Gene Information

Name : clpC (CBF_3682)
Accession : YP_005676420.1
Strain : Clostridium botulinum 230613
Genome accession: NC_017297
Putative virulence/resistance : Virulence
Product : negative regulator of genetic competence MecB/ClpC
Function : -
COG functional category : -
COG ID : -
EC number : 3.4.21.-
Position : 3839668 - 3842103 bp
Length : 2436 bp
Strand : -
Note : identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728

DNA sequence :
ATGATGTTTGGAAGATTTACGGAAAGAGCTCAGAAAGTACTTATGAATGCTCAGGAAGAAGCAGAAAAATTTAAACATGG
ATATGTAGGTACAGAACATATTCTTTTAGGAATTTTAATAGAAGATGGAGTAGCCAAAGAATTATTAAATAATTTTAGTA
TAACAGAAGATAAGGTTAGACAGTTAATAGAAAGATATGAAGGAAAAGGGGAAATGGATCTTTATAAAAATGAGATTCCA
CTTACACCAAGAACAAAAAGGTTACTTGAAATGAGTTTATTAGAAGCTAGAAATTTAAATCATAATTATATAACTCCAGA
ACATATATTATTGGGATTAATAAGAGAAGCTGAAGGGGTAGCCTTTACCATTCTTTCTAATTTAGGCTTAGATGCTGAAA
GATTAAGAAAAGAGTTAATAAAGAATTTATCTGGGCAAGAAACTCCTAAAGATGAAGGCAGTAAAAAAAGTTCTAAAAGC
TCTACCCCTACATTAGATCAATTTGGAAGAGACTTAACTGAAATGGCAGAAGAGGGGAAGGTTGACCCTGTTATTGGAAG
AGATAAAGAAACCCAAAGAGTTTTAGAAATATTATGTAGAAGAACTAAGAACAATCCTTGCTTAATAGGTGAGCCAGGAG
TTGGGAAAACAGCAATAGCCGAAGGCTTAGCTCAAAATATAATTGATGGAAATATACCAGAAATATTAAAAAACAAAAGA
GTAGTTACATTAGACTTAACATCTATGATAGCAGGGGCCAAGTATAGGGGTGAATTTGAGGATAGATTAAAGAAAATAAT
GGAGGAAGTAAGAAGTTCTAAGGATACAATATTGTTTATAGATGAAATTCATACAATAGTTGGAGCTGGGGCAGCAGAAG
GGGCTATAGATGCAGCAAACATATTAAAACCAGCATTAGCGAGAGGAGAAATTCAATGTATAGGTGCAACTACACTAGAT
GAATATAGAAAGTATATAGAAAAAGATTCTGCTTTAGAGAGAAGATTCCAGCCTATAAACGTAGGAGAACCTACAAAAGA
AGAAACAATAGAAATTTTAAAGGGATTAAGAGATAAGTATGAAGCACATCATAGAGTTAAATTTACAGATGATGCTATAT
ATGCAGCAGTTAATTTATCTGATAGATATATAAGAGATAGATTTTTGCCAGATAAAGCGATAGATCTGATGGATGAAGCT
GGTTCCAAGGTTAGAATACAAAATTTAATTGCACCACCAGATCTGAAGAATATAGAAGAACAACTAGATAAAGTTGTTAA
AGAAAAAGAAGATGCAATAAGAGTGCAGGATTTTGAAAAAGCCGCTAATTTAAGAGATAAAGAAAAAGAATTAAAAGAAA
AGTTAGAAGGGTTGAAAAAGGATTGGAATGCAGAAAAAGAAGGTTCTAATTTAATTGTATCAGAACAACAAATAGCAGCA
GTAGTTTCAAATTGGACTAATATACCAGTTAATAAGCTTACTGAAAAGGAATCTGAAAGACTCTTGAAATTAGAAAATAT
TCTTCATAATAGGGTAATCGGCCAAGAAGAAGCTATTAAATCAGTATCAAGATCTGTAAGAAGAGCAAGAGTAGGCTTGA
AAGATCCAAAGAGACCAATAGGTTCATTTATATTTTTGGGACCAACAGGTGTAGGGAAAACTGAATTGACTAAAGCCTTA
GCAGAAGCTATGTTTGGAAATGAAAATAATATGATTAGGGTTGACATGTCAGAATATATGGAAAAACATTCAGTATCTAG
ATTAATAGGATCACCTCCAGGATATATAGGGCACGATGAAGGTGGTCAATTAACAGACAAGGTAAGGACAAATCCATATT
CAGTTGTTTTATTTGATGAAATAGAAAAAGCTCATCCAGAAGTGTTTAATATATTACTTCAAATATTAGAAGATGGAAGG
CTTACAGATGGAAAAGGAAAAACAGTAGATTTCAGAAATACTATAATCATAATGACATCTAATGTGGGAGCATCAACTAT
AAGTAGGCAAAAGACATTAGGTTTTAATACCTCCATAGAAGAAGAAAGAGAAACAGAATATGAAAAAATGAAGGATAACA
TTATGAATGAATTAAAACATTCATTTAGACCAGAATTCTTAAATAGAATAGATGATATAATAGTTTTCCATCAATTAAGA
GAAGAGCATATTAGAGAAATAGTTAAACTTATGCTAAAAACTGTATCAAATAGAGTTAAAGATCAAGGAATAAAATTAGA
GTTTACAGAAGAAGCAGAAAAAATATTGGCAAAAGAAGGATACGATACTAATTATGGAGCGAGACCTTTAAGAAGAGCTA
TAACTAAAATTGTAGAAGATAAATTATCAGAAGAAATATTAAAGGGAAATATTAAAAAAGGTGATTCAGTTAAAGTTAAT
ACAATTGAAGATAAATTAAATTTTTGTAAGATGTAA

Protein sequence :
MMFGRFTERAQKVLMNAQEEAEKFKHGYVGTEHILLGILIEDGVAKELLNNFSITEDKVRQLIERYEGKGEMDLYKNEIP
LTPRTKRLLEMSLLEARNLNHNYITPEHILLGLIREAEGVAFTILSNLGLDAERLRKELIKNLSGQETPKDEGSKKSSKS
STPTLDQFGRDLTEMAEEGKVDPVIGRDKETQRVLEILCRRTKNNPCLIGEPGVGKTAIAEGLAQNIIDGNIPEILKNKR
VVTLDLTSMIAGAKYRGEFEDRLKKIMEEVRSSKDTILFIDEIHTIVGAGAAEGAIDAANILKPALARGEIQCIGATTLD
EYRKYIEKDSALERRFQPINVGEPTKEETIEILKGLRDKYEAHHRVKFTDDAIYAAVNLSDRYIRDRFLPDKAIDLMDEA
GSKVRIQNLIAPPDLKNIEEQLDKVVKEKEDAIRVQDFEKAANLRDKEKELKEKLEGLKKDWNAEKEGSNLIVSEQQIAA
VVSNWTNIPVNKLTEKESERLLKLENILHNRVIGQEEAIKSVSRSVRRARVGLKDPKRPIGSFIFLGPTGVGKTELTKAL
AEAMFGNENNMIRVDMSEYMEKHSVSRLIGSPPGYIGHDEGGQLTDKVRTNPYSVVLFDEIEKAHPEVFNILLQILEDGR
LTDGKGKTVDFRNTIIIMTSNVGASTISRQKTLGFNTSIEEERETEYEKMKDNIMNELKHSFRPEFLNRIDDIIVFHQLR
EEHIREIVKLMLKTVSNRVKDQGIKLEFTEEAEKILAKEGYDTNYGARPLRRAITKIVEDKLSEEILKGNIKKGDSVKVN
TIEDKLNFCKM

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 55

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpC YP_005676420.1 negative regulator of genetic competence MecB/ClpC VFG0079 Protein 0.0 60
clpC YP_005676420.1 negative regulator of genetic competence MecB/ClpC VFG0080 Protein 1e-150 52