Gene Information

Name : fliI (HPGAM_07260)
Accession : YP_005781108.1
Strain : Helicobacter pylori Gambia94/24
Genome accession: NC_017371
Putative virulence/resistance : Virulence
Product : flagellum-specific ATP synthase
Function : -
COG functional category : -
COG ID : -
EC number : 3.6.3.14
Position : 1460496 - 1461800 bp
Length : 1305 bp
Strand : -
Note : COG1157 Flagellar biosynthesis/type III secretory pathway ATPase

DNA sequence :
ATGCCCCTAAAATCCTTAAAAAACCGCTTGAATCAGCATTTTGATCTATCGCCTCGCTATGGGAGCGTGAAAAAAATCAT
GCCCAATATCGTTTATGCGGATGGTTTTAACCCGTCTGTGGGCGATGTGGTGAAGATTGAAAAAAGCGATGGCAGCGAAT
GCGTGGGAATGGTGGTGGTGGCAGAAAAAGAGCAGTTTGGTTTCACGCCTTTTAATTTTGTAGAGGGGGCTAGGGCTGGC
GATAAGGTGCTGTTTTTAAAAGAGGGGTTGAATTTCCCTGTGGGCCGTAATCTTTTAGGGAGGGTGCTTAACCCTTTAGG
GCAAGTCATTGACAATAAGGGGGCGCTAGATTATGAACGATTAGCACCTGTCATTACAACGCCTATAGCCCCTTTAAAAA
GAGGTTTGATTGATGAGGTTTTTAGCGTGGGGGTGAAGAGCATTGATGGGCTTTTGACTTGCGGTAAGGGGCAAAAACTG
GGCATTTTTGCCGGCTCTGGGGTGGGTAAATCCACGCTAATGGGCATGATCACTAGGGGTTGCTTAGCGTCCATTAAAGT
GATCGCTTTGATTGGGGAAAGGGGCAGAGAAATCCCTGAATTTATAGAGAAAAACTTAAAAGGGGATTTAAGCTCTTGCG
TGTTGGTGGTCGCCACGAGCGATGATAGCCCTTTAATGCGCAAATACGGGGCGTTTTGCGCGATGAGCGTGGCGGAGTAT
TTTAAAAACCAAGGGCTAGACGTGTTGTTTATCATGGATTCAGTGACTCGTTTCGCTATGGCTCAAAGAGAAATCGGTTT
AGCCTTAGGCGAACCGCCCACTTCCAAAGGCTACCCCCCATCCGCGCTTTCCTTATTGCCTCAATTAATGGAAAGAGCGG
GCAAGGAAGAAAATAAGGGGAGCATCACGGCTTTTTTTAGCGTGCTAGTAGAGGGCGATGATTTGAGCGATCCCATAGCC
GATCAGGCCAGGAGTATTTTAGACGGGCATATTGTCTTAAGTAGGGAATTGACCGATTATGGGATCTACCCGCCTATTAA
TATTTTAAACTCCGCATCAAGGGTGGCTAAAGACATCATCAGCGAGTCTCAAAACCTTTGCGCGAGAAAATTCCGCCGTT
TGTATGCGTTATTGAAGGAAAATGAAATGCTCATTCGCATCGGCTCTTATCAAATGGGGAACGATAAAGAGCTTGATGAA
GCGATTAAGAAAAAGGCTTTAATGGAGCAGTTTTTAGCGCAAGATGAAAACGCTTTGCAGCCTTTTGAACAAAGCTTTCA
GCAGTTAGAAGAAATCTTAAGATAA

Protein sequence :
MPLKSLKNRLNQHFDLSPRYGSVKKIMPNIVYADGFNPSVGDVVKIEKSDGSECVGMVVVAEKEQFGFTPFNFVEGARAG
DKVLFLKEGLNFPVGRNLLGRVLNPLGQVIDNKGALDYERLAPVITTPIAPLKRGLIDEVFSVGVKSIDGLLTCGKGQKL
GIFAGSGVGKSTLMGMITRGCLASIKVIALIGERGREIPEFIEKNLKGDLSSCVLVVATSDDSPLMRKYGAFCAMSVAEY
FKNQGLDVLFIMDSVTRFAMAQREIGLALGEPPTSKGYPPSALSLLPQLMERAGKEENKGSITAFFSVLVEGDDLSDPIA
DQARSILDGHIVLSRELTDYGIYPPINILNSASRVAKDIISESQNLCARKFRRLYALLKENEMLIRIGSYQMGNDKELDE
AIKKKALMEQFLAQDENALQPFEQSFQQLEEILR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
lscN AAO18044.1 LscN Virulence TTSS locus Protein 2e-73 50
escN NP_290268.1 hypothetical protein Virulence LEE Protein 2e-78 47
escN AAC31513.1 L0034 Virulence LEE Protein 1e-78 47
ECs4568 NP_312595.1 EscN Virulence LEE Protein 2e-78 47
unnamed ACU09458.1 type III secretion apparatus H+-transporting two-sector ATPase Virulence LEE Protein 1e-78 47
escN AAC38383.1 EscN Virulence LEE Protein 2e-78 46
unnamed AAL06369.1 EscN Virulence LEE Protein 3e-77 45
escN YP_003232153.1 T3SS structure protein EscN Virulence LEE Protein 7e-77 45
escN AAK26715.1 EscN Virulence LEE Protein 1e-76 45
escN AAL57542.1 EscN Virulence LEE Protein 1e-76 45
escN CAC81862.1 EscN protein Virulence LEE II Protein 5e-77 45
hrcN AAT96195.1 HrcN Virulence T-PAI Protein 3e-54 45
hrcN AAT96141.1 HrcN Virulence T-PAI Protein 2e-54 45
hrcN AAP34339.1 HrcN Virulence Hrp PAI Protein 4e-82 44
hrcN NP_640767.1 type III secretion system ATPase Virulence Hrp PAI Protein 5e-81 44
hrcN YP_198730.1 type III secretion system ATPase Virulence Hrp PAI Protein 4e-81 44
hrpB6 AAB08461.1 HrpB6 Virulence Hrp PAI Protein 6e-80 44
hrpB6 BAB07852.1 HrpB6 Virulence Hrp PAI Protein 3e-81 44
hrcN YP_362163.1 type III secretion system ATPase Virulence Hrp PAI Protein 9e-80 44
hrpB6 AAF61281.1 HrpB6 Virulence Hrp PAI Protein 3e-81 44
escN AFO66300.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 2e-70 44
escN AFO66415.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 2e-70 44
ssaN CAA70537.1 secretion system apparatus Virulence SPI-2 Protein 3e-63 44
ssaN NP_460380.1 type III secretion system ATPase Virulence SPI-2 Protein 4e-63 44
ssaN YP_216423.1 type III secretion system ATPase Virulence SPI-2 Protein 1e-63 44
hrcN AAG33879.1 HrcN Virulence Hrp PAI Protein 4e-53 44
hrcN NP_791227.1 type III secretion cytoplasmic ATPase HrcN Virulence Hrp PAI Protein 3e-53 44
XC_3006 YP_244074.1 type III secretion system ATPase Virulence Hrp PAI Protein 3e-79 43
hrcN NP_636610.1 type III secretion system ATPase Virulence Hrp PAI Protein 3e-79 43
ysaN AAS66842.1 YsaN Not tested SSR-1 Protein 5e-59 43
escN YP_003236088.1 translocator EscN Virulence LEE Protein 3e-78 42
hrcN AAT96299.1 HrcN Virulence S-PAI Protein 4e-59 42
hrcN AAT96339.1 HrcN Virulence S-PAI Protein 2e-59 42
hrcN AAT96258.1 HrcN Virulence S-PAI Protein 1e-58 42
escN YP_003223475.1 translocator EscN Virulence LEE Protein 4e-77 41
escN CAI43874.1 EscN protein Virulence LEE Protein 3e-77 41
YPO0267 YP_002345348.1 type III secretion system ATPase Virulence Not named Protein 2e-72 41
ECs3730 NP_311757.1 ATP synthase SpaL Not tested LIM Protein 2e-53 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
fliI YP_005781108.1 flagellum-specific ATP synthase VFG0390 Protein 4e-79 52
fliI YP_005781108.1 flagellum-specific ATP synthase VFG0192 Protein 4e-77 51
fliI YP_005781108.1 flagellum-specific ATP synthase VFG0048 Protein 9e-79 50
fliI YP_005781108.1 flagellum-specific ATP synthase VFG2144 Protein 6e-78 48
fliI YP_005781108.1 flagellum-specific ATP synthase VFG0812 Protein 7e-79 47
fliI YP_005781108.1 flagellum-specific ATP synthase VFG0730 Protein 1e-78 46
fliI YP_005781108.1 flagellum-specific ATP synthase VFG1254 Protein 2e-77 45
fliI YP_005781108.1 flagellum-specific ATP synthase VFG0515 Protein 2e-63 44
fliI YP_005781108.1 flagellum-specific ATP synthase VFG2331 Protein 6e-72 43
fliI YP_005781108.1 flagellum-specific ATP synthase VFG1778 Protein 1e-55 42
fliI YP_005781108.1 flagellum-specific ATP synthase VFG1008 Protein 7e-60 41