Gene Information

Name : cagA (HPF32_0523)
Accession : YP_005775747.1
Strain : Helicobacter pylori F32
Genome accession: NC_017366
Putative virulence/resistance : Virulence
Product : cag pathogenicity island protein
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 567055 - 570576 bp
Length : 3522 bp
Strand : +
Note : -

DNA sequence :
ATGACTAACGAAACCATTGATCAAACAACAACACCAGACCAAACGGGTTTTGTTCCGCAACGATTTATCAATAATCTTCA
AGTAGCTTTTATCAAAGTTGATAACGCTGTCGCTTCATTTGATCCTGATCAAAAACCAATCGTTGATAAGAATGATAAGG
ATAACAGGCAAGCTTTTGAGAAAATCTCGCAACTAAGGGAAGAATACGCCAATAAAGCGATCAAAAATCCTGCCAAAAAG
AATCAGTATTTTTCAGACTTTATCAATAAGAGCAATGATTTGATCAACAAAGACAATCTCATTGCTGTAGATTCTTCCGT
AGAGAGCTTTCGGAAATTTGGGGATCAGCGTTACCAAATTTTTACGAGTTGGGTGTCCCTTCAAAAAGATCCGTCTAAAA
TCAACACCCAACAAATCCGAAATTTTATGGAAAATGTCATACAACCCCCTATCTCTGATGATAAAGAAAAAGCGGAGTTT
TTGAGGTCTGCCAAACAATCTTTTGCAGGAATTATCATAGGGAACCAAATCCGATCGGATGAAAAATTCATGGGCGTGTT
TGATGAATCTTTGAAAGCAAGGCAAGAAGCAGAAAAAAATGCAGAGCCTGCTGGTGGGGATTGGCTTGATATTTTTTTAT
CATTTGTATTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATCAAGAGCCAAGGCCTGATTTTGAACAAAAT
TTAGCCACTACCACCACCGACATACAAGGCTTACCGCCTGAAGCTAGAGATTTGCTTGATGAAAGGGGTAATTTTTTTAA
ATTCACTCTTGGTGATGTGGAGATGTTGGATGTTGAGGGAGTCGCTGACAAGGATCCCAATTACAAGTTCAATCAATTAT
TGATCCACAATAACGCTTTATCTTCTATGCTAATGGGGAGTCATAGTAACATAGAACCTGAAAAGGTTTCATTATTGTAT
GGGGATAATGGTGGCCCTGAAGCTAGGCATGATTGGAACGCTACCGTTGGTTATAAAAACCAACAAGGCAACAATGTGGC
CACACTCATTAATGCGCATCTTAATAACGGCAGCGGGTTAATCATAGCGGGTAATGAGGATGGGATTAAAAACCCTAGCT
TCTATCTCTATAAAGAAGATCAACTCACAGGTTTGAAACAAGCGTTGAGTCAAGAAGAGATCCAAAACAAAGTGGATTTC
ATGGAATTTCTCGCACAAAACAATGCTAAATTAGACAACTTGAGCGAGAAAGAGAAAGAAAAATTCCAAACTGAGATTGA
AAATTTCCAAAAAGACCGTAAGGCTTATTTGGACGCTCTAGGGAATGATCACATTGCTTTTGTTTCTAAAAAAGACCCAA
AACATTTAGCTTTGGTTACTGAGTTTGGTAATGGGGAATTGAGCTATACTCTCAAAGATTATGGGAAAAAACAAGATAAA
GCTTTAGATGGGGAGACAAAAACCACTCTTCAAGGTAGCCTAAAATATGATGGCGTGATGTTTGTCAATTATTCTAATTT
CAAATACACCAACGCCTCCAAGAGTCCTAATAAGGGTTTAGGCACTACGAATGGCGTTTCCCATTTGGAAGCGAATTTTA
GCAAAGTAGCTGTCTTTAATTTGCCTAATTTAAATAATCTCGCTATCACTAATTATATAAGGCGAGATTTAGAAGATAAA
CTGTGGGCTAAAGGATTGTCCCCACAAGAAGCTAATAAGCTCATCAAAGACTTTTTAAACAGCAACAAAGAAATGGTTGG
AAAAGTTTCAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAATTATGATGAAGTGAAAAAAGCTCAGAAAG
ATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAGCGAAAAAATTGGAGAGCAGAAACGACAACAAA
AATAGAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCACTTATCAGTCAAGAGGCTAGTAAGGA
AGCAAGAGTGGCCACTTTCGATCCGAATCTTAAAGGCGTCAGGAGCGAATTGTCTGATAAACTTGAAAATATCAACAAGA
ATTTGAAAGACTTTGGCAAATCTTTTGATGAACTCAAAAGTGGCAAAAATAATGATTTCAGCAAGGCAGAAGAAACGCTA
AAAGCCCTTAAAGACTCGGTGAAAGATTTAGGCATCAATCCAGAATGGATTTCAAAAATTGAAAACCTTAATGCAGCTTT
GAATGATTTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACACAAGCAAAAAGCGACCTTGAAAATTCCATTAAGG
ATGTGATCATTAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAGGCTGTATCAGAGATTAAATTAACAGGCGAT
TTCAGTAAGGTAGAGCAAGCCCTAGCCGAACTCAAAAACTTGTCATTGGATCTTGGAAAAAATTCTGATCTACAAAAATC
CGTTAAAAATGGTGTAAATGGAACCCTAGTCAGTAATGGGTTGTCTAAAACAGAAGCCACAACGCTCACCAAAAATTTTT
CGGACATCAGGAAAGAATTGAACGAGAAATTATTTGGAAATTCCAATAACAATAATAATGGACTCAAAAACAACACAGAG
CCTATTTATGCTCAAGTTAATAAAAAGAAAACAGGACAAGCAACTAGCCCTGAAGAGCCCATTTACGCTCAAGTTGCTAA
AAAGGTGAGTGCAAAAATTGACCAACTCAACGAAGCTACATCAGCAATAAATAGAAAAATTGACCGGATTAACAAAATTG
CATCAGCAGGTAAAGGAGTGGGCGGTTTCAGTGGAGCAGGGCGATCAGCTAGCCCTGAACCCATTTACGCTACAATTGAT
TTTGATGAGGCAAATCAAGCAGGCTTCCCTTTGAGAAGAAGTGCTGCAGTTAATGATCTCAGTAAAGTAGGGCTTTCAAG
GGAACAAGAATTGACTCGTAGAATTGGCGATCTCAGTCAGGCAGTGTCAGAAGCTAAAACAGGTCATTTTGGCAACCTAG
AACAAAAGATAGATGAACTCAAAGATTCTACAAAAAAGAATGCTTTGAAGCTATGGGTTGAAAGTGCGAAACAAGTGCCT
ACTAGTTTGCAAGCGAAATTGGACAATTACGCTACTAACAGCCACACACGCATTAATAGCAATGTCCAAAGTGGAACAAT
CAATGAAAAAGCGACCGGCATGCTAACGCAAAAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCGCATA
ATGTGGGAAGTGCTCCTTTGTCAGCGTATGATAAAATTGGATTCAACCAAAAGAATATGAAAGATTATTCTGACTCGTTC
AAGTTTTCCACCAAGTTGAACAATGCCGTAAAAGACATTAAGTCTAGCTTTGTGCAATTTTTAACCAATACATTTTCTAC
AGGATCTTACAGCTTGATGAAAGCAAATGTGGAACATGGAGTCAAAAATACTAATACAAAAGGTGGTTTCCAAAAATCTT
AA

Protein sequence :
MTNETIDQTTTPDQTGFVPQRFINNLQVAFIKVDNAVASFDPDQKPIVDKNDKDNRQAFEKISQLREEYANKAIKNPAKK
NQYFSDFINKSNDLINKDNLIAVDSSVESFRKFGDQRYQIFTSWVSLQKDPSKINTQQIRNFMENVIQPPISDDKEKAEF
LRSAKQSFAGIIIGNQIRSDEKFMGVFDESLKARQEAEKNAEPAGGDWLDIFLSFVFNKKQSSDLKETLNQEPRPDFEQN
LATTTTDIQGLPPEARDLLDERGNFFKFTLGDVEMLDVEGVADKDPNYKFNQLLIHNNALSSMLMGSHSNIEPEKVSLLY
GDNGGPEARHDWNATVGYKNQQGNNVATLINAHLNNGSGLIIAGNEDGIKNPSFYLYKEDQLTGLKQALSQEEIQNKVDF
MEFLAQNNAKLDNLSEKEKEKFQTEIENFQKDRKAYLDALGNDHIAFVSKKDPKHLALVTEFGNGELSYTLKDYGKKQDK
ALDGETKTTLQGSLKYDGVMFVNYSNFKYTNASKSPNKGLGTTNGVSHLEANFSKVAVFNLPNLNNLAITNYIRRDLEDK
LWAKGLSPQEANKLIKDFLNSNKEMVGKVSNFNKAVAEAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVAKKLESRNDNK
NRMEAKAQANSQKDKIFALISQEASKEARVATFDPNLKGVRSELSDKLENINKNLKDFGKSFDELKSGKNNDFSKAEETL
KALKDSVKDLGINPEWISKIENLNAALNDFKNGKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVSEIKLTGD
FSKVEQALAELKNLSLDLGKNSDLQKSVKNGVNGTLVSNGLSKTEATTLTKNFSDIRKELNEKLFGNSNNNNNGLKNNTE
PIYAQVNKKKTGQATSPEEPIYAQVAKKVSAKIDQLNEATSAINRKIDRINKIASAGKGVGGFSGAGRSASPEPIYATID
FDEANQAGFPLRRSAAVNDLSKVGLSREQELTRRIGDLSQAVSEAKTGHFGNLEQKIDELKDSTKKNALKLWVESAKQVP
TSLQAKLDNYATNSHTRINSNVQSGTINEKATGMLTQKNPEWLKLVNDKIVAHNVGSAPLSAYDKIGFNQKNMKDYSDSF
KFSTKLNNAVKDIKSSFVQFLTNTFSTGSYSLMKANVEHGVKNTNTKGGFQKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cagA YP_005775747.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 100
HP0547 BAD13880.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 99
cagA AAF17597.1 CagA Virulence cag PAI Protein 0.0 99
HP0547 BAD13799.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 97
cagA YP_005779046.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 97
cagA BAC10435.1 CagA Virulence cag PAI Protein 0.0 97
cagA BAC10431.1 CagA Virulence cag PAI Protein 0.0 97
HP0547 BAD14072.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 97
HP0547 BAD13963.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 97
cagA BAD51755.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 97
cagA BAC10421.1 CagA Virulence cag PAI Protein 0.0 97
cagA BAD51762.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 97
cagA BAD51754.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 97
cagA BAC10424.1 CagA Virulence cag PAI Protein 0.0 97
cagA BAC10430.1 CagA Virulence cag PAI Protein 0.0 97
cagA YP_005777288.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagA BAC10419.1 CagA Virulence cag PAI Protein 0.0 96
cagA BAD51749.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 96
cagA BAC10420.1 CagA Virulence cag PAI Protein 0.0 96
cagA BAD51744.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 96
cagA BAC10433.1 CagA Virulence cag PAI Protein 0.0 96
HP0547 BAD14018.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagA YP_005774524.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 95
cagA BAC10426.1 CagA Virulence cag PAI Protein 0.0 95
HP0547 BAD13853.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 95
HP0547 BAD13826.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 93
cagA BAC10422.1 CagA Virulence cag PAI Protein 0.0 93
cagA BAC10427.1 CagA Virulence cag PAI Protein 0.0 88
cagA BAD51764.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 86
cagA BAC10423.1 CagA Virulence cag PAI Protein 0.0 84
cagA BAD51752.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 83
cagA BAD51756.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA BAD51759.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAC10429.1 CagA Virulence cag PAI Protein 0.0 81
HP0547 BAD13935.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAD51758.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA YP_003728762.1 cytotoxin-associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51753.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA AGC69806.1 cag pathogenicity island protein A Virulence cag PAI Protein 0.0 81
cagA BAD51766.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51751.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51760.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51750.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51761.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA AAR03939.1 CagA Virulence cag PAI Protein 0.0 79
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen Virulence cag PAI Protein 0.0 78
cagA AAR03909.1 CagA Virulence cag PAI Protein 0.0 78
HP0547 NP_207343.1 cag pathogenicity island protein (cag26) Virulence cag PAI Protein 0.0 78
cagA AAR03970.1 CagA Virulence cag PAI Protein 0.0 78
cagA AAR03881.1 CagA Virulence cag PAI Protein 0.0 78
cagA AAC44706.1 CagA Virulence cag PAI Protein 0.0 77
HP0547 BAD14045.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAD51747.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 77
cagA BAC10428.1 CagA Virulence cag PAI Protein 0.0 77
HP0547 BAD13908.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA AAF17598.1 CagA Virulence cag PAI Protein 0.0 76
cagA BAC10432.1 CagA Virulence cag PAI Protein 0.0 75
HP0547 BAD13990.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 75

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cagA YP_005775747.1 cag pathogenicity island protein VFG0306 Protein 0.0 78