Gene Information

Name : cagA (HPF57_0574)
Accession : YP_005777288.1
Strain : Helicobacter pylori F57
Genome accession: NC_017367
Putative virulence/resistance : Virulence
Product : cag pathogenicity island protein
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 594999 - 598511 bp
Length : 3513 bp
Strand : +
Note : -

DNA sequence :
ATGACTAACGAAACTATTGATCAAACACCAAACCAAACGGATTTTGTTCCGCAACGATTTATCAATAATCTTCAAGTAGC
TTTTATTAAAGTTGATAACGCTGTCGCTTCATTTGATCCTGATCAAAAACCAATCGTTGATAAGAATGATAGGGATAACA
GGCAAGCTTTTGAGAGAATCTCGCAACTAAGGGAAGAATACGCCAATAAAGCGATTAAAAATCCTGCCAAAAAGAATCAG
TATTTTTCAGACTTTATCAATAAGAGCAATGATTTGATCAACAAAGACAATCTCATTGCTGTAGATTCTTCCGTAGAGAG
CTTTCGGAAATTTGGGGATCAGCGTTACCAAATTTTTACGAGTTGGGTGTCCCTTCAAAAAGATCCGTCTAAAATCAACA
CCCAACAAATCCGAAATTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAGGAAAAAGCGGAGTTTTTGAGG
TCTGCCAAACAATCTTTTGCAGGAATTATCATAGGGAATCAAATCCGATCGGATGAAAAATTCATGGGCGTGTTTGATGA
ATCTTTGAAAGCAAGGCAAGAAGCAGAAAAAAATGCAGAGCCTGCTGGTGGGGATTGGCTTGATATTTTTTTATCATTTG
TATTCAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATCAAGAGCCAAGGCCTGATTTTGAACAAAATTTATCC
ACTACCACTACCGACATACAAGGCTTACCGCCTGAAGCTAGAGATTTGCTTGATGAAAGGGGTAATTTTTTTAAATTCAC
TCTTGGTGATGTGGAGATGTTGGATGTTGAGGGAGTCGCTGACAAGGATCCTAATTACAAGTTCAATCAATTATTGATCC
ACAATAACGCTCTATCTTCTGTGCTAATGGGGGGTCATAGCAGCATAGAACCTGAAAAAGTTTCATTATTGTATGGAGAT
AATGGTGGTCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTTATAAAAACCAACAAGGCAGTAATGTGGCCACACT
CATTAATGCACACCTTAATAACGGCAGCGGGTTAATCATAGCGGGTAATGAAAATGGGATTAAAAACCCTAGCTTCTATC
TCTATAAAGAAGATCAACTCACAGGCTTGAAACAAGCGTTGAGTCAAGAAGAGATCCAAAACAAAGTGGATTTCATGGAA
TTTCTCGCGCAAAACAACGCTAAATTAGATAACTTGAGCGAGAAAGAGAAGGAAAAATTCCAAGCTGAGATTGAAAATTT
CCAAAAAGACCGTAAGGCTTATTTGGACGCCCTAGGGAATGATCACATTGCTTTTGTTTCTAAAAAAGACCCAAAACATT
TAGCTTTGGTTACTGAGTTTGGTAATGGGGAAGTGAGCTATACCCTCAAAGATTATGGGAAAAAACAAGATAAAGCTTTA
GATGGGGAGACAAAAACCACTCTTCAAGGTAGCCTAAAATATGATGGCCTGATGTTTGTCAATTATTCCAATTTCAAATA
CACCAACGCTTCCAAGAGTCCTGATAAGGGCGTGGGCGCTACGAATGGCGTTTCGCATTTGGAAGCAAATTTTAGCAAGG
TAGCTGTCTTTAATTTGCCTAATTTAAATAATCTCGCTATCACTAATTATATAAGGCGAGATTTAGAAGATAAATTGTGG
GCTAAAGGATTGTCCTCACAAGAAGCTAATAAGCTCATCAAAGACTTTTTGAACAGCAACAAAGAATTGCTTGGAAAAGT
TTCAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAATTATGATGAAGTGAAAAAAGCTCAGAAAGATCTTG
AAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAGCGAAAAAATTGGAGAGCAGAAACGACAACAAAAATAGA
ATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCACTTATCAATCAAGAGGCTAGTAAGGAAGCAAG
AGCGGCCGCTTTCGATCCGAATCTTAAAGGCATCAGGAGCGAATTGTCTGATAAACTTGAAAATATCAACAAGAATTTGA
AAGACTTTGGCAAATCTTTTGATGAACTCAAAAGTGGCAAAAATAAGGATTTCAGCAAGGCAGAAGAAACGCTAAAAGCC
CTTAAAGACTCGGTGAAAGATTTAGGCATCAATCCAGAATGGATTTCAAAAATTGAAAACCTTAATACAGCTTTGAATGA
TTTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACACAAGCAAAAAGCGACCTTGAAAATTCCATTAAGGATGTGA
TCATTAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAGGCTGTATCAGAGACTAAATTAACAGGCAATTTCAGT
AAGGTAGAGCAAGCCCTAGCCGAACTCAAAAGCTTGTCATTGGATCTTGGAAAAAATTCTGATCTACAAAAATCCGTTAA
AAATGGTGTAAATGGAACCCTAGTCGGTAATGGGTTGTCTAAAACAGAAGCCACAACGCTCACCAAAAATTTTTCGGACA
TCAGGAAAGAATTGAACGAGAAATTATTTGGAAATTCCAATAACAATAATAATGGACTCAAAAACAACACAGAGCCTATT
TATGCTCAAGTTAATAAAAAGAAAGCAGGACAAGCAGCTAGCCCTGAAGAGCCCATTTACGCTCAAGTTGCCAAAAAGGT
GAGTGCAAAAATTGACCAACTCAACGAAGCTACATCAGCAATAAATAGAAAAATTGACCGGATTAACAAAATTGCATCAG
CAGGTAAAGGAGTGGGCGGTTTCAGTGGAGCAGGGCGATCAGCTAGCCCTGAACCCATTTACGCTACAATTGATTTTGAT
GAGGCAAATCAAGCAGGCTTCCCTTTGAGAAGATACGCTGGATTTGATGATCTCAGTAAAGTAGGGCTTTCAAGGGAACA
AGAATTGACTCGTAGAATTGGCGATCTCAATCAGGCGGTATCAGAAGCTAAAACAGGTCGTTTTGACAACCTAGAACAAA
AGATAGATGAACTCAAAGATTCTACGAAAAAGAATGCTTTGAAGCTATGGGTTGAAAGCACGAAACAAGTGCCTACTAGT
TTGCAAGCGAAATTGGACAATTACGCTACTAACAGCCACACACGCATTAATAGCAATGTCCAAAGTGGAACAATCAATGA
AAAAGCGACCGGTATGCTAACGCAAAAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCGCATAATGTGG
GAAGTGCTCATTTGTCAGAGTATGATAAAATTGGATTCAACCAAAAGAATATGAAAGATTATTCTGATTCGTTCAAGTTT
TCCACCAAGTTGAACAATGCCGTAAAAGACATTAAGTCTAGCTTTGTGCAATTTTTAACCAATACATTTTCTACAGGATC
TTACAGCTTGATGAAAGCAAATGCGGAACATGGAGTCAAAAATACTACAAAAAGTGGTTTCCAGAAATCTTAA

Protein sequence :
MTNETIDQTPNQTDFVPQRFINNLQVAFIKVDNAVASFDPDQKPIVDKNDRDNRQAFERISQLREEYANKAIKNPAKKNQ
YFSDFINKSNDLINKDNLIAVDSSVESFRKFGDQRYQIFTSWVSLQKDPSKINTQQIRNFMENIIQPPISDDKEKAEFLR
SAKQSFAGIIIGNQIRSDEKFMGVFDESLKARQEAEKNAEPAGGDWLDIFLSFVFNKKQSSDLKETLNQEPRPDFEQNLS
TTTTDIQGLPPEARDLLDERGNFFKFTLGDVEMLDVEGVADKDPNYKFNQLLIHNNALSSVLMGGHSSIEPEKVSLLYGD
NGGPEARHDWNATVGYKNQQGSNVATLINAHLNNGSGLIIAGNENGIKNPSFYLYKEDQLTGLKQALSQEEIQNKVDFME
FLAQNNAKLDNLSEKEKEKFQAEIENFQKDRKAYLDALGNDHIAFVSKKDPKHLALVTEFGNGEVSYTLKDYGKKQDKAL
DGETKTTLQGSLKYDGLMFVNYSNFKYTNASKSPDKGVGATNGVSHLEANFSKVAVFNLPNLNNLAITNYIRRDLEDKLW
AKGLSSQEANKLIKDFLNSNKELLGKVSNFNKAVAEAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVAKKLESRNDNKNR
MEAKAQANSQKDKIFALINQEASKEARAAAFDPNLKGIRSELSDKLENINKNLKDFGKSFDELKSGKNKDFSKAEETLKA
LKDSVKDLGINPEWISKIENLNTALNDFKNGKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVSETKLTGNFS
KVEQALAELKSLSLDLGKNSDLQKSVKNGVNGTLVGNGLSKTEATTLTKNFSDIRKELNEKLFGNSNNNNNGLKNNTEPI
YAQVNKKKAGQAASPEEPIYAQVAKKVSAKIDQLNEATSAINRKIDRINKIASAGKGVGGFSGAGRSASPEPIYATIDFD
EANQAGFPLRRYAGFDDLSKVGLSREQELTRRIGDLNQAVSEAKTGRFDNLEQKIDELKDSTKKNALKLWVESTKQVPTS
LQAKLDNYATNSHTRINSNVQSGTINEKATGMLTQKNPEWLKLVNDKIVAHNVGSAHLSEYDKIGFNQKNMKDYSDSFKF
STKLNNAVKDIKSSFVQFLTNTFSTGSYSLMKANAEHGVKNTTKSGFQKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cagA YP_005777288.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 100
cagA BAC10431.1 CagA Virulence cag PAI Protein 0.0 97
HP0547 BAD13963.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 97
cagA BAC10426.1 CagA Virulence cag PAI Protein 0.0 97
cagA YP_005779046.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 97
cagA BAD51762.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 97
cagA BAD51754.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 97
cagA BAC10424.1 CagA Virulence cag PAI Protein 0.0 97
cagA BAC10430.1 CagA Virulence cag PAI Protein 0.0 97
cagA BAC10435.1 CagA Virulence cag PAI Protein 0.0 96
HP0547 BAD14072.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagA BAC10421.1 CagA Virulence cag PAI Protein 0.0 96
HP0547 BAD13799.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagA BAD51744.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 96
cagA YP_005775747.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagA BAD51749.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 96
cagA BAD51755.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 96
cagA BAC10420.1 CagA Virulence cag PAI Protein 0.0 96
HP0547 BAD13880.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagA AAF17597.1 CagA Virulence cag PAI Protein 0.0 96
cagA BAC10419.1 CagA Virulence cag PAI Protein 0.0 95
cagA YP_005774524.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 95
cagA BAC10433.1 CagA Virulence cag PAI Protein 0.0 95
HP0547 BAD14018.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 95
cagA BAC10422.1 CagA Virulence cag PAI Protein 0.0 93
HP0547 BAD13826.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 93
HP0547 BAD13853.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 89
cagA BAC10427.1 CagA Virulence cag PAI Protein 0.0 89
cagA BAD51764.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 86
cagA BAC10423.1 CagA Virulence cag PAI Protein 0.0 83
cagA BAD51752.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 83
cagA BAD51756.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA BAD51759.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAC10429.1 CagA Virulence cag PAI Protein 0.0 81
HP0547 BAD13935.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAD51760.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51758.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA AGC69806.1 cag pathogenicity island protein A Virulence cag PAI Protein 0.0 81
cagA YP_003728762.1 cytotoxin-associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51753.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51751.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51766.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51750.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51761.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA AAR03970.1 CagA Virulence cag PAI Protein 0.0 79
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen Virulence cag PAI Protein 0.0 78
cagA AAR03909.1 CagA Virulence cag PAI Protein 0.0 78
HP0547 NP_207343.1 cag pathogenicity island protein (cag26) Virulence cag PAI Protein 0.0 78
cagA AAR03881.1 CagA Virulence cag PAI Protein 0.0 78
cagA AAR03939.1 CagA Virulence cag PAI Protein 0.0 78
cagA AAC44706.1 CagA Virulence cag PAI Protein 0.0 77
cagA BAD51747.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 77
HP0547 BAD14045.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA BAC10428.1 CagA Virulence cag PAI Protein 0.0 76
HP0547 BAD13908.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA BAC10432.1 CagA Virulence cag PAI Protein 0.0 75
HP0547 BAD13990.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 75
cagA AAF17598.1 CagA Virulence cag PAI Protein 0.0 75

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cagA YP_005777288.1 cag pathogenicity island protein VFG0306 Protein 0.0 78