Gene Information

Name : metB (HMPREF4655_20348)
Accession : YP_005769485.1
Strain : Helicobacter pylori 35A
Genome accession: NC_017360
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : -
COG ID : -
EC number : 2.5.1.48
Position : 339759 - 340901 bp
Length : 1143 bp
Strand : +
Note : COG: COG0626; Pfam: PF01053; InterPro: IPR000277

DNA sequence :
ATGCGCATGCAAACAAAATTAATCCATGGGGGTATTAGTGAGGACGCAACAACCGGAGCGGTGAGCGTGCCTATTTATCA
AACTTCCACCTACCGCCAAGACGCCATAGGCCGTCATAAGGGCTATGAATACTCTCGCTCAGGCAACCCCACGCGCTTTG
CTTTAGAAGAACTCATCGCCGATTTAGAAGGGGGGGTTAAGGGGTTTGCTTTTGCCTCTGGACTAGCTGGGATCCACGCC
GTTTTTTCCCTCTTGCAATCAGGCGATCATGTGCTATTGGGCGATGATGTTTATGGGGGGACTTTTCGCTTGTTCAATAA
AGTGCTTGTCAAAAACGACCTTTCTTGCACCATTATAGACGCTAGCGATATATCCCAGATCAAAAAGGCTATCAAGCCCA
ACACCAAAGCCCTTTATTTGGAAACTCCTAGTAACCCCTTGCTTAAAATCACGGATTTAGTGCAATGCGCTAGTGTTGCT
AAAGATCATGGTTTGCTCACTATCGTGGATAACACCTTTGCCACCCCCTATTGCCAAAACCCGCTTCTTTTGGGAGCGGA
CATCGTGGTGCATAGCGGCACCAAATACTTGGGCGGTCATAGCGATGTGGTCGCTGGGCTTGTAACCACTAATAATGAAG
CGCTAGCCCAAGAGATCGCTTTTTTCCAAAACGCTATCGGTGGGGTTTTAGGCCCTCAAGACAGCTGGCTGTTGCAAAGA
GGGATTAAAACGCTAGGATTGCGCATGGAAGCCCATCAAAAAAACGCGCTTTGCGTGGCTGAGTTTTTAGAAAAACACCC
TAAAGTGGAAAAGGTTTATTACCCGGGCTTGAGCGCTCACCCTAACCACGAACTGGCCAAAAAACAGATGCGTGGCTTTA
GCGGGATGCTCTCTTTCACTCTCAAAAATGACAGCGAGGCGGTTGCTTTTGTAGAAAGCCTTAAACTATTCATTTTGGGC
GAGAGTTTGGGCGGAGTGGAAAGTTTGGTGGGGATTCCAGCGCTTATGACCCATGCGTGTATCCCTAAAGCGCAACGAGA
AGCTGCCGGGATTAGAGATGGTCTGGTGCGCTTGTCTGTGGGGATTGAGCATGAACAGGATTTGTTAGAAGATTTAGAGC
AAGCGTTCACTAAAATAGGCTAA

Protein sequence :
MRMQTKLIHGGISEDATTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA
VFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNDLSCTIIDASDISQIKKAIKPNTKALYLETPSNPLLKITDLVQCASVA
KDHGLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQR
GIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLSAHPNHELAKKQMRGFSGMLSFTLKNDSEAVAFVESLKLFILG
ESLGGVESLVGIPALMTHACIPKAQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFTKIG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 3e-97 54
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-98 54
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 7e-74 48

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
metB YP_005769485.1 cystathionine gamma-synthase BAC0207 Protein 1e-61 43