Gene Information

Name : HPSA_00545 (HPSA_00545)
Accession : YP_005770740.1
Strain : Helicobacter pylori SouthAfrica7
Genome accession: NC_017361
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : -
COG ID : -
EC number : 2.5.1.48
Position : 110107 - 111249 bp
Length : 1143 bp
Strand : -
Note : COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases

DNA sequence :
ATGCGCATGCAAACCAAATTGATCCATGGAGGCATTAGTGAGGACGCCACAACGGGGGCAGTGAGCGTGCCTATTTATCA
AACTTCCACCTACCGCCAAGACGCCATAGGCCGCCCAAAAGGCTATGAATACTCTCGCTCAGGCAACCCCACGCGCTTTG
CATTAGAAGAGCTTATTGCTGATTTAGAAGGGGGGGTTAAGGGGTTTGCTTTTGCCTCTGGTTTAGCCGGGATTCACGCT
GTCTTTTCGCTCTTGCAATCAGGCGATCATGTGCTATTGGGCGATGATGTCTATGGGGGGACTTTCCGCTTGTTTGACAA
GGTGCTTTCTAAAAACGGGCTTTCTTGCACCATTATAGACACTAGCGATATTTCTCAAATACAAAAGGCTATCAAGCCCA
ACACCAAAGCCCTTTATTTGGAATCCCCTAGTAACCCTTTGCTTAAAATCACGGATTTGAAGCAATGCGCGAGTGTTGCT
AAAACGCATGGCCTGCTCACTATCGTGGACAACACCTTTGCCACGCCTTATTGCCAAAATCCGCTTCTTTTGGGAGCGGA
TATTGTAGTGCATAGCGGCACAAAATATTTAGGCGGGCATAGCGATGTGGTCGCCGGGCTTGTAACCACGAATAATGAAG
CATTAGCCCAAGAGATCGCTTTTTTCCAAAACGCTATTGGGGGGGTGCTAGGCCCTCAAGACAGCTGGCTGTTGCAAAGA
GGGATTAAAACGCTAGCATTGCGCATGGAAGCCCATCAAAAAAACGCCTTTTGTGTGGCTGAGTTTTTAGAAAAACACCC
TAAAGTGGAAAAGGTTTATTACCCGGGCTTGCCCACTCACCCTAATCACGATCTAGCCAAAGCTCAGATGCACGGTTTTA
GCGGAATGCTTTCTTTCACTCTCAAAAACGACAACGAAGCGACTCTTTTTGTAGAAAGCCTTAAATTATTCATTTTAGGC
GAGAGTTTGGGCGGGGTGGAAAGTTTGGTGGGTATTCCAGCGTTTATGACCCATGCGTGTATCCCTAAAGTGCAACGAGA
AGCCGCAGGGATTAGAGATGGCTTGGTGCGCTTGTCTGTGGGGATTGAGCATGAAAAGGATTTGTTAGAAGATTTAGAGC
AAGCGTTCGCTAAAATAAGCTAA

Protein sequence :
MRMQTKLIHGGISEDATTGAVSVPIYQTSTYRQDAIGRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA
VFSLLQSGDHVLLGDDVYGGTFRLFDKVLSKNGLSCTIIDTSDISQIQKAIKPNTKALYLESPSNPLLKITDLKQCASVA
KTHGLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQR
GIKTLALRMEAHQKNAFCVAEFLEKHPKVEKVYYPGLPTHPNHDLAKAQMHGFSGMLSFTLKNDNEATLFVESLKLFILG
ESLGGVESLVGIPAFMTHACIPKVQREAAGIRDGLVRLSVGIEHEKDLLEDLEQAFAKIS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 7e-101 54
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 4e-102 54
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 6e-74 48

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HPSA_00545 YP_005770740.1 cystathionine gamma-synthase BAC0207 Protein 7e-64 43