Gene Information

Name : HPLT_02705 (HPLT_02705)
Accession : YP_005772684.1
Strain : Helicobacter pylori Lithuania75
Genome accession: NC_017362
Putative virulence/resistance : Virulence
Product : cytotoxin-associated protein A
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 538929 - 542471 bp
Length : 3543 bp
Strand : +
Note : COG0419 ATPase involved in DNA repair

DNA sequence : 
ATGACTAACGAAACCATTAACCAACAACCACAAACCGAAGCGGCTTTTAACCCGCAGCAATTTATCAATAATCTTCAAGT
GGCTTTTCTTAAAGTTGATAATGTTGTCTCTTCATTTGATCCTGATCAAAAACCAATCGTTGATAAGAATGATAGGGATA
ATAGGCAAGCTTTTGAGAAAATCTCGCAGCTAATGGAGGAATTTGCTAATAAAGCGATCAAAAATCCTGCCAAAAAGAAT
CAGTATTTTTCAAGCTTTATCAGTAAGAGCAATGATTTAATTGACAAAGGCAGTCTCATTGATACAGGTTCTTCCGTAAA
GAGCTTTCAGAAATTTGGGACTCAGCGTTACCAAATTTTTATGAATTGGGTGTCCCATCAAAAAGATCCATCTAAAATCA
ACACCCAAGAAATCCGAGGTTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAAGAGAAAGCGGAGTTTTTG
AGGTCTGCCAAACAAGCTTTTGCAGGAATTATCATAGGAAACCAAATCCGATCGGATCAAAAATTCATGGGCGTGTTTGA
TGAATCTTTGAAAGAGAGGCAAGAAGCAGAAAAAAATGGAGAGCCTAATGGTGGGGATTGGTTTGATATTTTTTTATCAT
TTGTGTTTGGCAAAAAACAATATTCCGATCTCAAAGAAACGCTCAATCAAGAGCCAATGTCTAATGTTGAACAAAATATA
GCTACTACCACCACTGACATACAAGGCTTACCGCCTGAATCTAGGGATTTGCTTGATGAAAGGGGTAATTTTTCTAAATT
CACTCTTGGTGATATGGAAATGTTAGATGTTGAGGGAGTCGCTGACATTGATCCCAATTACAAGTTCAACCAATTAGTGA
TTCACAATAACGCTCTGTCTTCTGTGTTAATGGGGAGTCATAATGGCATAGAACCTGAAAAAGTTTCATTATTGTATGGG
GGCAATGGTGGTCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTTATAAAAACCAACAAGGCGACAATGTGGCTAC
ACTCATTAATGTGCATATGAAAAACGGCAGTGGGTTAGTCATAGCAGGTGGTGAGAAAGGGGTTAACAACCCTAGTTTTT
ATCTCTACAAAGAAGACCAGCTCACAGGCTCACAACGAGCATTGAGTCAAAAAGAGATCCAAAACAAAGTAGATTTCATG
GAATTTCTTGCACAAAACAATGCTAAATTAGATAACTTGAGCAAGAAAGAGAAAGAAAAATTCCAAAATGAGATTGAAGA
TTTTCAAAAAGACTCTAAGGCTTATTTAGACGCCCTAGGGAATGATCACATTGCTTTTGTTTCTAAAAAAGACAAAAAAC
ATTTAGCTTTAGTTGCTGAGTTTGGTAATGGGGACTTGAGCTACACTCTCAAAGATTATGGGAAAAAACAAGATAAAGCT
TTAGATAGGGAGATAAAAACCACTCTTCAAGGTAACCTAAAACATGATGGCGTGATGTTTGTTAATTATTCTAATTTCAA
ATACACCAACGCCTCCAAGAGTCCTGATAAGGGTGTGGGTGCTACGAATGGCGTTTCCCATTTGGAAGCAAATCTTAGCA
AGGTAGCTGTCTTTAATTTGCCTAATTTAAATAATCTCGCTATCACTAGTTATATAAGGCGAGACTTAGAAGATAAACTG
TGGGCTAAAGGATTGTCCCCACAAGAAGCTAATAAGCTCATCAAAGACTTTTTGAACAGCAACAAAGAATTGGTTGAAAA
AGCTTTAAACTTCAATAAAACTGTAGCTGAAGCTAAAAACACAGGCAATTATGATGAAGTGAAACGAACTCAGAAAGATC
TTGAAAAATCTATAAGGAAACGAGAGCATTTAGAGAAAGAAGTAGTGAAAAAATTGGAGAACAGAAACGACAACAAAAAT
AGAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCAATTATCAATGAAGAGGCTGGTAAGGAAGC
AAGAGCGGCCGCTTGCGTTCAGAATCTTAAAGGCATCAGAATGGAATTGTCTGATAAGCTTGAAAACATCAACAAGAATT
TGAAAGACTTTGATAAATCTTTTGATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGACAGAAGAAACGCTAAAA
GCCCTTAAAGACTCGGTGAAAGATTTAGGTATCAATCCAGAATGGATTTCAAAAGTTGAAAACCTTAATACAGCTTTGAA
TGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACGCAAGCAAAAAGCGACCTTGAAAATTCCATTAAAGATG
TGATCATCAATCAAAAGGTAACGGATAAAGTTGACAATCTCAATCAAGCGGTATCAATAGCTAAGGAAACAGGCGATTTC
AGTGGGGTAGAGCAAGCGCTAGCCGATCTCAAGAATTTCTCAAAAGGACAATTGGCTCAACAAGCTCAAAAAAATGAAGA
TTTCAATACTGGAAAAAATTCTGAACTATACCAATCCGTTAAGAATGGTGTAAATAAAACCCTAGTCGGTAATGGGTTAT
CTGGAATAGAGGCCACAGCTCTCGCCAAAAAATTTTCGGATATCAAGAAAGAATTGAATGAGAAATTTAAAAATTTCAAC
AACAATAACAATAATGGACTCAAAAACGAACCCATTTATGCTAAAGTTAATAAAAAGAAAATAGGAGAAGTAGCTAGCCC
TGAAGAACCCATTTATACTCAAGTTGCTAAAAAGGTAAATGCAAAAATTGACCGACTCAATCAAATAGCAAGTGGTTTGG
GTGATGTAGGGCAAGCAACGGGCTTCCCTTTGAAAAGGCATACTAAAGTTGATGATCTCAGTAAGGTAGGGCTTTCAGCT
AGCCCTGAACCCATTTACGCTACGATTGATGATCTCGGCGGACCTTTCCCTTTGAAAAGGCATACTAAAGTTGATGATCT
CAGTAAGGTAGGGCTTTCAAGGAATCAAGAATTGGCTCAGAAAATTGACAATCTCAACCAGGCGGTATTAGAAGCTAAAA
CATCTCATTTTGACAACCTAGATCAAATGATAGACAAGCTCAAAGATTCTACAAAAAAGAATGTTATGAATCTATATGTT
GAAAGTGCAAAAAAAGTGCCTACTAGTTTGTCAGCGAAATTGGACGATTACGCTACTAACAGCCACACACGCATTAATAG
CAATGTCAAAAATGGAACAATCAATGAAAAAGCGACTGGTATGCTAACGCAAAAAAACCCTGAGTGGCTCAAGCTCGTGA
ATGATAAGATAGTTGCGCATAATGTGGGAAGCGCTCCTTTGTCAGCGTATGATAAAATTGGATTCAACCAAAAGAATATG
AAAGATTATTCTGATTCGTTCAAGTTTTCCACCAGGTTGAACAATGCCGTAAAAGACATTAAGTCTGGCTTTACGCAATT
TTTAACCAATATATTTTCTACGGGATCTTACAGCTTGATGAAAGCAAGTGTGGAACATGGAGTCAAAAATACTAATACAA
AAGGTGGTTTCCAGAAATCTTAA

Protein sequence : 
MTNETINQQPQTEAAFNPQQFINNLQVAFLKVDNVVSSFDPDQKPIVDKNDRDNRQAFEKISQLMEEFANKAIKNPAKKN
QYFSSFISKSNDLIDKGSLIDTGSSVKSFQKFGTQRYQIFMNWVSHQKDPSKINTQEIRGFMENIIQPPISDDKEKAEFL
RSAKQAFAGIIIGNQIRSDQKFMGVFDESLKERQEAEKNGEPNGGDWFDIFLSFVFGKKQYSDLKETLNQEPMSNVEQNI
ATTTTDIQGLPPESRDLLDERGNFSKFTLGDMEMLDVEGVADIDPNYKFNQLVIHNNALSSVLMGSHNGIEPEKVSLLYG
GNGGPEARHDWNATVGYKNQQGDNVATLINVHMKNGSGLVIAGGEKGVNNPSFYLYKEDQLTGSQRALSQKEIQNKVDFM
EFLAQNNAKLDNLSKKEKEKFQNEIEDFQKDSKAYLDALGNDHIAFVSKKDKKHLALVAEFGNGDLSYTLKDYGKKQDKA
LDREIKTTLQGNLKHDGVMFVNYSNFKYTNASKSPDKGVGATNGVSHLEANLSKVAVFNLPNLNNLAITSYIRRDLEDKL
WAKGLSPQEANKLIKDFLNSNKELVEKALNFNKTVAEAKNTGNYDEVKRTQKDLEKSIRKREHLEKEVVKKLENRNDNKN
RMEAKAQANSQKDKIFAIINEEAGKEARAAACVQNLKGIRMELSDKLENINKNLKDFDKSFDEFKNGKNKDFSKTEETLK
ALKDSVKDLGINPEWISKVENLNTALNEFKNGKNKDFSKVTQAKSDLENSIKDVIINQKVTDKVDNLNQAVSIAKETGDF
SGVEQALADLKNFSKGQLAQQAQKNEDFNTGKNSELYQSVKNGVNKTLVGNGLSGIEATALAKKFSDIKKELNEKFKNFN
NNNNNGLKNEPIYAKVNKKKIGEVASPEEPIYTQVAKKVNAKIDRLNQIASGLGDVGQATGFPLKRHTKVDDLSKVGLSA
SPEPIYATIDDLGGPFPLKRHTKVDDLSKVGLSRNQELAQKIDNLNQAVLEAKTSHFDNLDQMIDKLKDSTKKNVMNLYV
ESAKKVPTSLSAKLDDYATNSHTRINSNVKNGTINEKATGMLTQKNPEWLKLVNDKIVAHNVGSAPLSAYDKIGFNQKNM
KDYSDSFKFSTRLNNAVKDIKSGFTQFLTNIFSTGSYSLMKASVEHGVKNTNTKGGFQKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cagA AAR03939.1 CagA Virulence cag PAI Protein 0.0 94
cagA BAD51758.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 93
cagA BAC10432.1 CagA Virulence cag PAI Protein 0.0 93
HP0547 BAD13990.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 93
cagA BAD51750.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 92
cagA BAD51751.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 92
cagA BAD51760.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 92
cagA BAD51766.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 92
cagA BAD51756.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 91
cagA BAD51752.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 91
cagA YP_003728762.1 cytotoxin-associated protein A Virulence cag PAI Protein 0.0 91
cagA BAD51761.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 91
cagA AGC69806.1 cag pathogenicity island protein A Virulence cag PAI Protein 0.0 91
cagA BAD51759.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 89
cagA BAD51764.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 89
cagA BAD51753.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 89
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen Virulence cag PAI Protein 0.0 88
cagA AAR03881.1 CagA Virulence cag PAI Protein 0.0 87
cagA AAF17598.1 CagA Virulence cag PAI Protein 0.0 87
cagA AAR03909.1 CagA Virulence cag PAI Protein 0.0 86
HP0547 BAD14045.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 85
HP0547 NP_207343.1 cag pathogenicity island protein (cag26) Virulence cag PAI Protein 0.0 85
cagA AAR03970.1 CagA Virulence cag PAI Protein 0.0 85
cagA AAC44706.1 CagA Virulence cag PAI Protein 0.0 83
cagA BAC10428.1 CagA Virulence cag PAI Protein 0.0 83
HP0547 BAD13908.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 83
cagA BAD51747.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA YP_005777288.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAC10426.1 CagA Virulence cag PAI Protein 0.0 81
HP0547 BAD14072.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA YP_005779046.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA YP_005774524.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAC10421.1 CagA Virulence cag PAI Protein 0.0 81
HP0547 BAD13799.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAC10435.1 CagA Virulence cag PAI Protein 0.0 81
cagA BAD51754.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA YP_005775747.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAC10419.1 CagA Virulence cag PAI Protein 0.0 81
cagA BAC10433.1 CagA Virulence cag PAI Protein 0.0 81
HP0547 BAD14018.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
HP0547 BAD13935.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAC10429.1 CagA Virulence cag PAI Protein 0.0 81
cagA BAD51744.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51755.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51749.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAC10420.1 CagA Virulence cag PAI Protein 0.0 80
cagA BAC10431.1 CagA Virulence cag PAI Protein 0.0 80
HP0547 BAD13963.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 80
cagA BAD51762.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
HP0547 BAD13880.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 80
cagA AAF17597.1 CagA Virulence cag PAI Protein 0.0 80
cagA BAC10427.1 CagA Virulence cag PAI Protein 0.0 76
HP0547 BAD13853.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 74
cagA BAC10423.1 CagA Virulence cag PAI Protein 0.0 70
cagA BAC10430.1 CagA Virulence cag PAI Protein 0.0 70
cagA BAC10424.1 CagA Virulence cag PAI Protein 0.0 69
cagA BAC10422.1 CagA Virulence cag PAI Protein 0.0 69
HP0547 BAD13826.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 69

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HPLT_02705 YP_005772684.1 cytotoxin-associated protein A VFG0306 Protein 0.0 85