Gene Information

Name : cagA (HPF30_0779)
Accession : YP_005774524.1
Strain : Helicobacter pylori F30
Genome accession: NC_017365
Putative virulence/resistance : Virulence
Product : cag pathogenicity island protein
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 831324 - 834848 bp
Length : 3525 bp
Strand : -
Note : -

DNA sequence :
ATGACTAATGAAACCATTGATCAAACAATAACACCAGATCAAACACCAAACCAAACGGATTTTGTTCCGCAACGATTTAT
CAATAATCTTCAAGTAGCTTTTATCAAAGTTGATAACGCTGTCGCTTCATTTGATCCCGATCAAAAACCAATCGTTGATA
AGAATGATAGGGATAACAGGCAAGCTTTTGAGAAAATCTCGCAACTAAGGGAAGAATACGCCAATAAAGCGATCAAAAAT
CCCACCAAAAAGAATCAGTATTTTTCAGACTTTATCAATAAGAGCAATGATTTGATCAACAAAGACAATCTCATTGCTGT
AGATTCTTCCGTAGAGAGCTTTCGGAAATTTGGGGATCAGCGTTACCAAATTTTTACGAGTTGGGTGTCCCTTCAAAAAG
ATCCGTCTAAAATCAACACCCAACAAATCCGAAATTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAGGAA
AAAGCGGAGTTTTTGAGGTCTGCCAAACAATCTTTTGCAGGAATTATCATAGGGAACCAAATCCGATCGGATGAAAAATT
CATGGGCGTGTTTGATGAATCTTTGAAAGCAAGGCAAGAAGCAGAAAAAAATGCAGAGCCTGCTGGTGGGGATTGGCTTG
ATATTTTTTTATCATTTGTGTTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATCAAGAGCCAAGGCCTGAT
TTTGAACAAAATTTAGCCACTACCACCACCGACATACAAGGCTTACCGCCTGAATCTAGGGATTTGCTTGATGAAAGGGG
TAATTTTTTTAAATTCACTCTTGGTGATATGGAAATGTTGGATGTTGAGGGAGTCGCTGACAAGGATCCCAATTACAAGT
TCAATCAATTATTGATCCACAATAACGCTCTATCTTCTGTGCTAATGGGGGGTCATAGCAACATAGAACCTGAAAAAGTT
TCATTATTGTATGGAGATAATGGTGGTCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTTACAAAAACCAACAAGG
CAACAATGTGGCCACACTCATTAATGCGCACCTTCGCAACGGCAGTGGGTTAGTCATAGTGGGTAATGAGGATGGGATTA
AAAACCCTAGCTTCTATCTCTATAAAGAAGATCAACTCACAGGTTTGAAACAAGCGTTGAGTCAAGAAGAGATCCAAAAC
AAAGTGGATTTCATGGAATTTCTTGCACAAAACAATGCTAAATTAGACAACTTGAGCGAGAAAGAGAAAGAAAAATTCCA
AACTGAGATTGAAGATTTCCAAAAAGACCGTAAGGCTTATTTAGACGCCCTAGGGAATGATCGCATCGCTTTTGTTTCTA
AAAAAGACCCAAAACATTTAGCTTTGGTTACTGAGTTTGGTAATGGGGAAGTGAGCTATACCCTCAAAGATTATGGGAAA
AAACAAGATAAAGCTTTAGATGGGGAGACAAAAACCACTCTTCAAGGTAGCCTAAAATATGATGGCGTGATGTTTGTCAA
TTATTCTAATTTCAAATACACCAACGCCTCCAAGAGTCCTGATAAGGGCGTGGGCACTACGAATGGCGTTTCCCATTTGG
AAGCAAATTTTAGCAAGGTAGCTGTCTTTAATTTACCTAATTTAAATAATCTCGCTATCACTAATTATATAAGGCGAGAT
TTAGAAGATAAATTGTTGGCTAAAGGATTGTCCCCACAAGAAGCTAATAAGCTCATCAAAGACTTTTTGAACAGCAACAA
AGAAATGGTTGGAAAAGTTTCAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAATTATGATGAAGTGAAAA
AAGCTCAGAAAGATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAGCGAAAAAATTGGAGAGCAGA
AACGACAACAAAAATAGAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCACTTATCAATCAAGA
GGCTAGTAAGGAAGCAAGAGCGGCCGCTTTCGATCCGAATCTTAAAGGCATCAGGAGCGAATTGTCTGATAAACTTGAAA
ATATCAACAAGAATTTGAAAGACTTTGGCAAATCTGTTGATGAACTCAAAAATGGCAAAAATAATGATTTCAGCAAGGCA
GAAGAAACGCTAAAAGCCCTTAAAGACTCGGTGAAAGATTTAGGCATCAATCCAGAATGGATTTCAAAAATTGAAAACCT
TAATGCAGCTTTGAATGATTTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACACAAGCAAAAAGCGACCTTGAAA
ATTCCATTAAGGATGTGATCATTAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAGGCTGTATCAGAGACTAAA
TTAACAGGCGATTTCAGTAAGGTAGAGCAAGCCCTAGCCGAACTCAAAAGCTTGTCATTGGATCTTGGAAAAAATTCTGA
TCTACAAAAATCCGTTAAAAATGGTGTAAATGGAACCCTAGTCGGTAATGGGTTATCTAAAACAGAAGCCACAACGCTCA
CCAAAAATTTTTCGGACATCAGGAAAGAATTGAACGAGAAATTATTTGGAAATTCCAATAACAATAATAATGGACTCAAA
AACGAACCCATTTATGCTCAAGTTAATAAAAAGAAAGCAGGACAAGTAGCTAGCCCTGAAGAGCCCATTTACGCTCAAGT
TGCTAAAAAGGTGAGTGCAAAAATTGACCAACTCAACGAAGCTACATCAGCAATAAATAGAAAAATTGACCGGATTAACA
AAATTGCATCAGCAGGTAAAGGAGTGGGCGGTTTCAGTGGAGCAGGGCAATCAGCTAGCCCTGAACCCATTTACGCTACA
ATTGATTTTGATGATGCAAATCAAGCAGGCTTCCCTCTTAGGAGAAGTGCTGCAGTTAATGATCTCAGTAAAGTAGGGCT
TTCAAGGGAACAAGAATTGACTCGTAGAATTGGCGATCTCAATCAGGCGGTATCAGAAGCTAAAACAGGTCGTTTTGACA
ACCTAGAACAAAAGATAGATGAACTCAAAGATTCTACGAAAAAGAATGCTTTGAAGCTATGGGTTGAAAGCGCGAAACAA
GTGCCTATTGGTTTGCAAGCGAAATTGGACAATTACGCTACTAACAGCCACACACGCATTAATAGCAATGTCCAAAGTGG
AACAATCAATGAAAAAGCGACCGGCATGCTAACGCAAAGAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTG
CACATAATGTGGGAAGTGCTCATTTGTCAGAGTATGATAAAATTGGATTCAACCAAAAGAATATGAAAGATTATTCTGAT
TCGTTCAAGTTTTCCACCAAGTTGAACAATGCCGTAAAAGACATTAAGTCTAGCTTTGTGCAATTTTTAACCAACACATT
TTCTACAGGATCTTACAGCTTGATGAAAGCAAATGTGGAACATGGAGTCAAAAATACTACAAAAAGTGGTTTCCAGAAAT
CTTAA

Protein sequence :
MTNETIDQTITPDQTPNQTDFVPQRFINNLQVAFIKVDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLREEYANKAIKN
PTKKNQYFSDFINKSNDLINKDNLIAVDSSVESFRKFGDQRYQIFTSWVSLQKDPSKINTQQIRNFMENIIQPPISDDKE
KAEFLRSAKQSFAGIIIGNQIRSDEKFMGVFDESLKARQEAEKNAEPAGGDWLDIFLSFVFNKKQSSDLKETLNQEPRPD
FEQNLATTTTDIQGLPPESRDLLDERGNFFKFTLGDMEMLDVEGVADKDPNYKFNQLLIHNNALSSVLMGGHSNIEPEKV
SLLYGDNGGPEARHDWNATVGYKNQQGNNVATLINAHLRNGSGLVIVGNEDGIKNPSFYLYKEDQLTGLKQALSQEEIQN
KVDFMEFLAQNNAKLDNLSEKEKEKFQTEIEDFQKDRKAYLDALGNDRIAFVSKKDPKHLALVTEFGNGEVSYTLKDYGK
KQDKALDGETKTTLQGSLKYDGVMFVNYSNFKYTNASKSPDKGVGTTNGVSHLEANFSKVAVFNLPNLNNLAITNYIRRD
LEDKLLAKGLSPQEANKLIKDFLNSNKEMVGKVSNFNKAVAEAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVAKKLESR
NDNKNRMEAKAQANSQKDKIFALINQEASKEARAAAFDPNLKGIRSELSDKLENINKNLKDFGKSVDELKNGKNNDFSKA
EETLKALKDSVKDLGINPEWISKIENLNAALNDFKNGKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVSETK
LTGDFSKVEQALAELKSLSLDLGKNSDLQKSVKNGVNGTLVGNGLSKTEATTLTKNFSDIRKELNEKLFGNSNNNNNGLK
NEPIYAQVNKKKAGQVASPEEPIYAQVAKKVSAKIDQLNEATSAINRKIDRINKIASAGKGVGGFSGAGQSASPEPIYAT
IDFDDANQAGFPLRRSAAVNDLSKVGLSREQELTRRIGDLNQAVSEAKTGRFDNLEQKIDELKDSTKKNALKLWVESAKQ
VPIGLQAKLDNYATNSHTRINSNVQSGTINEKATGMLTQRNPEWLKLVNDKIVAHNVGSAHLSEYDKIGFNQKNMKDYSD
SFKFSTKLNNAVKDIKSSFVQFLTNTFSTGSYSLMKANVEHGVKNTTKSGFQKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cagA YP_005774524.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 100
cagA BAC10419.1 CagA Virulence cag PAI Protein 0.0 97
cagA YP_005777288.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagA BAC10435.1 CagA Virulence cag PAI Protein 0.0 96
HP0547 BAD14072.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagA BAD51744.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 96
cagA BAD51754.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 96
cagA YP_005775747.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagA BAC10431.1 CagA Virulence cag PAI Protein 0.0 96
cagA YP_005779046.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
HP0547 BAD13963.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagA BAD51755.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 96
cagA BAD51749.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 96
cagA BAC10424.1 CagA Virulence cag PAI Protein 0.0 96
cagA BAC10430.1 CagA Virulence cag PAI Protein 0.0 96
cagA BAC10426.1 CagA Virulence cag PAI Protein 0.0 95
cagA BAC10421.1 CagA Virulence cag PAI Protein 0.0 95
HP0547 BAD13799.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 95
cagA BAC10420.1 CagA Virulence cag PAI Protein 0.0 95
HP0547 BAD13880.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 95
cagA AAF17597.1 CagA Virulence cag PAI Protein 0.0 95
cagA BAD51762.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 95
cagA BAC10433.1 CagA Virulence cag PAI Protein 0.0 95
HP0547 BAD14018.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 95
cagA BAC10422.1 CagA Virulence cag PAI Protein 0.0 95
HP0547 BAD13826.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 95
cagA BAC10427.1 CagA Virulence cag PAI Protein 0.0 87
HP0547 BAD13853.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 86
cagA BAD51764.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 85
cagA BAC10423.1 CagA Virulence cag PAI Protein 0.0 83
cagA BAD51752.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 83
cagA BAD51759.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA BAD51766.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA BAC10429.1 CagA Virulence cag PAI Protein 0.0 81
HP0547 BAD13935.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAD51760.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA AGC69806.1 cag pathogenicity island protein A Virulence cag PAI Protein 0.0 81
cagA BAD51750.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA YP_003728762.1 cytotoxin-associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51758.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51756.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51751.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51761.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51753.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA AAR03909.1 CagA Virulence cag PAI Protein 0.0 79
cagA AAR03881.1 CagA Virulence cag PAI Protein 0.0 79
cagA AAR03939.1 CagA Virulence cag PAI Protein 0.0 79
cagA AAC44706.1 CagA Virulence cag PAI Protein 0.0 78
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen Virulence cag PAI Protein 0.0 78
HP0547 NP_207343.1 cag pathogenicity island protein (cag26) Virulence cag PAI Protein 0.0 78
cagA AAR03970.1 CagA Virulence cag PAI Protein 0.0 78
HP0547 BAD14045.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAD51747.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 76
cagA BAC10428.1 CagA Virulence cag PAI Protein 0.0 76
HP0547 BAD13908.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA BAC10432.1 CagA Virulence cag PAI Protein 0.0 76
HP0547 BAD13990.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA AAF17598.1 CagA Virulence cag PAI Protein 0.0 75

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cagA YP_005774524.1 cag pathogenicity island protein VFG0306 Protein 0.0 78