Gene Information

Name : hsdM (SARLGA251_00560)
Accession : YP_005754069.1
Strain : Staphylococcus aureus LGA251
Genome accession: NC_017349
Putative virulence/resistance : Unknown
Product : type I restriction-modification system DNA methylase
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 65672 - 67186 bp
Length : 1515 bp
Strand : +
Note : Similar to Staphylococcus haemolyticus (strain JCSC1435) hsdm subname: full=type i restriction-modification system dna methylase UniProt:Q4LAF2 (EMBL:AP006716) (504 aa) fasta scores: E()=5.3e-195, 87.9% id in 504 aa

DNA sequence :
ATGGCAACAATTGGATTTGAAGAAAAGTTATGGCAAGCGGCGGATAAGTTACGTGGAAGTATGGATGCAGCAGAATATAA
AAATGTAGCATTAGGTATTATATTTTTGAAATATGTTTCTGATTCATTTGAGGAAAAGTATGAAGAATTATTAAATGATG
AATATGCCGATGAAGAAGATAAAGATGAATACTTAGCAGAAAATATTTTCTGGGTTCCTAAAGAATCAAGATGGCAATAC
ATAAATGATAATTCTAAGAAACCAGAAATTGGTCAAATTATCGATAAAGCTATGATAGCAATTGAAAGAGAAAATGAGTC
TTTAAAAGGAGTGCTACCTAAAGATTATGCAAGACCTGCATTAGATAAAGAGAAATTAGGAGATATTATCGACCTATTTA
CTTTCAAAGTTGGGGATTCTGAAAGTAAAAAACAAGACGTCTTAGGACGTGTTTATGAATATTTCATCGCTAAGTTTGCA
AGCGCTGAAGGTAAAAATGCAGGTGAATTCTATACACCAGCTTCAATAGTTAAATTACTTGTTGAAATGGTTGAACCATA
TGAAGGTAGAATCTATGACCCCTGCTGTGGTTCCGGCGGTATGTTTGTACAAAGTGAACGTTTTGTAGAACGTCACCAAG
GACGCTTAGATAATATTGCGGTATACGGTCAAGAATCAAATCCAACCACTTGGAAATTAGCAAAAATGAATTTGGCTATT
CGAGGTATAGATAATGATTTAGGTGATCATCATGCAGACACGTTTCATAATGATTTACATAAAGATTTGAAAGCTGATTT
TATATTGGCTAATCCACCATTCAATGCAAGTGATTGGGGACGAGAAAAATTACTAGATGATTACCGCTGGAAATTTGGTA
TTCCACCTAAAGGCAATGCCAACTATGCATGGATTGAACATATGATTTCTAAACTTGCCCCAAGTGGTACAGCAGGATTT
GTATTAGCGAATGGTTCAATGTCTACAAGTGGTAAAGATGAATTAGAAATACGTAAAAACTTAATTGAACAAGACTTAGT
TGAATGTATAGTTACATTACCAGGGCAACTATTCTATTCAACTCAAATTCCAGTATGTTTGTGGTTCGTGACAAAAAATA
AAGCTAAAAACGGCAAGAATGAACGACGTGGAGAAGTACTATTTATAGATGCTAGAAATATAGGAAGCATGGTATCAAGA
ACATTAAAAGAATTCTCAGATGATGAAATAAAAGATATAGCAAATGTTTATCACTCATGGCGTGGAACAAACAATAACCA
ATATGAAGATAAAGCAGGTTTCTGTAAAGTAGCAAAGACAGAAGAAATAAAAAACAATGAATATATCTTAACGCCGGGAC
GTTATGTAGGATTAGCAGAAGTAGAAGAAGACTCAGAACCATTTGAACAGAAAATGGAAAGAATCACAGCAGATTTAAGT
GAACAATTTGCGAAATCAAAAGAACTCGAGGACCAAATCCGTAAGTCATTGGAGGGATTAGGTTATGGAGTTTGA

Protein sequence :
MATIGFEEKLWQAADKLRGSMDAAEYKNVALGIIFLKYVSDSFEEKYEELLNDEYADEEDKDEYLAENIFWVPKESRWQY
INDNSKKPEIGQIIDKAMIAIERENESLKGVLPKDYARPALDKEKLGDIIDLFTFKVGDSESKKQDVLGRVYEYFIAKFA
SAEGKNAGEFYTPASIVKLLVEMVEPYEGRIYDPCCGSGGMFVQSERFVERHQGRLDNIAVYGQESNPTTWKLAKMNLAI
RGIDNDLGDHHADTFHNDLHKDLKADFILANPPFNASDWGREKLLDDYRWKFGIPPKGNANYAWIEHMISKLAPSGTAGF
VLANGSMSTSGKDELEIRKNLIEQDLVECIVTLPGQLFYSTQIPVCLWFVTKNKAKNGKNERRGEVLFIDARNIGSMVSR
TLKEFSDDEIKDIANVYHSWRGTNNNQYEDKAGFCKVAKTEEIKNNEYILTPGRYVGLAEVEEDSEPFEQKMERITADLS
EQFAKSKELEDQIRKSLEGLGYGV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hsdM BAH57701.1 type I restriction-modification system DNA methylase Not tested Type-VII SCCmec Protein 0.0 89
hsdM YP_251979.1 type I restriction-modification system DNA methylase Not tested SCCmec Protein 0.0 88
hsdM BAD24842.1 HsdM protein Not tested Type-V SCCmec Protein 0.0 87
api49 CAF28523.1 putative HsdM-like N-methyl transferase Not tested YAPI Protein 2e-122 49