Gene Information

Name : HPKB_0795 (HPKB_0795)
Accession : YP_005762303.1
Strain : Helicobacter pylori 52
Genome accession: NC_017354
Putative virulence/resistance : Virulence
Product : cytotoxin-associated protein A
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 830992 - 834618 bp
Length : 3627 bp
Strand : -
Note : Consensus COG by CONSORF: COG0419

DNA sequence :
ATGACTAACGAAATCATTGATCAAACAACAACACCAAATCAAACAGATTTTGTTCCGCAACGATTTATTAATAATCTTCA
AGTGGCTTTTCTTAAAGTTGATAACGCTGTTGCTTCATTTGATCCCGATCAAAAACCAATCGTTGATAAGAATGATAGGG
ATAATAGGCAAGCTTTTGAGAAAATCTCGCAACTAAAGGAAGAATACGCCAATAAAGCGATCAAAAATCCCACCAAAAAG
AATCAGTATTTTTCAGACTTTATCAATAAGAGCAATGATTTGATCAACAAAGACAATCTCATTGCTGTAGATTCTTCCGT
AGAGAGCTTTCGGAAATTTGGGGATCAGCGTTACCAAATTTTTATGAATTGGGTGTCCCATCAAAAAGATCCGTCTAAAA
TCAACACCCAACAAATCCGAAATTTTATGGAAAATATCATACAACCTCCTATCTCTGATGATAAGGAAAAAGCGGAGTTT
TTGAGGTCTGCCAAACAATCTTTTGCAGGAATTATCATAGGGAACCAAATCCGATCGGATCAAAAATTCATGGGCGTGTT
TGATGAATCTTTGAAAGAAAGGCAAGAAGCAGAAAAAAATGGAGAGCCTGCTGGTGGGGATTGGCTTGATATTTTTTTAT
CATTTGTGTTTAACAAAAAACAATCTTCCGATCTCAAAGAAACGCTCAATCAAGAGCCAAGGCCTGATTTTGAACAAAAT
TTAGCCACTACCACCACCAACATACAAGGCTTACCGCCTGAATCTAGGGATTTGCTTGATGAAAGGGGTAATTTTTTTAA
ATTCACTCTTGGTGATGTGGAGATGTTGGATGTTGAGGGAGTCGCTGACAAGGATCCCAATTACAAGTTCAATCAATTAT
TGATCCACAATAACGCTCTATCTTCTGTGCTAATGGGGGGTCATAGCAACATAGAACCTGAAAAAGTTTCATTATTGTAT
GGGGGCAATGGTGGTCCTGAAGCTAGGCATGATTGGAACGCTACCGTTGGTTACAAAAACCAACAAGGCAACAATGTGGC
CACACTCATTAATGCGCATCTTAATAACGGTAGTGGGTTAATCATAGCGGGTAATGAAAATGGGATTAAAAATCCTAGCT
TCTATCTCTATAAAGAAGATCAACTCACAGGCTTGAAACAAGCGTTGAGTCAAGAAGAGATCCAAAACAAAGTGGATTTC
ATGGAATTTCTCGTGCAAAACAACGCTAAATTAGATAACTTGAGCGAGAAAGAGAAAGAAAAATTCCAAACTGAGATTGA
AAATTTCCAAAAAGACCGTAAGGCTTATTTGGACGCTCTAGGGAATGATCACATTGCTTTTGTTTCTAAAAAAGACCCAA
AACATTTAGCTTTGGTTACTGAGTTTGGTAATGGGGAAGTGAGCTACACTCTCAAAGATTATGGGAAAAAACAAGATAAA
GCTTTAGATGGGGAGACAAAAACCACTCTTCAAGGTAACCTAAAACATGATGGCGTGATGTTTGTCAATTATTCCAATTT
CAAATACACCAATGCCTCCAAGAGTCCTGATAAGGGTGTAGGTGCTACGAATGGCGTTTCCCGTTTGGAAGCAAATCTTA
GCAAGGTAGCTGTCTTTAATTTGCCTAATTTAAATAATCTCGCTATCACTAATTATATAAGGCGAGATTTAGAAGATAAA
CTGTGGGCTAAAGGATTGTCCCCACAAGAAGCTAATAAGCTCATCAAAGACTTTTTAAACAGCAACAAAGAATTGCTTGG
AAAAGTTTCAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAATTATGACGAAGTGAAAAAAGCTCAGAAAG
ATCTTGAAAAATCTCTAAGGAAACGAGAGCATTTAGAGAAAGAAGTAGCGAAAAAATTGGAGAGCAGAAACGACAACAAA
AATAGAATGGAAGCAAAAGCTCAAGCTAACAGCCAAAAAGATAAGATTTTTGCGTTGATCAATCAAGAGGCTAGTAAGGA
AGCAAGAGCGGTCGCTTTCGATCCGAATCTTAAAGGCGTCAGGAGCGAATTGTCTGATAAACTTGAAAATATCAACAAGA
ATTTGAAAGACTTTGGCAAATCTTTTGATGAACTCAAAAGTGGCAAAAATAATGATTTCAATAAGGCAGAAGAAACGCTA
AAAGCCCTTAAAGACTCGGTGAAAGATTTAGGCATCAATCCAGAATGGATTTCAAAAATTGAAAACCTTAATGCAGCTTT
GAATGATTTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACACAAGCAAAAAGCGACTTTGAAAATTCCATTAAGG
ATGTGATCATCAATCAAAAGATAACGGATAAAGTTGACAATCTCAATCAGGCTGTATCAGAGACTAAATTAACAGGCGAT
TTCAGTAAGGTAGAGCAAGCCCTAGCCGAACTCAAAAACTTGTCATTGGATCTTGGAAAAAATTCTGATCTACAAAAATC
CGTTAAAAATGGTGTAAATGGAACCCTAGTCGGTAATGGGTTGTCTAAAACAGAAGCCACAACGCTCGCCAAAAATTTTT
CGGACATCAGGAAAGAATTGAACGAGAAATTATTTGGAAATTCCAATAACAATAATAATGGACTCAAAAACAGCACAGAG
CCCATTTACGCTAAAGTTGCTAAAAAGGTGAGTGTAAAAATTGACCAACTCAACGAAGCTACATCAGCAATAAATAGAAA
AATTGACCGGATTAACAAAATTGCATCAGCAGGTAAAGGAGTGGGCGGTTTCAGTGGAGCAGGGCGATCAGCTAGCCCTG
AACCCATTTACGCTCAAGTTGCTAAAAAGGTGAGTGCAAAAATTGACCAACTCAACGAAGCTACATCAGCAATAAATAGA
AAAATTGACCGGATTAACAAAATTGCATCAGCAGGTAAAGGAGTGGGCGGTTTCAGTGGAGCAGGGCGATCAGCTAGCCC
TGAACCCATTTACGCTACAATTGATTTTGATGAGGCAAATCAAGCAGGCTTCCCTCTTATGAGAAGTGCTGCAGTTAATG
ATCTCAGTAAAGTAGGGCTTTCAAGGGAACAAGAATTGACTCGTAGAATTGGCGATCTCAATCAGGCGGTATCAGAAGCT
AAAACAGGTCATTTTGGCAACCTAGAACAAAAGATAGATGAACTCAAAGATTCTACGAAAAAGAATGCTTTGAAGCTATG
GGTTGAAAGCGCGAAACAAGTGCCTACTGGTTTGCAAGCGAAATTAGACAATTACGCTACTAACAGCCACACACGCATTA
ATAGCAATGTCCAAAGTGGAGCAATCAATGAAAAAGCGACCGGTATGCTGATGCAAAAAAATCCTGAGTGGCTCAAGCTC
GTGAATGATAAGATAGTTGCGCATAATGTGGGAAGCACTCCTTTGTCAGAGTATGATAAAATTGGATTCAACCAAAAGAA
TATGAAAGATTATTCTGATTCGTTCAAGTTTTCCACCAAGTTGAACAATGCTGTAAAAGACGTTAAGTCTGACTTTGTGC
AATTTTTAACCAATGCATTTTCTACAGGATCTTACAGCTTGATGAAAGCAAATGCGGAACATGGAGTCAAAAATACTAAT
ACAAAAGGTGGTTTCCAAAAATCTTAA

Protein sequence :
MTNEIIDQTTTPNQTDFVPQRFINNLQVAFLKVDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLKEEYANKAIKNPTKK
NQYFSDFINKSNDLINKDNLIAVDSSVESFRKFGDQRYQIFMNWVSHQKDPSKINTQQIRNFMENIIQPPISDDKEKAEF
LRSAKQSFAGIIIGNQIRSDQKFMGVFDESLKERQEAEKNGEPAGGDWLDIFLSFVFNKKQSSDLKETLNQEPRPDFEQN
LATTTTNIQGLPPESRDLLDERGNFFKFTLGDVEMLDVEGVADKDPNYKFNQLLIHNNALSSVLMGGHSNIEPEKVSLLY
GGNGGPEARHDWNATVGYKNQQGNNVATLINAHLNNGSGLIIAGNENGIKNPSFYLYKEDQLTGLKQALSQEEIQNKVDF
MEFLVQNNAKLDNLSEKEKEKFQTEIENFQKDRKAYLDALGNDHIAFVSKKDPKHLALVTEFGNGEVSYTLKDYGKKQDK
ALDGETKTTLQGNLKHDGVMFVNYSNFKYTNASKSPDKGVGATNGVSRLEANLSKVAVFNLPNLNNLAITNYIRRDLEDK
LWAKGLSPQEANKLIKDFLNSNKELLGKVSNFNKAVAEAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVAKKLESRNDNK
NRMEAKAQANSQKDKIFALINQEASKEARAVAFDPNLKGVRSELSDKLENINKNLKDFGKSFDELKSGKNNDFNKAEETL
KALKDSVKDLGINPEWISKIENLNAALNDFKNGKNKDFSKVTQAKSDFENSIKDVIINQKITDKVDNLNQAVSETKLTGD
FSKVEQALAELKNLSLDLGKNSDLQKSVKNGVNGTLVGNGLSKTEATTLAKNFSDIRKELNEKLFGNSNNNNNGLKNSTE
PIYAKVAKKVSVKIDQLNEATSAINRKIDRINKIASAGKGVGGFSGAGRSASPEPIYAQVAKKVSAKIDQLNEATSAINR
KIDRINKIASAGKGVGGFSGAGRSASPEPIYATIDFDEANQAGFPLMRSAAVNDLSKVGLSREQELTRRIGDLNQAVSEA
KTGHFGNLEQKIDELKDSTKKNALKLWVESAKQVPTGLQAKLDNYATNSHTRINSNVQSGAINEKATGMLMQKNPEWLKL
VNDKIVAHNVGSTPLSEYDKIGFNQKNMKDYSDSFKFSTKLNNAVKDVKSDFVQFLTNAFSTGSYSLMKANAEHGVKNTN
TKGGFQKS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cagA BAC10422.1 CagA Virulence cag PAI Protein 0.0 95
HP0547 BAD13826.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 95
cagA BAC10435.1 CagA Virulence cag PAI Protein 0.0 93
HP0547 BAD14072.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 93
cagA YP_005775747.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 93
cagA BAD51754.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 93
cagA BAC10427.1 CagA Virulence cag PAI Protein 0.0 93
cagA YP_005774524.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 92
cagA BAC10421.1 CagA Virulence cag PAI Protein 0.0 92
HP0547 BAD13799.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 92
cagA BAC10431.1 CagA Virulence cag PAI Protein 0.0 92
cagA BAD51744.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 92
cagA YP_005779046.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 92
HP0547 BAD13963.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 92
cagA BAD51755.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 92
cagA BAD51749.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 92
cagA BAC10420.1 CagA Virulence cag PAI Protein 0.0 92
cagA BAC10419.1 CagA Virulence cag PAI Protein 0.0 92
HP0547 BAD13880.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 92
cagA AAF17597.1 CagA Virulence cag PAI Protein 0.0 92
cagA BAD51762.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 92
cagA BAC10433.1 CagA Virulence cag PAI Protein 0.0 91
HP0547 BAD14018.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 91
HP0547 BAD13853.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 91
cagA BAC10423.1 CagA Virulence cag PAI Protein 0.0 91
cagA BAC10424.1 CagA Virulence cag PAI Protein 0.0 89
cagA BAC10430.1 CagA Virulence cag PAI Protein 0.0 88
cagA YP_005777288.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 87
cagA BAC10426.1 CagA Virulence cag PAI Protein 0.0 86
cagA BAD51764.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 84
cagA BAD51752.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 81
cagA BAD51759.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51756.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 80
cagA BAD51750.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA BAD51760.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA BAD51758.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA BAD51766.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 79
cagA BAC10429.1 CagA Virulence cag PAI Protein 0.0 79
HP0547 BAD13935.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 79
cagA BAD51751.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA BAD51761.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA YP_003728762.1 cytotoxin-associated protein A Virulence cag PAI Protein 0.0 78
cagA BAD51753.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 78
cagA AGC69806.1 cag pathogenicity island protein A Virulence cag PAI Protein 0.0 78
cagA BAC10428.1 CagA Virulence cag PAI Protein 0.0 77
HP0547 BAD13908.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA BAC10432.1 CagA Virulence cag PAI Protein 0.0 77
HP0547 BAD13990.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 77
cagA AAR03970.1 CagA Virulence cag PAI Protein 0.0 76
cagA AAR03881.1 CagA Virulence cag PAI Protein 0.0 76
cagA AAR03939.1 CagA Virulence cag PAI Protein 0.0 76
cagA AAC44706.1 CagA Virulence cag PAI Protein 0.0 75
HP0547 BAD14045.1 cag pathogenicity island protein Virulence cag PAI Protein 0.0 75
cagA AAR03909.1 CagA Virulence cag PAI Protein 0.0 75
HP0547 NP_207343.1 cag pathogenicity island protein (cag26) Virulence cag PAI Protein 0.0 75
cagA BAD51747.1 cytotoxin associated protein A Virulence cag PAI Protein 0.0 75
cagA AAF17598.1 CagA Virulence cag PAI Protein 0.0 74
cagA NP_223213.1 cag island protein, cytotoxicity associated immunodominant antigen Virulence cag PAI Protein 0.0 68

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HPKB_0795 YP_005762303.1 cytotoxin-associated protein A VFG0306 Protein 0.0 75