Gene Information

Name : clpB (HMPREF4655_20506)
Accession : YP_005769631.1
Strain : Helicobacter pylori 35A
Genome accession: NC_017360
Putative virulence/resistance : Virulence
Product : chaperone protein ClpB
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 492062 - 494632 bp
Length : 2571 bp
Strand : +
Note : COG: COG0542; Pfam: PF02861, PF00004, PF07724; InterPro: IPR003593

DNA sequence :
ATGAATTTATTTGAAAAAATGACCGACCAATTGCATGAGACTTTAGACAGCGCGCTCGCTCTAGCTTTACACCATAAAAA
CGCTGAAGTAACGCCCTTGCACATGCTTTTTGTCATGCTCAATAACTCCCAAGGCATCCTCATTCAAGCCTTACAAAAAA
TGTCTGTGGATATTCAAGCCTTAAGGCTTAGCGTTCAAAGCGAATTGAATAAGTTGGCTAAAGTTTCACAAATCAACAAG
CAAAATATCCAATTAAACCAAGCTCTAATCCAAAGTTTAGAAAACGCTCAAGGCTTGATGGCTAAAATTGGCGATTCTTT
CATCGCTACAGATGTGTATCTTTTGGCGAACATGAGCCTTTTTGAAAGCGTTCTAAAACCTTATTTAGACACTAAGGAAT
TGCAAAAAACTTTAGAATCTTTAAGAAAAGGCACGACTATCCAAGGTAAAAACGATGATTCTAATTTGGAAAGTTTGGAG
AAATTTGGCATTGATTTGACGCAAAAAGCCTTAGAAAATAAGCTCGATCCGGTGATTGGGAGGGATGAAGAAATCATTCG
CATGATGCAAATTTTGATAAGAAAAACAAAAAATAACCCTATTTTACTGGGTGAGCCTGGAGTGGGGAAAACGGCGGTTG
TGGAGGGTTTGGCCCAACGCATTGTGAATAAGGAAGTGCCTAAAACGCTTTTAAACAAACGAGTCGTCGCTTTAGATTTA
AGCTTATTGGTGGCTGGAGCCAAATACAGAGGCGAGTTTGAAGAGCGCTTGAAAAAGGTGATTGAAGAAGTTAAAAAAAG
CGCGAATGTGATTTTATTCATTGATGAAATCCACACGATTGTAGGGGCTGGGGCTAGTGAGGGGGGCATGGATGCGGCTA
ATATTTTAAAACCCGCGCTCGCTAGGGGGGAATTGCACACGATTGGAGCGACCACTTTGAAAGAATACCGCAAGTATTTT
GAAAAAGACATGGCACTACAAAGGCGTTTCCAACCCATTTTACTCAATGAGCCTAGCATCAATGAGGCTTTACAGATTTT
AAGGGGGTTAAAAGAAACTTTAGAAACGCACCATAATATCACTATCAATGACTCCGCGCTTATAGCGAGCGCTAAACTCT
CTAGCCGTTATATCACCGATAGGTTTTTACCCGATAAAGCGATTGATTTGATTGATGAGGGGGCGGCCCAATTAAAAATG
CAAATGGAATCAGAGCCGGCAAAACTCTCTAGCGTTAAGCGCTCCATTCAAAGATTAGAAATGGAAAGACAAGCCCTTGA
AATGGAAAAAAAAGAGAGCAATGCCAAACGCATGCAAGAAATCCTTAAAGAATTGAGCGATTTGAAAGAAGAAAAAATCC
AATTAGAAGCGCAATTTGAGAACGAAAAAGAAGTGTTTAGAGAAATTTCACGCTTGAAAATGGAAACGGAAAGCTTGAAA
AAAGAGGCTGAGAGGTTTAAGCGCAATGGGGATTACCAGCAAGCGGGTGAAATTGAATACTCTAAAATCCCTGAAAATAA
AAAGAAAGAAGAAGAATTGCAGCATAAATGGGAAGCGATGCAACAAAACGGGGCGTTGTTGCAAAACGCTTTAACCGAAA
ACAACATCGCTGAGATCGTGAGCCAATGGACGCATATCCCGGTCCAAAAAATGCTCCAGAGCGAAAAAAATAGGGTTTTA
AACATTGAAAGCGAATTGCAAAAAAGAGTGGTGGGGCAAGAAAAAGCAATCAAAGCGATCGCTAAAGCGATTAAAAGGAA
TAAGGCCGGGCTTAGCGATAGCAATAAACCCATAGGGAGCTTTCTCTTTTTAGGGCCAACGGGCGTGGGTAAAACTGAGA
GCGCTAAAGCTTTGGCGCAATTCTTGTTTGATAGTGATAAAAATCTTATAAGAATTGACATGAGCGAATACATGGAAAAA
CATGCCATAAGCCGTCTTATTGGGGCTGCTCCTGGGTATGTGGGCTATGAAGAAGGCGGGCAATTGACCGAAGCGGTGCG
CAGAAAACCCTATAGCGTGGTGCTGTTAGATGAAGTGGAAAAAGCCCATCCGGATGTGTTTAATCTCTTGTTGCAGGTTT
TAGATGAAGGGCATTTAACCGATAGTAAGGGCGTGAGGGTGGATTTCAAAAATACGATTTTGATTTTAACCAGCAATGTG
GCTAGCGGCGCGCTTTTAGAAGAAAATTTGAGTGAAGCCGATAAACAAAAAGCGATCAAAGAGAGTTTGAGGCAATTCTT
CAAGCCGGAATTTTTAAACCGCTTAGATGAAATCATCTCCTTTAACGCCCTAGATAGCCATGCTGTCGCTAATATCGTGG
GGATTCTCTTTGAAAACATTCAAAAAAAAGCGCTTGAAAGAGGCATTAATATAACCCTAGACGAAGAGGCAAAAGAATTG
ATCGCTGAAGCGGGATTTGACAGATTTTATGGCGCTAGACCCTTAAAGCGTGCGCTCTATGAAATGGTAGAAGACAAACT
CGCTGAACTCATTTTAGAGGATAAAATTAAAGAGAATGACAGCGTGGCGTTTGTGGTAGAAAATAACGAAATTGTGCCTA
AGATTAAGTGA

Protein sequence :
MNLFEKMTDQLHETLDSALALALHHKNAEVTPLHMLFVMLNNSQGILIQALQKMSVDIQALRLSVQSELNKLAKVSQINK
QNIQLNQALIQSLENAQGLMAKIGDSFIATDVYLLANMSLFESVLKPYLDTKELQKTLESLRKGTTIQGKNDDSNLESLE
KFGIDLTQKALENKLDPVIGRDEEIIRMMQILIRKTKNNPILLGEPGVGKTAVVEGLAQRIVNKEVPKTLLNKRVVALDL
SLLVAGAKYRGEFEERLKKVIEEVKKSANVILFIDEIHTIVGAGASEGGMDAANILKPALARGELHTIGATTLKEYRKYF
EKDMALQRRFQPILLNEPSINEALQILRGLKETLETHHNITINDSALIASAKLSSRYITDRFLPDKAIDLIDEGAAQLKM
QMESEPAKLSSVKRSIQRLEMERQALEMEKKESNAKRMQEILKELSDLKEEKIQLEAQFENEKEVFREISRLKMETESLK
KEAERFKRNGDYQQAGEIEYSKIPENKKKEEELQHKWEAMQQNGALLQNALTENNIAEIVSQWTHIPVQKMLQSEKNRVL
NIESELQKRVVGQEKAIKAIAKAIKRNKAGLSDSNKPIGSFLFLGPTGVGKTESAKALAQFLFDSDKNLIRIDMSEYMEK
HAISRLIGAAPGYVGYEEGGQLTEAVRRKPYSVVLLDEVEKAHPDVFNLLLQVLDEGHLTDSKGVRVDFKNTILILTSNV
ASGALLEENLSEADKQKAIKESLRQFFKPEFLNRLDEIISFNALDSHAVANIVGILFENIQKKALERGINITLDEEAKEL
IAEAGFDRFYGARPLKRALYEMVEDKLAELILEDKIKENDSVAFVVENNEIVPKIK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 3e-139 46

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpB YP_005769631.1 chaperone protein ClpB VFG0079 Protein 1e-158 43
clpB YP_005769631.1 chaperone protein ClpB VFG2076 Protein 1e-111 42