Gene Information

Name : HMPREF0462_0869 (HMPREF0462_0869)
Accession : YP_005785436.1
Strain : Helicobacter pylori 83
Genome accession: NC_017375
Putative virulence/resistance : Virulence
Product : cytotoxicity-associated immunodominantigen
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 855121 - 858651 bp
Length : 3531 bp
Strand : -
Note : Pfam: PF03507; InterPro: IPR005169

DNA sequence :
ATGACTAATGAAACCATTGATCAAACAATAACACCGGATCAAACACCAAACCAAACGGATTTTGTTCCGCAACGATTTAT
CAATAATCTTCAAGTAGCTTTTATTAAAGTTGATAACGCTGTCGCTTCATTTGATCCTGATCAAAAACCAATCGTTGATA
AGAATGATAGGGATAACAGGCAAGCTTTTGAGAAAATCTCGCAACTAAGGGAAGAATACGCCAATAAAGCGATCAAAAAT
CCCACCAAAAAGAATCAGTATTTTTCAGACTTTATCAATAAGAGCAATGATTTAATCAACAAAGACAATCTCATTGCTGT
AGATTCTTCCGTAGAGAGCTTTCGGAAATTTGGGGATCAGCGTTACCAAATTTTTACGAGTTGGGTGTCCCTTCAAAAAG
ATCCGTCTAAAATCAACACCCAACAAATCCAAAATTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAGGAA
AAAGCGGAGTTTTTGAGGTCTGCCAAACAATCTTTTGCAGGAATTATCATAGGAAATCAAATCCGATCGGATGAAAAATT
CATGGGCGTGTTTGATGAATCTTTGAAAGCAAGGCAAGAAGCAGAAAAAAATGCAGAGCCTGCTGGTGAGGATTGGCTTG
ATATTTTTCTCTCATTTGTGTTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATCAAGAGCCAAGGCCTGAT
TTTGAACAAAATTTAGCCACTACCACCACCGACATACAAGGTTTACCGCCTGAAGCTAGAGATTTGCTTGATGAAAGGGG
TAATTTTTCTAAATTCACTCTTGGTGATGTGGAGATGTTGGATGTTGAGGGAGTCGCTGACAAGGATCCCAATTATAAGT
TCAATCAATTATTGATCCACAATAACGCTTTATCTTCTGTGCTAATGGGGAGTCATAGCAACATAGAACCTGAAAAAGTT
TCATTATTGTATGGAGATAATGGTGGTCCTGAAGCTAGGCATGATTGGAACGCTACCGTTGGTTATAAAGACCAACAAGG
CAGTAATGTGGCCACACTCATTAATGCACATCTTAATAACGGCAGTGGGTTAATCATAGCGGGTAATGAGGATGGGATTA
AAAACCCTAGCTTTTATCTCTATAAAGAAGATCAACTCACAGGTTTGAAACAAGCGTTGAGTCAAGAAGAGATCCAAAAC
AAAGTGGATTTCATGGAATTTCTTGCACAAAATAATGCTAAATTAGACAACTTGAGCAAGGAAGAGAAAGAAAAATTCCA
AACTGAGATTGAAAATTTCCAAAAAGACCGTAAGGCTTATTTGGACGCTCTAGGGAATGATCACATTGCTTTTGTTTCTA
AAAAAGACCCAAATCATTTAGCTTTGGTTACTGAGTTTGGTAATGGGGAATTGAGCTATACTCTCAAAGATTATGGGAAA
AAACAAGATAAAGCTTTAGATGGGGAGACAAAAACCACTCTTCAAGGTAGCCTAAAATATGATGGCGTGATGTTTGTCAA
TTATTCCAATTTCAAATACACCAACGCCTCCAAGAGTCCTAATAAGGGTTTAGGTGCTACGAATGGCGTTTCCCATTTGG
AAGCAAATTTTAGCAAAGTAGCTGTCTTTAATTTGCCTAATTTAAATAATCTCGCTATCACTAATTATATAAGGCGAGAT
TTAGAAGATAAATTGTTGGCTAAAGGATTGTCCCCACAAGAAGCTAATAAGCTCATCAAAGACTTTTTGAACAGCAACAA
AGAAATGGTTGGAAAAGTTTCAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAATTATGATGAAGTGAAAA
AAGCTCAGAAAGATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTGGAGAAAGAAGTAGCGAAAAAATTGGAGAGCAGA
AACGACAACAAAAATAGAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCACTTATCAATAAAGA
GGCTAGTAAGGAAGCAAGAGCGGCCGCTTTCGATCCGAATCTTAAAGGCATCAGGATCGAATTGTCTGATAAACTTGAAA
ATATCAACAAGAATTTGAAAGACTTTGGCAAATCTTTTGATGAACTCAAAAATGGCAAAAATAATGATTTCAGCAAGGCA
GAAGAAACGCTAAAAGCCCTTAAAGACTCGGTGAAAGATTTAGGCATCAATCCAGAATGGATTTCAAAAATTGAAAACCT
TAATGCAGCTTTGAATGATTTCAAAAATGGCAAAAATAAGGATTTCAGTAAGGTAACACAAGCAAAAAGCGACCTTGAAA
ATTCCATTAAGGATGTGATCATTAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAGGCTGTATCAGAGACTAAA
TTAACAGGCGATTTCAGTAAGGTAGAGCAAGCCCTAGCCGAACTCAAAAACTTGTCATTGGATTTTGGAAAAAATTCTGA
TCTACAAAAATCCGTTAAAAATGGTGTAAATGGAACCCTAGTCGGTAATGGGTTGTCTAAAACAGAAGCCACAACGCTCA
CCAAAAATTTTTCGGAAATCAGGAAAGAATTGAACGAGAAATTATTTGGAAATTCCAATAATAATAATAATGGACTCAAA
AACAACACAGAGCCTATTTACGCTCAAGTTAATAAAAAGAAAACAGGACAAGCAACTAGCCCTGAAGAGCCCATTTACGC
TCAAGTTGCTAAAAAGGTGAGTGCAAAAATTGACCAACTCAACGAAGCTACATTAGCAATAAATAGGAAAATTGACCGGA
TTAACAAAATTGCATCAGCAGGTAAAGGAGTGGGCAATTTCAGTGGAGCAGAGCGATCAGCTAGCCCTGAACCCATTTAC
GCTACAATTGATTTTGATGAGGCAAATCAAGCAGGCTTCCCTTTGAGAAGAAGCGCTGCAGTTAATGATCTCAGTAAAGT
AGGGCTTTCAAGGGAACAAGAATTGACTCGTAGAATTGGCGATCTCAATCAGGCAGTGTCAAAAGCTAAAACAGGTTATT
TTGACAACCTAGAACAAAAGATAGATGAACTCAAAGATTCTACAAAAAAGAATGCTTTGAAGCTATGGGTTGAAAGCGCG
AAACAAGTGCCTGCTGGTTTGCAGGCGAAATTGGACAATTACGCTACTAACAGCCACACACGCATTAATAGCAATGTCCA
AACTGGAACAATCAATGAAAAAGCGACCGGTATGCTAACGCAAAAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAGA
TAGTTGCACATAATGTGGGAAGCGCTCATTTGTCAGAGTATGATAAAATTGGATTCAACCAAAAGAATATGAAAGATTAT
TCTGATTCGTTCAAGTTTTCCACCAAGTTGAACAATGCCGTAAAAGACATTAAGTCTAGCTTTGTGCAATTTTTAACCAA
CACATTTTCTACAGGATCTTACAGCTTGATGAAAGCAAATGTGGAACATGGAGTCAAAAACACTACAAAAAGTGGTTTCC
AGAAATCTTAA

Protein sequence :
MTNETIDQTITPDQTPNQTDFVPQRFINNLQVAFIKVDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLREEYANKAIKN
PTKKNQYFSDFINKSNDLINKDNLIAVDSSVESFRKFGDQRYQIFTSWVSLQKDPSKINTQQIQNFMENIIQPPISDDKE
KAEFLRSAKQSFAGIIIGNQIRSDEKFMGVFDESLKARQEAEKNAEPAGEDWLDIFLSFVFNKKQSSDLKETLNQEPRPD
FEQNLATTTTDIQGLPPEARDLLDERGNFSKFTLGDVEMLDVEGVADKDPNYKFNQLLIHNNALSSVLMGSHSNIEPEKV
SLLYGDNGGPEARHDWNATVGYKDQQGSNVATLINAHLNNGSGLIIAGNEDGIKNPSFYLYKEDQLTGLKQALSQEEIQN
KVDFMEFLAQNNAKLDNLSKEEKEKFQTEIENFQKDRKAYLDALGNDHIAFVSKKDPNHLALVTEFGNGELSYTLKDYGK
KQDKALDGETKTTLQGSLKYDGVMFVNYSNFKYTNASKSPNKGLGATNGVSHLEANFSKVAVFNLPNLNNLAITNYIRRD
LEDKLLAKGLSPQEANKLIKDFLNSNKEMVGKVSNFNKAVAEAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVAKKLESR
NDNKNRMEAKAQANSQKDKIFALINKEASKEARAAAFDPNLKGIRIELSDKLENINKNLKDFGKSFDELKNGKNNDFSKA
EETLKALKDSVKDLGINPEWISKIENLNAALNDFKNGKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVSETK
LTGDFSKVEQALAELKNLSLDFGKNSDLQKSVKNGVNGTLVGNGLSKTEATTLTKNFSEIRKELNEKLFGNSNNNNNGLK
NNTEPIYAQVNKKKTGQATSPEEPIYAQVAKKVSAKIDQLNEATLAINRKIDRINKIASAGKGVGNFSGAERSASPEPIY
ATIDFDEANQAGFPLRRSAAVNDLSKVGLSREQELTRRIGDLNQAVSKAKTGYFDNLEQKIDELKDSTKKNALKLWVESA
KQVPAGLQAKLDNYATNSHTRINSNVQTGTINEKATGMLTQKNPEWLKLVNDKIVAHNVGSAHLSEYDKIGFNQKNMKDY
SDSFKFSTKLNNAVKDIKSSFVQFLTNTFSTGSYSLMKANVEHGVKNTTKSGFQKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cagA BAC10430.1 CagA Virulence cag PAI Protein 0.0 98
HP0547 BAD14072.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 97
cagA BAD51755.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 97
cagA YP_005775747.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 97
cagA BAC10435.1 CagA Virulence cag PAI Protein 0.0 97
cagA BAC10424.1 CagA Virulence cag PAI Protein 0.0 97
cagA YP_005777288.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
HP0547 BAD13880.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagA AAF17597.1 CagA Virulence cag PAI Protein 0.0 96
cagA BAC10431.1 CagA Virulence cag PAI Protein 0.0 96
HP0547 BAD13963.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagA BAC10420.1 CagA Virulence cag PAI Protein 0.0 96
cagA BAD51744.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 96
cagA YP_005779046.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagA BAD51754.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 96
cagA BAC10421.1 CagA Virulence cag PAI Protein 0.0 96
HP0547 BAD13799.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagA BAC10419.1 CagA Virulence cag PAI Protein 0.0 96
cagA YP_005774524.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagA BAD51762.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 96
cagA BAD51749.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 96
cagA BAC10433.1 CagA Virulence cag PAI Protein 0.0 96
HP0547 BAD14018.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagA BAC10426.1 CagA Virulence cag PAI Protein 0.0 95
HP0547 BAD13853.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 95
cagA BAC10427.1 CagA Virulence cag PAI Protein 0.0 95
cagA BAC10422.1 CagA Virulence cag PAI Protein 0.0 93
HP0547 BAD13826.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 93
cagA BAD51764.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 85
cagA BAC10423.1 CagA Virulence cag PAI Protein 0.0 84
cagA BAD51752.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA BAC10429.1 CagA Virulence cag PAI Protein 0.0 82
HP0547 BAD13935.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 82
cagA BAD51759.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA YP_003728762.1 cytotoxin-associated protein A Virulence cag PAI Protein 0.0 81
cagA AGC69806.1 cag pathogenicity island protein A Virulence cag PAI Protein 0.0 81
cagA BAD51756.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51760.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51750.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51751.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51758.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51766.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51753.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51761.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA AAR03939.1 CagA Virulence cag PAI Protein 0.0 80
cagA AAR03970.1 CagA Virulence cag PAI Protein 0.0 79
HP0547 NP_207343.1 cag pathogenicity island protein (cag26) Virulence cag PAI Protein 0.0 79
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen Virulence cag PAI Protein 0.0 78
cagA AAR03909.1 CagA Virulence cag PAI Protein 0.0 78
cagA AAR03881.1 CagA Virulence cag PAI Protein 0.0 78
cagA AAC44706.1 CagA Virulence cag PAI Protein 0.0 77
HP0547 BAD14045.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAD51747.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 77
cagA BAC10428.1 CagA Virulence cag PAI Protein 0.0 77
HP0547 BAD13908.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAC10432.1 CagA Virulence cag PAI Protein 0.0 75
HP0547 BAD13990.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 75
cagA AAF17598.1 CagA Virulence cag PAI Protein 0.0 74

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HMPREF0462_0869 YP_005785436.1 cytotoxicity-associated immunodominantigen VFG0306 Protein 0.0 79