Gene Information

Name : cagA (HMPREF4655_21054)
Accession : YP_005770141.1
Strain : Helicobacter pylori 35A
Genome accession: NC_017360
Putative virulence/resistance : Virulence
Product : cytotoxicity-associated immunodominant antigen A
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 1035429 - 1038959 bp
Length : 3531 bp
Strand : -
Note : Pfam: PF03507; InterPro: IPR005169

DNA sequence :
ATGACTAATGAAACCATTGTTCAAACAACAACACCAGATCAAACACTAAACCAAACGGATTTTGTTCCGCAACGATTTAT
CAATAATCTTCAAGTAGCTTTTATTAAAGTTGATAACGCTGTCGCTTCATTTGATCCCGATCAAAAACCAATCGTTGATA
AGAATGATAGGGATAACAGGCAAGCTTTTGAGAAAATCTCGCAACTAAGGGAAGAATACGCCAATAAAGCGATCAAAAAT
CCCACCAAAAAGAATCAGTATTTTTCAGACTTTATCAATAAGAGCAATGATTTGATCAACAAAGACAATCTCATTGCTGT
AGATTCTTCCGTAGAGAGCTTTCGGAAATTTGGGGATCAGCGTTACCAAATTTTTACGAGTTGGGTGTCCCTTCAAAAAG
ATCCGTCTAAAATCAACACCCAACAAATCCGAAATTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAGGAA
AAAGCAGAGTTTTTGAGGTCTGCCAAACAATCTTTTGCAGGAATTATCATAGGGAACCAAATCCGATCGGATGAAAAATT
CATGGGCGTGTTTGATGAATCTTTGAAAGCAAGGCAAGAAGCAGAAAAAAATGCAGAGCCTGCTGGTGGGGATTGGCTTG
ATATTTTTTTATCATTTGTGTTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATCAAGAGCCAATGCCCAAT
GTTGAACAAAATTTAGCCACTACCACCACCGACATACAAGGCTTACCGCCTGAAGCTAGAGATTTGCTTGATGAAAGGGG
TAATTTTTCTAAATTCACTCTTGGTGATGTGGAAATGTTGGATGTTGAGGGAGTCGCTGATAAGGATCCCAATTACAAGT
TCAATCAATTATTGATCCACAATAACGCTCTATCTTCTGTGCTAATGGGGAGTCATAGTAGCATAGAACCTGAAAAAGTT
TCATTATTGTATGGGGATAATGGTGGCCCTGAAGCTAGGCATGATTGGAACGCTACCGTTGGTTATAAAAACCAACAAGG
CAACAATGTGGCCACACTCATTAATGCGCATCTTAATAACGGCAGTGGGTTAGTCATAGCGGGTAATGAAAATGGGATTA
AAAACCCTAGCTTCTATCTCTATAAAGAAGATCAACTCACAGGTTTGAAACAAGCAATGAGTCAAGAAGAGATCCAAAAC
AAAGTGGATTTCATGGAATTTCTTGTGCAAAACAATGCTAAACTAAATAACTTGAGCGAGAAAGAGAAAGAAAAATTCCA
AACTGAGATTGAAAATTTCCAAAAAGACCGTAAGGCTTATTTGGACGCTCTAGGGAATGATCACATTGCTTTTGTTTCTA
AAAAAGACCCAAAACATTTAGCTTTGGTTACTGAGTTTGGTAATGGGGAAGTGAGCTATACTCTCAAAGATTATGGGAAA
AAACAAGATAAAGCTTTAGATGGGGAGACAAAAACCACTCTTCAAGGTAGCCTAAAATATGATGGCGTGATGTTTGTTGA
TTATTCTAATTTCAAATACACCAACGCCTCCAAGAGTCCTGATAAGGGCGTGGGCGCTACGAATGGCGTTTCCCATTTGG
AAGCAAATTTTAGCAAAGTAGCTGTCTTTAATTTGCCTAATTTAAATAATCTCGCTATCACTAATCATATAAGGCGAGAT
TTAGAAGATAAATTGTTGGCTAAAGGATTGTCCCCACAAGAAGCTAATAAGCTCATCAAAGACTTTTTGAACGGCAACAA
AGAAATGGTTGGAAAAGTTTTAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAATTATGGCGAAGTGAAAA
AAGCTCAGAAAGATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAGCGAAAAAATTGGAGAGCAGA
AACGACAACAAAAATAGAATGGAAGCAAAAGCTCAGGCTAACAGCCAAAAAGATAAGATTTTTGCGTTGATCAATAAAGA
GGCTAGTAAGGAAGCAAGAGCGGCCGCTTTCGATCCGAATCTTAAAGGCATTAGGAGCGAATTGTCTGATAAACTTGAAA
ATATCAACAAGAATTTGAAAGACTTTGGCAAATCTTTTGATGAACTCAAAAATGGCAAAAATAATGATTTCAGCAAGGCG
GAAGAAACGCTAAAAGCCCTTAAAGACTCGGTGAAAGATTTAGGCATCAATCCAGAATGGATTTCAAAAATTGAAAACCT
TAATGCAGCTTTGAATGATTTCAAAAATGGCAAAAATAATGATTTCAGCAAGGTAACACAAGCAAAAAGCGACCTTGAAA
ATTCCATTAAGGATGTGATCATCAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAGGCTGTATCAGAGACTAAA
TTAACAGGCGATTTCAGTAAGGTAGAGCAAGCCCTAGCCGAACTCAAAAGCTTGTCATTTGATCTTGGAAAAAATTCTGA
TCTACAAAAATCCGTTAAAAATGGTGTAAATGGAACCCTAGTCGGTAATGGGTTGTCTAAAACAGAAGCCACAACGCTCA
CCAAAAATTTTTCGGACATCAGGAAAGAATTGAACGAGAAATTATTTGGAAATTCCAATAACAATAATAATGGACTCAAA
AACAGCACAGAGCCTATTTATGCTAAAGTTAATAAAAAGAAAACAGGACAAGCAGCTAGCCCTGAAGAGCCCATTTACGC
TCAAGTTGCTAAAAAGGTGAGTGCAAAAATTGACCAACTCAACGAAGCTACATTAGCAATAAATAGAAAAATTGACCGGA
TTAACAAAATTGCATCAGCAGGTAAAGGAGTGGGCGGTTTCAGTGGAGCAGGGCGATCAGCTAGCCCTGAACCCATTTAC
GCTACAATTGATTTTGATGAGACAAATCAAGCAGGCTTCCCTTTGAGAAGAAGTGCTGCAGTTAATGATCTCAGTAAAGT
AGGGCTTTCAAGGGAACAAGAATTGACTCGTAGAATTGGCGATCTCAATCAGGCGGTATCAGAAGCTAAAACAGGTCATT
TTGACAACCTAGAACAAAAGATAGATGAACTCAAAGATTCTACAAAAAAGAATGCTTTGAAGCTATGGGTTGAAAGCGCG
AAACAAGTGCCTACTGGTTTGTCAGCGAAATTGGACAATTACGCTACTAACAGCCACACACGCATTAATAGCAATGTCCA
AAGTGGAACAATCAATGAAAAAGCGACCGGTGTGCTAACGCAAAAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAGA
TAGTTGCACATAATGTGGGAAGCGCTCATTTGTCAGAGTATGATAAAATTGGATTCAACCAAAAGAATATGAAAGATTAT
TCTGATTCGTTCAAGTTTTCCACCAAGTTGAACAATGCCGTAAAAGACATTAAGTCTAGCTTTGTGCAATTTTTAACCAA
TACATTTTCTACAGGATCTTACAGCTTGATGAAAGCAAATGTGGAACATGGAGTCAAAAATACTACAAAAAGTGGTTTCC
AAAAATCTTAA

Protein sequence :
MTNETIVQTTTPDQTLNQTDFVPQRFINNLQVAFIKVDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLREEYANKAIKN
PTKKNQYFSDFINKSNDLINKDNLIAVDSSVESFRKFGDQRYQIFTSWVSLQKDPSKINTQQIRNFMENIIQPPISDDKE
KAEFLRSAKQSFAGIIIGNQIRSDEKFMGVFDESLKARQEAEKNAEPAGGDWLDIFLSFVFNKKQSSDLKETLNQEPMPN
VEQNLATTTTDIQGLPPEARDLLDERGNFSKFTLGDVEMLDVEGVADKDPNYKFNQLLIHNNALSSVLMGSHSSIEPEKV
SLLYGDNGGPEARHDWNATVGYKNQQGNNVATLINAHLNNGSGLVIAGNENGIKNPSFYLYKEDQLTGLKQAMSQEEIQN
KVDFMEFLVQNNAKLNNLSEKEKEKFQTEIENFQKDRKAYLDALGNDHIAFVSKKDPKHLALVTEFGNGEVSYTLKDYGK
KQDKALDGETKTTLQGSLKYDGVMFVDYSNFKYTNASKSPDKGVGATNGVSHLEANFSKVAVFNLPNLNNLAITNHIRRD
LEDKLLAKGLSPQEANKLIKDFLNGNKEMVGKVLNFNKAVAEAKNTGNYGEVKKAQKDLEKSLRKREHLEKEVAKKLESR
NDNKNRMEAKAQANSQKDKIFALINKEASKEARAAAFDPNLKGIRSELSDKLENINKNLKDFGKSFDELKNGKNNDFSKA
EETLKALKDSVKDLGINPEWISKIENLNAALNDFKNGKNNDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVSETK
LTGDFSKVEQALAELKSLSFDLGKNSDLQKSVKNGVNGTLVGNGLSKTEATTLTKNFSDIRKELNEKLFGNSNNNNNGLK
NSTEPIYAKVNKKKTGQAASPEEPIYAQVAKKVSAKIDQLNEATLAINRKIDRINKIASAGKGVGGFSGAGRSASPEPIY
ATIDFDETNQAGFPLRRSAAVNDLSKVGLSREQELTRRIGDLNQAVSEAKTGHFDNLEQKIDELKDSTKKNALKLWVESA
KQVPTGLSAKLDNYATNSHTRINSNVQSGTINEKATGVLTQKNPEWLKLVNDKIVAHNVGSAHLSEYDKIGFNQKNMKDY
SDSFKFSTKLNNAVKDIKSSFVQFLTNTFSTGSYSLMKANVEHGVKNTTKSGFQKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
HP0547 BAD13799.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 97
cagA YP_005779046.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 97
cagA BAC10431.1 CagA Virulence cag PAI Protein 0.0 97
HP0547 BAD13963.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 97
cagA BAD51755.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 97
cagA BAC10421.1 CagA Virulence cag PAI Protein 0.0 97
cagA BAD51749.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 97
cagA BAC10424.1 CagA Virulence cag PAI Protein 0.0 97
cagA BAC10430.1 CagA Virulence cag PAI Protein 0.0 97
cagA YP_005777288.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
HP0547 BAD13880.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagA AAF17597.1 CagA Virulence cag PAI Protein 0.0 96
cagA BAD51754.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 96
cagA BAC10435.1 CagA Virulence cag PAI Protein 0.0 96
HP0547 BAD14072.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagA BAD51744.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 96
cagA BAC10420.1 CagA Virulence cag PAI Protein 0.0 96
cagA YP_005775747.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagA YP_005774524.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagA BAD51762.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 96
cagA BAC10433.1 CagA Virulence cag PAI Protein 0.0 96
HP0547 BAD14018.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 96
cagA BAC10426.1 CagA Virulence cag PAI Protein 0.0 95
cagA BAC10419.1 CagA Virulence cag PAI Protein 0.0 95
HP0547 BAD13853.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 95
cagA BAC10422.1 CagA Virulence cag PAI Protein 0.0 93
HP0547 BAD13826.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 93
cagA BAC10427.1 CagA Virulence cag PAI Protein 0.0 87
cagA BAD51764.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 85
cagA BAC10423.1 CagA Virulence cag PAI Protein 0.0 83
cagA BAD51752.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA BAD51759.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51756.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA YP_003728762.1 cytotoxin-associated protein A Virulence cag PAI Protein 0.0 81
cagA AGC69806.1 cag pathogenicity island protein A Virulence cag PAI Protein 0.0 81
HP0547 BAD13935.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAC10429.1 CagA Virulence cag PAI Protein 0.0 81
cagA BAD51753.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51766.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51750.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51751.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51758.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51761.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51760.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen Virulence cag PAI Protein 0.0 79
HP0547 NP_207343.1 cag pathogenicity island protein (cag26) Virulence cag PAI Protein 0.0 79
cagA AAR03970.1 CagA Virulence cag PAI Protein 0.0 79
cagA AAR03939.1 CagA Virulence cag PAI Protein 0.0 79
cagA AAR03909.1 CagA Virulence cag PAI Protein 0.0 78
HP0547 BAD13908.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
cagA BAC10428.1 CagA Virulence cag PAI Protein 0.0 78
cagA AAR03881.1 CagA Virulence cag PAI Protein 0.0 78
cagA AAC44706.1 CagA Virulence cag PAI Protein 0.0 77
HP0547 BAD14045.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAD51747.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 77
cagA AAF17598.1 CagA Virulence cag PAI Protein 0.0 77
cagA BAC10432.1 CagA Virulence cag PAI Protein 0.0 75
HP0547 BAD13990.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 75

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cagA YP_005770141.1 cytotoxicity-associated immunodominant antigen A VFG0306 Protein 0.0 79