Gene Information

Name : mecR1 (SARLGA251_00270)
Accession : YP_005754042.1
Strain : Staphylococcus aureus LGA251
Genome accession: NC_017349
Putative virulence/resistance : Resistance
Product : methicillin resistance protein MecR1
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 37779 - 39533 bp
Length : 1755 bp
Strand : +
Note : Similar to Staphylococcus aureus mecr1 recname: full=methicillin resistance mecr1 protein UniProt:P0A0B1 (EMBL:L14020) (585 aa) fasta scores: E()=4.7e-106, 44.8% id in 585 aa

DNA sequence : 
TTGCTACAACAATTCTTGATAATGAGTATAATTAGTTCAATTATGACTTTGTTATTAATTATGATTGTCCGTATTATATG
TATTAAGTATTTTAAGGCTCAGTTAAATCATAAAGTTTGGTTACTAGTTGTTCTTTCAATATTTTTACCTTTAATACCGA
TAAATAATTTATTGCAACTTAACATTCCAGGTATACTTTCATCTGATATGATTTCACATTCATCTAAGTCTATAAATCAT
AATTTATCAAATGAAAATACTAATTTAACAAAAGATTTAGCTTTGGATATCCAGCATCATGAAATGCCGTTTATCCTAAT
TATTTTACTAGTAGTTTGGTTTATTGGATTAATATTTTTTAGCTTTAAATTTATTTCTGCTATTAAGCAAATTGCCTTTA
TAAAAGACTTGTCTATTAGATCTCCAATATTAGATAACCAATTAAAAAAATGTATAAATGATTTAAACATCAAAGAAAAA
TCTATTGCAATTATTCATGTAGATGAAGTAGAGAATCCAATGGTCTTTTGGCTAGGAAAGTACTATATTGTTTTGCCTAC
AAATATAATGGATATGATGGAAGAAGAAGAAATTGATTATATAATTAGCCATGAACTCATTCATATTAAGAATAAGGATT
TATGGGGCAATTATATATTCACAATTTTCACTAGTATAGTATGGTTCAATCCAGCATTACATTTAGCAAAAAAATTATTT
AATATTGATTGTGAAATTTCATGTGATAATCAAGTTCTTACAAAATTAAGTCAATCAAATCACACAAGCTATGGTAAGGC
AATTTTGAAATGTTGGGCTATACAGAAACAATCAGTTAATAATTTTGCAGCAAAATATTTATTAGGCACACAATCTAATT
TAAAGAGTCGTATTGTGAATGTTTCAAAATTTAAAAATACTCGAAATCGTAAATGGAAATTCTTACCCTATGTGGTTTTA
TCTGTATTGATTTTACTGCAAGGGTTGATGGTTTCTGATCATTCTGACAAGAATGAATATACGGATGATATCAAATACAC
AAACTTGAAAGGATTAGGTTCTCATTTCTCAGGTTTTAAGGGTAGCTTTGTATTATATGATAATCAGAAAAAAGAGTATT
TCTTATATAACGAAAAAGAAAGTAGAAAAAGATACACACCTGATTCTACATATAAACCGTATTTAGCATTAATTGGATTT
GATAAAAATGTTATGTCATTGAATAATACTGAACAAAAATGGAATGGCAATGAAAATGTTTTTAAAGAATGGAATCAAAA
TCAAAATTTAAGTTCAGCAATGAGGTATTCTGTGAATTGGTATTTTGAGAATATAGATAGAAGTATAAAAAATAAAGATC
TTAAAAATTATATAAGTGAATTACAGTATGGTAATGAAAACATATCAGGAAGTAAAAATTATTGGAATGAGTCCTCTTTA
AAAATTTCTGCAATAGAACAAGTTAAGTTGTTAATGAAGATAGATAATCAACAACTTAAATTTGATGAAAATTATATCAA
CGCTGTAAAAGATAGTATTACGCTAAAAAAAGCTAACCAATATAGATATCTAGGTAAAACTGGAACAGGTATTATAAACG
GCAAGGAAACGAATGGATGGTTTATTGGAACAATTGAGAAAAACGGAAAATCTTACTACTTTGCCACACACTTAGACGGT
AAGAATAATGCCAGTGGTAAGAAAGCGAAAGATATTTCTGAAAAAATTCTTGAAGAAATGGAGTTAATGCAATGA

Protein sequence : 
MLQQFLIMSIISSIMTLLLIMIVRIICIKYFKAQLNHKVWLLVVLSIFLPLIPINNLLQLNIPGILSSDMISHSSKSINH
NLSNENTNLTKDLALDIQHHEMPFILIILLVVWFIGLIFFSFKFISAIKQIAFIKDLSIRSPILDNQLKKCINDLNIKEK
SIAIIHVDEVENPMVFWLGKYYIVLPTNIMDMMEEEEIDYIISHELIHIKNKDLWGNYIFTIFTSIVWFNPALHLAKKLF
NIDCEISCDNQVLTKLSQSNHTSYGKAILKCWAIQKQSVNNFAAKYLLGTQSNLKSRIVNVSKFKNTRNRKWKFLPYVVL
SVLILLQGLMVSDHSDKNEYTDDIKYTNLKGLGSHFSGFKGSFVLYDNQKKEYFLYNEKESRKRYTPDSTYKPYLALIGF
DKNVMSLNNTEQKWNGNENVFKEWNQNQNLSSAMRYSVNWYFENIDRSIKNKDLKNYISELQYGNENISGSKNYWNESSL
KISAIEQVKLLMKIDNQQLKFDENYINAVKDSITLKKANQYRYLGKTGTGIINGKETNGWFIGTIEKNGKSYYFATHLDG
KNNASGKKAKDISEKILEEMELMQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
mecR1 YP_005754042.1 methicillin resistance protein MecR1 Not tested Type-XI SCCmec Protein 0.0 100
mecR1 BAA82219.2 sensor transducer protein MecR1 Not tested Type-II SCCmec Protein 4e-109 45
mecR1 YP_039516.1 methicillin resistance protein MecR1 Not tested Type-II SCCmec Protein 5e-109 45
mecR1 NP_370566.1 methicillin resistance protein Not tested Type-II SCCmec Protein 5e-109 45
mecR1 NP_373279.1 methicillin resistance protein Not tested Type-II SCCmec Protein 5e-109 45
mecR1 YP_190061.1 methicillin-resistance regulatory protein MecR1 Not tested Type-II SCCmec Protein 5e-109 45
mecR1 BAC57479.1 signaltransducer protein MecR1 Not tested Type-IIIinv SCCmec Protein 4e-109 45

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
mecR1 YP_005754042.1 methicillin resistance protein MecR1 FR823292.1.gene4.p01 Protein 0.0 100
mecR1 YP_005754042.1 methicillin resistance protein MecR1 HE993884.1.gene10.p0 Protein 0.0 85
mecR1 YP_005754042.1 methicillin resistance protein MecR1 NC_002758.1120002.p0 Protein 2e-109 45
mecR1 YP_005754042.1 methicillin resistance protein MecR1 NC_009782.5560215.p0 Protein 2e-109 45
mecR1 YP_005754042.1 methicillin resistance protein MecR1 NC_002745.1122813.p0 Protein 2e-109 45
mecR1 YP_005754042.1 methicillin resistance protein MecR1 NC_002952.2861159.p0 Protein 2e-109 45