Gene Information

Name : HPCU_00500 (HPCU_00500)
Accession : YP_005766194.1
Strain : Helicobacter pylori Cuz20
Genome accession: NC_017358
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : -
COG ID : -
EC number : 2.5.1.48
Position : 100375 - 101517 bp
Length : 1143 bp
Strand : -
Note : COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases

DNA sequence :
ATGCACATGCAAACAAAATTAATCCATGGGGGTATTAGTGAGGATGCGACAACGGGGGCGGTGAGCGTGCCTATTTATCA
AACTTCCACCTACCGCCAAGACGCCATAGGCCGCCACAAGGGCTATGAATACTCTCGCTCAGGCAACCCCACGCGCTTTG
CTTTAGAAGAGCTCATCGCCGATTTAGAAGGGGGGGTTAAGGGGTTTGCTTTTGCCTCTGGTTTAGCTGGGATCCACGCC
GTTTTTTCCCTCTTGCAATCAGGCGATCATGTGCTATTAGGCGATGATGTCTATGGGGGGACTTTTCGCTTGTTCAATAA
AGTGCTTGTCAAAAACGGGCTTTCTTGCACCATTATAGACACTAGCGATCTATCCCAGATCAAAAAGGCTATCAAGCCCA
ACACCAAAGCCCTTTATTTAGAAACCCCTAGTAACCCCCTGCTTAAAATCACGGATTTAGCGCAATGCGCCAGTGTCGCT
AGAGATCATGGTTTGCTCACTATCGTGGATAACACCTTTGCCACCCCCTATTGCCAAAACCCGCTTCTTTTGGGGGCGGA
CATTGTGGTGCATAGCGGCACCAAATACTTAGGCGGGCATAGCGATGTGGTCGCTGGGCTTGTAACCACTAGTAATGAAG
CGCTAGCCCAAGAGATCGCTTTTTTCCAAAACGCTATCGGTGGGGTTTTAGGCCCTCAAGACAGCTGGCTGTTGCAAAGA
GGGATTAAAACGCTAGGATTACGCATGGAGGCCCATCAAAAAAACGCTCTTTGCGTGGCTGAGTTTTTAGAAAAACACCC
TAAAGTGGAAAGGGTTTATTACCCGGGCCTAAGCGCTCACCCTAACCACGAGTTGGCCAAAAAACAGATGCGTGGCTTTA
GCGGGATGCTCTCTTTCACTCTCAAAAATGACAGCGAAGCGGTTGCTTTTGTAGAAAGCCTTAAATTATTCATTTTAGGC
GAGAGTTTGGGCGGGGTGGAAAGTTTGGTGGGGATTCCAGCATTCATGACCCATGCGTGTATCCCCAAAGTGCAACGAGA
AGCTGCCGGGATTAGAGATGGCCTGGTGCGCTTGTCTGTGGGGATTGAGCATGAACAGGATTTGTTAGAAGATTTAAAGC
AAGCGTTCGCTAAAATAAAATAA

Protein sequence :
MHMQTKLIHGGISEDATTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA
VFSLLQSGDHVLLGDDVYGGTFRLFNKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVA
RDHGLLTIVDNTFATPYCQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTSNEALAQEIAFFQNAIGGVLGPQDSWLLQR
GIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLSAHPNHELAKKQMRGFSGMLSFTLKNDSEAVAFVESLKLFILG
ESLGGVESLVGIPAFMTHACIPKVQREAAGIRDGLVRLSVGIEHEQDLLEDLKQAFAKIK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-101 54
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-102 54
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 2e-75 47

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HPCU_00500 YP_005766194.1 cystathionine gamma-synthase BAC0207 Protein 4e-65 44