Gene Information

Name : HPSAT_04065 (HPSAT_04065)
Accession : YP_005768457.1
Strain : Helicobacter pylori Sat464
Genome accession: NC_017359
Putative virulence/resistance : Virulence
Product : cag pathogenicity island protein (cagA, cag26)
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 807367 - 810846 bp
Length : 3480 bp
Strand : -
Note : -

DNA sequence :
ATGGCTAACGACAATCAAATAAAAAATCCATATCTAGATCAAACACCAAGCCAAACGGCTTTTGATCCACAACAATTTAT
CAATAATCTTCAAGTGGCTTTCATTAAAGTTGATAGCGCTGTCGCTTCATTTGATCCCGATCAAAAACCAATCGTTGATA
AGAACGATAGGGATAACAGGCAAGCTTTTAATAAAATCTCGCAATTAAGAGAAGAATACGCCAATAAAGCGATCAAAAAT
CCCACCAAAAAGAATCAGTATTTTTCAGAATTTATCGGTAAGAGCAATGATTTGATCAACAAAGACAATCTCATTGATAC
AGATTCTTCCACAAAGAGCTTTGAGAAATTTGGGACTGAGCGTTACCAAATTTTTATGAATTGGGTGTCCCATCAAAAAG
ATCCGTCTAAAATCAACACCCAAAAAATCCGAAATTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAAGAA
AAAGCGGAGTTTTTGAGGTCTGCCAAACAATCTTTTGCAGGAATTATCATAGGAAACCAAATCCGATCGGATGAAAAATT
CATGGGCGTGTTTGAAGAATCTTTGAAAGAGAGGCAAGAAGCAGAAAAAAAAGGAGAGCTTGCTGGTGGGGATTGGTTTG
ATATTTTTTTATCGTTTGTGTTTGGCAAAGAACAATCTTCTGATCTCAAAGAAACGCTCAATCAAGAGCCAAGGCCTAGC
GTTGAACAAAATATAGCCACTACCCCCACCGACATACAAGGCTTACCGCCTGAAGCTAGGGATTTGCTTGATGAAAGAGG
TAATTTTTCTAAATTCACTCTTGGTGATATGGAAATGTTGGATGTTGAGGGTGTCGCCGACATTGATCCTAATTACAAGT
TCAACCAGTTATTGATTCACAATAACGCTCTGTCTTCTATGCTAATGGGGAGTCATAGCAACATAGAACCTGAAAAAGTT
TCATTGTTGTATGGGGATAATGGTGGCCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTTATAAAAACCAACAAGG
CAACAATGTGGCCACACTCATCAATATGCATCTTAAAAACGGCAGTGGGTTAGTCATAGCGGGTAATGAAAATGGGATTA
ACAACCCTAGCTTCTATCTCTACAAAAAAGACCAACTCACAGGCTTGAAACAAGCGTTGAGTCAAGAAGAGATCCAAAAC
AAAGTGGATTTCATGGAATTTCTTGCACAAAACAACGCCAGATTAGATAACTTGAGCGAGGAAGAGAAAGGAAAGTTCCA
AAATGAGATTGGAAATTTCCAAAAAGACCCTAAGGCTTATTTAGACGCCCTAGGGAATGATCGCATTGCTTTTGTTTCTA
AAAAAGACCAAAAGCATTTAGCTTTGGTTACTGAGTTTGGTAATGGGGGATTGAGCTATACCCTTAAAGATTATGGGAAA
AAACAAGATAGAGCTTTAGATAGGGAGACAAAAACCACTCTTCAAGGTAACCTAAAAGATGATGGCGTGATGTTTGTCAA
TTATTCCAATTTCAAATACACCAACGCCTCCAAGAGTCCTAATGAGGGTATAGGTGCTACGAATGGCGTTTCCCATTTGG
AAGCAAATTTTAGCAAGGTAGCTGTCTTTAATTTGTCTGATTTAAATAGTCTCGCTATCTCTAGTTTTGCAAGGCGGAAC
TTAGAGGATACACTGATCGCTAAGGGATTGCCCCCAAAAGAAGCTAATAAGATCATCAAAGACTTTTTGAACAGCAACAA
GGAATTGCTTGGAAAATCTTTAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAATACAGGCAATTATGACGGAGTGAAAA
AAGCTCAAAAAGATCTTGAAAAATCTATAAGGAAACGAGAGCTTTTAGAGAAAGAAGTAACGAAAAAATTTGAGAGCAAG
AGCGGCAACAAAAATAAAATGGAAGCAAAAGCTCAAGCTAACAGCAAAAAAGATGAGATTTTTGCGCTTATCAATAAAGA
GGCTTATAAGGATGCAAGAATCACCGCTTACGCTCAGAATCTTAAAAACATCAAGAGGGAATTGTCTGATAAAATTGAAA
ATATCAACAAGAATTTGAAAGACTTTGGTCAATCTTTTGATGCGCTCAAAAGTGGCAAAAATAAGGATTTCAGCAAGGCA
GAAGAAACGCTAAAAGCCCTTAAAAGTTCGGTGAAAGATTTGGGTATCAATCCAGAATGGATTTCAAAAGTTGAAAACCT
TAATGCAGCTTTGAATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACACAAGCAAAAAGCGACCTTGAAA
ATTCCATTAAGGATGTGCTCATCAATCAAGAGATAACGGATAAAGTTGACAATCTCAATCAGGCTGTATTAATAGCTAAA
GCGATAGGCGATTTCAGTGGGGTAGAGCAAGCGCTAGCCGAACTCAAAAACTTCTCAACGGATCAAAAAGTTGGAAAAAA
TTCTGATCTACAAAAATCCGTTAAAAATGGTGTAAATGAAATCCTAGTCGGTAATGGGTTATCTAAAACAGAAGCCACAA
CGCTCACCAAAAAATTTTCGGACATTAAGAAAGAATTGAATGAGAAATTTGCAAATTTCAACAAAAATAATGATGGACTT
AAAAACAGTGCAGAGCCCATTTATGCTCAAGTTAATAAAAAGAAAACAGGACAAGCAGCTAGCCCTGAAGAGCCCATTTA
CACTCAAGTTGCTAAAAAGGTAAATGCAAAAATTGATCAACTCAACAAAAATGCATCAGCAAGTAAAGGAGTGGGCGATT
TTAGTGGAGCAGGGCGATTAGATAGCCCTGAACCCATTTACGCTACGATTGATGATCTCGGCGGATCTTTCTCTTTGAAA
AGGCATGCTAAAGTTGATGATCTCACTAAGGTAGGGCTTTCAAGGGAGCAAGAATTGACTCAGAAAATTGGCAATCTCAA
TCAGGCAGTGTCAGAAGCTAAAGCAGGTTTTTTTGGCAACCTAGAACAAACGATGGATAGACTCAAAGATTCTACAAAAA
AGAATGTTGTGAATCTATGGGTTGAAGATACAAAAAAAGTGCCTACTAGTTTGCAAGCGAAATTGGACAATTACACTACT
AACAACCACACACGCATTAATAGCAATGTCAAAAATGGAACAATCAATGAAAAAGCGATCGGCATGCTAACGCAAAAAAA
CCCTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCGCATAATGTGGGAAGCACTCCTTTGTCAGATTATGATAAAA
TTGGATTCAACCAAAAGAATATGAAAGATTATTCTGATTCGTTCAAGTTTTCCACCAAGTTGAGCAATGCCGTAAAAAAC
ATTAAGTCTGGCTTTGAGCAATTTTTAACCGATTGCATTTCTGCAGGATCTTACAACCCGATGAAAGCGGAACATGGAGT
TAAAAATATTAATACAAAAAGTGGTTTCCAGAAATCTTAA

Protein sequence :
MANDNQIKNPYLDQTPSQTAFDPQQFINNLQVAFIKVDSAVASFDPDQKPIVDKNDRDNRQAFNKISQLREEYANKAIKN
PTKKNQYFSEFIGKSNDLINKDNLIDTDSSTKSFEKFGTERYQIFMNWVSHQKDPSKINTQKIRNFMENIIQPPISDDKE
KAEFLRSAKQSFAGIIIGNQIRSDEKFMGVFEESLKERQEAEKKGELAGGDWFDIFLSFVFGKEQSSDLKETLNQEPRPS
VEQNIATTPTDIQGLPPEARDLLDERGNFSKFTLGDMEMLDVEGVADIDPNYKFNQLLIHNNALSSMLMGSHSNIEPEKV
SLLYGDNGGPEARHDWNATVGYKNQQGNNVATLINMHLKNGSGLVIAGNENGINNPSFYLYKKDQLTGLKQALSQEEIQN
KVDFMEFLAQNNARLDNLSEEEKGKFQNEIGNFQKDPKAYLDALGNDRIAFVSKKDQKHLALVTEFGNGGLSYTLKDYGK
KQDRALDRETKTTLQGNLKDDGVMFVNYSNFKYTNASKSPNEGIGATNGVSHLEANFSKVAVFNLSDLNSLAISSFARRN
LEDTLIAKGLPPKEANKIIKDFLNSNKELLGKSLNFNKAVAEAKNTGNYDGVKKAQKDLEKSIRKRELLEKEVTKKFESK
SGNKNKMEAKAQANSKKDEIFALINKEAYKDARITAYAQNLKNIKRELSDKIENINKNLKDFGQSFDALKSGKNKDFSKA
EETLKALKSSVKDLGINPEWISKVENLNAALNEFKNGKNKDFSKVTQAKSDLENSIKDVLINQEITDKVDNLNQAVLIAK
AIGDFSGVEQALAELKNFSTDQKVGKNSDLQKSVKNGVNEILVGNGLSKTEATTLTKKFSDIKKELNEKFANFNKNNDGL
KNSAEPIYAQVNKKKTGQAASPEEPIYTQVAKKVNAKIDQLNKNASASKGVGDFSGAGRLDSPEPIYATIDDLGGSFSLK
RHAKVDDLTKVGLSREQELTQKIGNLNQAVSEAKAGFFGNLEQTMDRLKDSTKKNVVNLWVEDTKKVPTSLQAKLDNYTT
NNHTRINSNVKNGTINEKAIGMLTQKNPEWLKLVNDKIVAHNVGSTPLSDYDKIGFNQKNMKDYSDSFKFSTKLSNAVKN
IKSGFEQFLTDCISAGSYNPMKAEHGVKNINTKSGFQKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cagA BAC10423.1 CagA Virulence cag PAI Protein 0.0 84
cagA BAC10430.1 CagA Virulence cag PAI Protein 0.0 84
cagA YP_005777288.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 83
cagA BAC10426.1 CagA Virulence cag PAI Protein 0.0 83
cagA BAD51755.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 83
cagA BAC10435.1 CagA Virulence cag PAI Protein 0.0 83
HP0547 BAD14072.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 83
cagA BAC10431.1 CagA Virulence cag PAI Protein 0.0 83
HP0547 BAD13963.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 83
cagA BAD51754.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 83
HP0547 BAD13880.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 83
cagA AAF17597.1 CagA Virulence cag PAI Protein 0.0 83
cagA YP_005775747.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 83
cagA BAD51749.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA BAC10419.1 CagA Virulence cag PAI Protein 0.0 82
cagA BAD51762.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA BAC10433.1 CagA Virulence cag PAI Protein 0.0 82
HP0547 BAD14018.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 82
cagA BAC10420.1 CagA Virulence cag PAI Protein 0.0 82
cagA YP_005779046.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 82
cagA BAC10421.1 CagA Virulence cag PAI Protein 0.0 82
HP0547 BAD13799.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 82
cagA BAD51744.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 82
cagA YP_005774524.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 82
cagA AGC69806.1 cag pathogenicity island protein A Virulence cag PAI Protein 0.0 82
cagA BAD51759.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51758.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51760.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51756.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51752.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51764.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51753.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA YP_003728762.1 cytotoxin-associated protein A Virulence cag PAI Protein 0.0 81
HP0547 BAD13826.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAC10422.1 CagA Virulence cag PAI Protein 0.0 81
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen Virulence cag PAI Protein 0.0 80
cagA BAD51766.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
HP0547 NP_207343.1 cag pathogenicity island protein (cag26) Virulence cag PAI Protein 0.0 80
cagA BAD51751.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51750.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA AAR03881.1 CagA Virulence cag PAI Protein 0.0 80
cagA AAR03939.1 CagA Virulence cag PAI Protein 0.0 80
cagA AAC44706.1 CagA Virulence cag PAI Protein 0.0 79
cagA BAD51761.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA AAR03909.1 CagA Virulence cag PAI Protein 0.0 79
cagA AAR03970.1 CagA Virulence cag PAI Protein 0.0 79
cagA BAC10427.1 CagA Virulence cag PAI Protein 0.0 79
cagA AAF17598.1 CagA Virulence cag PAI Protein 0.0 79
HP0547 BAD14045.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 78
cagA BAD51747.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
HP0547 BAD13853.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAC10428.1 CagA Virulence cag PAI Protein 0.0 77
HP0547 BAD13908.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAC10429.1 CagA Virulence cag PAI Protein 0.0 76
HP0547 BAD13935.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
HP0547 BAD13990.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 75
cagA BAC10432.1 CagA Virulence cag PAI Protein 0.0 75
cagA BAC10424.1 CagA Virulence cag PAI Protein 0.0 69

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HPSAT_04065 YP_005768457.1 cag pathogenicity island protein (cagA, cag26) VFG0306 Protein 0.0 80