMAK
AIGDFSGVEQALAELKNFSTDQKNESFNVQKSVKNGVNGTLVGNGLSETEATTLTKKISDIRKELNEKFANSNNNNNGLK
NSAEPIYAKVNKKKTGQVASPEESIYDQLAKEVKAKIDKLNKIASASKSDSSEPIYATIDDLGGPFPLSRLGRSDSSEPI
YATIDDLGGPSLKRYAKVDDLSKVGLSRDQKLTQKIGNLDQAVSEAKAGFFGNLEQTIDRLKDSTKKNVVNLWVESAKKV
PAILQEKLDNYATNSHTRINSNVKNGTINEKATGMLTQKNPEWLKLVNDKIVAHNVGSTPLSDYDKIGFNQKNMKGYSDS
FKFSTKLNNAVKNIKSGFEQFLTDCISAGSYNPIKAEHGVKNINTKSGFQKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cagA BAC10430.1 CagA Virulence cag PAI Protein 0.0 84
cagA BAC10424.1 CagA Virulence cag PAI Protein 0.0 84
cagA BAC10422.1 CagA Virulence cag PAI Protein 0.0 82
HP0547 BAD13826.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 82
HP0547 BAD14072.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAC10421.1 CagA Virulence cag PAI Protein 0.0 81
HP0547 BAD13799.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAC10431.1 CagA Virulence cag PAI Protein 0.0 81
cagA BAD51755.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
HP0547 BAD13963.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAC10435.1 CagA Virulence cag PAI Protein 0.0 81
cagA YP_005779046.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA YP_005775747.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAD51754.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
HP0547 BAD13880.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA AAF17597.1 CagA Virulence cag PAI Protein 0.0 81
cagA BAD51749.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51762.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA YP_005777288.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAC10426.1 CagA Virulence cag PAI Protein 0.0 81
cagA BAC10433.1 CagA Virulence cag PAI Protein 0.0 81
HP0547 BAD14018.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAD51756.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAC10420.1 CagA Virulence cag PAI Protein 0.0 80
cagA BAD51744.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA YP_005774524.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 80
cagA BAC10419.1 CagA Virulence cag PAI Protein 0.0 80
cagA BAD51752.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51764.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51759.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA BAD51753.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA BAD51750.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
HP0547 NP_207343.1 cag pathogenicity island protein (cag26) Virulence cag PAI Protein 0.0 79
cagA BAD51758.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA BAD51766.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA BAD51747.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA BAD51761.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA BAD51751.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA BAD51760.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA AAR03881.1 CagA Virulence cag PAI Protein 0.0 79
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen Virulence cag PAI Protein 0.0 78
cagA AGC69806.1 cag pathogenicity island protein A Virulence cag PAI Protein 0.0 78
cagA YP_003728762.1 cytotoxin-associated protein A Virulence cag PAI Protein 0.0 78
cagA AAR03909.1 CagA Virulence cag PAI Protein 0.0 78
HP0547 BAD13908.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
cagA BAC10428.1 CagA Virulence cag PAI Protein 0.0 78
HP0547 BAD13853.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
cagA AAR03939.1 CagA Virulence cag PAI Protein 0.0 78
cagA AAC44706.1 CagA Virulence cag PAI Protein 0.0 77
cagA AAR03970.1 CagA Virulence cag PAI Protein 0.0 77
HP0547 BAD14045.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAC10429.1 CagA Virulence cag PAI Protein 0.0 77
HP0547 BAD13935.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAC10427.1 CagA Virulence cag PAI Protein 0.0 77
cagA AAF17598.1 CagA Virulence cag PAI Protein 0.0 76
cagA BAC10432.1 CagA Virulence cag PAI Protein 0.0 76
HP0547 BAD13990.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA BAC10423.1 CagA Virulence cag PAI Protein 0.0 71

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HPPN120_02680 YP_005788210.1 cag pathogenicity island protein (cagA, cag26) VFG0306 Protein 0.0 79