Gene Information

Name : mecA (HMPREF0772_10435)
Accession : YP_005746517.1
Strain : Staphylococcus aureus TCH60
Genome accession: NC_017342
Putative virulence/resistance : Resistance
Product : penicillin-binding protein 2
Function : -
COG functional category : -
COG ID : -
EC number : 3.4.16.4
Position : 478737 - 480743 bp
Length : 2007 bp
Strand : +
Note : COG: COG0768

DNA sequence : 
ATGAAAAAGATAAAAATTGTTCCACTTATTTTAATAGTTGTAGTTGTCGGGTTTGGTATATATTTTTATGCTTCAAAAGA
TAAAGAAATTAATAATACTATTGATGCAATTGAAGATAAAAATTTCAAACAAGTTTATAAAGATAGCAGTTATATTTCTA
AAAGCGATAATGGTGAAGTAGAAATGACTGAACGTCCGATAAAAATATATAATAGTTTAGGCGTTAAAGATATAAACATT
CAGGATCGTAAAATAAAAAAAGTATCTAAAAATAAAAAACGAGTAGATGCTCAATATAAAATTAAAACAAACTACGGTAA
CATTGATCGCAACGTTCAATTTAATTTTGTTAAAGAAGATGGTATGTGGAAGTTAGATTGGGATCATAGCGTCATTATTC
CAGGAATGCAGAAAGACCAAAGCATACATATTGAAAATTTAAAATCAGAACGTGGTAAAATTTTAGACCGAAACAATGTG
GAATTGGCCAATACAGGAACAGCATATGAGATAGGCATCGTTCCAAAGAATGTATCTAAAAAAGATTATAAAGCAATCGC
TAAAGAACTAAGTATTTCTGAAGACTATATCAAACAACAAATGGATCAAAATTGGGTACAAGATGATACCTTCGTTCCAC
TTAAAACCGTTAAAAAAATGGATGAATATTTAAGTGATTTCGCAAAAAAATTTCATCTTACAACTAATGAAACAGAAAGT
CGTAACTATCCTCTAGGAAAAGCGACTTCACATCTATTAGGTTATGTTGGTCCCATTAACTCTGAAGAATTAAAACAAAA
AGAATATAAAGGCTATAAAGATGATGCAGTTATTGGTAAAAAGGGACTCGAAAAACTTTACGATAAAAAGCTCCAACATG
AAGATGGCTATCGTGTCACAATCGTTGACGATAATAGCAATACAATCGCACATACATTAATAGAGAAAAAGAAAAAAGAT
GGCAAAGATATTCAACTAACTATTGATGCTAAAGTTCAAAAGAGTATTTATAACAACATGAAAAATGATTATGGCTCAGG
TACTGCTATCCACCCTCAAACAGGTGAATTATTAGCACTTGTAAGCACACCTTCATATGACGTCTATCCATTTATGTATG
GCATGAGTAACGAAGAATATAATAAATTAACCGAAGATAAAAAAGAACCTCTGCTCAACAAGTTCCAGATTACAACTTCA
CCAGGTTCAACTCAAAAAATATTAACAGCAATGATTGGGTTAAATAACAAAACATTAGACGATAAAACAAGTTATAAAAT
CGATGGTAAAGGTTGGCAAAAAGATAAATCTTGGGGTGGTTACAACGTTACAAGATATGAAGTGGTAAATGGTAATATCG
ACTTAAAACAAGCAATAGAATCATCAGATAACATTTTCTTTGCTAGAGTAGCACTCGAATTAGGCAGTAAGAAATTTGAA
AAAGGCATGAAAAAACTAGGTGTTGGTGAAGATATACCAAGTGATTATCCATTTTATAATGCTCAAATTTCAAACAAAAA
TTTAGATAATGAAATATTATTAGCTGATTCAGGTTACGGACAAGGTGAAATACTGATTAACCCAGTACAGATCCTTTCAA
TCTATAGCGCATTAGAAAATAATGGCAATATTAACGCACCTCACTTATTAAAAGACACGAAAAACAAAGTTTGGAAGAAA
AATATTATTTCCAAAGAAAATATCAATCTATTAACTGATGGTATGCAACAAGTCGTAAATAAAACACATAAAGAAGATAT
TTATAGATCTTATGCAAACTTAATTGGCAAATCCGGTACTGCAGAACTCAAAATGAAACAAGGAGAAACTGGCAGACAAA
TTGGGTGGTTTATATCATATGATAAAGATAATCCAAACATGATGATGGCTATTAATGTTAAAGATGTACAAGATAAAGGA
ATGGCTAGCTACAATGCCAAAATCTCAGGTAAAGTGTATGATGAGCTATATGAGAACGGTAATAAAAAATACGATATAGA
TGAATAA

Protein sequence : 
MKKIKIVPLILIVVVVGFGIYFYASKDKEINNTIDAIEDKNFKQVYKDSSYISKSDNGEVEMTERPIKIYNSLGVKDINI
QDRKIKKVSKNKKRVDAQYKIKTNYGNIDRNVQFNFVKEDGMWKLDWDHSVIIPGMQKDQSIHIENLKSERGKILDRNNV
ELANTGTAYEIGIVPKNVSKKDYKAIAKELSISEDYIKQQMDQNWVQDDTFVPLKTVKKMDEYLSDFAKKFHLTTNETES
RNYPLGKATSHLLGYVGPINSEELKQKEYKGYKDDAVIGKKGLEKLYDKKLQHEDGYRVTIVDDNSNTIAHTLIEKKKKD
GKDIQLTIDAKVQKSIYNNMKNDYGSGTAIHPQTGELLALVSTPSYDVYPFMYGMSNEEYNKLTEDKKEPLLNKFQITTS
PGSTQKILTAMIGLNNKTLDDKTSYKIDGKGWQKDKSWGGYNVTRYEVVNGNIDLKQAIESSDNIFFARVALELGSKKFE
KGMKKLGVGEDIPSDYPFYNAQISNKNLDNEILLADSGYGQGEILINPVQILSIYSALENNGNINAPHLLKDTKNKVWKK
NIISKENINLLTDGMQQVVNKTHKEDIYRSYANLIGKSGTAELKMKQGETGRQIGWFISYDKDNPNMMMAINVKDVQDKG
MASYNAKISGKVYDELYENGNKKYDIDE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
mecA NP_373278.1 penicillin binding protein 2 prime Not tested Type-II SCCmec Protein 0.0 100
mecA YP_492752.1 penicillin-binding protein 2' Not tested Type-IV SCCmec Protein 0.0 100
mecA BAB72113.1 penicillin-binding protein 2' Not tested Type-IVa SCCmec Protein 0.0 100
mecA YP_190062.1 penicillin-binding protein 2' Not tested Type-II SCCmec Protein 0.0 100
mecA BAB72132.1 penicillin-binding protein 2' Not tested Type-IVb SCCmec Protein 0.0 100
mecA BAA82220.1 penicillin binding protein 2' Not tested Type-II SCCmec Protein 0.0 100
mecA YP_039515.1 penicillin-binding protein 2 prime Not tested Type-II SCCmec Protein 0.0 100
SAMSHR1132_00320 YP_005324556.1 penicillin-binding protein 2 prime Not tested Type-IIIinv SCCmec Protein 0.0 100
mecA NP_644846.1 penicillin binding protein 2 prime Not tested Type-IV SCCmec Protein 0.0 100
mecA NP_370565.1 penicillin binding protein 2 prime Not tested Type-II SCCmec Protein 0.0 100
unnamed ACL99850.1 penicillin binding protein 2a Not tested Type-V SCCmec Protein 0.0 99
mecA YP_184944.1 penicillin-binding protein 2' Not tested Type-I SCCmec Protein 0.0 99
SAPIG0042 YP_005732852.1 penicillin-binding protein 3 (pbp 3) (pspb20) Not tested Type-V SCCmec Protein 0.0 99
mecA BAB47623.1 penicillin-binding protein 2' Not tested Type-III SCCmec Protein 0.0 99
mecA YP_252006.1 penicillin binding protein 2 prime Not tested SCCmec Protein 0.0 99
mecA BAA86650.1 penicillin-binding protein 2' Not tested Type-I SCCmec Protein 0.0 99
mecA BAC57478.1 penicillin-binding protein 2' Not tested Type-IIIinv SCCmec Protein 0.0 99
mecA BAC67568.1 penicillin-binding protein 2' Not tested Type-IVc SCCmec Protein 0.0 99
mecA BAD24826.1 penicillin-binding protein 2' Not tested Type-V SCCmec Protein 0.0 99
mecA BAG06200.1 penicillin-binding protein 2' Not tested Type-VII SCCmec Protein 0.0 99
mecA YP_005754041.1 beta-lactam-inducible penicillin-binding protein Not tested Type-XI SCCmec Protein 0.0 65

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
mecA YP_005746517.1 penicillin-binding protein 2 NC_002745.1122812.p0 Protein 0.0 100
mecA YP_005746517.1 penicillin-binding protein 2 NC_009782.5559258.p0 Protein 0.0 100
mecA YP_005746517.1 penicillin-binding protein 2 NC_002952.2861157.p0 Protein 0.0 100
mecA YP_005746517.1 penicillin-binding protein 2 NC_002758.1120001.p0 Protein 0.0 100
mecA YP_005746517.1 penicillin-binding protein 2 NC_003923.1004781.p0 Protein 0.0 100
mecA YP_005746517.1 penicillin-binding protein 2 NC_010079.5776902.p0 Protein 0.0 100
mecA YP_005746517.1 penicillin-binding protein 2 NC_007793.3913904.p0 Protein 0.0 100
mecA YP_005746517.1 penicillin-binding protein 2 AB096217.gene.p01 Protein 0.0 99
mecA YP_005746517.1 penicillin-binding protein 2 NC_002951.3236763.p0 Protein 0.0 99
mecA YP_005746517.1 penicillin-binding protein 2 FR823292.1.gene3.p01 Protein 0.0 65