Gene Information

Name : mecA (SARLGA251_00260)
Accession : YP_005754041.1
Strain : Staphylococcus aureus LGA251
Genome accession: NC_017349
Putative virulence/resistance : Resistance
Product : beta-lactam-inducible penicillin-binding protein
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 35681 - 37678 bp
Length : 1998 bp
Strand : -
Note : Similar to Staphylococcus aureus pbp recname: full=beta-lactam-inducible penicillin-binding protein UniProt:P07944 (EMBL:Y00688) (670 aa) fasta scores: E()=2e-160, 61.3% id in 674 aa

DNA sequence :
ATGAAAAAAATTTATATTAGTGTGCTAGTTCTTTTACTAATTATGATTATAATAACTTGGTTATTCAAAGATGACGATAT
TGAGAAAACAATTAGTTCTATTGAAAAAGGAAACTATAACGAAGTATATAAAAATAGTTCAGAAAAATCTAAACTGGCAT
ATGGAGAAGAAGAAATTGTAGATAGGAATAAAAAAATTTACAAAGATTTAAGTGTCAATAACTTAAAAATTACTAATCAT
GAAATTAAAAAAACTGGAAAAGATAAAAAGCAAGTTGATGTTAAATATAACATATATACAAAATATGGAACTATACGACG
TAATACACAATTAAACTTTATTTATGAAGATAAGCATTGGAAATTAGATTGGAGACCAGACGTAATAGTACCTGGTTTGA
AAAATGGACAGAAAATTAATATAGAAACATTAAAATCAGAGCGAGGCAAAATAAAAGATAGAAATGGTATAGAATTAGCT
AAAACTGGAAATACATATGAAATCGGTATTGTCCCTAACAAAACACCCAAAGAAAAATATGATGATATTGCTCGTGACTT
ACAAATTGATACAAAAGCTATAACCAATAAAGTTAATCAAAAATGGGTTCAGCCAGATTCATTTGTACCAATTAAAAAGA
TAAATAAACAAGATGAATATATAGACAAATTAATTAAATCATACAATTTACAAATAAACACTATAAAAAGCCGTGTTTAT
CCATTGAACGAAGCAACAGTACACCTTTTAGGTTATGTGGGTCCAATTAATTCTGACGAGTTAAAAAGTAAGCAATTTAG
AAACTATAGCAAAAATACTGTTATTGGAAAAAAAGGCTTAGAACGCCTCTATGATAAACAATTGCAAAACACTGATGGTT
TTAAGGTATCCATTGCAAATACTTATGACAATAAACCTTTAGACACATTATTGGAGAAAAAGGCTGAAAACGGAAAAGAT
CTTCATTTAACTATAGATGCTAGAGTACAAGAAAGTATTTATAAACATATGAAAAATGACGATGGATCTGGTACAGCATT
ACAACCAAAAACTGGAGAAATTTTAGCTTTGGTAAGTACCCCATCGTACGATGTTTATCCATTCATGAATGGATTAAGCA
ATAATGACTACCGTAAATTAACTAACAATAAAAAAGAGCCTTTGCTCAACAAATTTCAAATCACTACATCACCAGGTTCA
ACCCAAAAAATATTAACATCTATTATAGCCTTAAAAGAAAATAAACTAGACAAAAATACTAATTTTGATATTTATGGTAA
GGGTTGGCAAAAAGATGCATCATGGGGGAATTATAATATCACAAGATTTAAAGTAGTAGACGGCAATATCGATTTAAAGC
AAGCAATAGAATCATCAGACAACATATTTTTTGCCCGCATTGCATTAGCATTAGGAGCCAAAAAATTTGAGCAAGGTATG
CAAGATTTGGGAATCGGTGAAAATATCCCGAGTGATTATCCCTTTTATAAAGCACAAATCTCAAATAGTAATTTAAAAAA
TGAAATATTATTAGCAGATTCAGGATATGGCCAAGGCGAGATACTAGTAAACCCTATACAAATTTTATCAATATACAGTG
CTTTAGAAAATAACGGAAATATACAAAATCCTCATGTTTTACGTAAAACAAAATCTCAAATATGGAAAAAAGATATTATA
CCTAAAAAAGACATAGATATATTAACTAATGGTATGGAACGTGTAGTTAATAAAACACATAGGGATGATATATACAAAAA
TTATGCCCGAATTATTGGTAAATCTGGCACAGCAGAATTAAAAATGAATCAAGGGGAAACTGGAAGACAAATAGGTTGGT
TTGTTTCATATAATAAAAATAATCCTAATATGTTAATGGCGATTAATGTTAAAGACGTTCAAAATAAAGGGATGGCCAGC
TATAATGCTACTATATCTGGAAAAGTTTATGATGATTTGTATGATAATGGAAAAACTCAATTTGATATAGATCAGTAA

Protein sequence :
MKKIYISVLVLLLIMIIITWLFKDDDIEKTISSIEKGNYNEVYKNSSEKSKLAYGEEEIVDRNKKIYKDLSVNNLKITNH
EIKKTGKDKKQVDVKYNIYTKYGTIRRNTQLNFIYEDKHWKLDWRPDVIVPGLKNGQKINIETLKSERGKIKDRNGIELA
KTGNTYEIGIVPNKTPKEKYDDIARDLQIDTKAITNKVNQKWVQPDSFVPIKKINKQDEYIDKLIKSYNLQINTIKSRVY
PLNEATVHLLGYVGPINSDELKSKQFRNYSKNTVIGKKGLERLYDKQLQNTDGFKVSIANTYDNKPLDTLLEKKAENGKD
LHLTIDARVQESIYKHMKNDDGSGTALQPKTGEILALVSTPSYDVYPFMNGLSNNDYRKLTNNKKEPLLNKFQITTSPGS
TQKILTSIIALKENKLDKNTNFDIYGKGWQKDASWGNYNITRFKVVDGNIDLKQAIESSDNIFFARIALALGAKKFEQGM
QDLGIGENIPSDYPFYKAQISNSNLKNEILLADSGYGQGEILVNPIQILSIYSALENNGNIQNPHVLRKTKSQIWKKDII
PKKDIDILTNGMERVVNKTHRDDIYKNYARIIGKSGTAELKMNQGETGRQIGWFVSYNKNNPNMLMAINVKDVQNKGMAS
YNATISGKVYDDLYDNGKTQFDIDQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
mecA YP_005754041.1 beta-lactam-inducible penicillin-binding protein Not tested Type-XI SCCmec Protein 0.0 100
mecA BAA82220.1 penicillin binding protein 2' Not tested Type-II SCCmec Protein 0.0 65
mecA YP_190062.1 penicillin-binding protein 2' Not tested Type-II SCCmec Protein 0.0 65
SAPIG0042 YP_005732852.1 penicillin-binding protein 3 (pbp 3) (pspb20) Not tested Type-V SCCmec Protein 0.0 65
mecA YP_184944.1 penicillin-binding protein 2' Not tested Type-I SCCmec Protein 0.0 65
mecA YP_252006.1 penicillin binding protein 2 prime Not tested SCCmec Protein 0.0 65
mecA BAA86650.1 penicillin-binding protein 2' Not tested Type-I SCCmec Protein 0.0 65
mecA YP_039515.1 penicillin-binding protein 2 prime Not tested Type-II SCCmec Protein 0.0 65
mecA BAC57478.1 penicillin-binding protein 2' Not tested Type-IIIinv SCCmec Protein 0.0 65
mecA BAD24826.1 penicillin-binding protein 2' Not tested Type-V SCCmec Protein 0.0 65
SAMSHR1132_00320 YP_005324556.1 penicillin-binding protein 2 prime Not tested Type-IIIinv SCCmec Protein 0.0 65
mecA BAC67568.1 penicillin-binding protein 2' Not tested Type-IVc SCCmec Protein 0.0 65
unnamed ACL99850.1 penicillin binding protein 2a Not tested Type-V SCCmec Protein 0.0 65
mecA NP_644846.1 penicillin binding protein 2 prime Not tested Type-IV SCCmec Protein 0.0 65
mecA BAB47623.1 penicillin-binding protein 2' Not tested Type-III SCCmec Protein 0.0 65
mecA NP_370565.1 penicillin binding protein 2 prime Not tested Type-II SCCmec Protein 0.0 65
mecA BAB72113.1 penicillin-binding protein 2' Not tested Type-IVa SCCmec Protein 0.0 65
mecA NP_373278.1 penicillin binding protein 2 prime Not tested Type-II SCCmec Protein 0.0 65
mecA BAB72132.1 penicillin-binding protein 2' Not tested Type-IVb SCCmec Protein 0.0 65
mecA YP_492752.1 penicillin-binding protein 2' Not tested Type-IV SCCmec Protein 0.0 65
mecA BAG06200.1 penicillin-binding protein 2' Not tested Type-VII SCCmec Protein 0.0 65

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
mecA YP_005754041.1 beta-lactam-inducible penicillin-binding protein FR823292.1.gene3.p01 Protein 0.0 100
mecA YP_005754041.1 beta-lactam-inducible penicillin-binding protein NC_002745.1122812.p0 Protein 0.0 65
mecA YP_005754041.1 beta-lactam-inducible penicillin-binding protein NC_009782.5559258.p0 Protein 0.0 65
mecA YP_005754041.1 beta-lactam-inducible penicillin-binding protein NC_002952.2861157.p0 Protein 0.0 65
mecA YP_005754041.1 beta-lactam-inducible penicillin-binding protein AB096217.gene.p01 Protein 0.0 65
mecA YP_005754041.1 beta-lactam-inducible penicillin-binding protein NC_002758.1120001.p0 Protein 0.0 65
mecA YP_005754041.1 beta-lactam-inducible penicillin-binding protein NC_003923.1004781.p0 Protein 0.0 65
mecA YP_005754041.1 beta-lactam-inducible penicillin-binding protein NC_010079.5776902.p0 Protein 0.0 65
mecA YP_005754041.1 beta-lactam-inducible penicillin-binding protein NC_007793.3913904.p0 Protein 0.0 65
mecA YP_005754041.1 beta-lactam-inducible penicillin-binding protein NC_002951.3236763.p0 Protein 0.0 65