Gene Information

Name : ureC (HMPREF0462_0123)
Accession : YP_005784690.1
Strain : Helicobacter pylori 83
Genome accession: NC_017375
Putative virulence/resistance : Virulence
Product : urease alpha subunit
Function : -
COG functional category : -
COG ID : -
EC number : 3.5.1.5
Position : 113430 - 115139 bp
Length : 1710 bp
Strand : -
Note : COG: COG0804; Pfam: PF00449,PF01979; InterPro: IPR005848

DNA sequence :
ATGAAAAAGATTAGCAGAAAAGAATATGTTTCTATGTATGGCCCTACTACAGGCGATAAAGTGAGATTGGGCGATACAGA
CTTGATCGCTGAAGTGGAACATGACTACACCATTTATGGCGAAGAGCTTAAATTCGGTGGCGGTAAAACTTTAAGAGAAG
GCATGAGCCAATCCAACAACCCCAGCAAAGAAGAACTGGATTTAATCATCACTAACGCTTTAATCGTGGATTATACCGGT
ATTTATAAAGCGGATATTGGTATTAAAGATGGCAAAATCGCTGGCATTGGCAAAGGCGGTAACAAAGACATGCAAGATGG
CGTTAAAAACAATCTTAGCGTGGGTCCTGCTACTGAAGCACTAGCTGGTGAAGGTTTGATCGTAACTGCTGGTGGTATTG
ACACACACATCCACTTCATCTCCCCCCAACAAATCCCTACAGCTTTTGCAAGCGGTGTAACAACTATGATTGGTGGCGGA
ACTGGCCCTGCTGATGGCACTAACGCAACCACTATCACTCCAGGCAGAAGAAACTTAAAATGGATGCTCAGAGCGGCTGA
AGAATATTCCATGAACTTAGGTTTCTTAGCTAAAGGTAACGCTTCTAACGATGCGAGCTTAGCCGATCAAATTGAAGCCG
GTGCGATTGGCTTTAAAATCCACGAAGACTGGGGAACAACTCCTTCTGCAATCAACCATGCGTTAGATGTTGCGGACAAA
TACGATGTGCAAGTCGCTATCCACACAGACACTTTGAATGAAGCCGGTTGTGTAGAAGACACTATGGCAGCCATTGCCGG
ACGCACTATGCACACTTTCCACACTGAAGGCGCTGGTGGCGGACACGCTCCTGATATTATTAAAGTGGCCGGTGAACACA
ACATTCTGCCCGCTTCCACTAACCCCACTATCCCTTTCACCGTGAATACAGAAGCAGAACACATGGACATGCTTATGGTG
TGCCACCACTTGGATAAAAGCATTAAAGAAGATGTTCAGTTCGCTGATTCAAGGATCCGCCCTCAAACCATTGCGGCTGA
AGACACTTTGCATGACATGGGGATTTTCTCAATCACCAGTTCTGACTCTCAAGCTATGGGTCGTGTGGGTGAAGTTATCA
CCAGAACTTGGCAAACAGCTGACAAGAACAAAAAAGAATTTGGCCGCTTGAAAGAAGAAAAAGGCGATAACGACAACTTC
AGGATCAAACGCTACTTGTCTAAATACACCATTAACCCAGCGATCGCTCATGGGATTAGCGAGTATGTAGGTTCTGTAGA
AGTGGGCAAAGTGGCTGACTTGGTATTGTGGAGTCCCGCATTCTTTGGCGTGAAACCCAACATGATCATCAAAGGCGGAT
TCATTGCATTAAGTCAAATGGGCGATGCGAACGCTTCTATTCCTACCCCACAACCGGTTTATTACAGAGAAATGTTCGCT
CATCATGGTAAAGCTAAATACGATGCAAACATCACTTTTGTGTCTCAAGCGGCTTATGACAAAGGCATTAAAGAAGAATT
AGGGCTTGAAAGACAAGTGTTACCGGTAAAAAATTGCAGAAACATCACTAAAAAAGACATGCAATTCAACGACACTACCG
CTCACATTGAAGTCAATCCTGAAACTTACCATGTGTTCGTGGATGGCAAAGAAGTAACTTCTAAACCAGCCACTAAAGTG
AGCTTGGCGCAACTCTTTAGCATTTTCTAG

Protein sequence :
MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTG
IYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGG
TGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNASNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADK
YDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMV
CHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNF
RIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFA
HHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNPETYHVFVDGKEVTSKPATKV
SLAQLFSIF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 7e-157 62
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 7e-157 62
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-146 60
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-146 60
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 2e-146 60
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-146 60

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ureC YP_005784690.1 urease alpha subunit VFG0270 Protein 0.0 99