Gene Information

Name : HPIN_04145 (HPIN_04145)
Accession : YP_005782140.1
Strain : Helicobacter pylori India7
Genome accession: NC_017372
Putative virulence/resistance : Virulence
Product : cytotoxin-associated protein A
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 837722 - 841366 bp
Length : 3645 bp
Strand : -
Note : COG0419 ATPase involved in DNA repair

DNA sequence : 
ATGACTAACGAAACCATTAACCAACAACCACAAGCCGAAGCGGCTTTTAACCCGCGGCAATTTATCAATAATCTTCAAGT
AGCTTTTCTTAAAGTTGATAACGCTGTCGCTTCATACGATCCTGATCAAAAACCAATCGTTGATAAGAACGATAGGGATA
ACAGGCAAGCTTTTGATGGAATCTCGCAATTAAGGGAAGAATACTCCAATAAAGCGATCAAAAATCCTACCAAAAAGAAT
CAGTATTTTTCAGACTTTATCAATAAGAGCAATGATTTAATCAACAAAGACGCTCTCATTGATGTAGAATCTTCCACAAA
GAGCTTTCAGAAATTTGGGGATCAGCGTTACCGAATTTTCACAAGTTGGGTGTCCCATCAAAACGATCCGTCTAAAATCA
ACACCCGATCGATCCGAAATTTTATGGAAAATATCATACAACCCCCTATCTCTGATGACAAAGAAAAAGCGGAGTTTTTG
AAATCTGCCAAACAATCTTTTGCAGGAATCATTATAGGGAATCAAATCCGAACGGATCAAAAGTTCATGGGCGTGTTTGA
TGAGTCCTTGAAAGAAAGGCAAGAAGCAGAAAAAAATGGAGGGCCTACTGGTGGGGATTGGTTGGATATTTTTTTATCAT
TTATATTTGACAAAAAACAATCTTCTGATGTCAAAGAAGCAATCAATCAAGAACCAGTTCCCCATGTCCAACCAGATATA
GCCACTACCACCACCGACATACAAGGCTTACCGCCTGAAGCTAGGGATTTGCTTGATGAAAGGGGTAATTTTTCTAAATT
CACTCTTGGTGATATGGAAATGTTAGATGTTGAGGGAGTCGCCGACATTGATCCTAATTACAAGTTCAACCAATTATTGA
TTCACAATAACGCTCTGTCTTCTGTGTTAATGGGGAGTCATAATGGCATAGAACCTGAAAAAGTTTCATTGTTGTATGGG
GACAATGGTGGTCCTGGAGCTAGACACGATTGGAACGCCACCGTTGGTTATAAAGACCAACAAGGTAACAATGTGGCTAC
AATAATTAATGTGCATATGAAAAACGGCAGTGGCTTAGTCATAGCAGGTGGTGAGAAAGGGATTAACAACCCTAGTTTTT
ATCTCTACAAAGAAGACCAACTCACAGGCTCACAACGAGCATTAAGTCAAGAAGAGATCCGAAACAAAATAGATTTCATG
GAATTTCTTGCACAAAATAATGCTAAATTAGACAACTTGAGCGAGAAAGAGAAGGAAAAATTCCGAACTGAGATTAAAGA
TTTCCAAAAAGACTCTAAGGCTTATTTAGACGCCCTAGGGAATGATCGTATTGCTTTTGTTTCTAAAAAAGACACAAAAT
ATTCAGCTTTAATTACTGGGTTTGGTAATGGGGATTTGAGCTACACTCTCAAAGATTATGGGAAAAAAGCAGATAAAGCT
TTAGATAGGGAGGCAAAAATCACTCTTCAAGGTAGCCTAAAACATGATGGCGTGATGTTTGTTGATTATTCTAATTTCAA
ATACACCAACGCCTCCAAGAATCCCAATAAGGGTGTAGGCGTTACGAATGGCGTTTCCCATTTAGAAGCAGGCTTTAACA
AGGTAGCTGTCTTTAATTTGCCTAATTTGAATAATCTCGCTATCACTAATTTTATAAGGCGGGATTTAGAGGATAAACTA
ATCGCTAAAGGATTGTCCCCACAAGAAGCTAATAAGATCATCAAAGACTTTTTGAGCAACAACAAAGAATTGGTTGGAAA
AGTTTCAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAATTATGACGAAGTGAAAAAAGCTCAGAAAGATC
TTGAAAAATCTCTAAAGAAACGAGGGCATTTGGAGAAAGATGTAGCGAAAAATTTGGAGAGCAAAAGCAGCAACAAAAAC
AAAATGGAAGCGAAATCTCAAGCTAACAGCCAAAAAGATGAGATTTTTGCGTTGATTAATAAAGAGGCTAATAGGGAAGC
AAGAGCTGCCGCTTACACTCAGAATCTTAAAGACATCAAAAGGGAATTGTCTGATAAACTTGAAAATGTCAACAAGAATT
TGAAAGACTTTAGTAAATCTTTTGATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGCAGAAGAAACGCTAAAA
GCCCTTAAAGGCTCGGTGAAAGATTTAGGCATCAATCCAGAATGGATTTCAAAAGTTGAAAATCTTAATGCAGCTTTGAA
TGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACCCAAGCAAAAAGCGACCTTGAAAATTCCGTTAAAGATG
TGATCATCAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAAGCGGTATCAGTGGCTAAAGCAACGGGCGATTTC
AGTAGGGTAGAGCAAGCGTTAGCCGATCTCAAAAACTTCTCAAAGGAGCAATTGGCTCAACAAGCTCAAAAAAATGAAGA
TTTCAATACTGGAAAAAAATCTGAAATATACCAATCCGTTAAGAATGGTGTGAATGGAACCCTAGTCGGTAATGGGCTAT
CTCAAGCAGAAGCCACAACTCTTTCTAAAAACTTTTCGGACATCAAGAAAGAGTTGAAAGCAAAACTTGGGAATTTCAAT
AACAACAATAATGGACTCAAAAACGAACCCATTTACGCTAAAGTTAATAAAAAGAAAGCAGGGCAAGCAGCTAGCCTTGA
AGAACCCATTTACGCTCAAGTTGCTAAAAAGGTGAATGCAAAAATTGACCGACTCAATCAAATAGCAAGTGGTTTGGGTA
ATGTAGGGCAAGCAGCGGGCTTCCCTTTGAAAAAGCATGATAAAGTTGATGATCTCAGTAAGGTAGGGCTTTCAGCTAGC
CCTGAACCCATTTACGCTACGATTGATGATCTCGGCGGACCTTTCCCTTTGAAAAAGCATGATAAAGTTGATGATCTCAG
TAAGGTAGGGCTTTCAGCTAGCCCTGAACCCATTTACGCTACGATTGATGATCTCGGCGGACCTTTCCCTTTGAAAAGGC
ATGATAAAGTTGATGATCTCAGTAAGGTAGGGCTTTCAAGGAATCAAGAATTGGCTCAGAAAATTGACAATCTCAATCAA
GCGGTATCAGAAGCTAAAGCAGGTTTTTTTGGCAATCTAGAGCAAACGATAGACAAGCTCAAAGATTCTGCAAAACACAA
TCCCATGAATCTATGGGTTGAAAGCGCGAAACAAGTACCTGCTAGTTTGTCAGCGAAACTAGACAATTACGCTACTAACA
GTCACACACGCATTAGTAGCAATATCAAAAATGGAGCAATCAATGAAAAAGCGACCGGCATGCTAACGCAAAAAAACCCT
GAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCGCATAATGTGGGAAGCGTTTCTTTGTCAGAGTATGATAAAATTGG
CTTCAACCAGAAGAATATGAAAGATTATTCTGATTCGTTCAAGTTTTCCACCAAGTTGAACAATGCCGCAAAAGACATTA
AGTCTGGCTTTACGCAATTTTTAACCAATATATTTTCTACAGCATCTTATTACTGCTTGGCGGGAGAAAATGCAGAGCAT
GGAATCAAGAATGCTAATACAAAAGGTGGTTTCCAAAAATCTTAA

Protein sequence : 
MTNETINQQPQAEAAFNPRQFINNLQVAFLKVDNAVASYDPDQKPIVDKNDRDNRQAFDGISQLREEYSNKAIKNPTKKN
QYFSDFINKSNDLINKDALIDVESSTKSFQKFGDQRYRIFTSWVSHQNDPSKINTRSIRNFMENIIQPPISDDKEKAEFL
KSAKQSFAGIIIGNQIRTDQKFMGVFDESLKERQEAEKNGGPTGGDWLDIFLSFIFDKKQSSDVKEAINQEPVPHVQPDI
ATTTTDIQGLPPEARDLLDERGNFSKFTLGDMEMLDVEGVADIDPNYKFNQLLIHNNALSSVLMGSHNGIEPEKVSLLYG
DNGGPGARHDWNATVGYKDQQGNNVATIINVHMKNGSGLVIAGGEKGINNPSFYLYKEDQLTGSQRALSQEEIRNKIDFM
EFLAQNNAKLDNLSEKEKEKFRTEIKDFQKDSKAYLDALGNDRIAFVSKKDTKYSALITGFGNGDLSYTLKDYGKKADKA
LDREAKITLQGSLKHDGVMFVDYSNFKYTNASKNPNKGVGVTNGVSHLEAGFNKVAVFNLPNLNNLAITNFIRRDLEDKL
IAKGLSPQEANKIIKDFLSNNKELVGKVSNFNKAVAEAKNTGNYDEVKKAQKDLEKSLKKRGHLEKDVAKNLESKSSNKN
KMEAKSQANSQKDEIFALINKEANREARAAAYTQNLKDIKRELSDKLENVNKNLKDFSKSFDEFKNGKNKDFSKAEETLK
ALKGSVKDLGINPEWISKVENLNAALNEFKNGKNKDFSKVTQAKSDLENSVKDVIINQKITDKVDNLNQAVSVAKATGDF
SRVEQALADLKNFSKEQLAQQAQKNEDFNTGKKSEIYQSVKNGVNGTLVGNGLSQAEATTLSKNFSDIKKELKAKLGNFN
NNNNGLKNEPIYAKVNKKKAGQAASLEEPIYAQVAKKVNAKIDRLNQIASGLGNVGQAAGFPLKKHDKVDDLSKVGLSAS
PEPIYATIDDLGGPFPLKKHDKVDDLSKVGLSASPEPIYATIDDLGGPFPLKRHDKVDDLSKVGLSRNQELAQKIDNLNQ
AVSEAKAGFFGNLEQTIDKLKDSAKHNPMNLWVESAKQVPASLSAKLDNYATNSHTRISSNIKNGAINEKATGMLTQKNP
EWLKLVNDKIVAHNVGSVSLSEYDKIGFNQKNMKDYSDSFKFSTKLNNAAKDIKSGFTQFLTNIFSTASYYCLAGENAEH
GIKNANTKGGFQKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cagA BAD51747.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 92
cagA AAR03881.1 CagA Virulence cag PAI Protein 0.0 91
cagA AAR03970.1 CagA Virulence cag PAI Protein 0.0 90
cagA AAR03909.1 CagA Virulence cag PAI Protein 0.0 90
cagA BAC10428.1 CagA Virulence cag PAI Protein 0.0 90
HP0547 BAD13908.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 90
HP0547 NP_207343.1 cag pathogenicity island protein (cag26) Virulence cag PAI Protein 0.0 89
HP0547 BAD14045.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 89
cagA AAF17598.1 CagA Virulence cag PAI Protein 0.0 88
cagA AAC44706.1 CagA Virulence cag PAI Protein 0.0 87
cagA AAR03939.1 CagA Virulence cag PAI Protein 0.0 87
cagA BAC10429.1 CagA Virulence cag PAI Protein 0.0 85
HP0547 BAD13935.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 85
cagA BAD51759.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 85
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen Virulence cag PAI Protein 0.0 84
cagA BAD51750.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 84
cagA BAD51758.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 84
cagA BAC10432.1 CagA Virulence cag PAI Protein 0.0 84
HP0547 BAD13990.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 84
cagA BAD51760.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 83
cagA BAD51751.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 83
cagA BAD51753.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA YP_003728762.1 cytotoxin-associated protein A Virulence cag PAI Protein 0.0 82
cagA BAD51752.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA AGC69806.1 cag pathogenicity island protein A Virulence cag PAI Protein 0.0 82
cagA BAD51761.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA BAD51756.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51766.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51764.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA YP_005774524.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
HP0547 BAD13963.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAC10435.1 CagA Virulence cag PAI Protein 0.0 77
HP0547 BAD14072.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAC10419.1 CagA Virulence cag PAI Protein 0.0 77
cagA BAD51755.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 77
cagA BAC10431.1 CagA Virulence cag PAI Protein 0.0 77
cagA BAC10420.1 CagA Virulence cag PAI Protein 0.0 76
cagA BAD51754.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 76
HP0547 BAD14018.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA BAC10426.1 CagA Virulence cag PAI Protein 0.0 76
cagA YP_005777288.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA BAC10433.1 CagA Virulence cag PAI Protein 0.0 76
cagA BAD51749.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 76
cagA BAC10421.1 CagA Virulence cag PAI Protein 0.0 76
HP0547 BAD13799.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA YP_005779046.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA BAD51762.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 76
HP0547 BAD13880.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA AAF17597.1 CagA Virulence cag PAI Protein 0.0 76
cagA YP_005775747.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA BAD51744.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 75
HP0547 BAD13853.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 75
cagA BAC10427.1 CagA Virulence cag PAI Protein 0.0 75
cagA BAC10430.1 CagA Virulence cag PAI Protein 0.0 75
cagA BAC10423.1 CagA Virulence cag PAI Protein 0.0 75
cagA BAC10424.1 CagA Virulence cag PAI Protein 0.0 74
cagA BAC10422.1 CagA Virulence cag PAI Protein 0.0 67
HP0547 BAD13826.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 67

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HPIN_04145 YP_005782140.1 cytotoxin-associated protein A VFG0306 Protein 0.0 89