Gene Information

Name : HMPREF4655_21077 (HMPREF4655_21077)
Accession : YP_005770164.1
Strain : Helicobacter pylori 35A
Genome accession: NC_017360
Putative virulence/resistance : Virulence
Product : cag pathogenicity island protein
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 1059362 - 1064755 bp
Length : 5394 bp
Strand : +
Note : COG: COG2948; Pfam: PF07337, PF03743; InterPro: IPR010853

DNA sequence :
ATGAATGAAGAAAACGATAAACTTGAAACTTCTAAAAAAACCCAACAACATTCACCCCAAGATTTATCCAATGAAGAAGC
AACAGAAGCCAATCACTTTGAAGATTCTTCAAAAGAATCCAAAGAAAGATCAGAACATCATCTTGACAACCCCACAGAAA
CTAAAACCAATTTTGATGAATACGAGTCAGAAGAAACCCAAACTCAAATGGATTCTGGAGGTAATGAAACTTCAGAATCT
AGCAATGGCAGTCTAGCAGACAAGTTATTCAAAAAAGCTAGAAAATTAGTTGATAATAAAAGACCTTTCACTCAGCAAAA
GAATTTAGATGAAGAAATCCAAGAACCGAACGAAGAAGACGATCAGGAAAATAATGGGTATCAAGAAGAAACTCAAATGG
ACTTAATTGATGATGAAACTTCTAAAAAAACCCAACAACATTCACCCCAAGATTTATCCAATGAAGAAGCAACAGAAGCC
AATCACTTTGAAGATTCTTCAAAAGAATCCAAAGAAAGCTCAGAACATCATCTTGACAACCCCACAGAAACTAAAACCAA
TTTTGATGAATACGAGTCAGAAGAAATAACTAACGATTCTAACGATCAAGAGATTATCAAAGGAAGCAAAAAGAAATACA
TTATTGGTGGCATTGTAGTCGCTGTTCTTATCGTGATTATTTTATTTTCTAGAAGCATTTTTCACTACTTCATGCCTTTG
GAAGATAAAAGCTCTCGTTTTAGCAAAGATAGGAATCTTTATGTCAATGATGAAATCCAAATAAGGCAAGAGTATAACCG
ATTGCTGAAAGAACGGAATGAAAAAGGCAATATGATCGATAAGAATCTTTTCTTCAATGACGATCCCAATAGAACCTTAT
ACAACTATTTGAATATTGCAGAAATTGAGGACAAAAACCCATTGAGGGACTTTTATGAATGTATTAGTAATGGTGGCAAC
TATGAAGAATGTTTGAAGCTTATCAAAGACAAAAAACTTCAAGATCAAATGAAAAAGACTTTAGAGGCTTATAATGACTG
CATCAAAAATGCCAAAACTGAAGAAGAAAGGATCAAGTGTTTAGATCTAATCAAAGATGAAAACCTGAAAAAAAGCTTAC
TGAACCAACAAAAAGTTCAAGTGGCGCTAGATTGTTTGAAAAACGCTAAAACCGATGAAGAAAGAAACGAGTGCCTAAAA
CTCATAAATGACCCTGAGATTAGAGAGAAATTCCGTAAGGAATTAGGGCTTCAAAAAGAGCTTCAAGAGTATAAGGATTG
TATCAAAAACGCCAAAACAGAAGCTGAGAAAAACGAATGCTTGAAAGGCTTGTCTAAAGAAGCTATAGAAAGATTGAAAC
AGCAAGCGCTAGATTGTTTGAAAAACGCTAAAACCGATGAAGAACGAAAAGAGTGCTTGAAAAATATTCCCCAAGACTTG
CAAAAAGAACTACTAGCTGATATGAGCGTCAAGGCTTACAAGGATTGCGTATCAAAAGCTAGGAATGAAAAAGAGAAAAA
AGAATGCGAAAAATTACTCACGCCTGAAGCGAAAAAAAAGTTAGAACAACAGGTTCTAGATTGTTTGAAAAACGCTAAAA
CTGATGAAGAACGAAAAAAATGTTTGAAAGATCTCCCTAAAGACTTACAAAGCGATATTTTAGCCAAAGAAAGTCTTAAA
GCTTATAAAGACTGCGTTTCAAGAGCTAGGAATGAAAAAGAGAAAAAAGAATGCGAGAAGTTACTCACGCCTGAAGCGAA
AAAACTTTTAGAAGAAGAAGCCAAAGAGAGCGTTAAGGCTTATTTGGACTGCGTATCTCAAGCCAAAACTGAAGCTGAGA
AAAAAGAATGCGAGAAATTGCTCACGCCTGAAGCGAAAAAAAAGTTAGAAGAAGCTAAAAAAAGCGTTAAGGCTTATTTG
GATTGCGTATCTCAAGCCAAAACTGAAGCTGAGAAAAAAGAATGCGAGAAATTACTCACGCCTGAAGCAAAAAAGCTTTT
AGAGCGACAAGCGCTAGATTGTTTGAAAAACGCTAAAACTGATGAAGAACGAAAAAAGTGTTTGAAAGATCTCCCTAAAG
ACTTGCAGAAAAAGGTTTTAGCCAAAGAGAGCGTTAAGGCTTACTTGGATTGCGTATCTCAAGCTAAAACTGAAGCTGAG
AAAAAAGAATGCGAGAAATTACTCACCCCTGAAGCGAAAAAGCTTTTAGAAGAAGCTAAAGAAAGTCTTAAAGCTTATAA
AGACTGCGTTTCAAGAGCTAGGAATGAAAAAGAGAAAAAAGAATGCGAGAAGTTACTCACGCCTGAAGCGAAAAAACTTT
TAGAAGAAGAAGCCAAAGAGAGCGTTAAGGCTTATTTGGACTGCGTATCTCAAGCCAAAACTGAAGCTGAGAAAAAAGAA
TGCGAGAAATTGCTCACGCCTGAAGCGAAAAAAAAGTTAGAAGAAGCTAAAAAAAGCGTTAAGGCTTATTTGGATTGCGT
ATCTCAAGCCAAAACTGAAGCTGAGAAAAAAGAATGCGAGAAATTACTCACGCCTGAAGCAAAAAAGCTTTTAGAGCGAC
AAGCGCTAGATTGTTTGAAAAACGCTAAAACTGATGAAGAACGAAAAAGGTGTGTCAAAGATCTTCCTAAAGACTTGCAG
AAAAAGGTTTTAGCTAAAAAAAGCGTTAAAGCTTATAAAGACTGCGTTTCAAGAGCTAGGAATGAAAAAGAGAAAAAAGA
ATGCGAGAAATTACTCACCCCTGAAGCGAAAAAGCTTTTAGAAGAAGCTAAAGAAAGTCTTAAAGCTTATAAAGACTGCG
TTTCAAGAGCTAGGAATGAAAAAGAGAAAAAAGAATGCGAGAAATTACTCACCCCTGAAGCGAAAAAGCTTTTAGAAGAA
GCTAAAGAAAGTCTTAAAGCTTATAAAGACTGCGTTTCAAGAGCTAGGAATGAAAAAGAGAAAAAAGAATGCGAGCAATT
ACTCACCCCTGAAGCGAAAAAGCTTTTAGAGCAACAAGCGCTAGATTGTTTGAAAAACGCTAAAACCGAAGCTGAGAAAA
AAAGGTGTGTCAAAGATCTTCCTAAAGACTTGCAGAAAAAGGTTTTAGCCAAAGAGAGCGTTAAGGCTTATTTGGACTGC
GTTTCAAGAGCTAGGAATGAAAAAGAGAAAAAAGAATGCGAGCAATTACTCACCCCTGAAGCGAAAAAGCTTTTAGAAGA
AGCTAAAGAGAGTCTTAAAGCTTATAAAGACTGCCTCTCTCAAGCTAGAAATGAAGAAGAAAGGAGAGCTTGCGAGAAAT
TACTCACCCCTGAAGCGAAAAAACTCTTAGAGCAAGAAGTTAAGAAGAGCGTTAAGGCTTATTTGGACTGCGTATCAAAA
GCTAGGAATGAAAAAGAGAAACAAGAATGCGAGAAATTACTCACCCCTGAAGCGAGAAAATTTTTAGCGAAGCAAGTGCT
AAGTTGTTTGGAAAAAGCTAGAAATGAAGAAGAAAGAAAAGCGTGTCTTAAAAATATCCCTAAAGACTTACAGAAAAATG
TTTTAGCTAAAGAGAGTCTTAAAGCTTATAAAGACTGCCTCTCTCAAGCTAGAAATGAAGAAGAAAGGAGAGCTTGCGAG
AAATTACTCACCCCTGAAGCGAGAAAACTCTTAGAGCAAGAAGTTAAGAAGAGCGTTAAGGCTTATTTGGACTGCGTTTC
AAGAGCTAGGAATGAAAAAGAGAAACAAGAATGCGAGAAATTACTCACCCCTGAAGCGAGAAAATTTTTAGCGAAAGAAC
TCCAACAAAAAGATAAAGCGATCAAAGATTGCTTGAAAAACGCCGATCCTAACGACAGAGCGGCTATTATGAAGTGTTTG
GATGGTTTGAGCGATGAAGAGAAGCTCAAATACCTGCAAGAAGCTAGAGAAAAGGCTGTCTTGGATTGTTTGAAAACGGC
TAGGACCGATGAAGAAAAAAGAAAATGTCAAAACCTTTATAGCGATTTGATCCAAGAAATCCAAAATAAAAGAATACAAA
GCAAACAAAATCAATTGAGTAAAACAGAAAGATTGCATCAAGCAAGCGAGTGCTTGGATAACTTAGATGACCCTACTGAT
CAAGAAGCCATAGAACAATGTTTAGAAGGCTTGAGCGATAGTGAAAGGGCGCTAATTCTAGGAATTAAACGACAAGCTGA
TGAAGTGGATCTGATTTATAGCGATCTAAGAAACCGCAAAACCTTTGATAACATGGCGGCTAAAGGTTATCCATTGTTGC
CAATGGATTTCAAAAATGGCGGCGATATTGCCACTATTAACGCCACTAATGTTGATGCGGACAAAATAGCTAGCGATAAT
CCTATTTATGCTTCCATAGAGCCTGATATTACTAAGCAATACGAAACAGAAAAAACCATTAAGGATAAGAATTTAGAAGC
TAAATTAGCTAAGGCTTTAGGTGGCAATAAAAAAGATGACGATAAAGAAAAAAGTAAAAAATCCACAGCAGAAGCTAGAG
TAGAAAGCAATAAGATAGACAAAGATGTCGCAGAAACTGCCAAAAATATCAGTGAAATCGCTCTTAAGAACAAAAAAGAA
AAGAGTGGGGAATTTGTAGATGAAAATGGTAATCCCATTGATGACAAAAAGAAAACAGAAACACAAGATGAAACAAGCCC
TGTCAAACAGGCCTTTATAGGCAAGAGTGATCCCACATTTGTTTTAGCGCAATACACCCCTATTGAAATCACTCTGACTT
CTAAAGTAGATGCCACTCTCACAGGTATAGTGAGTGGGGTTGTAGCCAAAGATGTATGGAACATGAACGGCACTATGATC
TTACTAGACAAAGGCACTAAGGTGTATGGGAATTACCAAAGCGTGAAGGGTGGCACACCCATTATGACACGCTTAATGAT
AGTCTTTACTAAAGCCATTACGCCTGATGGTGTGATAATACCTCTAGCAAACGCTCAAGCAGCAGGCATGCTGGGTGAAG
CAGGGGTAGATGGCTATGTGAATAACCACTTTATGAAGCGCATAGGCTTTGCTGTGATAGCAAGCGTGGTTAATAGCTTC
TTGCAAACTGCGCCTATCATAGCTCTAGATAAACTCATAGGCCTTGGCAAAGGTAGAAGTGAAAGGACACCTGAATTTAA
TTACGCTTTGGGTCAAGCTATCAATGGTAGTATGCAAAGTTCAGCTCAGATGTCTAATCAAATTCTAGGGCAACTGATGA
ATATCCCCCCAAGTTTTTACAAAAATGAGGGCGATAGTATTAAGATTCTCACAATGGACGACATTGATTTTAGTGGCGTG
TATGATGTTAAAATTACCAACAAATCTGTGGTAGATGAAATTATCAAACAAAGCACTAAAACTTTGTCTAGAGAGCATGA
AGAAATCACCACAAGCCCCAAAGGTGGCAATTAA

Protein sequence :
MNEENDKLETSKKTQQHSPQDLSNEEATEANHFEDSSKESKERSEHHLDNPTETKTNFDEYESEETQTQMDSGGNETSES
SNGSLADKLFKKARKLVDNKRPFTQQKNLDEEIQEPNEEDDQENNGYQEETQMDLIDDETSKKTQQHSPQDLSNEEATEA
NHFEDSSKESKESSEHHLDNPTETKTNFDEYESEEITNDSNDQEIIKGSKKKYIIGGIVVAVLIVIILFSRSIFHYFMPL
EDKSSRFSKDRNLYVNDEIQIRQEYNRLLKERNEKGNMIDKNLFFNDDPNRTLYNYLNIAEIEDKNPLRDFYECISNGGN
YEECLKLIKDKKLQDQMKKTLEAYNDCIKNAKTEEERIKCLDLIKDENLKKSLLNQQKVQVALDCLKNAKTDEERNECLK
LINDPEIREKFRKELGLQKELQEYKDCIKNAKTEAEKNECLKGLSKEAIERLKQQALDCLKNAKTDEERKECLKNIPQDL
QKELLADMSVKAYKDCVSKARNEKEKKECEKLLTPEAKKKLEQQVLDCLKNAKTDEERKKCLKDLPKDLQSDILAKESLK
AYKDCVSRARNEKEKKECEKLLTPEAKKLLEEEAKESVKAYLDCVSQAKTEAEKKECEKLLTPEAKKKLEEAKKSVKAYL
DCVSQAKTEAEKKECEKLLTPEAKKLLERQALDCLKNAKTDEERKKCLKDLPKDLQKKVLAKESVKAYLDCVSQAKTEAE
KKECEKLLTPEAKKLLEEAKESLKAYKDCVSRARNEKEKKECEKLLTPEAKKLLEEEAKESVKAYLDCVSQAKTEAEKKE
CEKLLTPEAKKKLEEAKKSVKAYLDCVSQAKTEAEKKECEKLLTPEAKKLLERQALDCLKNAKTDEERKRCVKDLPKDLQ
KKVLAKKSVKAYKDCVSRARNEKEKKECEKLLTPEAKKLLEEAKESLKAYKDCVSRARNEKEKKECEKLLTPEAKKLLEE
AKESLKAYKDCVSRARNEKEKKECEQLLTPEAKKLLEQQALDCLKNAKTEAEKKRCVKDLPKDLQKKVLAKESVKAYLDC
VSRARNEKEKKECEQLLTPEAKKLLEEAKESLKAYKDCLSQARNEEERRACEKLLTPEAKKLLEQEVKKSVKAYLDCVSK
ARNEKEKQECEKLLTPEARKFLAKQVLSCLEKARNEEERKACLKNIPKDLQKNVLAKESLKAYKDCLSQARNEEERRACE
KLLTPEARKLLEQEVKKSVKAYLDCVSRARNEKEKQECEKLLTPEARKFLAKELQQKDKAIKDCLKNADPNDRAAIMKCL
DGLSDEEKLKYLQEAREKAVLDCLKTARTDEEKRKCQNLYSDLIQEIQNKRIQSKQNQLSKTERLHQASECLDNLDDPTD
QEAIEQCLEGLSDSERALILGIKRQADEVDLIYSDLRNRKTFDNMAAKGYPLLPMDFKNGGDIATINATNVDADKIASDN
PIYASIEPDITKQYETEKTIKDKNLEAKLAKALGGNKKDDDKEKSKKSTAEARVESNKIDKDVAETAKNISEIALKNKKE
KSGEFVDENGNPIDDKKKTETQDETSPVKQAFIGKSDPTFVLAQYTPIEITLTSKVDATLTGIVSGVVAKDVWNMNGTMI
LLDKGTKVYGNYQSVKGGTPIMTRLMIVFTKAITPDGVIIPLANAQAAGMLGEAGVDGYVNNHFMKRIGFAVIASVVNSF
LQTAPIIALDKLIGLGKGRSERTPEFNYALGQAINGSMQSSAQMSNQILGQLMNIPPSFYKNEGDSIKILTMDDIDFSGV
YDVKITNKSVVDEIIKQSTKTLSREHEEITTSPKGGN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
HP0527 BAD13833.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 98
cagY YP_005777271.1 cag pathogenicity island protein Y VirB10-like protein Virulence cag PAI Protein 0.0 98
HP0527 BAD14052.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 98
cagY YP_005774542.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 97
HP0527 BAD13970.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagY AGC69792.1 cag pathogenicity island protein Y Virulence cag PAI Protein 0.0 96
HP0527 NP_207323.1 cag pathogenicity island protein (cag7) Virulence cag PAI Protein 0.0 95
HP0527 BAD14026.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 94
cagY AGC69786.1 cag pathogenicity island protein Y Virulence cag PAI Protein 0.0 94
cagY AGC69789.1 cag pathogenicity island protein Y Virulence cag PAI Protein 0.0 94
HP0527 BAD13888.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 93
HP0527 BAD13860.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 92
cagY YP_005775730.1 cag pathogenicity island protein Y VirB10-like protein Virulence cag PAI Protein 0.0 92
cagY AGC69787.1 cag pathogenicity island protein Y Virulence cag PAI Protein 0.0 90
HP0527 BAD13806.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 87
HP0527 BAD13998.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 84

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HMPREF4655_21077 YP_005770164.1 cag pathogenicity island protein VFG0287 Protein 0.0 95