Gene Information

Name : HPV225_0552 (HPV225_0552)
Accession : YP_005763483.1
Strain : Helicobacter pylori v225d
Genome accession: NC_017355
Putative virulence/resistance : Virulence
Product : Cytotoxicity-associated immunodominant antigen
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 530126 - 533629 bp
Length : 3504 bp
Strand : +
Note : -

DNA sequence :
ATGGCTAACGAAACCATCAATCAAACAAAAAAACCAGATCAAACACCAAGCCAAACGGCTTTTAATCCACAACAATTTAT
CAGTAATCTTCAAGTGGCTTTTATTAAACTTGATAGTGCTGTCGCTTCATTTGATCCCGATCAAAAACCAATCGTTGATA
AGAACGATAGGGATAACAGGCAAGCTTTTAATGTAATCTCGCAATTAAGGGAAGAATACGCCAATAAAGCGATCAAAAAT
CCCACCAAAAAGAATCAGTATTTTTCAGACTTTATCGATAAGAGCAATGATTTGATCAACAAAGACAATCTCATTGATAT
AGATTCTTCCACAAAGAGCTTTGAAAAATTTGGGGCTCAGCGTTACCAAATTTTTATGAATTGGGTGTCCCATCAAAAAG
ATCCGTCTAAAATCAACACCCAAAAAATCCGAAATTTTATGGAAAATATCATACAACCCCCTATCTCTGATGATAAAGAA
AAAGCGGAGTTTTTGAGGTCTGCCAAACAATCTTTTGCAGGAATTATCATAGGGAACCAAATCCGATCGGATGAAAAATT
CATGGGCGTGTTTGATGAATCTTTGAAAGAGAGGCAAGAAGCAGAAAAAAATGGAGAGCCTGCTGGTGGGGATTGGCTTG
ATATTTTTTTATCGTTTGTATTTAACAAAGAACAATCTTCTGATCTCAAAGAAACGCTCAATCAAGAGCCAAGGCCTAAT
GTTGAACAAAATGTAGCCTCTACCCCCACCCACATACAAGGCTTACCGCCTGAAGCTAGGGATTTGCTTGATGAAAGGGG
TGATTTTTCTAAATTCACTCTTGGTGATATGGAGATGTTGGATGTTGAGGGTGTCGCCGACATTGATCCTAATTACAAGT
TCAACCAGTTATTGATTCACAATAACGCTCTGTCTTCTATGCTAATGGGGAGTCATAGCAGCATAGAACCTGAAAAAGTT
TCATTGTTGTATGGGGATAATGGTGGTCCTGAAGCTAGGCATGATTGGAACGCCACCGTTGGTTATAAAAACCAACAAGG
CAACAATGTGGCCACACTCATCAATGCGCATCTTAAAAACGGCAGCGGGTTAGTCATAGCGGGTAATGGAAATGGGATTA
ACAACCCTAGCTTCTATCTCTACAAAACAGACCAACTCACAGGCTTGGAACAAGCGTTGAGTCAAGAAGAGATCCAAAAC
AAAGTGGATTTCATGGAACTTCTTGCACAAAACAACGCTAGATTAGATAACTTGAGCGAGGAAGAGAAAGAAAAGTTCCA
AACTGAGATTGGAAATTTCCAAAAAGACCCTAAGGCTTATTTAGACTCCCTAGGGAATGATCGCATTGCTTTTGTTTCTA
AAAAAGACCAAAAGCATTTAGCTTTGGTTACTGAGTTTGGTAATGGGGAATTGAGCTATACTCTCAAAGATTATGGGAAA
AAACAAGATAGAGCTTTAGATAGGGAGACAAAAACCACTCTTCAAGGTAACCTAAAGCATGATGGCGTGATGTTTGTCAA
TTATTCCAATTTCAAATACACCAACGCCTCCAAGAGTCCTGATGAGGGTATAGGCGCTACGAATGGCGTTTCCCATTTGG
AAGCAAATTTTAGCAAGGTGGCTGTCTTTAATTTGCCTGATTTAAATGGTCTCGCTATCTCTAGTTTTGCAAGGCGGAAT
TTAGAGGATAAACTGATCGCTAAAGGATTGCCCCCAAAAGACGCTAATAAGATCATCAAAGACTTTTTGAACAGCAACAA
GGAATTGCTTGAAAAAGCTTTAGACTTCAATAAAGCTGTAGCTGAAGCTAAAAATACAGGCAATTATGACGGAGTGAAAA
AAGCTCAAAAAGATCTTGAAAAATCTATAAGGAAACGAGAGCGTTTAGAGCAAGAAATAACGAAAAAATTTGAGAACAAG
AGCGGCAACAAAAATAAAATGGAAGCGAAAGTTCAAGCTAACAGCCAAAAAGATGGGATTTTTAAGCTTATCAATGAAGA
GGCTCATAAGGAAGCAAGAATCGCCGCTTACGCTCAGAATCTTAAAGGCATCAGGAGGGAATTGTCTGATAAAATTGAAA
ATATCAACAAGAATTTGAAAGACTTTGATAAATCTTTTGATGCGCTCAAAAGTGGCAAAAATAAGGATTTCAGCAAGGCA
GAAGAAACGCTAAAAGCCCTTGAAAGCTCGGTGAAAGATTTGGGTATCAATCCAGAATGGATTTCAAAAGTTGAAAACCT
TAATGCAGCTTTGAATGAATTCGAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACACAAGCAAAAAGCGACCTTGAAA
ATTCCATTAAGGATGTGCTCATCAATCAAGAGATAACGGATAAAGTTGACAATCTCAATCAGGCTGTATTAACAGCTAAA
GCGATAGGCGATTTTAGTGGGGTAGAGCAAGCGTTAGCCGAACTCAAAAACTTCTCAACGAATCAAAAGTCTGATCTACA
AAAATCCGTTAAAAATGGTGTAAATGGAACCCTAGTCGGTAATGGGTTATCTAAAACAGAAGCCACAACGCTCACCAAAA
AATTTTCGGACATTAAGAAAGAATTGAATGAGAAATTTGCAAATTTCAACAACAATAATAATGGACTCAAAAACAGCACA
GAGCCCATTTACGCTAAAGTTAACAAAAAGAAAACAGGACAAGTAGCTAGCCCTGAAGAGTCCATTTACACTCAAGTTGC
TAAACAGGTAAATGCAAAAATTGACCAACTCAACAAAATTGCATCAGCAAGTAAAGGAGTGGGCGATTTTAGTGGATTAG
GGCAATCAGATAGCTCTGAACCCATTTACGCTACGATTGATGATCTCGGCGGACCTTTCCCTTTGAGTAGATTAGGGCGA
TCAGATAGCCCTGAACCCATTTACGCTACAATTGATCTCAGTAAGGTAGGGCTTTCAAGGGAGCAAGAATTGACTCAGAA
AATTGGCAATCTCACTCAGAAAATTGGCAATCTCAATCAGGCAGTGTCAGAAGCTAAAGCAGGTTTTTTTGGCAACCTAG
AACAAACGATGGATAGACTCAAAGATTCTACAAAAAAGAATGTTGTGAATCTATGGGTTGAAAGTGTAAAAGTAGTGCCT
GCTAGTTCGCAAGCGAAATTGGACAATTACGCTACTAACAGCCACACACGCATTAATAGCAATGTCAAAAATGGAACAAT
CAATGAAAAAGCGATCGGCATGCTAACGCAAAAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAGATAGTTGCGCATA
ATGTGGGAAGCGCTCCTTTGTCAGCTTATGATAAAATTGGATTCAACCAAAAGAATATGAAAGATTATTCTGATTCGTTC
AAGTTTTCCACCAAGTTGAACAATGCCGTAAAAAACATTAAGTCTGGCTTTAAGCAACTTTTAACCGATTGCATTTCTGC
AGGATCTTACAGCCCGAAGAAAGCGGAATATGGAGTTACAAAAAGTGGTTTCCAGAAATCTTAA

Protein sequence :
MANETINQTKKPDQTPSQTAFNPQQFISNLQVAFIKLDSAVASFDPDQKPIVDKNDRDNRQAFNVISQLREEYANKAIKN
PTKKNQYFSDFIDKSNDLINKDNLIDIDSSTKSFEKFGAQRYQIFMNWVSHQKDPSKINTQKIRNFMENIIQPPISDDKE
KAEFLRSAKQSFAGIIIGNQIRSDEKFMGVFDESLKERQEAEKNGEPAGGDWLDIFLSFVFNKEQSSDLKETLNQEPRPN
VEQNVASTPTHIQGLPPEARDLLDERGDFSKFTLGDMEMLDVEGVADIDPNYKFNQLLIHNNALSSMLMGSHSSIEPEKV
SLLYGDNGGPEARHDWNATVGYKNQQGNNVATLINAHLKNGSGLVIAGNGNGINNPSFYLYKTDQLTGLEQALSQEEIQN
KVDFMELLAQNNARLDNLSEEEKEKFQTEIGNFQKDPKAYLDSLGNDRIAFVSKKDQKHLALVTEFGNGELSYTLKDYGK
KQDRALDRETKTTLQGNLKHDGVMFVNYSNFKYTNASKSPDEGIGATNGVSHLEANFSKVAVFNLPDLNGLAISSFARRN
LEDKLIAKGLPPKDANKIIKDFLNSNKELLEKALDFNKAVAEAKNTGNYDGVKKAQKDLEKSIRKRERLEQEITKKFENK
SGNKNKMEAKVQANSQKDGIFKLINEEAHKEARIAAYAQNLKGIRRELSDKIENINKNLKDFDKSFDALKSGKNKDFSKA
EETLKALESSVKDLGINPEWISKVENLNAALNEFENGKNKDFSKVTQAKSDLENSIKDVLINQEITDKVDNLNQAVLTAK
AIGDFSGVEQALAELKNFSTNQKSDLQKSVKNGVNGTLVGNGLSKTEATTLTKKFSDIKKELNEKFANFNNNNNGLKNST
EPIYAKVNKKKTGQVASPEESIYTQVAKQVNAKIDQLNKIASASKGVGDFSGLGQSDSSEPIYATIDDLGGPFPLSRLGR
SDSPEPIYATIDLSKVGLSREQELTQKIGNLTQKIGNLNQAVSEAKAGFFGNLEQTMDRLKDSTKKNVVNLWVESVKVVP
ASSQAKLDNYATNSHTRINSNVKNGTINEKAIGMLTQKNPEWLKLVNDKIVAHNVGSAPLSAYDKIGFNQKNMKDYSDSF
KFSTKLNNAVKNIKSGFKQLLTDCISAGSYSPKKAEYGVTKSGFQKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cagA BAC10422.1 CagA Virulence cag PAI Protein 0.0 82
HP0547 BAD13826.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 82
cagA YP_005777288.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA AAF17597.1 CagA Virulence cag PAI Protein 0.0 81
cagA BAC10431.1 CagA Virulence cag PAI Protein 0.0 81
HP0547 BAD13963.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAD51755.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51754.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAC10435.1 CagA Virulence cag PAI Protein 0.0 81
cagA YP_005775747.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
HP0547 BAD14072.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
HP0547 BAD13880.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAD51749.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51762.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAC10433.1 CagA Virulence cag PAI Protein 0.0 81
HP0547 BAD14018.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 81
cagA BAC10426.1 CagA Virulence cag PAI Protein 0.0 80
cagA BAD51764.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51756.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAC10420.1 CagA Virulence cag PAI Protein 0.0 80
cagA BAC10421.1 CagA Virulence cag PAI Protein 0.0 80
HP0547 BAD13799.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 80
cagA BAD51744.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA YP_005779046.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 80
cagA BAC10419.1 CagA Virulence cag PAI Protein 0.0 80
cagA YP_005774524.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 80
cagA BAD51759.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA BAD51752.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA BAD51753.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA AGC69806.1 cag pathogenicity island protein A Virulence cag PAI Protein 0.0 79
cagA YP_003728762.1 cytotoxin-associated protein A Virulence cag PAI Protein 0.0 79
cagA BAD51766.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
HP0547 NP_207343.1 cag pathogenicity island protein (cag26) Virulence cag PAI Protein 0.0 79
cagA BAC10424.1 CagA Virulence cag PAI Protein 0.0 79
cagA BAD51750.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA BAD51751.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA BAD51760.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA BAD51758.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA AAR03970.1 CagA Virulence cag PAI Protein 0.0 78
cagA BAD51761.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA BAD51747.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA BAC10423.1 CagA Virulence cag PAI Protein 0.0 78
cagA AAR03939.1 CagA Virulence cag PAI Protein 0.0 78
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen Virulence cag PAI Protein 0.0 77
cagA AAR03909.1 CagA Virulence cag PAI Protein 0.0 77
cagA BAC10428.1 CagA Virulence cag PAI Protein 0.0 77
HP0547 BAD13908.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
HP0547 BAD13853.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAC10427.1 CagA Virulence cag PAI Protein 0.0 77
cagA AAR03881.1 CagA Virulence cag PAI Protein 0.0 77
cagA BAC10430.1 CagA Virulence cag PAI Protein 0.0 77
cagA AAC44706.1 CagA Virulence cag PAI Protein 0.0 76
HP0547 BAD14045.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
HP0547 BAD13935.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA BAC10429.1 CagA Virulence cag PAI Protein 0.0 76
cagA BAC10432.1 CagA Virulence cag PAI Protein 0.0 76
HP0547 BAD13990.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 76
cagA AAF17598.1 CagA Virulence cag PAI Protein 0.0 75

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HPV225_0552 YP_005763483.1 Cytotoxicity-associated immunodominant antigen VFG0306 Protein 0.0 79