Gene Information

Name : ureB (HMPREF4655_20299)
Accession : YP_005769443.1
Strain : Helicobacter pylori 35A
Genome accession: NC_017360
Putative virulence/resistance : Virulence
Product : urease subunit beta
Function : -
COG functional category : -
COG ID : -
EC number : 3.5.1.5
Position : 290980 - 292689 bp
Length : 1710 bp
Strand : -
Note : COG: COG0804; Pfam: PF00449, PF01979; InterPro: IPR005848

DNA sequence :
ATGAAAAAGATTAGCAGAAAAGAATATGTTTCTATGTATGGTCCTACTACAGGCGATAAAGTGAGATTGGGCGATACAGA
CTTGATCGCTGAAGTAGAACATGACTACACCATTTATGGCGAAGAGCTTAAATTCGGTGGCGGTAAAACCCTAAGAGAAG
GCATGAGCCAATCCAACAACCCTAGTAAAGAAGAATTGGATTTAATCATCACTAACGCTTTAATCGTGGATTATACCGGT
ATTTATAAAGCGGATATTGGTATTAAGGATGGCAAAATCGCTGGCATTGGTAAAGGCGGTAACAAAGACATGCAAGATGG
CGTTAAAAACAATCTTAGCGTGGGTCCTGCTACTGAAGCGCTAGCTGGTGAAGGTTTGATCGTAACTGCTGGTGGTATTG
ACACACACATCCACTTCATCTCCCCCCAACAAATCCCTACAGCTTTTGCAAGCGGTGTAACAACTATGATTGGTGGCGGA
ACTGGCCCTGCTGATGGCACTAACGCAACCACTATCACTCCAGGCAGAAGAAATTTAAAATGGATGCTCAGAGCGGCTGA
AGAATATTCTATGAACTTAGGTTTCTTAGCTAAAGGTAACGCTTCTAACGATGCGAGCTTAGCCGATCAAATTGAAGCCG
GTGCGATTGGTTTTAAAATCCACGAAGACTGGGGAACAACTCCTTCTGCAATCAATCATGCGTTAGATGTTGCGGACAAA
TACGATGTGCAAGTCGCTATCCACACAGACACTTTGAATGAAGCTGGTTGTGTAGAAGACACTATGGCAGCCATTGCTGG
ACGCACTATGCACACTTTCCACACTGAAGGCGCTGGTGGCGGACACGCTCCTGATATTATTAAAGTGGCCGGCGAACACA
ACATTCTGCCCGCTTCCACTAACCCCACTATCCCTTTCACTGTGAATACAGAAGCAGAACACATGGACATGCTTATGGTG
TGCCACCACTTGGATAAAAGCATTAAAGAAGATGTTCAGTTCGCTGATTCAAGGATTCGCCCTCAAACCATTGCGGCTGA
AGACACTTTGCATGACATGGGGATTTTCTCAATCACTAGTTCTGACTCTCAAGCTATGGGTCGTGTGGGTGAAGTTATCA
CCAGAACTTGGCAAACAGCTGACAAAAACAAAAAAGAATTTGGCCGCTTGAAAGAAGAAAAAGGCGATAACGACAACTTC
AGAATCAAACGCTACTTGTCTAAATACACCATTAACCCAGCGATCGCTCATGGGATTAGCGAGTATGTAGGTTCTGTAGA
AGTGGGCAAAGTGGCTGACTTGGTATTGTGGAGTCCAGCATTCTTTGGCGTGAAACCCAACATGATCATCAAAGGTGGGT
TCATTGCGTTAAGTCAAATGGGCGATGCGAACGCTTCTATCCCTACCCCACAACCAGTTTATTACAGAGAAATGTTCGCT
CATCATGGTAAAGCCAAATACGATGCAAACATCACTTTTGTGTCTCAAGCGGCTTATGACAAAGGCATTAAAGAAGAATT
AGGGCTTGAAAGACAAGTGTTACCGGTAAAGAATTGCAGAAACATCACTAAAAAAGACATGCAATTCAACGACACTACCG
CTCACATTGATGTCAATCCTGAAACTTACCATGTATTCGTGGATGGCAAAGAAGTAACTTCTAAACCAGCCACTAAAGTG
AGCTTGGCACAACTCTTTAGCATTTTCTAG

Protein sequence :
MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNNPSKEELDLIITNALIVDYTG
IYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEALAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGG
TGPADGTNATTITPGRRNLKWMLRAAEEYSMNLGFLAKGNASNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADK
YDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTNPTIPFTVNTEAEHMDMLMV
CHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSSDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNF
RIKRYLSKYTINPAIAHGISEYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFA
HHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIDVNPETYHVFVDGKEVTSKPATKV
SLAQLFSIF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 8e-157 62
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 8e-157 62
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-146 60
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-146 60
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 2e-146 60
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-146 60

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ureB YP_005769443.1 urease subunit beta VFG0270 Protein 0.0 99