Gene Information

Name : HPSAT_04140 (HPSAT_04140)
Accession : YP_005768472.1
Strain : Helicobacter pylori Sat464
Genome accession: NC_017359
Putative virulence/resistance : Virulence
Product : cag pathogenicity island protein (cagY, cag7)
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 820264 - 825423 bp
Length : 5160 bp
Strand : +
Note : COG2948 Type IV secretory pathway, VirB10 components

DNA sequence :
ATGAATGAAGAAAACGATAAACTTGAAACTTCTAAAAAAACCCAACAACATTCACCCCAAGATTTATCCAATGAAGAAAC
AATAAAAGCCAATCACTTTGAAGATTCTTCAAAAGAATCCAAAGAAAACTCAGATCATCATCTTGACAACTCCACAGAAA
CTAAAACCAATTTTGATGGAGAAAAGTCAGAAGAAACCCAAACTCAAATGGATTCTGGAGATAATGAAACTTCAGAATCT
AGCAATCTAGCAGACAAGTTATTCAAAAAAGCCAGAAAATTAGTTGATAATAAAAGACCTTTCACTCAGCAAAAGAATTT
AGATGAAGAAATCCAAGAACCGAACGAAGAAGACGATCAAGAAAATAATGGGTATCAAGAAGAAATTCAAATGGATTTAA
TTGATGATGAAACTTCTAAAAAAACCCAACAACATTCACCCCAAGATTTATCCAATGAAGAAACAATAAAAGCCAATCAC
TTTGAAGATTCTTCAAAAGAATCCAAAGAAAACTCAGATCATCATCTTGACAACTCCACAGAAACTAAAACCAATTTTGA
TGGAGAAAAGTCAGAAGAAATAACTAACGATTCTAACGATCAAGAGATTATCAAAGGAAGCAAAAAGAAATACATTATTG
GTGGCATTGTAGTCGCTGTTCTTATCGTGATTATTTTATTTTCTAGAAGCATTTTTCACTATTTCATACCTTTGGAAGAT
AAAAGCTCTCGTTTTAGCAAAGACAGGAATCTTTATGTCAATGATGAAATCCAAATAAGGCAAGAGTATAACCGATTGCT
GAAAGAACGGAATGAAAAAGGCAATATGATCGATAAGAATCTTTTCTTCAATGACGATCCCAATAGAACCTTATACAACT
ATTTGAATATTGCAGAAATTGAGGACAAAAACCCATTGAGAGCCTTTTATGAATGTATTAGTAATGGTGGTAACTATGAA
GAATGTTTGAAGCTTATCAAAGACAAAAAACTTCAAGATCAAATGAAAAAGACTTTAGAGGCTTATAATGACTGCATCAA
AAATGCCAAAACTGAAGAAGAAAGGATCAAGTGTTTAGATTTAATCAAAGATGAAAACCTGAAAAAAAGCTTACTGAACC
AACAAAAAGTTCAAGTGGCACTAGATTGTTTGAAAAACGCTAAAACCGATGAAGAACGAAACGAGTGCCTAAAACTCATA
AATGACCCTGAGATTAGAGAGAAATTCCGTAAGGAATTAGAGCTTCAAAAAGAGCTTCAAGAGTATAAGGATTGTATCAA
AAACGCCAAAACAGAAGCTGAGAAAAACGAATGCTTGAAAGGCTTGTCTAAGGAAGCTATAGAAAGATTGAAACAGCAAG
CGCTAGATTGTTTGAAAAACGCTAAAACCGATGAAGAACGAAAAAAGTGTTTGAAAAATATTCCCCAAGACTTGCAAAAA
GAACTACTAGCTGATATGAGCGTCAAGGCTTACAAGGATTGCGTATCAAAAGCTAGGAATGAAAAAGAGAAAAAAGAATG
CGAGAAATTACTCACGCCTGAAGCGAAAAAAAAGTTAGAACAACAGGTTCTAGATTGTTTGAAAAACGCTAAAACCGATG
AAGAACGAAAAAAGTGTTTGAAAGATCTCCCTAAAGACTTACAAAGCGATATTTTAGCTAAAGAGAGCGTTAAAGCTTAT
AAAGACTGCGTATCTCAAGCCAGAACTGAAGCTGAGAAAAAAGAATGCGAGAAATTACTCACGCCTGAAGCGAAAAAACT
TTTAGAAGAAGAAGCCAAAGAGAGCGTTAAAGCTTATTTGGATTGCGTATCTCAAGCCAAAACTGAAGCTGAGAAAAAAG
AATGCGAGAAATTACTCACGCCTGAAGCGAAAAAAAAGTTAGAAGAAGCTAAAAAAAGCGTTAAGGCTTACCTGGATTGC
GTATCTCAAGCCAAAACTGAAGCTGAGAAAAAAGAATGCGAGAAATTACTCACGCCTGAAGCGAGAAAGCTTTTAGAGCA
ACAAGCGCTAGATTGTTTGAAAAACGCTAAAACCGAAGCTGAGAAAAAAAGGTGTGTCAAAGATCTCCCTAAAGACTTGC
AGAAAAAGGTTTTAGCTAAAGAAAGCGTTAAGGCTTATTTGGATTGCGTATCTCAAGCCAAAACTGAAGCTGAGAAAAAA
GAATGCGAGAAATTGCTCACGCCTGAAGCGAAAAAACTTTTAGAAGAAGCTAAAGAGAGTCTTAAAGCTTATAAAGACTG
CGTTTCAAGAGCTAGGAATGAAAAAGAGAAAAAAGAATGCGAGAAATTGCTCACCCCTGAAGCGAAAAAACTTTTAGAGC
AACAAGCGCTAGATTGTTTGAAAAACGCTAAAACCGAAGCTGAGAAAAAAAGGTGTGTCAAAGATCTCCCTAAAGACTTG
CAGAAAAAGGTTTTAGCTAAAGAGAGCGTTAAGGCTTATTTGGACTGCGTATCTCAAGCCAAAACTGAAGCTGAGAAAAA
AGAATGCGAGAAATTACTCACCCCTGAAGCGAGAAAACTTTTAGAAGAAGCTAAAGAGAGTCTTAAAGCTTATAAAGACT
GCGTTTCAAGAGCTAGGAATGAAAAAGAGAAAAAAGAATGCGAGAAATTGCTCACCCCTGAAGCGAAAAAACTTTTAGAG
CAAGAAGTTAAGAAGAGCGTTAAGGCTTATTTGGACTGCGTATCTCAAGCCAAAACTGAAGCTGAGAAAAAAGAATGCGA
GAAATTACTCACGCCTGAAGCGAGAAAATTTTTAGCGAAGCAAGCGCTAGATTGTTTGAAAAACGCTAAAACCGAAGCTG
AGAAAAAAAGGTGTGTCAAAGATCTCCCTAAAGACTTGCAGAAAAAGGTTTTAGCTAAAGAGAGCGTTAAGGCTTATTTG
GACTGCGTTTCAAGAGCTAGGAATGAAAAAGAGAAAAAAGAATGCGAGAAATTACTCACCCCTGAAGCGAGAAAACTTTT
AGAAGAAGCTAAAGAGAGTCTTAAAGCTTATAAAGACTGCCTCTCTCAAGCTAGAAATGAAGAAGAAAGAAAAGCTTGCG
AGAAATTACTCACCCCTGAAGCGAGAAAACTTTTAGAGCAAGAAGTTAAGAAGAGCGTTAAGGCTTATTTGGACTGCGTA
TCTCAAGCCAAAACTGAAGCTGAGAAAAAAGAATGCGAGAAATTACTCACGCCTGAAGCGAGAAAATTTTTAGCGAAGCA
AGCGCTAAGTTGTTTGGAAAAAGCTAGAAATGAAGAAGAAAGAAAAGCATGTCTTAAAAATATCCCTAAAGACTTGCAGA
AAAATGTTTTAGCTAAAGAGAGTCTTAAAGCTTATAAAGACTGCCTCTCTCAAGCTAGAAATGAAGAAGAAAGAAAAGCT
TGCGAGAAATTGCTCACCCCTGAAGCGAGAAAGCTTTTAGAGCAAGAAGTTAAGAAGAGCGTTAAGGCTTATTTGGACTG
CGTTTCAAGAGCTAGGAATGAAAAAGAGAAACAAGAATGCGAGAAATTGCTCACCCCTGAAGCGAGAAAATTTTTAGCGA
AAGAACTCCAACAAAAAGATAAAGCGATCAAAGATTGCTTGAAAAACGCCGATCCTAACGACAGAGCAGCTATTATGAAG
TGTTTGGATGGTTTGAGCGATGAAGAGAAGCTCAAATACCTGCAAGAAGCTAGAGAAAAGGCTGTCTTGGATTGTTTGAA
AACGGCTAGGACCGATGAAGAAAAAAGGAAATGTCAAAACCTTTATAGCGATTTGATCCAAGAAATCCAAAATAAAAGAA
CACAAAGCAAACAAAATCAATTGAGTAAAACAGAAAGATTGCATCAAGCAAGCGAGTGCTTGGATAACTTAGATGACCCT
ACTGATCAAGAAGCCATAGAGCAATGTTTAGAAGGCTTGAGCGATAGTGAAAGGGCGCTAATTCTAGGAATTAAACGACA
AGCTGATGAAGTGGATCTGATTTATAGCGATCTAAGAAACCGCAAAACCTTTGACAACATGGCGGCTAAAGGTTATCCAT
TGTTGCCAATGGATTTCAAAAATGGCGGCGATATTGCCACTATTAACGCCACTAATGTTGATGCGGACAAAATAGCTAGC
GATAATCCTATTTATGCTTCCATAGAGCCTGACATTACTAAGCAATACGAAACAGAAAAAACCATTAAGGATAAGAATTT
AGAAGCTAAATTAGCTAAGGCTTTAGGCGGCAATAAAAAAGATGATGATAAAGAAAAAAGTAAAAAATCCACAGCAGAAG
CTAGAGTAGAAAGCAATAAGATAGACAAAGATGTCGCAGAAACTGCCAAAAATATCAGTGAAATCGCTCTTAAGAACAAA
AAAGAAAAGAGTGGGGAATTTGTAGATGAAAATGGTAATCCCATTGATGACAAAAAGAAAACAGAAAAACAAGATGAAAC
AAGCCCTGTCAAACAGGCCTTTATAGGCAAGAGTGATCCCACATTTGTTTTAGCGCAATACACCCCTATTGAAATCACTC
TGACTTCTAAAGTAGATGCCACTCTCACAGGTATAGTGAGTGGGGTTGTGGCCAAAGATGTATGGAACATGAACGGCACC
ATGATCTTACTAGACAAAGGCACTAAGGTGTATGGGAATTATCAAAGCGTGAAAGGTGGCACACCCATTATGACACGCTT
AATGATAGTCTTTACTAAAGCCATTACGCCTGATGGTGTGATAATACCTCTAGCAAACGCTCAAGCAGCAGGCATGTTGG
GTGAAGCAGGGGTAGATGGCTATGTGAATAATCACTTTATGAAGCGCATAGGCTTTGCTGTGATAGCAAGCGTGGTTAAT
AGCTTCTTGCAAACTGCGCCTATCATAGCTCTAGATAAACTCATAGGCCTTGGCAAAGGTAGAAGTGAAAGGACACCTGA
ATTTAATTACGCTTTGGGTCAAGCTATCAATGGTAGTATGCAAAGTTCAGCTCAGATGTCTAATCAAATTCTAGGGCAAC
TGATGAATATCCCCCCAAGTTTTTACAAAAATGAGGGCGATAGTATTAAAATTCTCACAATGGACGATATTGATTTTAGT
GGCGTATATGATGTTAAAATTACCAACAAATCTGTGGTAGATGAAATTATCAAACAAAGCACTAAAACTTTGTCTAGAGA
GCATGAAGAAATCACCACAAGCCCCAAAGGTGGCAATTAA

Protein sequence :
MNEENDKLETSKKTQQHSPQDLSNEETIKANHFEDSSKESKENSDHHLDNSTETKTNFDGEKSEETQTQMDSGDNETSES
SNLADKLFKKARKLVDNKRPFTQQKNLDEEIQEPNEEDDQENNGYQEEIQMDLIDDETSKKTQQHSPQDLSNEETIKANH
FEDSSKESKENSDHHLDNSTETKTNFDGEKSEEITNDSNDQEIIKGSKKKYIIGGIVVAVLIVIILFSRSIFHYFIPLED
KSSRFSKDRNLYVNDEIQIRQEYNRLLKERNEKGNMIDKNLFFNDDPNRTLYNYLNIAEIEDKNPLRAFYECISNGGNYE
ECLKLIKDKKLQDQMKKTLEAYNDCIKNAKTEEERIKCLDLIKDENLKKSLLNQQKVQVALDCLKNAKTDEERNECLKLI
NDPEIREKFRKELELQKELQEYKDCIKNAKTEAEKNECLKGLSKEAIERLKQQALDCLKNAKTDEERKKCLKNIPQDLQK
ELLADMSVKAYKDCVSKARNEKEKKECEKLLTPEAKKKLEQQVLDCLKNAKTDEERKKCLKDLPKDLQSDILAKESVKAY
KDCVSQARTEAEKKECEKLLTPEAKKLLEEEAKESVKAYLDCVSQAKTEAEKKECEKLLTPEAKKKLEEAKKSVKAYLDC
VSQAKTEAEKKECEKLLTPEARKLLEQQALDCLKNAKTEAEKKRCVKDLPKDLQKKVLAKESVKAYLDCVSQAKTEAEKK
ECEKLLTPEAKKLLEEAKESLKAYKDCVSRARNEKEKKECEKLLTPEAKKLLEQQALDCLKNAKTEAEKKRCVKDLPKDL
QKKVLAKESVKAYLDCVSQAKTEAEKKECEKLLTPEARKLLEEAKESLKAYKDCVSRARNEKEKKECEKLLTPEAKKLLE
QEVKKSVKAYLDCVSQAKTEAEKKECEKLLTPEARKFLAKQALDCLKNAKTEAEKKRCVKDLPKDLQKKVLAKESVKAYL
DCVSRARNEKEKKECEKLLTPEARKLLEEAKESLKAYKDCLSQARNEEERKACEKLLTPEARKLLEQEVKKSVKAYLDCV
SQAKTEAEKKECEKLLTPEARKFLAKQALSCLEKARNEEERKACLKNIPKDLQKNVLAKESLKAYKDCLSQARNEEERKA
CEKLLTPEARKLLEQEVKKSVKAYLDCVSRARNEKEKQECEKLLTPEARKFLAKELQQKDKAIKDCLKNADPNDRAAIMK
CLDGLSDEEKLKYLQEAREKAVLDCLKTARTDEEKRKCQNLYSDLIQEIQNKRTQSKQNQLSKTERLHQASECLDNLDDP
TDQEAIEQCLEGLSDSERALILGIKRQADEVDLIYSDLRNRKTFDNMAAKGYPLLPMDFKNGGDIATINATNVDADKIAS
DNPIYASIEPDITKQYETEKTIKDKNLEAKLAKALGGNKKDDDKEKSKKSTAEARVESNKIDKDVAETAKNISEIALKNK
KEKSGEFVDENGNPIDDKKKTEKQDETSPVKQAFIGKSDPTFVLAQYTPIEITLTSKVDATLTGIVSGVVAKDVWNMNGT
MILLDKGTKVYGNYQSVKGGTPIMTRLMIVFTKAITPDGVIIPLANAQAAGMLGEAGVDGYVNNHFMKRIGFAVIASVVN
SFLQTAPIIALDKLIGLGKGRSERTPEFNYALGQAINGSMQSSAQMSNQILGQLMNIPPSFYKNEGDSIKILTMDDIDFS
GVYDVKITNKSVVDEIIKQSTKTLSREHEEITTSPKGGN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cagY AGC69789.1 cag pathogenicity island protein Y Virulence cag PAI Protein 0.0 93
HP0527 BAD13833.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 92
HP0527 BAD14052.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 92
cagY YP_005777271.1 cag pathogenicity island protein Y VirB10-like protein Virulence cag PAI Protein 0.0 91
HP0527 BAD13998.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 91
HP0527 BAD13943.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 91
cagY YP_005774542.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 91
cagY AGC69792.1 cag pathogenicity island protein Y Virulence cag PAI Protein 0.0 91
HP0527 BAD14026.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 90
HP0527 BAD13970.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 90
HP0527 NP_207323.1 cag pathogenicity island protein (cag7) Virulence cag PAI Protein 0.0 90
cag-Y AAF80198.1 Cag-Y Virulence cag PAI Protein 0.0 89
cagY AGC69786.1 cag pathogenicity island protein Y Virulence cag PAI Protein 0.0 89
HP0527 BAD13888.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 88
cagY YP_005779063.1 cag island protein Virulence cag PAI Protein 0.0 88
HP0527 BAD13779.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 88
HP0527 BAD13915.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 84
cagY AGC69787.1 cag pathogenicity island protein Y Virulence cag PAI Protein 0.0 84
orf13/14 NP_223194.1 cag island protein Virulence cag PAI Protein 0.0 83
cagY YP_005775730.1 cag pathogenicity island protein Y VirB10-like protein Virulence cag PAI Protein 0.0 83
HP0527 BAD13860.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 83
cagY AGC69785.1 cag pathogenicity island protein Y Virulence cag PAI Protein 0.0 79
cagY AGC69788.1 cag pathogenicity island protein Y Virulence cag PAI Protein 0.0 79

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HPSAT_04140 YP_005768472.1 cag pathogenicity island protein (cagY, cag7) VFG0287 Protein 0.0 90